JP2020178548A5 - - Google Patents

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JP2020178548A5
JP2020178548A5 JP2019081756A JP2019081756A JP2020178548A5 JP 2020178548 A5 JP2020178548 A5 JP 2020178548A5 JP 2019081756 A JP2019081756 A JP 2019081756A JP 2019081756 A JP2019081756 A JP 2019081756A JP 2020178548 A5 JP2020178548 A5 JP 2020178548A5
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genotype
bronchial asthma
data
humans
risk
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JP2019081756A
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Japanese (ja)
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JP2020178548A (en
JP7161440B2 (en
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気管支ぜんそくに罹患したヒトの遺伝子型データと、気管支ぜんそくに罹患していないヒトの遺伝子型データと、を学習データとして用いて機械学習したモデルを用いて、気管支ぜんそくと正の相関があるrs1800497、rs2305480、rs12688220、及びrs5945326と、気管支ぜんそくと負の相関があるrs6478108、rs2188380、rs11066001、rs6478106、rs1975197、及びrs633862を少なくとも含む一塩基多型セットの遺伝子型情報であって、 Using a machine-learned model using genotype data of humans with bronchial asthma and genotype data of humans without bronchial asthma as training data, there is a positive correlation with bronchial asthma rs1800497, Genotypic information of a single nucleotide polymorphism set containing at least rs2305480, rs12688220, and rs5945326 and rs6478108, rs2188380, rs11066001, rs6478106, rs1975197, and rs633862 that are negatively correlated with bronchial asthma.
rs1800497の遺伝子型がAA、rs2305480の遺伝子型がGG、rs12688220の遺伝子型がTC、rs5945326の遺伝子型がAG、rs6478108の遺伝子型がTT、rs2188380の遺伝子型がAA、rs11066001の遺伝子型がTT、rs6478106の遺伝子型がCC、rs1975197の遺伝子型がTT、及びrs633862の遺伝子型がGGであるか否かに関する遺伝子型情報に基づいて、気管支ぜんそくのリスクを判定する、方法。 rs1800497 genotype AA, rs2305480 genotype GG, rs12688220 genotype TC, rs5945326 genotype AG, rs6478108 genotype TT, rs2188380 genotype AA, rs11066001 genotype TT, rs6478106 A method for determining the risk of bronchial asthma based on genotype information regarding whether or not the genotype of rs1975197 is CC, the genotype of rs1975197 is TT, and the genotype of rs633862 is GG.
リスクの判定を受ける対象者の体液サンプル、細胞サンプル又は体毛を用いる、請求項1に記載の方法。The method according to claim 1, wherein a body fluid sample, a cell sample, or hair of a subject who receives a risk determination is used.
JP2019081756A 2019-04-23 2019-04-23 How to determine the risk of bronchial asthma Active JP7161440B2 (en)

Priority Applications (1)

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JP2019081756A JP7161440B2 (en) 2019-04-23 2019-04-23 How to determine the risk of bronchial asthma

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JP2019081756A JP7161440B2 (en) 2019-04-23 2019-04-23 How to determine the risk of bronchial asthma

Publications (3)

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JP2020178548A JP2020178548A (en) 2020-11-05
JP2020178548A5 true JP2020178548A5 (en) 2022-03-15
JP7161440B2 JP7161440B2 (en) 2022-10-26

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JP2019081756A Active JP7161440B2 (en) 2019-04-23 2019-04-23 How to determine the risk of bronchial asthma

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2006687A1 (en) * 2007-06-20 2008-12-24 Commissariat A L'energie Atomique Method of testing a subject thought to have or be predisposed to having asthma, allergie, atopic disease or atopic sensitization
US9790550B2 (en) * 2008-05-16 2017-10-17 The Children's Hospital Of Philadelphia Asthma susceptibility loci located at chromosome 1q31 for use in diagnostic and therapeutic methods
CA2841416A1 (en) * 2011-06-15 2012-12-20 Glaxosmithkline Intellectual Property (No.2) Limited Method of selecting therapeutic indications

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