JP2019535807A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019535807A5 JP2019535807A5 JP2019541679A JP2019541679A JP2019535807A5 JP 2019535807 A5 JP2019535807 A5 JP 2019535807A5 JP 2019541679 A JP2019541679 A JP 2019541679A JP 2019541679 A JP2019541679 A JP 2019541679A JP 2019535807 A5 JP2019535807 A5 JP 2019535807A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- oxygen
- sulfur
- independently
- heteroatoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022000195A JP7498200B2 (ja) | 2016-10-14 | 2022-01-04 | Tyk2阻害剤およびその使用 |
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408464P | 2016-10-14 | 2016-10-14 | |
| US62/408,464 | 2016-10-14 | ||
| US201662410334P | 2016-10-19 | 2016-10-19 | |
| US201662410327P | 2016-10-19 | 2016-10-19 | |
| US62/410,334 | 2016-10-19 | ||
| US62/410,327 | 2016-10-19 | ||
| US201662413829P | 2016-10-27 | 2016-10-27 | |
| US62/413,829 | 2016-10-27 | ||
| US201662415920P | 2016-11-01 | 2016-11-01 | |
| US62/415,920 | 2016-11-01 | ||
| US201762468749P | 2017-03-08 | 2017-03-08 | |
| US201762468767P | 2017-03-08 | 2017-03-08 | |
| US201762468807P | 2017-03-08 | 2017-03-08 | |
| US62/468,767 | 2017-03-08 | ||
| US62/468,807 | 2017-03-08 | ||
| US62/468,749 | 2017-03-08 | ||
| US201762546278P | 2017-08-16 | 2017-08-16 | |
| US62/546,278 | 2017-08-16 | ||
| PCT/US2017/056555 WO2018071794A1 (en) | 2016-10-14 | 2017-10-13 | Tyk2 inhibitors and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022000195A Division JP7498200B2 (ja) | 2016-10-14 | 2022-01-04 | Tyk2阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535807A JP2019535807A (ja) | 2019-12-12 |
| JP2019535807A5 true JP2019535807A5 (enExample) | 2020-11-19 |
| JP7082130B2 JP7082130B2 (ja) | 2022-06-07 |
Family
ID=61906011
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541679A Active JP7082130B2 (ja) | 2016-10-14 | 2017-10-13 | Tyk2阻害剤およびその使用 |
| JP2022000195A Active JP7498200B2 (ja) | 2016-10-14 | 2022-01-04 | Tyk2阻害剤およびその使用 |
| JP2023091142A Withdrawn JP2023106606A (ja) | 2016-10-14 | 2023-06-01 | Tyk2阻害剤およびその使用 |
| JP2025202716A Pending JP2026035684A (ja) | 2016-10-14 | 2025-11-25 | Tyk2阻害剤およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022000195A Active JP7498200B2 (ja) | 2016-10-14 | 2022-01-04 | Tyk2阻害剤およびその使用 |
| JP2023091142A Withdrawn JP2023106606A (ja) | 2016-10-14 | 2023-06-01 | Tyk2阻害剤およびその使用 |
| JP2025202716A Pending JP2026035684A (ja) | 2016-10-14 | 2025-11-25 | Tyk2阻害剤およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10323036B2 (enExample) |
| EP (2) | EP3526222B1 (enExample) |
| JP (4) | JP7082130B2 (enExample) |
| CN (2) | CN115448916B (enExample) |
| AU (3) | AU2017342464B2 (enExample) |
| CA (1) | CA3039202A1 (enExample) |
| ES (1) | ES2930198T3 (enExample) |
| IL (2) | IL315777A (enExample) |
| TW (2) | TWI763722B (enExample) |
| WO (1) | WO2018071794A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI788655B (zh) | 2015-02-27 | 2023-01-01 | 美商林伯士拉克許米公司 | 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途 |
| TWI707852B (zh) | 2015-09-02 | 2020-10-21 | 美商林伯士拉克許米公司 | Tyk2 抑制劑及其用途 |
| US10323036B2 (en) | 2016-10-14 | 2019-06-18 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
