JP2019529360A5 - - Google Patents
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- Publication number
- JP2019529360A5 JP2019529360A5 JP2019509544A JP2019509544A JP2019529360A5 JP 2019529360 A5 JP2019529360 A5 JP 2019529360A5 JP 2019509544 A JP2019509544 A JP 2019509544A JP 2019509544 A JP2019509544 A JP 2019509544A JP 2019529360 A5 JP2019529360 A5 JP 2019529360A5
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- particles
- protein
- lipid
- saposin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 32
- 239000012528 membrane Substances 0.000 claims description 31
- 108010052285 Membrane Proteins Proteins 0.000 claims description 20
- 150000002632 lipids Chemical class 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 15
- 108090000623 proteins and genes Proteins 0.000 claims description 15
- 102000018697 Membrane Proteins Human genes 0.000 claims description 11
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 230000004576 lipid-binding Effects 0.000 claims description 8
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 13
- 102000017852 Saposin Human genes 0.000 claims 11
- 108050007079 Saposin Proteins 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 102000004895 Lipoproteins Human genes 0.000 claims 9
- 108090001030 Lipoproteins Proteins 0.000 claims 9
- 210000003463 organelle Anatomy 0.000 claims 6
- 238000004587 chromatography analysis Methods 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- -1 alkylbenzene sulfonates Chemical class 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 239000003599 detergent Substances 0.000 claims 2
- 238000011161 development Methods 0.000 claims 2
- 238000000502 dialysis Methods 0.000 claims 2
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000001542 size-exclusion chromatography Methods 0.000 claims 2
- 238000005199 ultracentrifugation Methods 0.000 claims 2
- UMCMPZBLKLEWAF-BCTGSCMUSA-N 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 UMCMPZBLKLEWAF-BCTGSCMUSA-N 0.000 claims 1
- 101710129138 ATP synthase subunit 9, mitochondrial Proteins 0.000 claims 1
- 101710168506 ATP synthase subunit C, plastid Proteins 0.000 claims 1
- 101710114069 ATP synthase subunit c Proteins 0.000 claims 1
- 101710197943 ATP synthase subunit c, chloroplastic Proteins 0.000 claims 1
- 101710187091 ATP synthase subunit c, sodium ion specific Proteins 0.000 claims 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
- 229930186217 Glycolipid Natural products 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 238000003450 affinity purification method Methods 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002280 amphoteric surfactant Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 230000002457 bidirectional effect Effects 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 229960000074 biopharmaceutical Drugs 0.000 claims 1
- 239000003093 cationic surfactant Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- NLEBIOOXCVAHBD-QKMCSOCLSA-N dodecyl beta-D-maltoside Chemical compound O[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NLEBIOOXCVAHBD-QKMCSOCLSA-N 0.000 claims 1
- 238000009509 drug development Methods 0.000 claims 1
- 238000007876 drug discovery Methods 0.000 claims 1
- 238000007877 drug screening Methods 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 229930182478 glucoside Natural products 0.000 claims 1
- 150000008131 glucosides Chemical class 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 239000008241 heterogeneous mixture Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 102000019758 lipid binding proteins Human genes 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 238000001742 protein purification Methods 0.000 claims 1
- 238000011160 research Methods 0.000 claims 1
- 238000001338 self-assembly Methods 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 description 2
- 102000007592 Apolipoproteins Human genes 0.000 description 1
- 108010071619 Apolipoproteins Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022116793A JP7460700B2 (ja) | 2016-08-19 | 2022-07-22 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
