JP2022510481A5 - - Google Patents

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Publication number
JP2022510481A5
JP2022510481A5 JP2021532869A JP2021532869A JP2022510481A5 JP 2022510481 A5 JP2022510481 A5 JP 2022510481A5 JP 2021532869 A JP2021532869 A JP 2021532869A JP 2021532869 A JP2021532869 A JP 2021532869A JP 2022510481 A5 JP2022510481 A5 JP 2022510481A5
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JP
Japan
Prior art keywords
cells
polypeptide
cell
polypeptide according
item
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JP2021532869A
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English (en)
Japanese (ja)
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JP7732893B2 (ja
JP2022510481A (ja
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Priority claimed from PCT/US2019/065223 external-priority patent/WO2020123375A1/en
Publication of JP2022510481A publication Critical patent/JP2022510481A/ja
Publication of JP2022510481A5 publication Critical patent/JP2022510481A5/ja
Priority to JP2025088800A priority Critical patent/JP2025139593A/ja
Application granted granted Critical
Publication of JP7732893B2 publication Critical patent/JP7732893B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2021532869A 2018-12-10 2019-12-09 Pdcd-1ホーミングエンドヌクレアーゼバリアント Active JP7732893B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025088800A JP2025139593A (ja) 2018-12-10 2025-05-28 Pdcd-1ホーミングエンドヌクレアーゼバリアント

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862777471P 2018-12-10 2018-12-10
US62/777,471 2018-12-10
PCT/US2019/065223 WO2020123375A1 (en) 2018-12-10 2019-12-09 Pdcd-1 homing endonuclease variants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025088800A Division JP2025139593A (ja) 2018-12-10 2025-05-28 Pdcd-1ホーミングエンドヌクレアーゼバリアント

Publications (3)

Publication Number Publication Date
JP2022510481A JP2022510481A (ja) 2022-01-26
JP2022510481A5 true JP2022510481A5 (enExample) 2022-12-16
JP7732893B2 JP7732893B2 (ja) 2025-09-02

Family

ID=71077024

Family Applications (2)

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JP2021532869A Active JP7732893B2 (ja) 2018-12-10 2019-12-09 Pdcd-1ホーミングエンドヌクレアーゼバリアント
JP2025088800A Withdrawn JP2025139593A (ja) 2018-12-10 2025-05-28 Pdcd-1ホーミングエンドヌクレアーゼバリアント

Family Applications After (1)

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JP2025088800A Withdrawn JP2025139593A (ja) 2018-12-10 2025-05-28 Pdcd-1ホーミングエンドヌクレアーゼバリアント

Country Status (9)

Country Link
US (2) US12577547B2 (enExample)
EP (1) EP3893886A4 (enExample)
JP (2) JP7732893B2 (enExample)
KR (1) KR20210102299A (enExample)
CN (1) CN113330113A (enExample)
AU (1) AU2019395334B2 (enExample)
CA (1) CA3122094A1 (enExample)
IL (2) IL325732A (enExample)
WO (1) WO2020123375A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201901757YA (en) 2016-09-08 2019-03-28 Bluebird Bio Inc Pd-1 homing endonuclease variants, compositions, and methods of use
CA3122094A1 (en) 2018-12-10 2020-06-18 Bluebird Bio, Inc. Pdcd-1 homing endonuclease variants
JP2022513750A (ja) 2018-12-10 2022-02-09 2セブンティ バイオ インコーポレイテッド ホーミングエンドヌクレアーゼバリアント
CN119876082B (zh) * 2025-01-16 2025-09-30 苏州可尔生命科技有限公司 一种突变型ExoⅢ及其应用

