JP2020503280A - ヒドロキシ安息香酸誘導体、その方法および使用 - Google Patents

ヒドロキシ安息香酸誘導体、その方法および使用 Download PDF

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Publication number
JP2020503280A
JP2020503280A JP2019530099A JP2019530099A JP2020503280A JP 2020503280 A JP2020503280 A JP 2020503280A JP 2019530099 A JP2019530099 A JP 2019530099A JP 2019530099 A JP2019530099 A JP 2019530099A JP 2020503280 A JP2020503280 A JP 2020503280A
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compound according
mitochondrial
alkyl
aryl
antioxben
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JP2020503280A5 (https=
Inventor
フェルナンダ マルティンス ボルヘス マリア
フェルナンダ マルティンス ボルヘス マリア
ジョルジ グーベア シモエス ダ シルバ オリビエラ パウロ
ジョルジ グーベア シモエス ダ シルバ オリビエラ パウロ
カルロス サントス テイクセラ ホセ
カルロス サントス テイクセラ ホセ
カギデ フェイギン フェルナンド
カギデ フェイギン フェルナンド
カタリーナ ゴメス オリベイラ アナ
カタリーナ ゴメス オリベイラ アナ
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Universidade do Porto
Centro de Neurociencias e Biologia Celular
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Universidade do Porto
Centro de Neurociencias e Biologia Celular
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Application filed by Universidade do Porto, Centro de Neurociencias e Biologia Celular filed Critical Universidade do Porto
Publication of JP2020503280A publication Critical patent/JP2020503280A/ja
Publication of JP2020503280A5 publication Critical patent/JP2020503280A5/ja
Priority to JP2022200267A priority Critical patent/JP7689690B2/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019530099A 2016-12-29 2017-12-29 ヒドロキシ安息香酸誘導体、その方法および使用 Pending JP2020503280A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022200267A JP7689690B2 (ja) 2016-12-29 2022-12-15 ヒドロキシ安息香酸誘導体、その方法および使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT10981816 2016-12-29
PT109818 2017-12-29
PCT/IB2017/058508 WO2018122789A1 (en) 2016-12-29 2017-12-29 Hydroxybenzoic acid derivatives, methods and uses thereof

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JP2020503280A true JP2020503280A (ja) 2020-01-30
JP2020503280A5 JP2020503280A5 (https=) 2021-03-04

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JP2022200267A Active JP7689690B2 (ja) 2016-12-29 2022-12-15 ヒドロキシ安息香酸誘導体、その方法および使用

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US (1) US11078222B2 (https=)
EP (1) EP3562830B1 (https=)
JP (2) JP2020503280A (https=)
KR (1) KR102750630B1 (https=)
CN (1) CN110114365B (https=)
BR (1) BR112019011303B1 (https=)
CA (1) CA3048966A1 (https=)
WO (1) WO2018122789A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021085906A1 (ko) * 2019-10-30 2021-05-06 주식회사 퓨전바이오텍 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물
WO2023053059A1 (en) * 2021-09-30 2023-04-06 Universidade Do Porto Antifouling compound, method and uses thereof
US20250312360A1 (en) * 2022-05-13 2025-10-09 Virginia Tech Intellectual Properties, Inc. Mitochondrial antioxidant treatment for cask-linked neurodevelopmental disorders
KR20240040435A (ko) * 2022-09-21 2024-03-28 울산과학기술원 미토콘드리아 표적 화합물을 유효성분으로 포함하는 망막 변성 치료용 약학적 조성물
KR102894216B1 (ko) * 2022-12-15 2025-12-18 울산과학기술원 Trap-1 억제제
CN116210697B (zh) * 2023-03-02 2024-05-14 西北农林科技大学 反式肉桂酸在提高苹果树腐烂病抗性中的应用
KR20250126454A (ko) * 2024-02-16 2025-08-25 울산과학기술원 암 세포의 티오에스테라제 및 활성산소종에 의해 자가 조립 중합되는 단량체 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126719A1 (en) * 2009-04-27 2010-11-04 Mcw Research Foundation, Inc. Neuroprotective compounds and their use
WO2015075200A1 (en) * 2013-11-22 2015-05-28 Medical Research Council Mitochondria-targeted dicarbonyl sequestering compounds
JP2019537623A (ja) * 2016-10-14 2019-12-26 ウニヴェルシダージ ド ポルトＵｎｉｖｅｒｓｉｄａｄｅ Ｄｏ Ｐｏｒｔｏ ヒドロキシケイ皮酸誘導体、その方法および使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017155991A1 (en) * 2016-03-08 2017-09-14 The Regents Of The University Of Michigan Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126719A1 (en) * 2009-04-27 2010-11-04 Mcw Research Foundation, Inc. Neuroprotective compounds and their use
WO2015075200A1 (en) * 2013-11-22 2015-05-28 Medical Research Council Mitochondria-targeted dicarbonyl sequestering compounds
JP2019537623A (ja) * 2016-10-14 2019-12-26 ウニヴェルシダージ ド ポルトＵｎｉｖｅｒｓｉｄａｄｅ Ｄｏ Ｐｏｒｔｏ ヒドロキシケイ皮酸誘導体、その方法および使用
JP7111730B2 (ja) * 2016-10-14 2022-08-02 ウニヴェルシダージ ド ポルト ヒドロキシケイ皮酸誘導体、その方法および使用

Non-Patent Citations (6)

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Title
ASIN-CAYUELA, J. ET AL.: "Fine-tuning the hydrophobicity of amitochondria-targeted antioxidant", FEBS LETTERS, vol. 571, JPN6021030669, 2004, pages 9 - 16, ISSN: 0004613325 *
CORTES, LEONEL A. ET AL.: "Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity", PLOS ONE, vol. 10(8), JPN7021004174, 2015, pages 0136852 - 1, ISSN: 0004849473 *
HUANG, S. ET AL.: "New photostable naphthalimide-based fluorescent probe for mitochondrial imaging and tracking", BIOSENSORS & BIOELECTRONICS, vol. 71, JPN7021004173, 2015, pages 313 - 321, ISSN: 0004613322 *
MOSSALAM, M. ET AL.: "Solid Phase Synthesis of Mitochondrial Triphenylphosphonium-Vitamin E Metabolite Using a Lysine Link", PLOS ONE, vol. 8(1), JPN7021004175, 2013, pages 53272, ISSN: 0004613323 *
SANDOVAL-ACUNA, C. ET AL.: "Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TP", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 309, JPN6021039306, 2016, pages 2 - 14, ISSN: 0004849474 *
TEIXEIRA, J. ET AL.: "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid sca", FREE RADICAL RESEARCH, vol. 46, no. 5, JPN6021030665, 2012, pages 600 - 611, ISSN: 0004613324 *

Also Published As

Publication number Publication date
EP3562830C0 (en) 2023-06-07
WO2018122789A1 (en) 2018-07-05
CN110114365B (zh) 2022-12-13
CA3048966A1 (en) 2018-07-05
EP3562830B1 (en) 2023-06-07
BR112019011303A2 (pt) 2019-10-08
US11078222B2 (en) 2021-08-03
BR112019011303B1 (pt) 2023-03-14
JP2023051961A (ja) 2023-04-11
EP3562830A1 (en) 2019-11-06
CN110114365A (zh) 2019-08-09
KR102750630B1 (ko) 2025-01-06
KR20190132622A (ko) 2019-11-28
JP7689690B2 (ja) 2025-06-09
US20190330249A1 (en) 2019-10-31

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