JP2020507336A5 - - Google Patents
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- Publication number
- JP2020507336A5 JP2020507336A5 JP2019544727A JP2019544727A JP2020507336A5 JP 2020507336 A5 JP2020507336 A5 JP 2020507336A5 JP 2019544727 A JP2019544727 A JP 2019544727A JP 2019544727 A JP2019544727 A JP 2019544727A JP 2020507336 A5 JP2020507336 A5 JP 2020507336A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- culture medium
- condition
- container
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 9
- 239000001963 growth medium Substances 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 9
- 239000003636 conditioned culture medium Substances 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 6
- SNEIUMQYRCDYCH-LURJTMIESA-N N(alpha)-acetyl-L-arginine Chemical compound CC(=O)N[C@H](C(O)=O)CCCNC(N)=N SNEIUMQYRCDYCH-LURJTMIESA-N 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 239000004472 Lysine Substances 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 229930182830 galactose Natural products 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 239000005749 Copper compound Substances 0.000 claims 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- OVRNDRQMDRJTHS-OZRXBMAMSA-N N-acetyl-beta-D-mannosamine Chemical compound CC(=O)N[C@@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-OZRXBMAMSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 150000001880 copper compounds Chemical class 0.000 claims 2
- 230000006240 deamidation Effects 0.000 claims 2
- 230000036252 glycation Effects 0.000 claims 2
- 150000002506 iron compounds Chemical class 0.000 claims 2
- 150000002697 manganese compounds Chemical class 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 2
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 150000003752 zinc compounds Chemical class 0.000 claims 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-BKJPEWSUSA-N N-acetyl-D-hexosamine Chemical compound CC(=O)NC1C(O)O[C@H](CO)C(O)C1O OVRNDRQMDRJTHS-BKJPEWSUSA-N 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 150000003862 amino acid derivatives Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 238000006471 dimerization reaction Methods 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- -1 of Gakushio Substances 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 230000000704 physical effect Effects 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460387P | 2017-02-17 | 2017-02-17 | |
| US62/460,387 | 2017-02-17 | ||
| PCT/US2018/000030 WO2018151819A1 (en) | 2017-02-17 | 2018-02-16 | A method for producing biologic product variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020507336A JP2020507336A (ja) | 2020-03-12 |
| JP2020507336A5 true JP2020507336A5 (enExample) | 2021-03-25 |
| JP7252896B2 JP7252896B2 (ja) | 2023-04-05 |
Family
ID=61691554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019544727A Active JP7252896B2 (ja) | 2017-02-17 | 2018-02-16 | 生物学的産物バリアントを産生する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20190382718A1 (enExample) |
| EP (1) | EP3571289A1 (enExample) |
| JP (1) | JP7252896B2 (enExample) |
| KR (1) | KR102701102B1 (enExample) |
| CN (1) | CN110494554A (enExample) |
| IL (1) | IL268602B2 (enExample) |
| WO (1) | WO2018151819A1 (enExample) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1258959B (it) | 1992-06-09 | 1996-03-11 | Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota | |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| MXPA06008724A (es) | 2004-02-03 | 2007-02-16 | Xcellerex Llc | Sistema y metodo para elaboracion. |
| US7629167B2 (en) | 2004-06-04 | 2009-12-08 | Xcellerex, Inc. | Disposable bioreactor systems and methods |
| EP2004798A4 (en) | 2005-12-05 | 2010-11-24 | Ernest G Hope | PREVALIDED, MODULAR GOODS MANUFACTURING PRACTICE CORRESPONDING ESTABLISHMENT |
| PT2137655E (pt) | 2007-04-16 | 2012-09-14 | Momenta Pharmaceuticals Inc | Produtos de glicoproteína definidos e métodos relacionados |
| TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| WO2010138502A2 (en) * | 2009-05-26 | 2010-12-02 | Momenta Pharmaceuticals, Inc. | Production of glycoproteins |
| WO2011139708A2 (en) | 2010-04-26 | 2011-11-10 | Toyota Motor Engineering & Manufacturing North America, Inc. | Improved hydrogen release from complex metal hydrides by solvation in ionic liquids |
| US10371394B2 (en) | 2010-09-20 | 2019-08-06 | Biologics Modular Llc | Mobile, modular cleanroom facility |
| US9388373B2 (en) | 2011-03-08 | 2016-07-12 | University Of Maryland Baltimore County | Microscale bioprocessing system and method for protein manufacturing |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| AU2015211514B2 (en) * | 2014-01-29 | 2018-05-10 | Lg Chem, Ltd. | Method for modulating galactosylation of recombinant protein through optimization of culture medium |
-
2018
- 2018-02-16 WO PCT/US2018/000030 patent/WO2018151819A1/en not_active Ceased
- 2018-02-16 JP JP2019544727A patent/JP7252896B2/ja active Active
- 2018-02-16 US US16/486,571 patent/US20190382718A1/en not_active Abandoned
- 2018-02-16 EP EP18712028.2A patent/EP3571289A1/en active Pending
- 2018-02-16 IL IL268602A patent/IL268602B2/en unknown
- 2018-02-16 CN CN201880024307.1A patent/CN110494554A/zh active Pending
- 2018-02-16 KR KR1020197026583A patent/KR102701102B1/ko active Active
-
2023
- 2023-09-07 US US18/462,800 patent/US20240067923A1/en active Pending
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