|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
JP2861087B2
(ja)
*
|
1989-08-08 |
1999-02-24 |
三菱化学株式会社 |
N―アシル‐5‐ピラゾールカルボキサミド類およびこれを有効成分とする殺虫、殺ダニ剤
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
DE69334255D1
(de)
|
1992-02-06 |
2009-02-12 |
Novartis Vaccines & Diagnostic |
Marker für Krebs und biosynthetisches Bindeprotein dafür
|
|
IT1255527B
(it)
*
|
1992-09-29 |
1995-11-09 |
Mini Ricerca Scient Tecnolog |
Pirazolcarbossammidi ad attivita' insetticida ed acaricida
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
PT821671E
(pt)
|
1995-04-20 |
2001-04-30 |
Pfizer |
Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
ATE225343T1
(de)
|
1995-12-20 |
2002-10-15 |
Hoffmann La Roche |
Matrix-metalloprotease inhibitoren
|
|
DE19600097C1
(de)
|
1996-01-03 |
1997-07-31 |
Siemens Ag |
Verfahren und Vorrichtung zur Bestimmung einer Flüssigkeitshöhe mit Hilfe von Ultraschallimpulsen
|
|
DE69709319T2
(de)
|
1996-03-05 |
2002-08-14 |
Astrazeneca Ab, Soedertaelje |
4-anilinochinazolin derivate
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
WO1998002437A1
(en)
|
1996-07-13 |
1998-01-22 |
Glaxo Group Limited |
Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
|
|
EP0912559B1
(en)
|
1996-07-13 |
2002-11-06 |
Glaxo Group Limited |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
IL128189A0
(en)
|
1996-08-23 |
1999-11-30 |
Pfizer |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
EP0950059B1
(en)
|
1997-01-06 |
2004-08-04 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
ATE248812T1
(de)
|
1997-02-03 |
2003-09-15 |
Pfizer Prod Inc |
Arylsulfonylhydroxamsäurederivate
|
|
CA2279863A1
(en)
|
1997-02-07 |
1998-08-13 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
|
TR199901926T2
(xx)
|
1997-02-11 |
1999-12-21 |
Pfizer Inc. |
Arils�lfonil hidroksamik asit t�revleri
|
|
ATE292623T1
(de)
|
1997-05-07 |
2005-04-15 |
Sugen Inc |
2-indolinonderivate als modulatoren der proteinkinase-ativität
|
|
CA2291709A1
(en)
|
1997-05-30 |
1998-12-03 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
PT1003720E
(pt)
|
1997-08-08 |
2004-07-30 |
Pfizer Prod Inc |
Derivados de acido ariloxiarilsulfonilamino hidroxamico
|
|
WO1999010349A1
(en)
|
1997-08-22 |
1999-03-04 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
AU744939B2
(en)
|
1997-09-26 |
2002-03-07 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
ID23978A
(id)
|
1997-11-11 |
2000-06-14 |
Pfizer Prod Inc |
Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
CO5031249A1
(es)
|
1998-05-29 |
2001-04-27 |
Sugen Inc |
Pirrol substituido-2-indolinonas inhibidoras de proteinci-nasas
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
PT1004578E
(pt)
|
1998-11-05 |
2004-06-30 |
Pfizer Prod Inc |
Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico
|
|
IL143236A0
(en)
|
1998-12-16 |
2002-04-21 |
Warner Lambert Co |
Treatment of arthritis with mek inhibitors
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
JP2001172261A
(ja)
*
|
1999-12-20 |
2001-06-26 |
Mitsubishi Chemicals Corp |
ピラゾールカルボン酸アミド類、およびこれを有効成分とする殺虫、殺ダニ剤
|
|
ATE369359T1
(de)
|
2000-02-15 |
2007-08-15 |
Sugen Inc |
Pyrrol substituierte indolin-2-on protein kinase inhibitoren
|
|
DZ3401A1
(fr)
|
2000-07-19 |
2002-01-24 |
Warner Lambert Co |
Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques
|
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
ATE346064T1
(de)
*
|
2000-09-15 |
2006-12-15 |
Vertex Pharma |
Pyrazolverbindungen als protein-kinasehemmer
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
EP1384714A1
(en)
*
|
2001-04-06 |
2004-01-28 |
Nihon Nohyaku Co., Ltd. |
Pyrazolecarboxamide derivative, intermediate therefor, and pest control agent containing the same as active ingredient