| JP2024044505A JP7702167B2 (ja) | 2016-08-19 | 2024-03-21 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16184843.7 | 2016-08-19 | ||
| EP16184843.7A EP3284460A1 (en) | 2016-08-19 | 2016-08-19 | Saposin lipoprotein particles and libraries from crude membranes |
| PCT/EP2017/071043 WO2018033647A1 (en) | 2016-08-19 | 2017-08-21 | Saposin lipoprotein particles and libraries from crude membranes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116793A Division JP7460700B2 (ja) | 2016-08-19 | 2022-07-22 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529360A JP2019529360A (ja) | 2019-10-17 |
| JP2019529360A5 true JP2019529360A5 (https=) | 2020-09-17 |
| JP7149929B2 JP7149929B2 (ja) | 2022-10-07 |
Family
ID=56740926
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019509544A Active JP7149929B2 (ja) | 2016-08-19 | 2017-08-21 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
| JP2022116793A Active JP7460700B2 (ja) | 2016-08-19 | 2022-07-22 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
| JP2024044505A Active JP7702167B2 (ja) | 2016-08-19 | 2024-03-21 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116793A Active JP7460700B2 (ja) | 2016-08-19 | 2022-07-22 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
| JP2024044505A Active JP7702167B2 (ja) | 2016-08-19 | 2024-03-21 | 未精製膜からのサポシンリポタンパク質粒子およびライブラリー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11346843B2 (https=) |
| EP (2) | EP3284460A1 (https=) |
| JP (3) | JP7149929B2 (https=) |
| CN (1) | CN109640960B (https=) |
| CA (1) | CA3034136A1 (https=) |
| DK (1) | DK3463303T3 (https=) |
| ES (1) | ES2797257T3 (https=) |
| PT (1) | PT3463303T (https=) |
| WO (1) | WO2018033647A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3725304A1 (en) | 2019-04-15 | 2020-10-21 | Salipro Biotech AB | Production of salipro particles |
| CN110483618B (zh) * | 2019-09-11 | 2022-09-09 | 青岛科技大学 | 杂[4]芳烃衍生物及其制备和应用 |
| CN111040019B (zh) * | 2019-12-25 | 2022-06-07 | 上海交通大学 | 一种用于与TfR蛋白特异性结合的配体多肽及其应用 |
| TW202242114A (zh) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法 |
| US20220268785A1 (en) * | 2021-02-19 | 2022-08-25 | Northwestern University | Facile sample preparation for quantitative single-cell proteomics |
| WO2023001912A1 (en) | 2021-07-22 | 2023-01-26 | Salipro Biotech AB | Methods for structure determination and drug design using salipro particles |
| EP4123307A1 (en) | 2021-07-22 | 2023-01-25 | Salipro Biotech AB | Methods for structure determination and drug design using salipro particles |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872406B2 (en) * | 2000-02-11 | 2005-03-29 | Children's Hospital Research Foundation | Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems |
| DK1345959T3 (da) | 2000-11-20 | 2011-09-05 | Univ Illinois | Membranscaffoldproteiner |
| EP2314285B2 (en) | 2003-02-14 | 2019-09-18 | Children's Hospital & Research Center at Oakland | Lipophilic drug delivery vehicle and methods of use thereof |
| CN103585105A (zh) * | 2008-11-07 | 2014-02-19 | 儿童医院医疗中心 | 用于跨膜药物递送系统的鞘脂激活蛋白c以及相关蛋白和肽促融合性质 |
| GB0913823D0 (en) | 2009-08-07 | 2009-09-16 | Isis Innovation | Bilayers |
| EP2745834B1 (en) * | 2012-12-18 | 2016-09-28 | Jens Frauenfeld | Salipro particles |
| LT3043814T (lt) | 2013-09-13 | 2021-02-25 | Salipro Biotech AB | Antigenas ir jo gamybos būdas |
-
2016
- 2016-08-19 EP EP16184843.7A patent/EP3284460A1/en not_active Withdrawn
-
2017
- 2017-08-21 JP JP2019509544A patent/JP7149929B2/ja active Active
- 2017-08-21 CA CA3034136A patent/CA3034136A1/en active Pending
- 2017-08-21 EP EP17755497.9A patent/EP3463303B1/en active Active
- 2017-08-21 CN CN201780050737.6A patent/CN109640960B/zh active Active
- 2017-08-21 WO PCT/EP2017/071043 patent/WO2018033647A1/en not_active Ceased
- 2017-08-21 ES ES17755497T patent/ES2797257T3/es active Active
- 2017-08-21 PT PT177554979T patent/PT3463303T/pt unknown
- 2017-08-21 DK DK17755497.9T patent/DK3463303T3/da active
- 2017-08-21 US US16/326,545 patent/US11346843B2/en active Active
-
2022
- 2022-07-22 JP JP2022116793A patent/JP7460700B2/ja active Active
-
2024
- 2024-03-21 JP JP2024044505A patent/JP7702167B2/ja active Active
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