| GB201617871D0 (en) * | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| EP3528816A4 (en) * | 2016-10-21 | 2020-04-08 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| TW202515876A (zh) | 2017-03-08 | 2025-04-16 | 日商武田藥品工業股份有限公司 | Tyk2抑制劑及其用途 |
| SI3658557T1 (sl) | 2017-07-28 | 2024-10-30 | Takeda Pharmaceutical Company Limited | Zaviralci TYK2 in njihova uporaba |
| AR117398A1 (es) | 2018-03-12 | 2021-08-04 | Abbvie Inc | Inhibidores de la señalización mediada por tirosina cinasa 2 |
| CN112839648B (zh) * | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
| WO2020051424A1 (en) | 2018-09-07 | 2020-03-12 | Pic Therapeutics | Eif4e inhibitors and uses thereof |
| CN113271940A (zh) * | 2018-10-15 | 2021-08-17 | 林伯士拉克许米公司 | Tyk2抑制剂和其用途 |
| CA3120866A1 (en) * | 2018-11-30 | 2020-06-04 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| CN113348021B (zh) * | 2019-01-23 | 2025-07-11 | 武田药品工业株式会社 | Tyk2抑制剂和其用途 |
| SG11202108162SA (en) * | 2019-01-30 | 2021-08-30 | Bristol Myers Squibb Co | Amide-disubstituted pyridine or pyridazine compounds |
| SG11202112043PA (en) | 2019-04-30 | 2021-11-29 | Celgene Corp | Combination therapies comprising apremilast and tyk2 inhibitors |
| CA3147573A1 (en) | 2019-07-17 | 2021-01-21 | 2692372 Ontario, Inc. | Benzenesulfonamide derivatives and uses thereof |
| KR20220059519A (ko) * | 2019-09-11 | 2022-05-10 | 화이자 인코포레이티드 | 키나제 억제제에 의한 한선염의 치료 |
| WO2021170046A1 (en) | 2020-02-26 | 2021-09-02 | Beigene, Ltd. | Tyk-2 inhibitor |
| TW202146393A (zh) | 2020-03-03 | 2021-12-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
| WO2021237121A1 (en) * | 2020-05-21 | 2021-11-25 | Gossamer Bio Services, Inc. | Substituted pyridines |
| KR20230042278A (ko) * | 2020-06-22 | 2023-03-28 | 베이진 엘티디 | Tyk-2 저해제 |
| WO2022083560A1 (zh) * | 2020-10-19 | 2022-04-28 | 南京药石科技股份有限公司 | Tyk2选择性抑制剂及其用途 |
| GB2617477A (en) | 2020-11-20 | 2023-10-11 | 2692372 Ontario Inc | Benzenesulfonamide derivatives and uses thereof |
| US20240124440A1 (en) * | 2020-12-23 | 2024-04-18 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| AU2022222470A1 (en) | 2021-02-19 | 2023-09-21 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| CA3208361A1 (en) | 2021-02-19 | 2022-08-25 | Anjali Pandey | Tyk2 inhibitors and uses thereof |
| EP4294806A1 (en) | 2021-02-19 | 2023-12-27 | Sudo Biosciences Limited | Tyk2 inhibitors and uses thereof |
| CA3213816A1 (en) | 2021-03-16 | 2022-09-22 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| JP7740849B2 (ja) * | 2021-05-04 | 2025-09-17 | シャンハイ ゼイ バイオテクノロジー カンパニー リミテッド | 含窒素複素環ピリジン化合物 |
| CN115466289A (zh) * | 2021-06-11 | 2022-12-13 | 爱科诺生物医药(香港)有限公司 | 具有tyk2抑制活性的化合物,包含其的药物组合物,及其应用 |
| US12157732B2 (en) | 2021-08-25 | 2024-12-03 | PIC Therapeutics, Inc. | eIF4E inhibitors and uses thereof |
| CA3229560A1 (en) | 2021-08-25 | 2023-03-02 | Christopher L. Vandeusen | Eif4e inhibitors and uses thereof |
| US20240390369A1 (en) | 2021-09-30 | 2024-11-28 | Bristol-Myers Squibb Company | Methods for determining responsiveness to tyk2 inhibitors |