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
GB8918616D0 (en) 1989-08-15 1989-09-27 Univ Glasgow Herpes simplex virus type 1 mutant
US5804413A (en) 1992-07-31 1998-09-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains for gene transfer
GB9415319D0 (en) 1994-07-29 1994-09-21 Medical Res Council HSV viral vector
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6093570A (en) 1995-06-07 2000-07-25 The University Of North Carolina At Chapel Hill Helper virus-free AAV production
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
EP1002119A1 (en) 1997-07-31 2000-05-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Targeted hsv vectors
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
FR2777909B1 (fr) 1998-04-24 2002-08-02 Pasteur Institut Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex
US6692736B2 (en) 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
US7465583B2 (en) 2000-06-01 2008-12-16 The University Of North Carolina At Chapel Hill Duplexed parvovirus vectors
FR2872170B1 (fr) 2004-06-25 2006-11-10 Centre Nat Rech Scient Cnrse Lentivirus non interactif et non replicatif, preparation et utilisations
EP1828390B1 (en) 2004-12-15 2012-06-13 The University Of North Carolina At Chapel Hill Chimeric vectors
WO2007049095A1 (en) 2005-10-25 2007-05-03 Cellectis Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
AU2007347328B2 (en) 2007-02-19 2013-03-07 Cellectis LAGLIDADG homing endonuclease variants having novel substrate specificity and use thereof
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
JP5763341B2 (ja) 2007-09-27 2015-08-12 サンガモ バイオサイエンシーズ, インコーポレイテッド 生物学的活性のあるヌクレアーゼの迅速なインビボ同定法
ES2422291T3 (es) 2007-10-31 2013-09-10 Prec Biosciences Inc Meganucleasas monocatenarias diseñadas racionalmente con secuencias de reconocimiento no palindrómicas
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2396343B1 (en) 2009-02-11 2017-05-17 The University of North Carolina At Chapel Hill Modified virus vectors and methods of making and using the same
US9169494B2 (en) 2010-01-12 2015-10-27 The University Of North Carolina At Chapel Hill Restrictive inverted terminal repeats for viral vectors
WO2011097456A2 (en) 2010-02-05 2011-08-11 The University Of North Carolina At Chapel Hill Compositions and methods for enhanced parvovirus transduction
US20110256607A1 (en) 2010-04-16 2011-10-20 Georg Hausner Homing endonucleases
WO2011156430A2 (en) 2010-06-07 2011-12-15 Fred Hutchinson Cancer Research Center Generation and expression of engineered i-onui endonuclease and its homologues and uses thereof
SG189482A1 (en) 2010-10-27 2013-05-31 Cellectis Method for increasing the efficiency of double-strand break-induced mutagenesis
US8673557B2 (en) 2011-02-28 2014-03-18 Seattle Children's Research Institute Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
EP2836226B1 (en) 2012-02-24 2017-06-28 Fred Hutchinson Cancer Research Center Compositions and methods for the treatment of hemoglobinopathies
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
SG10201806573TA (en) 2012-05-25 2018-09-27 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
US20140015679A1 (en) 2012-07-15 2014-01-16 Green Badge LLC Specialty Plant Moisture Sensing
CA2912375C (en) 2013-05-13 2023-03-14 Cellectis Methods for engineering highly active t cell for immunotherapy
CA2913872C (en) 2013-05-31 2022-01-18 Cellectis A laglidadg homing endonuclease cleaving the t-cell receptor alpha gene and uses thereof
CA2913871C (en) 2013-05-31 2021-07-13 Cellectis A laglidadg homing endonuclease cleaving the c-c chemokine receptor type-5 (ccr5) gene and uses thereof
EP3027204B1 (en) 2013-07-29 2022-01-05 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
SMT202300039T1 (it) 2013-09-13 2023-03-17 Beigene Switzerland Gmbh Anticorpi anti-pd1 e loro uso come terapia e per diagnostica
US20190241910A1 (en) 2016-03-11 2019-08-08 Bluebird Bio, Inc. Genome edited immune effector cells
AU2017248259A1 (en) 2016-04-07 2018-10-25 Bluebird Bio, Inc. Chimeric antigen receptor T cell compositions
CA3031785A1 (en) 2016-07-25 2018-02-01 Bluebird Bio, Inc. Bcl11a homing endonuclease variants, compositions, and methods of use
EP3500696A4 (en) 2016-08-16 2020-04-08 Bluebird Bio, Inc. VARIANTS OF IL-10 ALPHA RECEPTOR HOMING ENDONUCLEASE, COMPOSITIONS AND METHODS OF USE
MA46018A (fr) * 2016-08-19 2019-06-26 Bluebird Bio Inc Activateurs d'édition du génome
US20190262398A1 (en) * 2016-08-23 2019-08-29 Bluebird Bio, Inc. Tim3 homing endonuclease variants, compositions, and methods of use
SG11201901757YA (en) * 2016-09-08 2019-03-28 Bluebird Bio Inc Pd-1 homing endonuclease variants, compositions, and methods of use
SG11201903230QA (en) 2016-10-11 2019-05-30 Bluebird Bio Inc TCRa HOMING ENDONUCLEASE VARIANTS
US11530395B2 (en) 2016-10-17 2022-12-20 2Seventy Bio, Inc. TGFBetaR2 endonuclease variants, compositions, and methods of use
CN106749666B (zh) * 2016-12-22 2018-12-25 福州大学 一种人源程序性死亡受体hPD-1单克隆抗体
CN106939049B (zh) 2017-04-20 2019-10-01 苏州思坦维生物技术股份有限公司 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用
IL270776B2 (en) * 2017-05-25 2024-11-01 Bluebird Bio Inc Cblb endonuclease variants, compositions, and methods of use
US11779654B2 (en) 2017-10-04 2023-10-10 2Seventy Bio, Inc. PCSK9 endonuclease variants, compositions, and methods of use
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
CA3122094A1 (en) 2018-12-10 2020-06-18 Bluebird Bio, Inc. Pdcd-1 homing endonuclease variants

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