CN109640960B - 来自粗制膜的鞘脂激活蛋白脂蛋白颗粒及文库 - Google Patents

来自粗制膜的鞘脂激活蛋白脂蛋白颗粒及文库 Download PDF

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CN109640960B
CN109640960B CN201780050737.6A CN201780050737A CN109640960B CN 109640960 B CN109640960 B CN 109640960B CN 201780050737 A CN201780050737 A CN 201780050737A CN 109640960 B CN109640960 B CN 109640960B
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membrane
particles
lipid
leu
protein
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CN109640960A (zh
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延斯·弗劳恩菲尔德
罗宾·勒文
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Salipro Biotech AB
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Salipro Biotech AB
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0012—Lipids; Lipoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
CN201780050737.6A 2016-08-19 2017-08-21 来自粗制膜的鞘脂激活蛋白脂蛋白颗粒及文库 Active CN109640960B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16184843.7 2016-08-19
EP16184843.7A EP3284460A1 (en) 2016-08-19 2016-08-19 Saposin lipoprotein particles and libraries from crude membranes
PCT/EP2017/071043 WO2018033647A1 (en) 2016-08-19 2017-08-21 Saposin lipoprotein particles and libraries from crude membranes

Publications (2)

Publication Number Publication Date
CN109640960A CN109640960A (zh) 2019-04-16
CN109640960B true CN109640960B (zh) 2022-08-12

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Country Status (9)

Country Link
US (1) US11346843B2 (https=)
EP (2) EP3284460A1 (https=)
JP (3) JP7149929B2 (https=)
CN (1) CN109640960B (https=)
CA (1) CA3034136A1 (https=)
DK (1) DK3463303T3 (https=)
ES (1) ES2797257T3 (https=)
PT (1) PT3463303T (https=)
WO (1) WO2018033647A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3725304A1 (en) 2019-04-15 2020-10-21 Salipro Biotech AB Production of salipro particles
CN110483618B (zh) * 2019-09-11 2022-09-09 青岛科技大学 杂[4]芳烃衍生物及其制备和应用
CN111040019B (zh) * 2019-12-25 2022-06-07 上海交通大学 一种用于与TfR蛋白特异性结合的配体多肽及其应用
TW202242114A (zh) 2020-12-23 2022-11-01 美商再生元醫藥公司 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法
US20220268785A1 (en) * 2021-02-19 2022-08-25 Northwestern University Facile sample preparation for quantitative single-cell proteomics
WO2023001912A1 (en) 2021-07-22 2023-01-26 Salipro Biotech AB Methods for structure determination and drug design using salipro particles
EP4123307A1 (en) 2021-07-22 2023-01-25 Salipro Biotech AB Methods for structure determination and drug design using salipro particles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030095999A1 (en) * 2000-02-11 2003-05-22 Xiaoyang Qi Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
CN103585105A (zh) * 2008-11-07 2014-02-19 儿童医院医疗中心 用于跨膜药物递送系统的鞘脂激活蛋白c以及相关蛋白和肽促融合性质
CN105188672A (zh) * 2012-12-18 2015-12-23 延斯·弗劳恩菲尔德 Salipro颗粒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1345959T3 (da) 2000-11-20 2011-09-05 Univ Illinois Membranscaffoldproteiner
EP2314285B2 (en) 2003-02-14 2019-09-18 Children's Hospital & Research Center at Oakland Lipophilic drug delivery vehicle and methods of use thereof
GB0913823D0 (en) 2009-08-07 2009-09-16 Isis Innovation Bilayers
LT3043814T (lt) 2013-09-13 2021-02-25 Salipro Biotech AB Antigenas ir jo gamybos būdas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030095999A1 (en) * 2000-02-11 2003-05-22 Xiaoyang Qi Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
CN103585105A (zh) * 2008-11-07 2014-02-19 儿童医院医疗中心 用于跨膜药物递送系统的鞘脂激活蛋白c以及相关蛋白和肽促融合性质
CN105188672A (zh) * 2012-12-18 2015-12-23 延斯·弗劳恩菲尔德 Salipro颗粒

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A saposin-lipoprotein nanoparticle system for membrane proteins;Jens Frauenfeld等;《nature methods》;20160307;第13卷(第4期);第345-351页 *
Lipid-Mediated Glycosylation of Endogenous Proteins in Isolated Plasma Membrane of Saccharomyces cerevisiae;GEERTRUIDA W. WELTEN-VERSTEGEN等;《JOURNAL OF BACTERIOLOGY》;19800131;第141卷(第1期);第342-349页 *
Structure of saposin A lipoprotein discs;Konstantin Popovic等;《PNAS》;20120221;第109卷(第8期);第2908-2912页 *

Also Published As

Publication number Publication date
JP2024096708A (ja) 2024-07-17
EP3463303A1 (en) 2019-04-10
JP7149929B2 (ja) 2022-10-07
JP7702167B2 (ja) 2025-07-03
ES2797257T3 (es) 2020-12-01
US20190204337A1 (en) 2019-07-04
CN109640960A (zh) 2019-04-16
JP7460700B2 (ja) 2024-04-02
WO2018033647A1 (en) 2018-02-22
CA3034136A1 (en) 2018-02-22
JP2019529360A (ja) 2019-10-17
EP3284460A1 (en) 2018-02-21
PT3463303T (pt) 2020-06-18
US11346843B2 (en) 2022-05-31
DK3463303T3 (da) 2020-06-15
EP3463303B1 (en) 2020-03-11
JP2022163077A (ja) 2022-10-25

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