|
|
JP2002363164A
(ja)
*
|
2001-04-06 |
2002-12-18 |
Mitsubishi Chemicals Corp |
ピラゾールカルボキサミド類、その中間体およびこれを有効成分とする有害生物防除剤
|
|
CN104876904A
(zh)
|
2002-03-08 |
2015-09-02 |
卫材R&D管理株式会社 |
用作医药品的大环化合物
|
|
TWI338685B
(en)
|
2002-03-13 |
2011-03-11 |
Array Biopharma Inc |
N3 alkylated benzimid azole derivatives as mek inhibitors
|
|
JP2007524596A
(ja)
|
2003-02-28 |
2007-08-30 |
トランスフォーム・ファーマシューティカルズ・インコーポレイテッド |
共結晶医薬組成物
|
|
US20070060589A1
(en)
|
2004-12-21 |
2007-03-15 |
Purandare Ashok V |
Inhibitors of protein arginine methyl transferases
|
|
EP1869019B1
(en)
|
2005-04-08 |
2014-08-27 |
Pfizer Products Inc. |
Bicyclic [3.1.0] heteroaryl amides as type i glycine transport inhibitors
|
|
EP1884513A4
(en)
*
|
2005-05-23 |
2010-04-28 |
Japan Tobacco Inc |
PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME
|
|
CA2618218C
(en)
|
2005-07-21 |
2015-06-30 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US8552050B2
(en)
|
2007-08-16 |
2013-10-08 |
Beth Israel Deaconess Medical Center |
Activators of pyruvate kinase M2 and methods of treating disease
|
|
JPWO2009028280A1
(ja)
*
|
2007-08-29 |
2010-11-25 |
三井化学アグロ株式会社 |
ピラゾールカルボン酸誘導体及びその製造方法、並びに殺菌剤
|
|
CA2699202C
(en)
|
2007-09-12 |
2016-09-27 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
US8354528B2
(en)
|
2007-10-25 |
2013-01-15 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
|
EP2344453B1
(en)
|
2008-10-09 |
2016-12-28 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Activators of human pyruvate kinase
|
|
EP2346831B1
(en)
|
2008-11-17 |
2015-01-07 |
Boehringer Ingelheim International GmbH |
Heteroaryl diamide compounds useful as mmp-13 inhibitors
|
|
EP2387570A1
(en)
|
2009-01-15 |
2011-11-23 |
Amgen, Inc |
Fluoroisoquinoline substituted thiazole compounds and methods of use
|
|
CN102448951B
(zh)
*
|
2009-04-06 |
2017-05-10 |
安吉奥斯医药品有限公司 |
丙酮酸激酶m2调节剂、治疗组合物和相关使用方法
|
|
PL2427441T3
(pl)
|
2009-05-04 |
2017-06-30 |
Agios Pharmaceuticals, Inc. |
Aktywatory PKM2 do stosowania w leczeniu raka
|
|
US8349832B2
(en)
|
2009-09-02 |
2013-01-08 |
Canthera Therapeutics |
Compounds and compositions for treating cancer
|
|
WO2011069298A1
(en)
|
2009-12-11 |
2011-06-16 |
F. Hoffmann-La Roche Ag |
Novel cyclopropane indolinone derivatives
|
|
CN105482129B
(zh)
|
2010-09-30 |
2018-07-27 |
黄奇英 |
抗癌萃取物及化合物
|
|
US8692001B2
(en)
|
2010-10-27 |
2014-04-08 |
Dynamix Pharmaceuticals Ltd. |
Sulfonamides for the modulation of PKM2
|
|
JP5837091B2
(ja)
*
|
2010-12-17 |
2015-12-24 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
ピルビン酸キナーゼm2(pkm2)調節剤としての新規n−(4−(アゼチジン−1−カルボニル)フェニル)−(ヘテロ−)アリールスルホンアミド誘導体
|
|
US9328077B2
(en)
|
2010-12-21 |
2016-05-03 |
Agios Pharmaceuticals, Inc |
Bicyclic PKM2 activators
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
EP2497775A1
(en)
|
2011-03-11 |
2012-09-12 |
Ruprecht-Karls-Universität Heidelberg |
Ferrocene-based compounds and their use as ROS regulating prodrugs
|
|
WO2012160447A1
(en)
*
|
2011-05-25 |
2012-11-29 |
Dynamix Pharmaceuticals Ltd. |
3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
|
|
WO2013005157A1
(en)
|
2011-07-05 |
2013-01-10 |
Lupin Limited |
Sulfone derivatives and their use as pkm2 modulators for the treatment of cancer
|
|
DK2909181T3
(da)
*
|
2012-10-16 |
2017-11-20 |
Tolero Pharmaceuticals Inc |
PKM2-modulatorer og fremgangsmåder til anvendelse deraf
|
|
US9458132B2
(en)
|
2012-11-08 |
2016-10-04 |
Agios Pharmaceuticals, Inc |
Therapeutic compounds and compositions and their use as PKM2 modulators
|
|
US9447054B2
(en)
|
2014-01-15 |
2016-09-20 |
Korea Institute Of Radiological & Medical Sciences |
Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
|