KR20190065382A - TCRα 호밍 엔도뉴클레아제 변이체 - Google Patents

TCRα 호밍 엔도뉴클레아제 변이체 Download PDF

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KR20190065382A
KR20190065382A KR1020197013234A KR20197013234A KR20190065382A KR 20190065382 A KR20190065382 A KR 20190065382A KR 1020197013234 A KR1020197013234 A KR 1020197013234A KR 20197013234 A KR20197013234 A KR 20197013234A KR 20190065382 A KR20190065382 A KR 20190065382A
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ala
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조던 자르주르
마크 포그슨
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블루버드 바이오, 인코포레이티드.
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    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
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    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/11Exodeoxyribonucleases producing 5'-phosphomonoesters (3.1.11)
    • C12Y301/11002Exodeoxyribonuclease III (3.1.11.2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2510/00Genetically modified cells

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Television Signal Processing For Recording (AREA)
  • Treating Waste Gases (AREA)
  • Peptides Or Proteins (AREA)
KR1020197013234A 2016-10-11 2017-10-11 TCRα 호밍 엔도뉴클레아제 변이체 Withdrawn KR20190065382A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662406689P 2016-10-11 2016-10-11
US62/406,689 2016-10-11
US201662414266P 2016-10-28 2016-10-28
US62/414,266 2016-10-28
PCT/US2017/056178 WO2018071565A1 (en) 2016-10-11 2017-10-11 TCRa HOMING ENDONUCLEASE VARIANTS

Publications (1)

Publication Number Publication Date
KR20190065382A true KR20190065382A (ko) 2019-06-11

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KR1020197013234A Withdrawn KR20190065382A (ko) 2016-10-11 2017-10-11 TCRα 호밍 엔도뉴클레아제 변이체

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Country Link
US (2) US11591582B2 (enExample)
EP (1) EP3534916A4 (enExample)
JP (1) JP7104710B2 (enExample)
KR (1) KR20190065382A (enExample)
CN (1) CN110036107B (enExample)
AU (1) AU2017342273B2 (enExample)
CA (1) CA3039812A1 (enExample)
IL (1) IL265895A (enExample)
MA (1) MA46717A (enExample)
MX (1) MX2019004156A (enExample)
RU (1) RU2019114035A (enExample)
SG (1) SG11201903230QA (enExample)
WO (1) WO2018071565A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
KR102622910B1 (ko) 2016-09-08 2024-01-10 2세븐티 바이오, 인코포레이티드 Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
US11591582B2 (en) 2016-10-11 2023-02-28 2Seventy Bio, Inc. TCRα homing endonuclease variants
WO2018075541A1 (en) 2016-10-17 2018-04-26 Bluebird Bio, Inc. TGFβR2 ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE
KR20210102925A (ko) 2018-12-10 2021-08-20 블루버드 바이오, 인코포레이티드. 호밍 엔도뉴클레아제 변이체
US20240336904A1 (en) * 2020-12-21 2024-10-10 2Seventy Bio, Inc. Compositions and methods for site-directed mutagenesis
WO2022266038A1 (en) 2021-06-14 2022-12-22 2Seventy Bio, Inc. Single stranded rna purification methods
EP4426832A1 (en) 2021-11-03 2024-09-11 The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone Precise genome editing using retrons
WO2023141602A2 (en) 2022-01-21 2023-07-27 Renagade Therapeutics Management Inc. Engineered retrons and methods of use
WO2024044723A1 (en) 2022-08-25 2024-02-29 Renagade Therapeutics Management Inc. Engineered retrons and methods of use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119158A1 (en) * 1998-12-17 2002-08-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
DE60203125T2 (de) * 2001-08-31 2006-04-06 Avidex Ltd., Abingdon Löslicher t zell rezeptor
KR100415267B1 (ko) * 2002-02-19 2004-01-16 오광수 2단 발효법에 의한 고 순도 멸치액젓 및 그 제조방법
EP1413626A1 (en) * 2002-10-23 2004-04-28 Vicuron Pharmaceuticals, Inc. Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
US20140148361A1 (en) 2010-06-07 2014-05-29 Barry L. Stoddard Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof
US9034813B2 (en) * 2010-09-17 2015-05-19 Ecolab Usa Inc. High performance low viscoelasticity foaming detergent compositions employing extended chain anionic surfactants
WO2012168910A1 (en) * 2011-06-10 2012-12-13 Basf Plant Science Company Gmbh Nuclease fusion protein and uses thereof
US8450107B1 (en) * 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
CN111676196A (zh) * 2012-05-25 2020-09-18 塞勒克提斯公司 工程化异体和免疫抑制耐受性t细胞的方法
US10000746B2 (en) * 2013-05-31 2018-06-19 Cellectis LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
US11591582B2 (en) 2016-10-11 2023-02-28 2Seventy Bio, Inc. TCRα homing endonuclease variants

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Publication number Publication date
WO2018071565A1 (en) 2018-04-19
AU2017342273A1 (en) 2019-05-09
US20220186198A1 (en) 2022-06-16
MX2019004156A (es) 2019-09-26
US11591582B2 (en) 2023-02-28
SG11201903230QA (en) 2019-05-30
US12264343B2 (en) 2025-04-01
RU2019114035A (ru) 2020-11-13
JP2019532674A (ja) 2019-11-14
CN110036107B (zh) 2024-12-27
CN110036107A (zh) 2019-07-19
US20230357736A1 (en) 2023-11-09
JP7104710B2 (ja) 2022-07-21
CA3039812A1 (en) 2018-04-19
EP3534916A4 (en) 2020-09-30
EP3534916A1 (en) 2019-09-11
AU2017342273B2 (en) 2023-07-06
IL265895A (en) 2019-06-30
MA46717A (fr) 2019-09-11

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Patent event date: 20190508

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