JP2020500940A - 向上したnk細胞ベースの治療 - Google Patents
向上したnk細胞ベースの治療 Download PDFInfo
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- JP2020500940A JP2020500940A JP2019551733A JP2019551733A JP2020500940A JP 2020500940 A JP2020500940 A JP 2020500940A JP 2019551733 A JP2019551733 A JP 2019551733A JP 2019551733 A JP2019551733 A JP 2019551733A JP 2020500940 A JP2020500940 A JP 2020500940A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
- A61K39/001114—CD74, Ii, MHC class II invariant chain or MHC class II gamma chain
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61P35/02—Antineoplastic agents specific for leukemia
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
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- Physics & Mathematics (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662432334P | 2016-12-09 | 2016-12-09 | |
| US62/432,334 | 2016-12-09 | ||
| EP17179414.2 | 2017-07-03 | ||
| EP17179414 | 2017-07-03 | ||
| PCT/EP2017/082234 WO2018104554A1 (en) | 2016-12-09 | 2017-12-11 | Improved nk-based cell therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020500940A true JP2020500940A (ja) | 2020-01-16 |
| JP2020500940A5 JP2020500940A5 (https=) | 2021-01-21 |
Family
ID=60935785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551733A Pending JP2020500940A (ja) | 2016-12-09 | 2017-12-11 | 向上したnk細胞ベースの治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230019381A1 (https=) |
| EP (2) | EP3551294B1 (https=) |
| JP (1) | JP2020500940A (https=) |
| KR (1) | KR20190110531A (https=) |
| CN (1) | CN110392595A (https=) |
| AU (1) | AU2017371514B2 (https=) |
| BR (1) | BR112019011461A2 (https=) |
| CA (1) | CA3045731A1 (https=) |
| ES (1) | ES2912173T3 (https=) |
| MX (1) | MX2019006597A (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024219474A1 (ja) * | 2023-04-21 | 2024-10-24 | 株式会社Logomix | Kir遺伝子クラスター領域、lilr遺伝子クラスター領域およびklr遺伝子クラスター領域のいずれか1以上の領域において欠失を有する細胞およびその製造方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112708675A (zh) * | 2020-12-25 | 2021-04-27 | 中山大学肿瘤防治中心 | 骨髓nk细胞联合mcl1抑制剂在抗白血病中的应用 |
| CN113267627B (zh) * | 2021-05-18 | 2022-09-20 | 首都医科大学附属北京地坛医院 | 用nk细胞上tigit和tim-3确定乙肝相关肝癌预后的系统 |
| CN114605560B (zh) * | 2022-03-30 | 2024-02-20 | 江苏蒙彼利生物科技有限公司 | 一种car-nk细胞及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0724532D0 (en) | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| US20130058921A1 (en) * | 2009-10-30 | 2013-03-07 | Frits VAN RHEE | Use of autologous effector cells and antibodies for treatment of multiple myeloma |
| US9775921B2 (en) * | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| JP2015505669A (ja) * | 2011-11-25 | 2015-02-26 | シンガポール ヘルス サービシーズ ピーティーイー リミテッド | ナチュラルキラー/t細胞リンパ腫(nktcl)の感受性予測、診断および治療 |
| EP3286211A1 (en) * | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
-
2017
- 2017-12-11 KR KR1020197019419A patent/KR20190110531A/ko not_active Ceased
- 2017-12-11 EP EP17825416.5A patent/EP3551294B1/en not_active Not-in-force
- 2017-12-11 CN CN201780076073.0A patent/CN110392595A/zh active Pending
- 2017-12-11 EP EP22156380.2A patent/EP4015043A1/en not_active Withdrawn
- 2017-12-11 MX MX2019006597A patent/MX2019006597A/es unknown
- 2017-12-11 JP JP2019551733A patent/JP2020500940A/ja active Pending
- 2017-12-11 BR BR112019011461A patent/BR112019011461A2/pt not_active IP Right Cessation
- 2017-12-11 AU AU2017371514A patent/AU2017371514B2/en not_active Ceased
- 2017-12-11 CA CA3045731A patent/CA3045731A1/en not_active Abandoned
- 2017-12-11 ES ES17825416T patent/ES2912173T3/es active Active
-
2022
- 2022-06-27 US US17/850,812 patent/US20230019381A1/en not_active Abandoned
Non-Patent Citations (5)
| Title |
|---|
| CLIN CANCER RES., 1998, VOL.4, P.2859-2868, JPN6021048413, ISSN: 0004876868 * |
| EXP HEMATOL., 2005, VOL.33, P.1160-1171, JPN6021048408, ISSN: 0004876869 * |
| LEUKEMIA, 2013, VOL.27, P.464-472, JPN6021048406, ISSN: 0004657122 * |
| LIFE SCIENCE, 1989, VOL.45 NO.26, P.2621-2626, JPN6021048410, ISSN: 0004876867 * |
| 臨床免疫, 2001, VOL.36 NO.5, P.777-783, JPN6021048402, ISSN: 0004657123 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024219474A1 (ja) * | 2023-04-21 | 2024-10-24 | 株式会社Logomix | Kir遺伝子クラスター領域、lilr遺伝子クラスター領域およびklr遺伝子クラスター領域のいずれか1以上の領域において欠失を有する細胞およびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3045731A1 (en) | 2018-06-14 |
| RU2019121144A3 (https=) | 2021-08-23 |
| EP3551294A1 (en) | 2019-10-16 |
| CN110392595A (zh) | 2019-10-29 |
| KR20190110531A (ko) | 2019-09-30 |
| MX2019006597A (es) | 2019-10-15 |
| EP3551294B1 (en) | 2022-02-16 |
| BR112019011461A2 (pt) | 2019-10-22 |
| AU2017371514B2 (en) | 2022-12-22 |
| US20230019381A1 (en) | 2023-01-19 |
| RU2019121144A (ru) | 2021-01-11 |
| ES2912173T3 (es) | 2022-05-24 |
| AU2017371514A1 (en) | 2019-07-04 |
| EP4015043A1 (en) | 2022-06-22 |
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