JP2020111571A5 - - Google Patents
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- JP2020111571A5 JP2020111571A5 JP2020002515A JP2020002515A JP2020111571A5 JP 2020111571 A5 JP2020111571 A5 JP 2020111571A5 JP 2020002515 A JP2020002515 A JP 2020002515A JP 2020002515 A JP2020002515 A JP 2020002515A JP 2020111571 A5 JP2020111571 A5 JP 2020111571A5
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- JP
- Japan
- Prior art keywords
- substituent group
- halogen
- substituted
- group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001424 substituent group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical group 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 101710186725 2-acylglycerol O-acyltransferase 2 Proteins 0.000 claims 2
- 102100024296 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Human genes 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000013824 Acidemia Diseases 0.000 claims 1
- 208000010444 Acidosis Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019003070 | 2019-01-11 | ||
| JP2019003070 | 2019-01-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020111571A JP2020111571A (ja) | 2020-07-27 |
| JP2020111571A5 true JP2020111571A5 (OSRAM) | 2022-03-04 |
| JP7068743B2 JP7068743B2 (ja) | 2022-05-17 |
Family
ID=71666534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020002515A Active JP7068743B2 (ja) | 2019-01-11 | 2020-01-10 | Ｍｇａｔ２阻害活性を有する縮合環誘導体を含有する医薬組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7068743B2 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114685502A (zh) * | 2020-12-25 | 2022-07-01 | 由理生物医药（上海）有限公司 | 作为kras-g12c抑制剂的螺环类化合物 |
| CN118948849A (zh) * | 2021-09-08 | 2024-11-15 | 盐野义制药株式会社 | 用于预防和治疗与抗肥胖作用有关的疾病的药物 |
| JP7713603B2 (ja) | 2022-02-09 | 2025-07-25 | クアンタ セラピューティクス， インコーポレイテッド | Ｋｒａｓモジュレーターおよびその使用 |
| CA3257281A1 (en) | 2022-05-25 | 2023-11-30 | Quanta Therapeutics Inc | PYRIMIDINE-BASED MODULATORS AND THEIR USES |
| WO2024192424A1 (en) | 2023-03-15 | 2024-09-19 | Quanta Therapeutics, Inc. | Kras modulators and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014009165A (ja) * | 2012-06-27 | 2014-01-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン化合物 |
| JPWO2014133134A1 (ja) * | 2013-02-28 | 2017-02-02 | 味の素株式会社 | 新規テトラヒドロピリドピリミジノン誘導体 |
| AU2015227142A1 (en) * | 2014-03-07 | 2016-10-20 | Bristol-Myers Squibb Company | Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders |
| EA032255B1 (ru) * | 2014-03-27 | 2019-04-30 | Янссен Фармацевтика Нв | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИНА И ПРОИЗВОДНЫЕ 5,6,7,8-ТЕТРАГИДРО-4H-ПИРАЗОЛО[1,5-a][1,4]ДИАЗЕПИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Ros1 |
| WO2017069224A1 (ja) * | 2015-10-22 | 2017-04-27 | 塩野義製薬株式会社 | Ｍｇａｔ２阻害活性を有するスピロ環誘導体 |
| TWI782056B (zh) * | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
-
2020
- 2020-01-10 JP JP2020002515A patent/JP7068743B2/ja active Active
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