JP2019536802A5 - - Google Patents
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- JP2019536802A5 JP2019536802A5 JP2019529901A JP2019529901A JP2019536802A5 JP 2019536802 A5 JP2019536802 A5 JP 2019536802A5 JP 2019529901 A JP2019529901 A JP 2019529901A JP 2019529901 A JP2019529901 A JP 2019529901A JP 2019536802 A5 JP2019536802 A5 JP 2019536802A5
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- JP
- Japan
- Prior art keywords
- cntfr
- polypeptide
- pharmaceutical composition
- composition according
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 102100031615 Ciliary neurotrophic factor receptor subunit alpha Human genes 0.000 claims 28
- 101000993348 Homo sapiens Ciliary neurotrophic factor receptor subunit alpha Proteins 0.000 claims 28
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 230000035772 mutation Effects 0.000 claims 10
- 102100029391 Cardiotrophin-like cytokine factor 1 Human genes 0.000 claims 9
- 101710107109 Cardiotrophin-like cytokine factor 1 Proteins 0.000 claims 9
- 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 claims 5
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 102000004357 Transferases Human genes 0.000 claims 2
- 108090000992 Transferases Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430757P | 2016-12-06 | 2016-12-06 | |
| US62/430,757 | 2016-12-06 | ||
| US201762481027P | 2017-04-03 | 2017-04-03 | |
| US62/481,027 | 2017-04-03 | ||
| PCT/US2017/064883 WO2018106790A1 (en) | 2016-12-06 | 2017-12-06 | Ciliary neurotrophic factor receptor ligand-binding agents and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536802A JP2019536802A (ja) | 2019-12-19 |
| JP2019536802A5 true JP2019536802A5 (https=) | 2021-01-21 |
| JP7257680B2 JP7257680B2 (ja) | 2023-04-14 |
Family
ID=62491581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529901A Active JP7257680B2 (ja) | 2016-12-06 | 2017-12-06 | 毛様体神経栄養因子受容体リガンド結合剤およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11208462B2 (https=) |
| EP (1) | EP3551648A4 (https=) |
| JP (1) | JP7257680B2 (https=) |
| KR (1) | KR102667654B1 (https=) |
| CN (2) | CN110234660B (https=) |
| AU (1) | AU2017370653B2 (https=) |
| CA (1) | CA3045925A1 (https=) |
| WO (1) | WO2018106790A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4028044A4 (en) * | 2019-09-10 | 2023-09-27 | The Board of Trustees of the Leland Stanford Junior University | Methods of treating kras mutant cancers |
| MA71452A (fr) * | 2022-07-12 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Anticorps dirigés contre le récepteur du facteur neurotrophique ciliaire (cntfr) et leurs procédés d'utilisation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5426177A (en) * | 1990-06-01 | 1995-06-20 | Regeneron Pharmaceuticals, Inc. | Ciliary neurotrophic factor receptor |
| CN1061623A (zh) * | 1990-06-01 | 1992-06-03 | 里珍纳龙药品有限公司 | 睫状神经营养性因子受体 |
| IT1284867B1 (it) * | 1996-07-10 | 1998-05-22 | Angeletti P Ist Richerche Bio | Varianti del fattore neurotrofico ciliare umano (hcntf) con uno spettro di azione differente dalla molecola di tipo selvatico |
| MXPA03007839A (es) * | 2001-03-02 | 2003-12-08 | Merck Patent Gmbh | Factor neurotrofico ciliar modificaco con inmunogenicidad reducida. |
| US20080254451A1 (en) * | 2004-12-28 | 2008-10-16 | Ares Trading S.A. | Compositions and Methods for Treating Schizophrenia and Related Disorders |
| CN100457778C (zh) * | 2005-09-02 | 2009-02-04 | 中国药品生物制品检定所 | 睫状神经营养因子(cntf)突变体及其生产方法和其用途 |
| DE102011104822A1 (de) * | 2011-06-18 | 2012-12-20 | Christian-Albrechts-Universität Zu Kiel | Ciliary-Neutrophic-Factor-Varianten |
-
2017
- 2017-12-06 CA CA3045925A patent/CA3045925A1/en active Pending
- 2017-12-06 AU AU2017370653A patent/AU2017370653B2/en active Active
- 2017-12-06 US US16/465,754 patent/US11208462B2/en active Active
- 2017-12-06 CN CN201780084930.1A patent/CN110234660B/zh active Active
- 2017-12-06 WO PCT/US2017/064883 patent/WO2018106790A1/en not_active Ceased
- 2017-12-06 KR KR1020197019343A patent/KR102667654B1/ko active Active
- 2017-12-06 CN CN202410001971.1A patent/CN118141922A/zh active Pending
- 2017-12-06 JP JP2019529901A patent/JP7257680B2/ja active Active
- 2017-12-06 EP EP17879568.8A patent/EP3551648A4/en active Pending
-
2021
- 2021-12-20 US US17/556,522 patent/US20220213171A1/en active Pending