JP2019534706A5 - - Google Patents
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- Publication number
- JP2019534706A5 JP2019534706A5 JP2019520386A JP2019520386A JP2019534706A5 JP 2019534706 A5 JP2019534706 A5 JP 2019534706A5 JP 2019520386 A JP2019520386 A JP 2019520386A JP 2019520386 A JP2019520386 A JP 2019520386A JP 2019534706 A5 JP2019534706 A5 JP 2019534706A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug conjugate
- seq
- heavy chain
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021190070A JP7383682B2 (ja) | 2016-10-17 | 2021-11-24 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2023191037A JP2023184697A (ja) | 2016-10-17 | 2023-11-08 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2025146227A JP2025175010A (ja) | 2016-10-17 | 2025-09-03 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662409081P | 2016-10-17 | 2016-10-17 | |
| US62/409,081 | 2016-10-17 | ||
| PCT/IB2017/056093 WO2018073680A1 (en) | 2016-10-17 | 2017-10-03 | Anti-edb antibodies and antibody-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021190070A Division JP7383682B2 (ja) | 2016-10-17 | 2021-11-24 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534706A JP2019534706A (ja) | 2019-12-05 |
| JP2019534706A5 true JP2019534706A5 (https=) | 2020-11-12 |
| JP7039577B2 JP7039577B2 (ja) | 2022-03-22 |
Family
ID=60117722
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520386A Active JP7039577B2 (ja) | 2016-10-17 | 2017-10-03 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2021190070A Active JP7383682B2 (ja) | 2016-10-17 | 2021-11-24 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2023191037A Pending JP2023184697A (ja) | 2016-10-17 | 2023-11-08 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2025146227A Pending JP2025175010A (ja) | 2016-10-17 | 2025-09-03 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021190070A Active JP7383682B2 (ja) | 2016-10-17 | 2021-11-24 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2023191037A Pending JP2023184697A (ja) | 2016-10-17 | 2023-11-08 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
| JP2025146227A Pending JP2025175010A (ja) | 2016-10-17 | 2025-09-03 | 抗ｅｄｂ抗体および抗体－薬物コンジュゲート |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US20190269791A1 (https=) |
| EP (3) | EP3525828B1 (https=) |
| JP (4) | JP7039577B2 (https=) |
| KR (1) | KR102338660B1 (https=) |
| CN (2) | CN116251196A (https=) |
| AU (3) | AU2017344440B2 (https=) |
| CA (1) | CA3040423A1 (https=) |
| DK (1) | DK3525828T3 (https=) |
| ES (1) | ES3007557T3 (https=) |
| FI (1) | FI3525828T3 (https=) |
| HR (1) | HRP20250056T1 (https=) |
| HU (1) | HUE070615T2 (https=) |
| IL (2) | IL310865A (https=) |
| LT (1) | LT3525828T (https=) |
| MX (2) | MX2019004434A (https=) |
| PL (1) | PL3525828T3 (https=) |
| PT (1) | PT3525828T (https=) |
| RS (1) | RS66524B1 (https=) |
| RU (1) | RU2758632C2 (https=) |
| SG (1) | SG11201903400WA (https=) |
| SI (1) | SI3525828T1 (https=) |
| WO (1) | WO2018073680A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| KR20210102334A (ko) * | 2018-12-12 | 2021-08-19 | 브리스톨-마이어스 스큅 컴퍼니 | 트랜스글루타미나제 접합을 위해 변형된 항체, 그의 접합체, 및 방법 및 용도 |
| KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
| CN112816453B (zh) * | 2021-02-09 | 2022-07-08 | 黑龙江大学 | 蛋白在预测药物性能上的应用 |
| WO2022246141A2 (en) * | 2021-05-20 | 2022-11-24 | Case Western Reserve University | Peptide drug conjugates specific to fibronectin isotypes for cancer therapy |
