JP2020500940A - 向上したnk細胞ベースの治療 - Google Patents

向上したnk細胞ベースの治療 Download PDF

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Publication number
JP2020500940A
JP2020500940A JP2019551733A JP2019551733A JP2020500940A JP 2020500940 A JP2020500940 A JP 2020500940A JP 2019551733 A JP2019551733 A JP 2019551733A JP 2019551733 A JP2019551733 A JP 2019551733A JP 2020500940 A JP2020500940 A JP 2020500940A
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cell
cells
cancer
cell line
use according
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JP2020500940A5 (https=
Inventor
マイケル エイモン ピーター オドワイアー,
マイケル エイモン ピーター オドワイアー,
ジンソン フー
ジンソン フー
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Onk Therapeutics Ltd
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Onk Therapeutics Ltd
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Priority claimed from PCT/EP2017/082234 external-priority patent/WO2018104554A1/en
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Publication of JP2020500940A5 publication Critical patent/JP2020500940A5/ja
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JP2019551733A 2016-12-09 2017-12-11 向上したnk細胞ベースの治療 Pending JP2020500940A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662432334P 2016-12-09 2016-12-09
US62/432,334 2016-12-09
EP17179414.2 2017-07-03
EP17179414 2017-07-03
PCT/EP2017/082234 WO2018104554A1 (en) 2016-12-09 2017-12-11 Improved nk-based cell therapy

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JP2020500940A true JP2020500940A (ja) 2020-01-16
JP2020500940A5 JP2020500940A5 (https=) 2021-01-21

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JP2019551733A Pending JP2020500940A (ja) 2016-12-09 2017-12-11 向上したnk細胞ベースの治療

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US (1) US20230019381A1 (https=)
EP (2) EP3551294B1 (https=)
JP (1) JP2020500940A (https=)
KR (1) KR20190110531A (https=)
CN (1) CN110392595A (https=)
AU (1) AU2017371514B2 (https=)
BR (1) BR112019011461A2 (https=)
CA (1) CA3045731A1 (https=)
ES (1) ES2912173T3 (https=)
MX (1) MX2019006597A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024219474A1 (ja) * 2023-04-21 2024-10-24 株式会社Logomix Kir遺伝子クラスター領域、lilr遺伝子クラスター領域およびklr遺伝子クラスター領域のいずれか1以上の領域において欠失を有する細胞およびその製造方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112708675A (zh) * 2020-12-25 2021-04-27 中山大学肿瘤防治中心 骨髓nk细胞联合mcl1抑制剂在抗白血病中的应用
CN113267627B (zh) * 2021-05-18 2022-09-20 首都医科大学附属北京地坛医院 用nk细胞上tigit和tim-3确定乙肝相关肝癌预后的系统
CN114605560B (zh) * 2022-03-30 2024-02-20 江苏蒙彼利生物科技有限公司 一种car-nk细胞及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724532D0 (en) 2007-12-17 2008-01-30 Nat Univ Ireland Trail variants for treating cancer
US20130058921A1 (en) * 2009-10-30 2013-03-07 Frits VAN RHEE Use of autologous effector cells and antibodies for treatment of multiple myeloma
US9775921B2 (en) * 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
JP2015505669A (ja) * 2011-11-25 2015-02-26 シンガポール ヘルス サービシーズ ピーティーイー リミテッド ナチュラルキラー/t細胞リンパ腫(nktcl)の感受性予測、診断および治療
EP3286211A1 (en) * 2015-04-23 2018-02-28 Novartis AG Treatment of cancer using chimeric antigen receptor and protein kinase a blocker

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CLIN CANCER RES., 1998, VOL.4, P.2859-2868, JPN6021048413, ISSN: 0004876868 *
EXP HEMATOL., 2005, VOL.33, P.1160-1171, JPN6021048408, ISSN: 0004876869 *
LEUKEMIA, 2013, VOL.27, P.464-472, JPN6021048406, ISSN: 0004657122 *
LIFE SCIENCE, 1989, VOL.45 NO.26, P.2621-2626, JPN6021048410, ISSN: 0004876867 *
臨床免疫, 2001, VOL.36 NO.5, P.777-783, JPN6021048402, ISSN: 0004657123 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024219474A1 (ja) * 2023-04-21 2024-10-24 株式会社Logomix Kir遺伝子クラスター領域、lilr遺伝子クラスター領域およびklr遺伝子クラスター領域のいずれか1以上の領域において欠失を有する細胞およびその製造方法

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RU2019121144A3 (https=) 2021-08-23
EP3551294A1 (en) 2019-10-16
CN110392595A (zh) 2019-10-29
KR20190110531A (ko) 2019-09-30
MX2019006597A (es) 2019-10-15
EP3551294B1 (en) 2022-02-16
BR112019011461A2 (pt) 2019-10-22
AU2017371514B2 (en) 2022-12-22
US20230019381A1 (en) 2023-01-19
RU2019121144A (ru) 2021-01-11
ES2912173T3 (es) 2022-05-24
AU2017371514A1 (en) 2019-07-04
EP4015043A1 (en) 2022-06-22

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