| EP4423086A1 (en) | 2021-10-25 | 2024-09-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| TW202340203A (zh) * | 2021-12-23 | 2023-10-16 | 英屬開曼群島商百濟神州有限公司 | Tyk2抑制劑的固體形式、製備方法及其用途 |
| WO2023220046A1 (en) * | 2022-05-10 | 2023-11-16 | Biogen Ma Inc. | Tyk2 inhibitors |
| WO2023248010A2 (en) | 2022-06-23 | 2023-12-28 | Synovo Gmbh | Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases |
| US20240124450A1 (en) | 2022-09-21 | 2024-04-18 | Pfizer Inc. | Novel SIK Inhibitors |
| CN115819429A (zh) * | 2022-12-13 | 2023-03-21 | 成都睿智化学研究有限公司 | 一种5-氯-2,3-二氢呋喃[2,3-c]吡啶的合成方法 |
| WO2024193689A1 (zh) * | 2023-03-23 | 2024-09-26 | 广东东阳光药业股份有限公司 | 吡啶并吡咯衍生物及其在药物中的用途 |
| WO2024211708A1 (en) * | 2023-04-06 | 2024-10-10 | Myrobalan Therapeutics, Inc. | Tyk2 inhibitors for treatment of glaucoma |
| WO2024217523A1 (en) * | 2023-04-20 | 2024-10-24 | Myrobalan Therapeutics Nanjing Co. Ltd | Selective tky2 inhibitors and uses thereof |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| GB599891A (en) * | 1944-11-17 | 1948-03-23 | Gen Aniline & Film Corp | 1-substituted-2,5-diketo-7-methyl-pyrimido-pyrazoles and process of preparing the same |
| US5516931A (en) | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| US5650270A (en) | 1982-02-01 | 1997-07-22 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US4709016A (en) | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US4650750A (en) | 1982-02-01 | 1987-03-17 | Giese Roger W | Method of chemical analysis employing molecular release tag compounds |
| DE60037345T2 (de) | 1999-12-10 | 2008-11-13 | Pfizer Products Inc., Groton | Pyrrolo(2,3-d)pyrimidin-Verbindungen |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| DE60217322T2 (de) | 2001-04-27 | 2007-10-04 | Zenyaku Kogyo K.K. | Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält |
| WO2003057689A1 (en) * | 2002-01-02 | 2003-07-17 | Fujisawa Pharmaceutical Co., Ltd. | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| PT1536827E (pt) | 2002-08-14 | 2009-03-20 | Silence Therapeutics Ag | Utilização de proteína cinase n beta |
| AU2004228668B2 (en) | 2003-04-03 | 2011-10-27 | Park Funding, Llc | PI-3 kinase inhibitor prodrugs |
| ES2382377T3 (es) | 2003-05-30 | 2012-06-07 | Gemin X Pharmaceuticals Canada Inc. | Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer |
| EP1692153A4 (en) | 2003-07-03 | 2007-03-21 | Univ Pennsylvania | INHIBITION OF EXPRESSION OF SYK-KINASE |
| CN1950389B (zh) * | 2004-03-04 | 2011-01-19 | 橘生药品工业株式会社 | 含氮稠环衍生物,含该衍生物的药物组合物,和其作为药物的用途 |
| WO2005113556A1 (en) | 2004-05-13 | 2005-12-01 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| AU2006206458B2 (en) | 2005-01-19 | 2012-10-25 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| PL1888550T3 (pl) | 2005-05-12 | 2014-12-31 | Abbvie Bahamas Ltd | Promotory apoptozy |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| US7989622B2 (en) | 2005-10-07 | 2011-08-02 | Exelixis, Inc. | Phosphatidylinositol 3-kinase inhibitors and methods of their use |
| JP5191391B2 (ja) | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| SG10202003901UA (en) | 2005-12-13 | 2020-05-28 | Incyte Holdings Corp | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| CN101437512A (zh) * | 2006-01-27 | 2009-05-20 | 阿雷生物药品公司 | 葡萄糖激酶活化剂 |
