JP2019534867A - カンナビノイド受容体結合リガンドを含む組成物 - Google Patents
カンナビノイド受容体結合リガンドを含む組成物 Download PDFInfo
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- JP2019534867A JP2019534867A JP2019516407A JP2019516407A JP2019534867A JP 2019534867 A JP2019534867 A JP 2019534867A JP 2019516407 A JP2019516407 A JP 2019516407A JP 2019516407 A JP2019516407 A JP 2019516407A JP 2019534867 A JP2019534867 A JP 2019534867A
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| JP2021073541A (ja) * | 2016-12-27 | 2021-05-13 | フェイスブック・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＦａｃｅｂｏｏｋ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｌｌｃ | 触覚デバイスの大規模集積化 |
Families Citing this family (20)
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| KR101656121B1 (ko) | 2010-03-17 | 2016-09-08 | 노바리크 게엠베하 | 안압 증가를 치료하기 위한 약학 조성물 |
| EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
| JP6039152B2 (ja) | 2012-09-12 | 2016-12-07 | ノバリック ゲーエムベーハー | 半フッ素化アルカン組成物 |
| DE202016008738U1 (de) | 2015-09-30 | 2019-04-09 | Novaliq Gmbh | Semifluorierte Verbindungen und ihre Zusammensetzungen |
| CN108349855B (zh) | 2015-09-30 | 2021-07-20 | 诺瓦利克有限责任公司 | 用于眼部给药的半氟化化合物 |
| CN116172987A (zh) | 2016-09-22 | 2023-05-30 | 诺瓦利克有限责任公司 | 用于治疗睑缘炎的药物组合物 |
| US10813976B2 (en) | 2016-09-23 | 2020-10-27 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| CN110678207A (zh) | 2017-04-21 | 2020-01-10 | 诺瓦利克有限责任公司 | 碘组合物 |
| US11278503B2 (en) | 2017-05-12 | 2022-03-22 | Novaliq Gmbh | Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions |
| CN111372566A (zh) | 2017-09-27 | 2020-07-03 | 诺瓦利克有限责任公司 | 用于治疗眼部疾病的包含拉坦前列素的眼科用组合物 |
| CN111182893A (zh) | 2017-10-04 | 2020-05-19 | 诺瓦利克有限责任公司 | 包含f6h8的眼用组合物 |
| WO2019071008A1 (en) | 2017-10-04 | 2019-04-11 | Pneuma Respiratory, Inc. | ELECTRONIC DEVICE FOR DELIVERY OF LINEAR SHAPE ADMINISTRATION OPERATED BY BREATHING AND METHODS OF USE |
| CA3082192A1 (en) | 2017-11-08 | 2019-05-16 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
| SG11202007858VA (en) | 2018-03-02 | 2020-09-29 | Novaliq Gmbh | Pharmaceutical compositions comprising nebivolol |
| SG11202102820VA (en) | 2018-10-12 | 2021-04-29 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| AU2020216470B2 (en) * | 2019-02-01 | 2023-05-04 | Aerie Pharmaceuticals, Inc. | Compounds, compositions and methods for treatment of myopia |
| KR20230109623A (ko) * | 2020-10-05 | 2023-07-20 | 맥스 바이올로지 컴퍼니 리미티드 | 질환을 치료 및 예방하기 위한 칸나비노이드-함유 조성물 및 용도 |
| US11191751B1 (en) * | 2020-10-08 | 2021-12-07 | Ads Therapeutics Llc | Topical ophthalmological atropine free base compositions |
| US11793945B2 (en) | 2021-06-22 | 2023-10-24 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
| WO2023064477A1 (en) * | 2021-10-13 | 2023-04-20 | Pneuma Respiratory, Inc. | Compositions for delivery of cannabinoids |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000511157A (ja) * | 1995-09-29 | 2000-08-29 | マイネルト，ハッソ | セミフルオロアルカン及びその使用 |
| JP2013513586A (ja) * | 2009-12-14 | 2013-04-22 | ノバリック ゲーエムベーハー | ドライアイ症候群の治療のための医薬組成物 |
| JP2013540140A (ja) * | 2010-10-20 | 2013-10-31 | ノバリック ゲーエムベーハー | 有効成分の送達のための液体医薬組成物 |
