JP2019528736A5 - - Google Patents
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- JP2019528736A5 JP2019528736A5 JP2019514770A JP2019514770A JP2019528736A5 JP 2019528736 A5 JP2019528736 A5 JP 2019528736A5 JP 2019514770 A JP2019514770 A JP 2019514770A JP 2019514770 A JP2019514770 A JP 2019514770A JP 2019528736 A5 JP2019528736 A5 JP 2019528736A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- mir
- composition
- seq
- modrna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023093720A JP2023123520A (ja) | 2016-09-16 | 2023-06-07 | ｍｏｄＲＮＡの細胞特異的発現 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395701P | 2016-09-16 | 2016-09-16 | |
| US62/395,701 | 2016-09-16 | ||
| PCT/US2017/052035 WO2018053414A1 (en) | 2016-09-16 | 2017-09-18 | Cell-specific expression of modrna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023093720A Division JP2023123520A (ja) | 2016-09-16 | 2023-06-07 | ｍｏｄＲＮＡの細胞特異的発現 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528736A JP2019528736A (ja) | 2019-10-17 |
| JP2019528736A5 true JP2019528736A5 (https=) | 2020-11-12 |
| JP7432362B2 JP7432362B2 (ja) | 2024-02-16 |
Family
ID=61619271
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514770A Active JP7432362B2 (ja) | 2016-09-16 | 2017-09-18 | ｍｏｄＲＮＡの細胞特異的発現 |
| JP2023093720A Pending JP2023123520A (ja) | 2016-09-16 | 2023-06-07 | ｍｏｄＲＮＡの細胞特異的発現 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023093720A Pending JP2023123520A (ja) | 2016-09-16 | 2023-06-07 | ｍｏｄＲＮＡの細胞特異的発現 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11299749B2 (https=) |
| EP (2) | EP3512567B1 (https=) |
| JP (2) | JP7432362B2 (https=) |
| CN (1) | CN110177578B (https=) |
| AU (2) | AU2017326535B2 (https=) |
| BR (1) | BR112019005144A2 (https=) |
| CA (1) | CA3036710A1 (https=) |
| ES (1) | ES2967788T3 (https=) |
| WO (1) | WO2018053414A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3512567B1 (en) * | 2016-09-16 | 2023-11-01 | Icahn School of Medicine at Mount Sinai | Cell-specific expression of modrna |
| JP7440868B2 (ja) * | 2018-03-30 | 2024-02-29 | 国立大学法人京都大学 | 細胞の製造方法 |
| BR112022002365A2 (pt) | 2019-08-09 | 2022-04-26 | Nutcracker Therapeutics Inc | Métodos e aparelhos para fabricar e para remover material de uma composição terapêutica |
| WO2021092440A1 (en) | 2019-11-07 | 2021-05-14 | Icahn School Of Medicine At Mount Sinai | Synthetic modified rna and uses thereof |
| EP4058584A4 (en) * | 2019-11-11 | 2023-12-20 | Icahn School of Medicine at Mount Sinai | GENE DELIVERY SYSTEMS FOR THE TREATMENT OF HEART FAILURE |
| EP4351623A1 (en) | 2021-06-09 | 2024-04-17 | Icahn School of Medicine at Mount Sinai | Gene combination as a broad spectrum antiviral |
| EP4355882A2 (en) * | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Engineered polynucleotides for cell-type or microenvironment-specific expression |
| CN114085834A (zh) * | 2021-11-16 | 2022-02-25 | 珠海中科先进技术研究院有限公司 | 一种癌细胞导向电路组及应用 |
| EP4514965A1 (en) * | 2022-04-27 | 2025-03-05 | The Penn State Research Foundation | Modrna-based cas endonuclease and base editor and uses thereof |
| US20230364267A1 (en) * | 2022-05-13 | 2023-11-16 | The Uab Research Foundation | Pre-clinical modified rna approaches used in large animals for muscle and vascular regeneration |
