JP2019527729A5 - - Google Patents
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- Publication number
- JP2019527729A5 JP2019527729A5 JP2019522614A JP2019522614A JP2019527729A5 JP 2019527729 A5 JP2019527729 A5 JP 2019527729A5 JP 2019522614 A JP2019522614 A JP 2019522614A JP 2019522614 A JP2019522614 A JP 2019522614A JP 2019527729 A5 JP2019527729 A5 JP 2019527729A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- polypropylene glycol
- therapeutic
- ppm
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662361793P | 2016-07-13 | 2016-07-13 | |
| US62/361,793 | 2016-07-13 | ||
| PCT/US2017/041691 WO2018013673A1 (en) | 2016-07-13 | 2017-07-12 | Stabilizing excipients for therapeutic protein formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019527729A JP2019527729A (ja) | 2019-10-03 |
| JP2019527729A5 true JP2019527729A5 (https=) | 2020-08-06 |
Family
ID=60941865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522614A Pending JP2019527729A (ja) | 2016-07-13 | 2017-07-12 | 治療用タンパク質製剤のための安定化賦形剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10279048B2 (https=) |
| EP (1) | EP3484520A4 (https=) |
| JP (1) | JP2019527729A (https=) |
| KR (1) | KR20190027878A (https=) |
| CA (1) | CA3030422C (https=) |
| WO (1) | WO2018013673A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
| WO2015196091A1 (en) | 2014-06-20 | 2015-12-23 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
| WO2019036619A1 (en) * | 2017-08-18 | 2019-02-21 | Reform Biologics, Llc | STABILIZING EXCIPIENTS FOR FORMULATIONS OF THERAPEUTIC PROTEIN |
| EP3761962A4 (en) * | 2018-03-07 | 2021-12-15 | ReForm Biologics, Inc. | EXCIPIENT COMPOUNDS FOR PROTEIN-BASED FORMULATIONS |
| WO2019180561A1 (en) | 2018-03-20 | 2019-09-26 | Mankind Pharma Ltd. | Stable pharmaceutical composition of vasopressin |
| DK4364724T3 (da) | 2018-05-10 | 2025-12-22 | Regeneron Pharma | Formuleringer med høj koncentration af VEGF-receptorfusionsprotein |
| KR20210062638A (ko) | 2018-09-20 | 2021-05-31 | 레보 테라퓨틱스 인코포레이티드 | 카르베토신의 안정한 비강내 제형 |
| AU2019345313A1 (en) | 2018-09-20 | 2021-03-18 | Levo Therapeutics, Inc. | Carbetocin drug product and process for preparing same |
| GB201904741D0 (en) * | 2019-04-04 | 2019-05-22 | Glaxosmithkline Ip Dev Ltd | Novel process |
| JP7394122B2 (ja) | 2019-04-19 | 2023-12-07 | 富士フイルム株式会社 | 細胞外小胞の保存安定化剤及び保存安定化方法 |
| CN116133689A (zh) * | 2020-07-07 | 2023-05-16 | 豪夫迈·罗氏有限公司 | 作为治疗性蛋白质制剂的稳定剂的替代表面活性剂 |
| TW202406551A (zh) * | 2022-04-22 | 2024-02-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 冷凍乾燥組成物(一) |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2510633C3 (de) * | 1975-03-12 | 1978-07-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe |
| US5183746A (en) * | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
| US6039977A (en) * | 1997-12-09 | 2000-03-21 | Alza Corporation | Pharmaceutical hydrogel formulations, and associated drug delivery devices and methods |
| PT1372611E (pt) | 2001-03-26 | 2006-08-31 | Novartis Ag | Composicao farmaceutica compreendendo uma estaurosporina francamente soluvel em agua, um tensioactivo et um polimero soluvel em agua |
| US7041088B2 (en) | 2002-10-11 | 2006-05-09 | Ethicon, Inc. | Medical devices having durable and lubricious polymeric coating |
| DE10325198B4 (de) | 2003-06-04 | 2007-10-25 | Clariant Produkte (Deutschland) Gmbh | Verwendung von alkoxylierten vernetzten Polyglycerinen als biologisch abbaubare Emulsionsspalter |
| US8025915B2 (en) | 2006-01-11 | 2011-09-27 | Schott Ag | Method of preparing a macromolecule deterrent surface on a pharmaceutical package |
| EP2237038B1 (en) | 2007-10-22 | 2015-04-29 | Becton Dickinson and Company | Medical articles coated with organopolysiloxane containing a protein solution and non-ionic surfactant |
| CN101795680A (zh) | 2007-11-16 | 2010-08-04 | 波苏蛋白试剂公司 | 稳定蛋白质的辅剂 |
| US9138462B2 (en) * | 2009-07-31 | 2015-09-22 | Sanofi-Aventis Deutschland Gmbh | Prodrugs comprising an insulin linker conjugate |
| SG10201502398RA (en) * | 2010-04-27 | 2015-05-28 | Scil Technology Gmbh | Stable MIA/CD-RAP formulations |
| US8802603B2 (en) | 2010-06-17 | 2014-08-12 | Becton, Dickinson And Company | Medical components having coated surfaces exhibiting low friction and low reactivity |
| SG186783A1 (en) | 2010-06-24 | 2013-02-28 | Genentech Inc | Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations |
| AP3981A (en) * | 2011-03-25 | 2017-01-05 | Amgen Inc | Anti - sclerostin antibody crystals and formulations thereof |
| CN104507953B (zh) | 2012-05-31 | 2018-05-18 | 新加坡科技研究局 | 通过用正电性有机添加剂处理来降低蛋白质制剂中蛋白质-污染物复合物和聚集物水平的方法 |
| US9119858B2 (en) | 2012-08-21 | 2015-09-01 | Genesys Research Institute, Inc. | Compositions and methods for treating or preventing anthracycline induced cardiotoxicity |
| US9592297B2 (en) * | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| CN104870019A (zh) | 2012-11-27 | 2015-08-26 | 阿特根公司 | 用于稳定蛋白质和Fc结构域融合的融合蛋白的组合物 |
| US20140342006A1 (en) | 2013-03-15 | 2014-11-20 | Ansun Biopharma, Inc. | Methods for Preparing Injectable Protein Microparticle Suspensions |
| CA2908819A1 (en) | 2013-04-22 | 2014-10-30 | Glycotope Gmbh | Anti-cancer treatments with anti-egfr antibodies having a low fucosylation |
| WO2015196091A1 (en) | 2014-06-20 | 2015-12-23 | Reform Biologics, Llc | Viscosity-reducing excipient compounds for protein formulations |
-
2017
- 2017-07-12 EP EP17828373.5A patent/EP3484520A4/en not_active Withdrawn
- 2017-07-12 US US15/647,669 patent/US10279048B2/en active Active
- 2017-07-12 KR KR1020197003892A patent/KR20190027878A/ko not_active Ceased
- 2017-07-12 WO PCT/US2017/041691 patent/WO2018013673A1/en not_active Ceased
- 2017-07-12 JP JP2019522614A patent/JP2019527729A/ja active Pending
- 2017-07-12 CA CA3030422A patent/CA3030422C/en active Active
- 2017-08-14 US US15/676,168 patent/US10016513B2/en active Active
-
2019
- 2019-03-15 US US16/354,557 patent/US10610600B2/en active Active
-
2020
- 2020-02-13 US US16/789,628 patent/US20200282065A1/en not_active Abandoned
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