| KR20080092412A (ko) * | 2006-02-06 | 2008-10-15 | 아이알엠 엘엘씨 | 단백질 키나제 억제제로서의 화합물 및 조성물 |
| WO2007129161A2 (en) | 2006-04-26 | 2007-11-15 | F. Hoffmann-La Roche Ag | Thieno [3, 2-d] pyrimidine derivative useful as pi3k inhibitor |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| PT2114900T (pt) * | 2007-01-31 | 2019-01-17 | Ym Biosciences Australia Pty | Compostos à base de tiopirimidina e as suas utilizações |
| KR101566840B1 (ko) | 2007-03-12 | 2015-11-06 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| EA200901133A1 (ru) * | 2007-03-20 | 2010-04-30 | Смитклайн Бичем Корпорейшн | Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение |
| WO2008118802A1 (en) | 2007-03-23 | 2008-10-02 | Regents Of The University Of Minnesota | Therapeutic compounds |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| GB0719644D0 (en) * | 2007-10-05 | 2007-11-14 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| HUE029767T2 (en) | 2008-03-11 | 2017-04-28 | Incyte Holdings Corp | JAK inhibitor azetidine and cyclobutane derivatives |
| EP2299816B1 (en) * | 2008-06-18 | 2013-11-13 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| MX2012015147A (es) * | 2010-06-30 | 2013-05-01 | Amgen Inc | Compuestos heterociclicos y su uso como inhibidores de la actividad pi3k. |
| JP2014500254A (ja) * | 2010-11-09 | 2014-01-09 | セルゾーム リミティッド | Tyk2阻害剤としてのピリジン化合物およびそのアザ類似体 |
| US9033542B2 (en) * | 2010-11-16 | 2015-05-19 | Dialight Corporation | LED luminaire utilizing an extended and non-metallic enclosure |
| BR112013011520A2 (pt) * | 2010-11-19 | 2019-09-24 | Hoffmann La Roche | pirazolo piridinas e pirazolo piridinas e seu uso como inibidores de tyk2 |
| ES2575604T3 (es) * | 2012-01-13 | 2016-06-29 | Bristol-Myers Squibb Company | Compuestos de piridilo sustituidos con tiazolilo o tiadiazolilo útiles como inhibidores cinasa |
| CN104169275B (zh) * | 2012-01-13 | 2017-06-09 | 百时美施贵宝公司 | 用作激酶抑制剂的三唑取代的吡啶化合物 |
| EP2802576B1 (en) * | 2012-01-13 | 2018-06-27 | Bristol-Myers Squibb Company | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors |
| KR102233252B1 (ko) | 2012-11-08 | 2021-03-26 | 브리스톨-마이어스 스큅 컴퍼니 | IL-12, IL-23 및/또는 IFNα 반응의 조절제로서 유용한 알킬-아미드-치환된 피리딜 화합물 |
| LT3495358T (lt) | 2012-11-08 | 2022-05-25 | Bristol-Myers Squibb Company | Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai |
| RU2671212C2 (ru) * | 2013-02-02 | 2018-10-30 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд | Замещенный 2-аминопиридин в качестве ингибитора протеинкиназы |
| WO2014210354A1 (en) * | 2013-06-28 | 2014-12-31 | Genentech, Inc. | Azaindazole compounds as inhibitors of t790m containing egfr mutants |
| WO2015038417A1 (en) * | 2013-09-10 | 2015-03-19 | Asana Biosciences, Llc | Compounds for regulating fak and/or src pathways |
| TWI582077B (zh) * | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物 |
| WO2015073267A1 (en) * | 2013-11-15 | 2015-05-21 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| ES2702126T3 (es) | 2013-12-10 | 2019-02-27 | Bristol Myers Squibb Co | Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa |
