JP2019532674A5 - - Google Patents
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- JP2019532674A5 JP2019532674A5 JP2019540313A JP2019540313A JP2019532674A5 JP 2019532674 A5 JP2019532674 A5 JP 2019532674A5 JP 2019540313 A JP2019540313 A JP 2019540313A JP 2019540313 A JP2019540313 A JP 2019540313A JP 2019532674 A5 JP2019532674 A5 JP 2019532674A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- item
- biologically active
- active fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 60
- 229920001184 polypeptide Polymers 0.000 claims description 56
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 56
- 210000004027 cell Anatomy 0.000 claims description 30
- 239000012634 fragment Substances 0.000 claims description 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 15
- 108091033319 polynucleotide Proteins 0.000 claims description 14
- 102000040430 polynucleotide Human genes 0.000 claims description 14
- 239000002157 polynucleotide Substances 0.000 claims description 14
- 230000004568 DNA-binding Effects 0.000 claims description 11
- 108060002716 Exonuclease Proteins 0.000 claims description 5
- 102000013165 exonuclease Human genes 0.000 claims description 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims description 4
- 102000004533 Endonucleases Human genes 0.000 claims description 3
- 108010042407 Endonucleases Proteins 0.000 claims description 3
- 108091008874 T cell receptors Proteins 0.000 claims description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 2
- 239000012642 immune effector Substances 0.000 claims description 2
- 229940121354 immunomodulator Drugs 0.000 claims description 2
- 108020004999 messenger RNA Proteins 0.000 claims description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 102220485790 Destrin_S40R_mutation Human genes 0.000 description 2
- 102220491802 High mobility group protein B1_S35E_mutation Human genes 0.000 description 2
- 102220553625 Lens fiber major intrinsic protein_E42S_mutation Human genes 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000002151 Pleural effusion Diseases 0.000 description 2
- 102220559237 Voltage-dependent L-type calcium channel subunit alpha-1C_N32R_mutation Human genes 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 102220481234 eIF5-mimic protein 2_R28D_mutation Human genes 0.000 description 2
- 210000004700 fetal blood Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000001165 lymph node Anatomy 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 102200104655 rs11555566 Human genes 0.000 description 2
- 102200131539 rs121912431 Human genes 0.000 description 2
- 102200131563 rs121912455 Human genes 0.000 description 2
- 102200081901 rs137854510 Human genes 0.000 description 2
- 102220040900 rs587778522 Human genes 0.000 description 2
- 102220085953 rs864622049 Human genes 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 230000002992 thymic effect Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 108090000652 Flap endonucleases Proteins 0.000 description 1
- 102000004150 Flap endonucleases Human genes 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662406689P | 2016-10-11 | 2016-10-11 | |
| US62/406,689 | 2016-10-11 | ||
| US201662414266P | 2016-10-28 | 2016-10-28 | |
| US62/414,266 | 2016-10-28 | ||
| PCT/US2017/056178 WO2018071565A1 (en) | 2016-10-11 | 2017-10-11 | TCRa HOMING ENDONUCLEASE VARIANTS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532674A JP2019532674A (ja) | 2019-11-14 |
| JP2019532674A5 true JP2019532674A5 (enExample) | 2020-11-19 |
| JP7104710B2 JP7104710B2 (ja) | 2022-07-21 |
Family