| EP4282963A1 (en) * | 2022-05-23 | 2023-11-29 | Eberhard Karls Universität Tübingen, Medizinische Fakultät | Nucleic acid modified biological cell with expansion-dependent gene expression |
| WO2024015729A1 (en) * | 2022-07-11 | 2024-01-18 | Icahn School Of Medicine At Mount Sinai | Regulatory system for expression of a gene of interest in a target cell and method of use thereof |
| US20260035707A1 (en) * | 2022-07-26 | 2026-02-05 | Modernatx, Inc. | Engineered polynucleotides for temporal control of expression |
| CN116785501A (zh) * | 2022-08-04 | 2023-09-22 | 上海交通大学医学院附属上海儿童医学中心 | 促进心脏组织修复的modRNA转染改造的细胞及其应用 |
| WO2024151975A1 (en) | 2023-01-13 | 2024-07-18 | Igor Lednev | Detecting degradation of a polynucleotide by raman spectroscopy |
| CN119120571B (zh) * | 2024-09-11 | 2026-03-17 | 武汉科技大学 | 一种治疗hiv感染的靶向外泌体嵌合抗原受体分子的构建及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08506008A (ja) | 1992-11-18 | 1996-07-02 | アーチ ディベロプメント コーポレイション | 心筋及び血管平滑筋へのアデノウィルス介在遺伝子移入 |
| US20090005336A1 (en) * | 2007-05-08 | 2009-01-01 | Zhiguo Wang | Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions |
| KR20240136456A (ko) * | 2009-12-07 | 2024-09-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 세포 리프로그래밍을 위한 정제된 변형 ｒｎａ를 포함하는 ｒｎａ 제제 |
| US9458509B2 (en) * | 2010-07-22 | 2016-10-04 | President And Fellows Of Harvard College | Multiple input biologic classifier circuits for cells |
| EP2694660B1 (en) | 2011-04-03 | 2018-08-08 | The General Hospital Corporation | Efficient protein expression in vivo using modified rna (mod-rna) |
| EP2584040A1 (en) * | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
| CA2915627A1 (en) * | 2012-06-15 | 2013-12-19 | The General Hospital Corporation | Inhibitors of micrornas that regulate production of atrial natriuretic peptide (anp) as therapeutics and uses thereof |
| WO2014093574A1 (en) * | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for altering cell phenotype |
| US10538740B2 (en) | 2014-03-20 | 2020-01-21 | Kyoto University | Method for sorting cardiomyocytes |
| WO2016040395A1 (en) * | 2014-09-08 | 2016-03-17 | Massachusetts Institute Of Technology | Rna-based logic circuits with rna binding proteins, aptamers and small molecules |
| EP3512567B1 (en) * | 2016-09-16 | 2023-11-01 | Icahn School of Medicine at Mount Sinai | Cell-specific expression of modrna |
-
2017
- 2017-09-18 EP EP17851710.8A patent/EP3512567B1/en active Active
- 2017-09-18 ES ES17851710T patent/ES2967788T3/es active Active
- 2017-09-18 AU AU2017326535A patent/AU2017326535B2/en active Active
- 2017-09-18 JP JP2019514770A patent/JP7432362B2/ja active Active
- 2017-09-18 CN CN201780070205.9A patent/CN110177578B/zh active Active
- 2017-09-18 BR BR112019005144-9A patent/BR112019005144A2/pt unknown
- 2017-09-18 WO PCT/US2017/052035 patent/WO2018053414A1/en not_active Ceased
- 2017-09-18 EP EP23205982.4A patent/EP4316587A3/en active Pending
- 2017-09-18 CA CA3036710A patent/CA3036710A1/en active Pending
-
2019
- 2019-03-15 US US16/354,814 patent/US11299749B2/en active Active
-
2022
- 2022-03-28 US US17/705,609 patent/US12215336B2/en active Active
-
2023
- 2023-06-07 JP JP2023093720A patent/JP2023123520A/ja active Pending
- 2023-11-23 AU AU2023270313A patent/AU2023270313A1/en active Pending
-
2024
- 2024-12-27 US US19/003,758 patent/US20250154523A1/en active Pending
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