| WO2015131080A1 (en) | 2014-02-28 | 2015-09-03 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| NO2721710T3 (enExample) * | 2014-08-21 | 2018-03-31 | ||
| TWI788655B (zh) | 2015-02-27 | 2023-01-01 | 美商林伯士拉克許米公司 | 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途 |
| EP3313840B1 (en) * | 2015-06-24 | 2019-07-24 | Bristol-Myers Squibb Company | Heteroaryl substituted aminopyridine compounds |
| US10323036B2 (en) | 2016-10-14 | 2019-06-18 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
-
2017
- 2017-10-13 US US15/783,250 patent/US10323036B2/en active Active
- 2017-10-13 EP EP17860009.4A patent/EP3526222B1/en active Active
- 2017-10-13 WO PCT/US2017/056555 patent/WO2018071794A1/en not_active Ceased
- 2017-10-13 CA CA3039202A patent/CA3039202A1/en active Pending
- 2017-10-13 CN CN202211114285.2A patent/CN115448916B/zh active Active
- 2017-10-13 CN CN201780069795.3A patent/CN109952303B/zh active Active
- 2017-10-13 JP JP2019541679A patent/JP7082130B2/ja active Active
- 2017-10-13 TW TW106135165A patent/TWI763722B/zh active
- 2017-10-13 IL IL315777A patent/IL315777A/en unknown
- 2017-10-13 IL IL265922A patent/IL265922B2/en unknown
- 2017-10-13 ES ES17860009T patent/ES2930198T3/es active Active
- 2017-10-13 TW TW111113673A patent/TWI825663B/zh active
- 2017-10-13 EP EP21157963.6A patent/EP3848370B1/en active Active
- 2017-10-13 AU AU2017342464A patent/AU2017342464B2/en active Active
-
2019
- 2019-04-30 US US16/399,296 patent/US10793574B2/en active Active
-
2020
- 2020-05-04 US US16/865,924 patent/US11220508B2/en active Active
-
2021
- 2021-09-03 AU AU2021225251A patent/AU2021225251A1/en not_active Abandoned
- 2021-09-17 US US17/448,013 patent/US20220073527A1/en not_active Abandoned
-
2022
- 2022-01-04 JP JP2022000195A patent/JP7498200B2/ja active Active
-
2023
- 2023-06-01 JP JP2023091142A patent/JP2023106606A/ja not_active Withdrawn
- 2023-09-26 AU AU2023237060A patent/AU2023237060B2/en active Active
-
2025
- 2025-11-25 JP JP2025202716A patent/JP2026035684A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019535807A5 (enExample) | ||
| JP2022509260A5 (enExample) | ||
| JP2022502515A5 (enExample) | ||
| IL271999B2 (en) | Tyk2 inhibitors and uses thereof | |
| JP2018532706A5 (enExample) | ||
| AU2018265130B2 (en) | Thienopyridines and benzothiophenes useful as IRAK4 inhibitors | |
| HRP20200179T1 (hr) | Spojevi heteroarila kao inhibitori irak i njihova uporaba | |
| JP2010522210A5 (enExample) | ||
| JP2019532930A5 (enExample) | ||
| JP2016530297A5 (enExample) | ||
| JP6640222B2 (ja) | ヘテロ環式誘導体およびその使用 | |
| RU2008130884A (ru) | Гетероциклические ингибиторы янус-киназы 3 | |
| JP2009532475A5 (enExample) | ||
| JP2017536369A5 (enExample) | ||
| JP2019530699A5 (enExample) | ||
| HRP20100032T1 (hr) | Tiadiazolidinoni kao inhibitori gsk-3 | |
| JP2013515729A5 (enExample) | ||
| JP2014512404A5 (enExample) | ||
| CA2510534A1 (en) | Compositions useful as inhibitors of protein kinases | |
| JP2020511438A5 (enExample) | ||
| JP2022500499A5 (enExample) | ||
| JP2016028076A5 (enExample) | ||
| JP2016540803A5 (enExample) | ||
| JP2024540292A5 (enExample) | ||
| CN102083809B (zh) | 基于阻断TCR-Nck相互作用的免疫抑制物 |