JP2020178568A5 - - Google Patents

Download PDF

Info

Publication number
JP2020178568A5
JP2020178568A5 JP2019082000A JP2019082000A JP2020178568A5 JP 2020178568 A5 JP2020178568 A5 JP 2020178568A5 JP 2019082000 A JP2019082000 A JP 2019082000A JP 2019082000 A JP2019082000 A JP 2019082000A JP 2020178568 A5 JP2020178568 A5 JP 2020178568A5
Authority
JP
Japan
Prior art keywords
genotype
bile stones
data
bile
humans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019082000A
Other languages
Japanese (ja)
Other versions
JP7106490B2 (en
JP2020178568A (en
Filing date
Publication date
Application filed filed Critical
Priority to JP2019082000A priority Critical patent/JP7106490B2/en
Priority claimed from JP2019082000A external-priority patent/JP7106490B2/en
Publication of JP2020178568A publication Critical patent/JP2020178568A/en
Publication of JP2020178568A5 publication Critical patent/JP2020178568A5/ja
Application granted granted Critical
Publication of JP7106490B2 publication Critical patent/JP7106490B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Claims (2)

胆石に罹患したヒトの遺伝子型データと、胆石に罹患していないヒトの遺伝子型データと、を学習データとして用いて機械学習したモデルを用いて、胆石と正の相関があるrs1027087、rs2075876、rs11154532、及びrs7412746と、胆石と負の相関があるrs1047781、rs11066280、rs2279434、rs2840381、及びrs1335645を少なくとも含む一塩基多型セットの遺伝子型情報であって、 Using a machine-learned model using genotype data of humans with bile stones and genotype data of humans without bile stones as training data, there is a positive correlation with bile stones rs1027087, rs2075876, rs11154532 , And rs7412746, and genotype information of a single nucleotide polymorphism set containing at least rs1047781, rs11066280, rs2279434, rs2840381, and rs1335645, which are negatively correlated with bile stones.
rs1027087の遺伝子型がAT、rs2075876の遺伝子型がAG、rs11154532の遺伝子型がTC、rs7412746の遺伝子型がCC、rs1047781の遺伝子型がAA、rs11066280の遺伝子型がTT、rs2279434の遺伝子型がTC、rs2840381の遺伝子型がTT、及びrs1335645の遺伝子型がTTであるか否かに関する遺伝子型情報に基づいて、胆石のリスクを判定する、方法。 rs1027087 genotype AT, rs2075876 genotype AG, rs11154532 genotype TC, rs7412746 genotype CC, rs1047781 genotype AA, rs11066280 genotype TT, rs2279434 genotype TC, rs2840381 A method for determining the risk of bile stones based on genotype information regarding whether or not the genotype of rs1335645 is TT and the genotype of rs1335645 is TT.
リスクの判定を受ける対象者の体液サンプル、細胞サンプル又は体毛を用いる、請求項1に記載の方法。The method according to claim 1, wherein a body fluid sample, a cell sample, or hair of a subject who receives a risk determination is used.
JP2019082000A 2019-04-23 2019-04-23 How to Determine Gallstone Risk Active JP7106490B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019082000A JP7106490B2 (en) 2019-04-23 2019-04-23 How to Determine Gallstone Risk

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2019082000A JP7106490B2 (en) 2019-04-23 2019-04-23 How to Determine Gallstone Risk

Publications (3)

Publication Number Publication Date
JP2020178568A JP2020178568A (en) 2020-11-05
JP2020178568A5 true JP2020178568A5 (en) 2022-03-18
JP7106490B2 JP7106490B2 (en) 2022-07-26

Family

ID=73022518

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019082000A Active JP7106490B2 (en) 2019-04-23 2019-04-23 How to Determine Gallstone Risk

Country Status (1)

Country Link
JP (1) JP7106490B2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004173505A (en) 2002-11-22 2004-06-24 Mitsuo Itakura Method for identifying disease-susceptible gene and program and system used therefor
CN1690221B (en) 2004-04-23 2010-05-05 上海人类基因组研究中心 Method and kit for detecting susceptibility of cholelithiasis
US20110038944A1 (en) 2009-08-13 2011-02-17 Washington State University Research Foundation Compositions and methods for diagnosis and treatment of hepatobiliary disease and associated disorders

Similar Documents

Publication Publication Date Title
JP2020178565A5 (en)
JP2020178589A5 (en)
JP2020178560A5 (en)
JP2020178586A5 (en)
JP2020178568A5 (en)
JP2020178555A5 (en)
JP2020174624A5 (en)
JP2020178582A5 (en)
JP2020178540A5 (en)
JP2020174613A5 (en)
JP2020178584A5 (en)
JP2020178557A5 (en)
JP2020178575A5 (en)
JP2020174625A5 (en)
JP2020174632A5 (en)
JP2020178539A5 (en)
JP2020178546A5 (en)
JP2020178541A5 (en)
JP2020174630A5 (en)
JP2020178548A5 (en)
JP2020174626A5 (en)
JP2020178538A5 (en)
JP2020174642A5 (en)
JP2020178545A5 (en)
JP2020178579A5 (en)