CN110869393A - 靶向cd73的抗体及抗体-药物偶联物、其制备方法和用途 - Google Patents

靶向cd73的抗体及抗体-药物偶联物、其制备方法和用途 Download PDF

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CN110869393A
CN110869393A CN201980001728.7A CN201980001728A CN110869393A CN 110869393 A CN110869393 A CN 110869393A CN 201980001728 A CN201980001728 A CN 201980001728A CN 110869393 A CN110869393 A CN 110869393A
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antibody
seq
variable region
chain variable
light chain
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CN110869393B (zh
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余科
金锐
刘亮
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Bailisikang Biomedical Hangzhou Co ltd
Fudan University
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Abstract

本发明公开了靶向CD73的抗体及抗体‑药物偶联物(ADC)、其制备方法和用途。还公开了制备所述的单克隆抗体和ADC的方法。本发明的单克隆抗体以及相应的ADC能够高效、高特异性地结合纯化的CD73蛋白和多种肿瘤细胞表面的CD73，阻断CD73酶的催化活性，其具有很高的亲和力及很低的免疫原性，并且具有显著抗肿瘤作用。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201980001728.7A 2018-03-07 2019-03-07 靶向cd73的抗体及抗体-药物偶联物、其制备方法和用途 Active CN110869393B (zh)

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CN201810188351 2018-03-07
CN2018105061118 2018-05-24
CN201810506111.8A CN110240654A (zh) 2018-03-07 2018-05-24 结合cd73的抗体-药物偶联物
PCT/CN2019/077369 WO2019170131A1 (zh) 2018-03-07 2019-03-07 靶向cd73的抗体及抗体-药物偶联物、其制备方法和用途

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CN112703206A (zh) * 2019-09-05 2021-04-23 复旦大学 靶向肿瘤的重组双功能融合蛋白及其应用
CN113061177A (zh) * 2020-12-31 2021-07-02 浙江大学 一种cd73酶活性相关的抗原表位及针对该表位的特异性抗体的制备方法
CN113440610A (zh) * 2021-08-30 2021-09-28 山东大学 共载cd73抗体和阿霉素的脂质体及其制备方法和应用
CN114075289A (zh) * 2020-08-17 2022-02-22 中山康方生物医药有限公司 抗cd73的抗体及其用途
CN116769034A (zh) * 2022-08-12 2023-09-19 南京蓬勃生物科技有限公司 抗cd73抗体或其抗原片段及其应用

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CN110575548A (zh) * 2018-06-07 2019-12-17 中国科学院上海药物研究所 靶向于cd73的抗体-药物偶联物及其制法和用途
CA3160159A1 (en) 2019-11-05 2021-05-14 LaNova Medicines Limited Antibody-drug conjugates targeting claudin 18.2
WO2021136475A1 (en) * 2019-12-31 2021-07-08 Genequantum Healthcare (Suzhou) Co., Ltd. A drug conjugate and applications thereof
CN113527489B (zh) * 2020-04-22 2024-04-26 中山康方生物医药有限公司 抗cd73的抗体及其用途
CN111714642A (zh) * 2020-06-18 2020-09-29 复旦大学 Cd73抗体-药物偶联物的应用
CN113842467A (zh) * 2020-06-28 2021-12-28 达石药业(广东)有限公司 用于抗体与药物偶联体（adc）制备的中间体及其制备方法和应用
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
EP4223741A1 (en) * 2020-09-29 2023-08-09 Mabwell (Shanghai) Bioscience Co., Ltd. Preparation method for bis-substituted bridging antibody-drug conjugate
WO2022104692A1 (en) * 2020-11-20 2022-05-27 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Engineered antibody, antibody-drug conjugate, and use thereof
JP2024502758A (ja) * 2021-01-13 2024-01-23 上海華奥泰生物藥業股▲フン▼有限公司 Ｃｄ７３結合タンパク質及びその使用
CN113045659B (zh) * 2021-03-18 2022-03-18 上海近岸科技有限公司 抗cd73人源化抗体
WO2022205316A1 (en) * 2021-04-01 2022-10-06 Shanghai Allygen Biologics Co., Ltd. Targeting conjugates comprising effector molecules and uses thereof
CN113398242B (zh) * 2021-06-04 2022-04-29 浙江大学 一种抗体耦联药物及其应用
WO2022268050A1 (zh) * 2021-06-22 2022-12-29 荣昌生物制药(烟台)股份有限公司 一种药物组合及其用途
CN113506508B (zh) * 2021-08-07 2022-08-23 河北师范大学 一种超疏水物理不可克隆性结构色防伪标签以及其制备方法
CN116265486A (zh) * 2021-12-17 2023-06-20 三生国健药业（上海）股份有限公司 结合人cd73的抗体、其制备方法和用途
TW202400242A (zh) * 2022-03-14 2024-01-01 大陸商上海華奧泰生物藥業股份有限公司 抗體藥物偶聯物及其應用
WO2023206242A1 (zh) * 2022-04-28 2023-11-02 江苏中新医药有限公司 无钩状效应的抗人cd73单克隆抗体
WO2023230605A1 (en) * 2022-05-26 2023-11-30 I-Mab Biopharma Co., Ltd. A method of treating solid tumor
CN117304316A (zh) * 2022-06-22 2023-12-29 复旦大学 靶向cd73的纳米抗体及纳米抗体-药物偶联物、其制备方法和用途
CN116178546A (zh) * 2022-10-13 2023-05-30 深圳市百士通科技开发有限公司 一种多功能重组抗体及其制备方法和应用

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