JP2020072741A5 - - Google Patents
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- JP2020072741A5 JP2020072741A5 JP2020017791A JP2020017791A JP2020072741A5 JP 2020072741 A5 JP2020072741 A5 JP 2020072741A5 JP 2020017791 A JP2020017791 A JP 2020017791A JP 2020017791 A JP2020017791 A JP 2020017791A JP 2020072741 A5 JP2020072741 A5 JP 2020072741A5
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- smoker status
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- 238000000034 method Methods 0.000 claims 11
- 230000004547 gene signature Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 230000000391 smoking effect Effects 0.000 claims 3
- 235000019505 tobacco product Nutrition 0.000 claims 3
- 101000941865 Homo sapiens Leucine-rich repeat neuronal protein 3 Proteins 0.000 claims 2
- 102100032657 Leucine-rich repeat neuronal protein 3 Human genes 0.000 claims 2
- 102000055157 Complement C1 Inhibitor Human genes 0.000 claims 1
- 108700040183 Complement C1 Inhibitor Proteins 0.000 claims 1
- 102000004480 Cyclin-Dependent Kinase Inhibitor p57 Human genes 0.000 claims 1
- 108010017222 Cyclin-Dependent Kinase Inhibitor p57 Proteins 0.000 claims 1
- 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 claims 1
- 101001036287 Homo sapiens DNA-binding protein inhibitor ID-3 Proteins 0.000 claims 1
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims 1
- 101000735213 Homo sapiens Palladin Proteins 0.000 claims 1
- 101000709121 Homo sapiens Ral guanine nucleotide dissociation stimulator-like 1 Proteins 0.000 claims 1
- 101000575639 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 Proteins 0.000 claims 1
- 101000693721 Homo sapiens SAM and SH3 domain-containing protein 1 Proteins 0.000 claims 1
- 101000893741 Homo sapiens Tissue alpha-L-fucosidase Proteins 0.000 claims 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims 1
- 102100029571 Immunoglobulin J chain Human genes 0.000 claims 1
- 102100035031 Palladin Human genes 0.000 claims 1
- 102100032665 Ral guanine nucleotide dissociation stimulator-like 1 Human genes 0.000 claims 1
- 102100026006 Ribonucleoside-diphosphate reductase subunit M2 Human genes 0.000 claims 1
- 102100025543 SAM and SH3 domain-containing protein 1 Human genes 0.000 claims 1
- 101150097162 SERPING1 gene Proteins 0.000 claims 1
- 102100040526 Tissue alpha-L-fucosidase Human genes 0.000 claims 1
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 claims 1
- 238000004590 computer program Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
Claims (7)
- 個人の喫煙者ステータスを特定するためのコンピュータ化した方法であって、前記方法は、
前記個人の遺伝子シグネチャに対する定量的な発現データを含むデータセットを受け取ることであって、前記遺伝子シグネチャがＬＲＲＮ３、ＣＤＫＮ１Ｃ、ＰＡＬＬＤ、ＳＡＳＨ１、ＲＧＬ１、およびＴＮＦＲＳＦ１７を含む、受け取ることと、
分類子を使用して、前記遺伝子シグネチャに対する前記定量的な発現データに基づくスコアを決定することであって、前記分類子が訓練データセットに基づき訓練され、各訓練データセットが前記遺伝子シグネチャに対するそれぞれの定量的発現データ、およびそれぞれの被験者のそれぞれの喫煙者ステータスを含む、決定することと、
前記スコアに基づき前記個人の前記喫煙者ステータスを特定すること
とを含む、方法。 - 前記データセットに基づく前記個人の前記スコアを前記個人についての以前のデータセットの以前のスコアと比較して、喫煙製品の代替品の前記個人に対する効果を決定することをさらに含む、請求項１に記載の方法。
- 前記喫煙製品の前記代替品が加熱式たばこ製品である、請求項２に記載の方法。
- 前記加熱式タバコ製品の効果が、前記個人による前記加熱式たばこ製品の使用開始後０〜５日の間の前記データセットにおけるＬＲＲＮ３発現の減少であるかどうかを決定することをさらに含む、請求項３に記載の方法。
- 前記喫煙製品の前記代替品の前記個人に対する前記効果に基づき、前記個人の前記喫煙者ステータスを更新することをさらに含む、請求項２〜４のいずれかに記載の方法。
- 前記遺伝子シグネチャが、ＩＧＪ、ＲＲＭ２、ＳＥＲＰＩＮＧ１、ＦＵＣＡ１、およびＩＤ３のうちの少なくとも１つを更に含む、請求項１〜５のいずれかに記載の方法。
- コンピュータ可読指示を含むコンピュータプログラムであって、実行時に請求項１〜６のいずれかに記載の方法の１つ以上の工程をプロセッサに実行させる、コンピュータプログラム。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361916443P | 2013-12-16 | 2013-12-16 | |
| US61/916,443 | 2013-12-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532548A Division JP6703479B2 (ja) | 2013-12-16 | 2014-12-11 | 個人の喫煙ステータスを予測するためのシステムおよび方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020072741A JP2020072741A (ja) | 2020-05-14 |
| JP2020072741A5 true JP2020072741A5 (ja) | 2020-07-02 |
Family
ID=52146462
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532548A Active JP6703479B2 (ja) | 2013-12-16 | 2014-12-11 | 個人の喫煙ステータスを予測するためのシステムおよび方法 |
| JP2020017791A Withdrawn JP2020072741A (ja) | 2013-12-16 | 2020-02-05 | 個人の喫煙ステータスを予測するためのシステムおよび方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532548A Active JP6703479B2 (ja) | 2013-12-16 | 2014-12-11 | 個人の喫煙ステータスを予測するためのシステムおよび方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11127486B2 (ja) |
| EP (1) | EP3084664B8 (ja) |
| JP (2) | JP6703479B2 (ja) |
| CN (2) | CN106415563B (ja) |
| CA (1) | CA2932649C (ja) |
