JP2019533715A - アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法 - Google Patents

アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法 Download PDF

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Publication number
JP2019533715A
JP2019533715A JP2019525021A JP2019525021A JP2019533715A JP 2019533715 A JP2019533715 A JP 2019533715A JP 2019525021 A JP2019525021 A JP 2019525021A JP 2019525021 A JP2019525021 A JP 2019525021A JP 2019533715 A JP2019533715 A JP 2019533715A
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subject
ldl
therapy
pcsk9
risk
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JP2019525021A
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JP2019533715A5 (enExample
Inventor
ムダリンアヤク ソマレタン，ランシ
ムダリンアヤク ソマレタン，ランシ
アンドリュー，ドナルド スコット，ロバート
アンドリュー，ドナルド スコット，ロバート
ワサーマン，スコット
ホナーポア，ナリモン
ニコルズ，スティーブン
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アムジエン・インコーポレーテツド
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Application filed by アムジエン・インコーポレーテツド filed Critical アムジエン・インコーポレーテツド
Publication of JP2019533715A publication Critical patent/JP2019533715A/ja
Publication of JP2019533715A5 publication Critical patent/JP2019533715A5/ja
Priority to JP2023019926A priority Critical patent/JP2023071715A/ja
Priority to JP2025033900A priority patent/JP2025102770A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2019525021A 2016-11-14 2017-11-13 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法 Pending JP2019533715A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023019926A JP2023071715A (ja) 2016-11-14 2023-02-13 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法
JP2025033900A JP2025102770A (ja) 2016-11-14 2025-03-04 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662421685P 2016-11-14 2016-11-14
US62/421,685 2016-11-14
US201762471874P 2017-03-15 2017-03-15
US62/471,874 2017-03-15
US201762515117P 2017-06-05 2017-06-05
US62/515,117 2017-06-05
US201762581244P 2017-11-03 2017-11-03
US62/581,244 2017-11-03
US201762584600P 2017-11-10 2017-11-10
US62/584,600 2017-11-10
PCT/US2017/061346 WO2018089912A2 (en) 2016-11-14 2017-11-13 Combined therapies for atherosclerosis, including atherosclerotic cardiovascular disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023019926A Division JP2023071715A (ja) 2016-11-14 2023-02-13 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法

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JP2019533715A true JP2019533715A (ja) 2019-11-21
JP2019533715A5 JP2019533715A5 (enExample) 2020-12-24

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JP2019525021A Pending JP2019533715A (ja) 2016-11-14 2017-11-13 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法
JP2023019926A Pending JP2023071715A (ja) 2016-11-14 2023-02-13 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法
JP2025033900A Pending JP2025102770A (ja) 2016-11-14 2025-03-04 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法

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JP2023019926A Pending JP2023071715A (ja) 2016-11-14 2023-02-13 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法
JP2025033900A Pending JP2025102770A (ja) 2016-11-14 2025-03-04 アテローム動脈硬化性心血管疾患を含むアテローム性動脈硬化症の併用療法

Country Status (17)

Country Link
US (1) US20200368350A1 (enExample)
EP (1) EP3538149A2 (enExample)
JP (3) JP2019533715A (enExample)
KR (2) KR20240096648A (enExample)
CN (1) CN110234350A (enExample)
AU (2) AU2017356219A1 (enExample)
BR (1) BR112019009726A2 (enExample)
CA (1) CA3043700A1 (enExample)
CL (2) CL2019001304A1 (enExample)
CO (1) CO2019004814A2 (enExample)
IL (1) IL266579A (enExample)
JO (1) JOP20190112A1 (enExample)
MA (1) MA46758A (enExample)
MX (3) MX2019005627A (enExample)
TN (1) TN2019000156A1 (enExample)
WO (1) WO2018089912A2 (enExample)
ZA (1) ZA201902975B (enExample)

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CA2954767A1 (en) * 2014-07-14 2016-01-21 Amgen Inc. Crystalline antibody formulations
JOP20190215A1 (ar) 2017-03-24 2019-09-19 Ionis Pharmaceuticals Inc مُعدّلات التعبير الوراثي عن pcsk9
AU2019315823A1 (en) * 2018-07-31 2021-04-01 Wen Tan New use of carbamate beta phenylethanolamine analogues for enhancing intracellular clearance of ldl cholesterol and for combining therapy with statins to enhance the efficacy and reduce adverse effects
WO2021012074A1 (en) * 2019-07-19 2021-01-28 Ebay Inc. Sample delta monitoring
CN112656792B (zh) * 2021-01-26 2022-07-05 首都医科大学宣武医院 洛美他派在制备用于治疗脑卒中引起的神经损伤药物中的用途

Citations (2)

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JP2014516953A (ja) * 2011-05-10 2014-07-17 アムジエン・インコーポレーテツド コレステロール関連障害を治療または予防する方法
US20160202239A1 (en) * 2015-01-09 2016-07-14 Global Genomics Group, LLC Blood based biomarkers for diagnosing atherosclerotic coronary artery disease

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SG171676A1 (en) 2006-05-11 2011-06-29 Alnylam Pharmaceuticals Inc Compositions and methods for inhibiting expression of the pcsk9 gene
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
TWI516501B (zh) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
WO2010078536A1 (en) * 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
EP2442792A4 (en) 2009-06-15 2015-12-23 Alnylam Pharmaceuticals Inc TESTING GENE PCSK9 LIPID-FORMULATED DSRNA
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
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Also Published As

Publication number Publication date
TN2019000156A1 (en) 2020-10-05
CN110234350A (zh) 2019-09-13
EP3538149A2 (en) 2019-09-18
JP2023071715A (ja) 2023-05-23
MX2025002106A (es) 2025-04-02
IL266579A (en) 2019-07-31
KR20190085963A (ko) 2019-07-19
CA3043700A1 (en) 2018-05-17
MX2024000805A (es) 2024-02-06
CL2019001304A1 (es) 2019-09-23
JOP20190112A1 (ar) 2019-05-14
CL2020002993A1 (es) 2021-05-14
ZA201902975B (en) 2020-01-29
KR20240096648A (ko) 2024-06-26
MX2019005627A (es) 2019-10-14
US20200368350A1 (en) 2020-11-26
CO2019004814A2 (es) 2019-07-31
AU2024278180A1 (en) 2025-01-09
WO2018089912A2 (en) 2018-05-17
BR112019009726A2 (pt) 2019-08-13
MA46758A (fr) 2019-09-18
AU2017356219A1 (en) 2019-05-30
JP2025102770A (ja) 2025-07-08
WO2018089912A3 (en) 2018-06-21

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