| WO2015074137A1 (en) * | 2013-11-20 | 2015-05-28 | Mary Lynch | Compositions and methods for treatment of ocular inflammation and pain |
| WO2016109531A1 (en) * | 2014-12-30 | 2016-07-07 | Axim Biotechnologies, Inc. | Ophthalmic solutions for glaucoma and conjunctivitis treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516333A (zh) | 2006-08-04 | 2009-08-26 | 英西斯治疗学股份有限公司 | 水性屈大麻酚制剂 |
| US8222292B2 (en) | 2007-08-06 | 2012-07-17 | Insys Therapeutics, Inc. | Liquid cannabinoid formulations |
| CA2741862C (en) | 2008-10-31 | 2017-10-17 | Mahmoud A. Elsohly | Compositions containing delta-9-thc-amino acid esters and process of preparation |
| AT509000B1 (de) * | 2009-10-23 | 2012-12-15 | Rausch Peter | Wasserlösliche zubereitungen von cannabinoiden und cannabispräparaten und deren anwendungen |
| US8758826B2 (en) | 2011-07-05 | 2014-06-24 | Wet Inc. | Cannabinoid receptor binding agents, compositions, and methods |
| CN113679697A (zh) * | 2012-09-12 | 2021-11-23 | 诺瓦利克有限责任公司 | 包含半氟化烷烃的混合物的组合物 |
| JP6039152B2 (ja) * | 2012-09-12 | 2016-12-07 | ノバリック ゲーエムベーハー | 半フッ素化アルカン組成物 |
| CN106061490A (zh) | 2013-10-09 | 2016-10-26 | 列奥尼达斯·A·约翰逊 | 一种治疗和预防眼部疾病症状或体征的方法及组合物 |
-
2017
- 2017-09-27 CA CA3036313A patent/CA3036313A1/en not_active Withdrawn
- 2017-09-27 AU AU2017333420A patent/AU2017333420A1/en not_active Abandoned
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000511157A (ja) * | 1995-09-29 | 2000-08-29 | マイネルト，ハッソ | セミフルオロアルカン及びその使用 |
| JP2013513586A (ja) * | 2009-12-14 | 2013-04-22 | ノバリック ゲーエムベーハー | ドライアイ症候群の治療のための医薬組成物 |
| JP2013540140A (ja) * | 2010-10-20 | 2013-10-31 | ノバリック ゲーエムベーハー | 有効成分の送達のための液体医薬組成物 |
| WO2015074137A1 (en) * | 2013-11-20 | 2015-05-28 | Mary Lynch | Compositions and methods for treatment of ocular inflammation and pain |
| WO2016109531A1 (en) * | 2014-12-30 | 2016-07-07 | Axim Biotechnologies, Inc. | Ophthalmic solutions for glaucoma and conjunctivitis treatment |
Non-Patent Citations (3)
| Title |
|---|
| AM J DRUG DELIV, vol. 2, no. 4, JPN6021023811, 2004, pages 229 - 240, ISSN: 0004827481 * |
| EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 88, JPN6021023813, 2014, pages 123 - 128, ISSN: 0004827482 * |
| INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 57, JPN6021023814, 2016, pages 417, ISSN: 0004827483 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021073541A (ja) * | 2016-12-27 | 2021-05-13 | フェイスブック・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＦａｃｅｂｏｏｋ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｌｌｃ | 触覚デバイスの大規模集積化 |
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| US20190343793A1 (en) | 2019-11-14 |
| EP3518921B1 (en) | 2021-08-11 |
| EP3518921A1 (en) | 2019-08-07 |
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| KR20190060787A (ko) | 2019-06-03 |
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| BR112019006194A2 (pt) | 2019-06-18 |
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| US9937225B2 (en) | Topical formulations and uses thereof | |
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