JP2019532674A5 - - Google Patents

Download PDF

Info

Publication number
JP2019532674A5
JP2019532674A5 JP2019540313A JP2019540313A JP2019532674A5 JP 2019532674 A5 JP2019532674 A5 JP 2019532674A5 JP 2019540313 A JP2019540313 A JP 2019540313A JP 2019540313 A JP2019540313 A JP 2019540313A JP 2019532674 A5 JP2019532674 A5 JP 2019532674A5
Authority
JP
Japan
Prior art keywords
polypeptide
seq
item
biologically active
active fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019540313A
Other languages
English (en)
Japanese (ja)
Other versions
JP7104710B2 (ja
JP2019532674A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/056178 external-priority patent/WO2018071565A1/en
Publication of JP2019532674A publication Critical patent/JP2019532674A/ja
Publication of JP2019532674A5 publication Critical patent/JP2019532674A5/ja
Application granted granted Critical
Publication of JP7104710B2 publication Critical patent/JP7104710B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019540313A 2016-10-11 2017-10-11 TCRαホーミングエンドヌクレアーゼバリアント Active JP7104710B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662406689P 2016-10-11 2016-10-11
US62/406,689 2016-10-11
US201662414266P 2016-10-28 2016-10-28
US62/414,266 2016-10-28
PCT/US2017/056178 WO2018071565A1 (en) 2016-10-11 2017-10-11 TCRa HOMING ENDONUCLEASE VARIANTS

Publications (3)

Publication Number Publication Date
JP2019532674A JP2019532674A (ja) 2019-11-14
JP2019532674A5 true JP2019532674A5 (enExample) 2020-11-19
JP7104710B2 JP7104710B2 (ja) 2022-07-21

Family

ID=61905974

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019540313A Active JP7104710B2 (ja) 2016-10-11 2017-10-11 TCRαホーミングエンドヌクレアーゼバリアント

Country Status (13)

Country Link
US (2) US11591582B2 (enExample)
EP (1) EP3534916A4 (enExample)
JP (1) JP7104710B2 (enExample)
KR (1) KR20190065382A (enExample)
CN (1) CN110036107B (enExample)
AU (1) AU2017342273B2 (enExample)
CA (1) CA3039812A1 (enExample)
IL (1) IL265895A (enExample)
MA (1) MA46717A (enExample)
MX (1) MX2019004156A (enExample)
RU (1) RU2019114035A (enExample)
SG (1) SG11201903230QA (enExample)
WO (1) WO2018071565A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
SG11201901757YA (en) 2016-09-08 2019-03-28 Bluebird Bio Inc Pd-1 homing endonuclease variants, compositions, and methods of use
SG11201903230QA (en) 2016-10-11 2019-05-30 Bluebird Bio Inc TCRa HOMING ENDONUCLEASE VARIANTS
US11530395B2 (en) 2016-10-17 2022-12-20 2Seventy Bio, Inc. TGFBetaR2 endonuclease variants, compositions, and methods of use
CA3122094A1 (en) 2018-12-10 2020-06-18 Bluebird Bio, Inc. Pdcd-1 homing endonuclease variants
JP2022513750A (ja) * 2018-12-10 2022-02-09 2セブンティ バイオ インコーポレイテッド ホーミングエンドヌクレアーゼバリアント
WO2022140150A1 (en) * 2020-12-21 2022-06-30 2Seventy Bio, Inc. Compositions and methods for site-directed mutagenesis
EP4355875A1 (en) 2021-06-14 2024-04-24 2seventy bio, Inc. Single stranded rna purification methods
US20250043269A1 (en) 2021-11-03 2025-02-06 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad Precise Genome Editing Using Retrons
WO2023141602A2 (en) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
AU2023329392A1 (en) 2022-08-25 2025-02-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
AU649074B2 (en) 1990-10-12 1994-05-12 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
US5652094A (en) 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
US20020119158A1 (en) * 1998-12-17 2002-08-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US6692736B2 (en) 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
PT1421115E (pt) * 2001-08-31 2005-07-29 Avidex Ltd Receptor de celulas t soluvel
KR100415267B1 (ko) * 2002-02-19 2004-01-16 오광수 2단 발효법에 의한 고 순도 멸치액젓 및 그 제조방법
EP1413626A1 (en) * 2002-10-23 2004-04-28 Vicuron Pharmaceuticals, Inc. Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
WO2011156430A2 (en) 2010-06-07 2011-12-15 Fred Hutchinson Cancer Research Center Generation and expression of engineered i-onui endonuclease and its homologues and uses thereof
US9034813B2 (en) * 2010-09-17 2015-05-19 Ecolab Usa Inc. High performance low viscoelasticity foaming detergent compositions employing extended chain anionic surfactants
BR112013030652A2 (pt) * 2011-06-10 2016-12-13 Basf Plant Science Co Gmbh polinucleotídeo que codifica um polipeptídeo, molécula de ácido nucleico, vetor, organismo não humano, polipeptídeo e método para introduzir um ácido nucleico de interesse em um genoma de um organismo não humano
US8450107B1 (en) * 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
SG10201806573TA (en) 2012-05-25 2018-09-27 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
CA2913872C (en) * 2013-05-31 2022-01-18 Cellectis A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof
SG11201903230QA (en) 2016-10-11 2019-05-30 Bluebird Bio Inc TCRa HOMING ENDONUCLEASE VARIANTS

Similar Documents

Publication Publication Date Title
RU2019114035A (ru) ВАРИАНТЫ ХОМИНГ-ЭНДОНУКЛЕАЗЫ ТКРα
JP7649370B2 (ja) 抗kras-g12d t細胞受容体
JP7461445B2 (ja) Hla-cw8拘束性の変異krasを認識するt細胞受容体
JP7026161B2 (ja) 免疫調節性融合タンパク質およびその使用
Marshall et al. NKG2C/E marks the unique cytotoxic CD4 T cell subset, ThCTL, generated by influenza infection
JP2022532557A5 (enExample)
KR20200065026A (ko) P53 암-특이적 돌연변이에 대한 항원 특이성을 갖는 t 세포를 단리하는 방법
JP2021505201A5 (enExample)
JP2019512242A (ja) がんに対する免疫療法で使用するための形質移入t細胞およびt細胞受容体
JP2019506175A5 (enExample)
WO2008042814A2 (en) Mart-1 t cell receptors
JP2021526860A5 (enExample)
CA3110878A1 (en) T cell modification
US20190135893A1 (en) Antigen-specific helper t-cell receptor genes
JP2022510481A5 (enExample)
IL299491A (en) Methods and compositions for editing the b2m locus in b cells
JP2016511221A5 (enExample)
Jeong et al. IFITM3 is upregulated characteristically in IL-15–mediated bystander-activated CD8+ T cells during influenza infection
Nair et al. Antiretroviral restriction factors in mice
Graham et al. Differential induction of CD94 and NKG2 in CD4 helper T cells. A consequence of influenza virus infection and interferon‐γ?
JP2017515795A5 (enExample)
US20230272431A1 (en) Methods and compositions for editing the b2m locus in b cells
JP2009515534A (ja) Hcv−反応性t細胞受容体
Vila De Mucha Transcriptional regulation of tumour infiltrating cytotoxic CD4+ T cell differentiation
Zhao Searching for Modulators of CD8+ T Cell Exhaustion