JP2020178536A5 - - Google Patents

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JP2020178536A5
JP2020178536A5 JP2019081623A JP2019081623A JP2020178536A5 JP 2020178536 A5 JP2020178536 A5 JP 2020178536A5 JP 2019081623 A JP2019081623 A JP 2019081623A JP 2019081623 A JP2019081623 A JP 2019081623A JP 2020178536 A5 JP2020178536 A5 JP 2020178536A5
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genotype
allergic conjunctivitis
data
humans
risk
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JP2019081623A
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JP2020178536A (en
JP7108574B2 (en
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アレルギー性結膜炎に罹患したヒトの遺伝子型データと、アレルギー性結膜炎に罹患していないヒトの遺伝子型データと、を学習データとして用いて機械学習したモデルを用いて、アレルギー性結膜炎と正の相関があるrs5945326、rs5955543、rs6651806、rs12688220、rs3905706、及びrs9277535と、アレルギー性結膜炎と負の相関があるrs2140773、rs1934179、及びrs3135363を少なくとも含む一塩基多型セットの遺伝子型情報であって、 Using a machine-learned model using genotype data of humans with allergic conjunctivitis and genotype data of humans without allergic conjunctivitis as training data, there is a positive correlation with allergic conjunctivitis. Genotypic information for a single-base polymorphic set containing at least rs5945326, rs5955543, rs6651806, rs12688220, rs3905706, and rs9277535 and rs2140773, rs1934179, and rs3135363 that are negatively correlated with allergic conjunctivitis.
rs5945326の遺伝子型がAG、rs5955543の遺伝子型がAG、rs6651806の遺伝子型がAC、rs12688220の遺伝子型がTC、rs3905706の遺伝子型がAG、rs9277535の遺伝子型がGG、rs2140773の遺伝子型がGG、rs1934179の遺伝子型がTC、及びrs3135363の遺伝子型がTT又はTCであるか否かに関する遺伝子型情報に基づいて、アレルギー性結膜炎のリスクを判定する、方法。 rs5945326 genotype AG, rs5955543 genotype AG, rs6651806 genotype AC, rs12688220 genotype TC, rs3905706 genotype AG, rs9277535 genotype GG, rs2140773 genotype GG, rs1934179 A method for determining the risk of allergic conjunctivitis based on genotype information regarding whether the genotype of rs3135363 is TC and the genotype of rs3135363 is TT or TC.
リスクの判定を受ける対象者の体液サンプル、細胞サンプル又は体毛を用いる、請求項1に記載の方法。The method according to claim 1, wherein a body fluid sample, a cell sample, or hair of a subject who receives a risk determination is used.
JP2019081623A 2019-04-23 2019-04-23 Methods for determining the risk of allergic conjunctivitis Active JP7108574B2 (en)

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JP2019081623A JP7108574B2 (en) 2019-04-23 2019-04-23 Methods for determining the risk of allergic conjunctivitis

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JP2019081623A JP7108574B2 (en) 2019-04-23 2019-04-23 Methods for determining the risk of allergic conjunctivitis

Publications (3)

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JP2020178536A JP2020178536A (en) 2020-11-05
JP2020178536A5 true JP2020178536A5 (en) 2022-03-15
JP7108574B2 JP7108574B2 (en) 2022-07-28

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JP2019081623A Active JP7108574B2 (en) 2019-04-23 2019-04-23 Methods for determining the risk of allergic conjunctivitis

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EP3402900A1 (en) 2016-01-12 2018-11-21 Interleukin Genetics, Inc. Methods for predicting response to treatment

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