| CA3225252A1 (en) | 2021-07-14 | 2023-01-19 | Jordan JARJOUR | Engineered t cell receptors fused to binding domains from antibodies |
| CN119546328A (zh) | 2022-04-08 | 2025-02-28 | 再生元制药公司 | 多部分受体和信号传导复合物 |
| WO2025011561A1 (en) * | 2023-07-10 | 2025-01-16 | Wuxi Xdc (Shanghai) Co., Ltd. | Antibody-drug conjugates and production thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2025208105A1 (en) * | 2024-03-29 | 2025-10-02 | Pyxis Oncology, Inc. | Constructs, compositions, and methods for treating extra domain b splice variant of fibronectin-expressing diseases and disorders |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| US5952329A (en) | 1996-01-23 | 1999-09-14 | The General Hospital Corporation | Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| ATE333900T1 (de) * | 2000-02-24 | 2006-08-15 | Philogen Spa | Zusamensetzungen und verfahren zur behandlung von angiogenese in pathologischen schädigungen |
| US7498029B2 (en) | 2001-05-01 | 2009-03-03 | The General Hospital Corporation | Photoimmunotherapies for cancer using combination therapies |
| US6997863B2 (en) | 2001-07-25 | 2006-02-14 | Triton Biosystems, Inc. | Thermotherapy via targeted delivery of nanoscale magnetic particles |
| AU2003210149B2 (en) * | 2002-01-03 | 2008-10-09 | Bayer Schering Pharma Aktiengesellschaft | Conjugates comprising an antibody specific for the ED-B domain of fibronectin and their use for the detection and treatment of tumours |
| CN100535013C (zh) | 2002-03-11 | 2009-09-02 | 菲洛根股份公司 | 应用抗体分子对肿瘤血管进行选择性定向 |
| HRP20050186A2 (en) * | 2002-07-31 | 2005-10-31 | Schering Aktiengesellschaft | New effector conjugates, process for their production and their pharmaceutical use |
| WO2006113546A2 (en) | 2005-04-15 | 2006-10-26 | Neogenix Oncology, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
| ATE459648T1 (de) * | 2005-05-11 | 2010-03-15 | Philogen Spa | Fusionsprotein von antikörper l19 gegen fibronectin ed-b und interleukin 12 |
| ES2403733T3 (es) | 2005-10-05 | 2013-05-21 | Commonwealth Scientific And Industrial Research Organisation | Proteínas de seda |
| EP1842553A1 (en) | 2006-04-07 | 2007-10-10 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti-EDb fibronectin domain antibody/IL2 fusion protein and a further small molecule |
| EP2015775B1 (en) * | 2006-05-03 | 2011-06-01 | Bayer Schering Pharma Aktiengesellschaft | Combination of an anti edb fibronectin domain antibody l19-sip and an anti-egfr antibody |
| TWI412367B (zh) * | 2006-12-28 | 2013-10-21 | 梅達雷克斯有限責任公司 | 化學鏈接劑與可裂解基質以及其之綴合物 |
| EP2142567B1 (en) | 2007-04-02 | 2013-01-16 | Philogen S.p.A. | The ed-a antigen of fibrinogen is associated with the neovasculature of tumour metastases |
| EP2612869B1 (en) | 2007-07-25 | 2015-01-14 | Philogen S.p.A. | Ed-a antigen of fibrinogen that is associated with lymphomas |
| ES2382058T3 (es) * | 2008-01-17 | 2012-06-04 | Philogen S.P.A. | Combinación de una proteína de fusión de un anticuerpo dirigido contra el EDB de la fibronectina-IL-2, y una molécula de unión a los linfocitos B, progenitores de los linfocitos B y/o sus homólogos cancerosos |
| EP3912643B8 (en) * | 2009-02-13 | 2023-08-23 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| EP2461832B1 (en) | 2009-08-05 | 2017-06-28 | Philogen S.p.A. | Targeting of bone marrow neovasculature |
| ES2534085T3 (es) | 2009-08-17 | 2015-04-17 | Roche Glycart Ag | Inmunoconjugados dirigidos |
