JP2020178558A5 - - Google Patents

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JP2020178558A5
JP2020178558A5 JP2019081864A JP2019081864A JP2020178558A5 JP 2020178558 A5 JP2020178558 A5 JP 2020178558A5 JP 2019081864 A JP2019081864 A JP 2019081864A JP 2019081864 A JP2019081864 A JP 2019081864A JP 2020178558 A5 JP2020178558 A5 JP 2020178558A5
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ulcerative colitis
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humans
positive
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JP2019081864A
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JP2020178558A (en
JP7106487B2 (en
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潰瘍性大腸炎に罹患したヒトの遺伝子型データと、潰瘍性大腸炎に罹患していないヒトの遺伝子型データと、を学習データとして用いて機械学習したモデルを用いて、潰瘍性大腸炎と正の相関があるrs1667255、rs2155219、rs13336428、及びrs3764147と、潰瘍性大腸炎と負の相関があるrs13015714、rs917997、rs4733781、及びrs1801252と、潰瘍性大腸炎と正の相関又は負の相関があるrs2075876と、を少なくとも含む一塩基多型セットの遺伝子型情報であって、 Using a machine-learned model using genotype data of humans with ulcerative colitis and genotype data of humans without ulcerative colitis as training data, ulcerative colitis and positive With rs1667255, rs2155219, rs13336428, and rs3764147 with rs1667255, rs13336428, and rs3764147, with rs13015714, rs917997, rs4733781 and rs1801252 with negative correlation with ulcerative colitis, and with rs2075876 with positive or negative correlation with ulcerative colitis. , Which is the genotype information of a one-base polymorphic set containing at least,
rs1667255の遺伝子型がAA、rs2155219の遺伝子型がTG、rs13336428の遺伝子型がAA、rs3764147の遺伝子型がAG、rs2075876の遺伝子型がGG、rs13015714の遺伝子型がTG、rs917997の遺伝子型がAG、rs4733781の遺伝子型がAC、rs2075876の遺伝子型がAG、及びrs1801252の遺伝子型がAAであるか否かに関する遺伝子型情報に基づいて、潰瘍性大腸炎のリスクを判定する、方法。 rs1667255 genotype AA, rs2155219 genotype TG, rs13336428 genotype AA, rs3764147 genotype AG, rs2075876 genotype GG, rs13015714 genotype TG, rs917997 genotype AG, rs4733781 A method for determining the risk of ulcerative colitis based on genotype information regarding whether or not the genotype of rs2075876 is AC, the genotype of rs2075876 is AG, and the genotype of rs1801252 is AA. リスクの判定を受ける対象者の体液サンプル、細胞サンプル又は体毛を用いる、請求項１に記載の方法。The method according to claim 1, wherein a body fluid sample, a cell sample, or hair of a subject who receives a risk determination is used.
JP2019081864A 2019-04-23 2019-04-23 How to determine your risk of ulcerative colitis Active JP7106487B2 (en)

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JP2019081864A JP7106487B2 (en) 2019-04-23 2019-04-23 How to determine your risk of ulcerative colitis

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JP2019081864A JP7106487B2 (en) 2019-04-23 2019-04-23 How to determine your risk of ulcerative colitis

Publications (3)

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JP2020178558A JP2020178558A (en) 2020-11-05
JP2020178558A5 true JP2020178558A5 (en) 2022-03-17
JP7106487B2 JP7106487B2 (en) 2022-07-26

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004173505A (en) 2002-11-22 2004-06-24 Mitsuo Itakura Method for identifying disease-susceptible gene and program and system used therefor
US8574845B2 (en) 2008-10-08 2013-11-05 Christian-Albrechts-Universitat Zu Kiel Method for identifying an increased susceptibility to ulcerative colitis
US20120171672A1 (en) 2009-04-14 2012-07-05 Prometheus Laboratories Inc. Inflammatory bowel disease prognostics
US9902996B2 (en) 2011-02-11 2018-02-27 Cedars-Sinai Medical Center Methods of predicting the need for surgery in crohn's disease
US11226340B2 (en) 2016-04-26 2022-01-18 Qu Biologics Inc. Therapeutically triggering an innate immune response in a target tissue

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