ID=61905974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540313A Active JP7104710B2 (ja) | 2016-10-11 | 2017-10-11 | ＴＣＲαホーミングエンドヌクレアーゼバリアント |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11591582B2 (enExample) |
| EP (1) | EP3534916A4 (enExample) |
| JP (1) | JP7104710B2 (enExample) |
| KR (1) | KR20190065382A (enExample) |
| CN (1) | CN110036107B (enExample) |
| AU (1) | AU2017342273B2 (enExample) |
| CA (1) | CA3039812A1 (enExample) |
| IL (1) | IL265895A (enExample) |
| MA (1) | MA46717A (enExample) |
| MX (1) | MX2019004156A (enExample) |
| RU (1) | RU2019114035A (enExample) |
| SG (1) | SG11201903230QA (enExample) |
| WO (1) | WO2018071565A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| WO2018049226A1 (en) | 2016-09-08 | 2018-03-15 | Bluebird Bio, Inc. | Pd-1 homing endonuclease variants, compositions, and methods of use |
| RU2019114035A (ru) | 2016-10-11 | 2020-11-13 | Блубёрд Био, Инк. | ВАРИАНТЫ ХОМИНГ-ЭНДОНУКЛЕАЗЫ ТКРα |
| CN110050066A (zh) | 2016-10-17 | 2019-07-23 | 蓝鸟生物公司 | TGFβR2核酸内切酶变体、组合物和使用方法 |
| KR20210102925A (ko) * | 2018-12-10 | 2021-08-20 | 블루버드 바이오, 인코포레이티드. | 호밍 엔도뉴클레아제 변이체 |
| EP4262850A4 (en) * | 2020-12-21 | 2025-07-09 | Novo Nordisk As | COMPOSITIONS AND METHODS FOR SITE-DIRECTED MUTAGENESIS |
| JP2024521475A (ja) | 2021-06-14 | 2024-05-31 | ２セブンティ バイオ インコーポレイテッド | 一本鎖ｒｎａ精製方法 |
| CA3237482A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020119158A1 (en) * | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| ATE290020T1 (de) * | 2001-08-31 | 2005-03-15 | Avidex Ltd | Löslicher t zell rezeptor |
| KR100415267B1 (ko) * | 2002-02-19 | 2004-01-16 | 오광수 | 2단 발효법에 의한 고 순도 멸치액젓 및 그 제조방법 |
| EP1413626A1 (en) * | 2002-10-23 | 2004-04-28 | Vicuron Pharmaceuticals, Inc. | Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926 |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| US20140148361A1 (en) | 2010-06-07 | 2014-05-29 | Barry L. Stoddard | Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof |
| US9034813B2 (en) * | 2010-09-17 | 2015-05-19 | Ecolab Usa Inc. | High performance low viscoelasticity foaming detergent compositions employing extended chain anionic surfactants |
| CN103620027B (zh) * | 2011-06-10 | 2017-11-21 | 巴斯夫植物科学有限公司 | 核酸酶融合蛋白及其用途 |
| US8450107B1 (en) * | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| DK3473707T3 (da) * | 2012-05-25 | 2025-03-17 | Cellectis | Fremgangsmåder til engineering af allogen og immunsuppressiv resistent t-celle til immunoterapi |
| DK3004338T3 (en) * | 2013-05-31 | 2019-04-08 | Cellectis Sa | LAGLIDADG HOMING ENDONUCLEASE DIVERSE T-CELL RECEPTOR ALPHA GENET AND APPLICATIONS THEREOF |
| RU2019114035A (ru) | 2016-10-11 | 2020-11-13 | Блубёрд Био, Инк. | ВАРИАНТЫ ХОМИНГ-ЭНДОНУКЛЕАЗЫ ТКРα |
-
2017
- 2017-10-11 RU RU2019114035A patent/RU2019114035A/ru not_active Application Discontinuation
- 2017-10-11 KR KR1020197013234A patent/KR20190065382A/ko not_active Withdrawn
- 2017-10-11 US US16/340,257 patent/US11591582B2/en active Active
- 2017-10-11 SG SG11201903230QA patent/SG11201903230QA/en unknown
- 2017-10-11 JP JP2019540313A patent/JP7104710B2/ja active Active
- 2017-10-11 WO PCT/US2017/056178 patent/WO2018071565A1/en not_active Ceased
- 2017-10-11 AU AU2017342273A patent/AU2017342273B2/en active Active
- 2017-10-11 MA MA046717A patent/MA46717A/fr unknown
- 2017-10-11 EP EP17859441.2A patent/EP3534916A4/en active Pending
- 2017-10-11 CA CA3039812A patent/CA3039812A1/en not_active Abandoned
- 2017-10-11 CN CN201780074992.4A patent/CN110036107B/zh active Active
- 2017-10-11 MX MX2019004156A patent/MX2019004156A/es unknown
-
2019
- 2019-04-08 IL IL265895A patent/IL265895A/en unknown
-
2023
- 2023-02-24 US US18/174,165 patent/US12264343B2/en active Active
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