| EP3842074A1 (en) | 2010-09-29 | 2021-06-30 | Philogen S.p.A. | Protein-drug conjugates |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| MY168297A (en) | 2011-11-17 | 2018-10-23 | Pfizer | Cytotoxic Peptides and Antibody Drug Conjugates Thereof |
| JP2015502397A (ja) | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| KR102447350B1 (ko) * | 2013-02-08 | 2022-09-23 | 노파르티스 아게 | 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위 |
| EP2988784A1 (en) * | 2013-04-25 | 2016-03-02 | Philogen S.p.A. | Antibody-drug conjugates |
| CN106459055B (zh) | 2014-01-27 | 2019-11-01 | 辉瑞大药厂 | 双功能细胞毒类药剂 |
| EP3102242A2 (en) | 2014-02-03 | 2016-12-14 | Philochem AG | Targeted drug conjugates |
| SI3134127T1 (sl) | 2014-04-25 | 2020-06-30 | Rinat Neuroscience Corp. | Konjugati zdravil s protitelesi z visoko stopnjo zdravila |
| TWI812873B (zh) | 2015-11-30 | 2023-08-21 | 美商輝瑞股份有限公司 | 用於部位專一性接合之抗體和抗體片段 |
| US10689458B2 (en) | 2015-11-30 | 2020-06-23 | Pfizer Inc. | Site specific HER2 antibody drug conjugates |
-
2017
- 2017-10-03 SG SG11201903400WA patent/SG11201903400WA/en unknown
- 2017-10-03 IL IL310865A patent/IL310865A/en unknown
- 2017-10-03 EP EP17784700.1A patent/EP3525828B1/en active Active
- 2017-10-03 DK DK17784700.1T patent/DK3525828T3/da active
- 2017-10-03 PT PT177847001T patent/PT3525828T/pt unknown
- 2017-10-03 AU AU2017344440A patent/AU2017344440B2/en active Active
- 2017-10-03 JP JP2019520386A patent/JP7039577B2/ja active Active
- 2017-10-03 CN CN202310030234.XA patent/CN116251196A/zh active Pending
- 2017-10-03 CN CN201780078019.XA patent/CN110087691B/zh active Active
- 2017-10-03 FI FIEP17784700.1T patent/FI3525828T3/fi active
- 2017-10-03 EP EP24223209.8A patent/EP4617283A2/en active Pending
- 2017-10-03 WO PCT/IB2017/056093 patent/WO2018073680A1/en not_active Ceased
- 2017-10-03 CA CA3040423A patent/CA3040423A1/en active Pending
- 2017-10-03 ES ES17784700T patent/ES3007557T3/es active Active
- 2017-10-03 LT LTEPPCT/IB2017/056093T patent/LT3525828T/lt unknown
- 2017-10-03 KR KR1020197013908A patent/KR102338660B1/ko active Active
- 2017-10-03 HU HUE17784700A patent/HUE070615T2/hu unknown
- 2017-10-03 US US16/342,275 patent/US20190269791A1/en not_active Abandoned
- 2017-10-03 SI SI201731585T patent/SI3525828T1/sl unknown
- 2017-10-03 RS RS20250049A patent/RS66524B1/sr unknown
- 2017-10-03 EP EP25168356.1A patent/EP4635516A2/en active Pending
- 2017-10-03 IL IL266112A patent/IL266112B2/en unknown
- 2017-10-03 HR HRP20250056TT patent/HRP20250056T1/hr unknown
- 2017-10-03 PL PL17784700.1T patent/PL3525828T3/pl unknown
- 2017-10-03 RU RU2019111303A patent/RU2758632C2/ru active
- 2017-10-03 MX MX2019004434A patent/MX2019004434A/es unknown
-
2019
- 2019-04-15 MX MX2024003463A patent/MX2024003463A/es unknown
-
2020
- 2020-10-26 AU AU2020260375A patent/AU2020260375B2/en active Active
-
2021
- 2021-11-24 JP JP2021190070A patent/JP7383682B2/ja active Active
-
2023
- 2023-02-09 US US18/166,774 patent/US11833216B2/en active Active
- 2023-10-23 US US18/492,055 patent/US20240181071A1/en active Pending
- 2023-10-23 US US18/492,348 patent/US20240156977A1/en active Pending
- 2023-11-08 JP JP2023191037A patent/JP2023184697A/ja active Pending
- 2023-12-04 US US18/528,539 patent/US20240261423A1/en active Pending
-
2024
- 2024-02-23 AU AU2024201216A patent/AU2024201216A1/en active Pending
-
2025
- 2025-09-03 JP JP2025146227A patent/JP2025175010A/ja active Pending
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