| HK (1) | HK1232312A1 (ja) |
| PL (1) | PL3084664T3 (ja) |
| WO (1) | WO2015091225A1 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107786492A (zh) * | 2016-08-24 | 2018-03-09 | 北京计算机技术及应用研究所 | 基于集成分类器的网络安全态势评估方法 |
| JP7022119B2 (ja) * | 2016-09-14 | 2022-02-17 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 個人の生物学的ステータスを予測するためのシステム、方法および遺伝子シグネチャ |
| JPWO2022118421A1 (ja) * | 2020-12-03 | 2022-06-09 | ||
| CN113187268B (zh) * | 2021-04-21 | 2022-09-16 | 成都博腾迈中央空调有限公司 | 组合式吸烟室及吸烟人员的健康管理方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0010937A (pt) | 1999-05-25 | 2002-02-26 | Aventis Pharma Inc | Análise matemática para a estimativa de mudanças no nìvel da expressão do gene |
| KR20040064275A (ko) | 2001-11-09 | 2004-07-16 | 소스 프리시전 메디슨, 인코포레이티드 | 유전자 발현 프로파일을 이용한 질병의 동정, 모니터링,치료 및 생물학적 상태의 확인 |
| DE102004003612B4 (de) * | 2004-01-25 | 2015-01-08 | grapho metronic Meß- und Regeltechnik GmbH | Verfahren und Auswertung eines Bildes von einem vorbestimmten Ausschnitt eines Druckerzeugnisses |
| CA2586374A1 (en) * | 2004-11-05 | 2007-01-25 | The Government Of The United States Of America, As Represented By The Se Cretary Of The Navy | Diagnosis and prognosis of infectious diseases clinical phenotypes and other physiologic states using host gene expression biomarkers in blood |
| WO2006135886A2 (en) * | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| WO2007041238A2 (en) * | 2005-09-29 | 2007-04-12 | Stratagene California | Methods of identification and use of gene signatures |
| US20070255113A1 (en) | 2006-05-01 | 2007-11-01 | Grimes F R | Methods and apparatus for identifying disease status using biomarkers |
| US8124332B2 (en) * | 2006-09-14 | 2012-02-28 | Institut Pasteur | Methods of using sIP-10, CD26 inhibitors and CXCR3 levels in a sample to assess clearance of infection, response to interferon therapy, and treating chronic infections |
| US20100119474A1 (en) | 2007-03-06 | 2010-05-13 | Cornell University | Chronic obstructive pulmonary disease susceptibility and related compositions and methods |
| EP2171084B1 (en) * | 2007-06-01 | 2012-02-01 | Agendia B.V. | Prognostic gene expression signature for non small cell lung cancer patients |
| CN101603084A (zh) * | 2009-07-08 | 2009-12-16 | 上海新春苗生物科技发展有限公司 | 吸烟引发肺癌风险基因测评及套组方法 |
| EP2521730A4 (en) * | 2010-01-04 | 2013-06-12 | Lineagen Inc | GEN BIOMARKER FOR THE LUNG FUNCTION |
| US20110256545A1 (en) * | 2010-04-14 | 2011-10-20 | Nancy Lan Guo | mRNA expression-based prognostic gene signature for non-small cell lung cancer |
| SG10201508656VA (en) * | 2010-07-09 | 2015-11-27 | Somalogic Inc | Lung cancer biomarkers and uses thereof |
| WO2012125712A2 (en) * | 2011-03-14 | 2012-09-20 | Respira Health, Llc | Lung tumor classifier for current and former smokers |
| CA2846837A1 (en) * | 2011-08-29 | 2013-03-07 | Cardiodx, Inc. | Methods and compositions for determining smoking status |
| CA2853945C (en) * | 2011-10-31 | 2020-09-22 | The Johns Hopkins University | Methods and compositions for treatment of autism |
| CA2806382C (en) * | 2012-02-20 | 2021-11-23 | Laboratory Corporation Of America Holdings | Diagnostic methods and markers for bacterial vaginosis |
| CN102757956B (zh) * | 2012-07-18 | 2015-04-01 | 云南省烟草农业科学研究院 | 烟草基因组分子标记探针与序列集合群及获得方法与应用 |
| US20140060552A1 (en) * | 2012-08-28 | 2014-03-06 | Ploom, Inc. | Methods and devices for delivery and monitoring of tobacco, nicotine, or other substances |
| WO2014134354A1 (en) * | 2013-03-01 | 2014-09-04 | North Carolina State University | Transcription factors that regulate nicotine biosynthesis in tobacco |
-
2014
- 2014-12-11 CN CN201480066495.6A patent/CN106415563B/zh active Active
- 2014-12-11 EP EP14818928.5A patent/EP3084664B8/en active Active
- 2014-12-11 WO PCT/EP2014/077473 patent/WO2015091225A1/en active Application Filing
- 2014-12-11 US US15/104,414 patent/US11127486B2/en active Active
- 2014-12-11 CA CA2932649A patent/CA2932649C/en active Active
- 2014-12-11 JP JP2016532548A patent/JP6703479B2/ja active Active
- 2014-12-11 PL PL14818928T patent/PL3084664T3/pl unknown
- 2014-12-11 CN CN202010375800.7A patent/CN111540410B/zh active Active
-
2017
- 2017-06-09 HK HK17105719.0A patent/HK1232312A1/zh unknown
-
2020
- 2020-02-05 JP JP2020017791A patent/JP2020072741A/ja not_active Withdrawn
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