JP2019527052A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019527052A5 JP2019527052A5 JP2018569171A JP2018569171A JP2019527052A5 JP 2019527052 A5 JP2019527052 A5 JP 2019527052A5 JP 2018569171 A JP2018569171 A JP 2018569171A JP 2018569171 A JP2018569171 A JP 2018569171A JP 2019527052 A5 JP2019527052 A5 JP 2019527052A5
- Authority
- JP
- Japan
- Prior art keywords
- microalgal
- acid
- cells
- ingredient
- spp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 41
- 210000004027 cell Anatomy 0.000 claims 31
- 235000012041 food component Nutrition 0.000 claims 14
- 239000005417 food ingredient Substances 0.000 claims 14
- 239000000047 product Substances 0.000 claims 11
- 230000012010 growth Effects 0.000 claims 8
- 239000001963 growth medium Substances 0.000 claims 8
- 235000021466 carotenoid Nutrition 0.000 claims 7
- 150000001747 carotenoids Chemical group 0.000 claims 7
- 239000003086 colorant Substances 0.000 claims 7
- 239000008406 cosmetic ingredient Substances 0.000 claims 7
- 235000015872 dietary supplement Nutrition 0.000 claims 7
- 239000004615 ingredient Substances 0.000 claims 7
- 239000013503 personal care ingredient Substances 0.000 claims 7
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims 6
- 239000002028 Biomass Substances 0.000 claims 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 6
- 235000013793 astaxanthin Nutrition 0.000 claims 6
- 239000001168 astaxanthin Substances 0.000 claims 6
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims 6
- 229940022405 astaxanthin Drugs 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 6
- 241000894007 species Species 0.000 claims 6
- 238000003786 synthesis reaction Methods 0.000 claims 6
- 150000003505 terpenes Chemical class 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 5
- 150000007524 organic acids Chemical class 0.000 claims 5
- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 241000195627 Chlamydomonadales Species 0.000 claims 4
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 241000195585 Chlamydomonas Species 0.000 claims 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 3
- 239000004202 carbamide Substances 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- YVLPJIGOMTXXLP-UUKUAVTLSA-N 15,15'-cis-Phytoene Natural products C(=C\C=C/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C YVLPJIGOMTXXLP-UUKUAVTLSA-N 0.000 claims 2
- YVLPJIGOMTXXLP-BAHRDPFUSA-N 15Z-phytoene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)CCC=C(/C)CCC=C(C)C)C)C)C)C YVLPJIGOMTXXLP-BAHRDPFUSA-N 0.000 claims 2
- OINNEUNVOZHBOX-QIRCYJPOSA-K 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O OINNEUNVOZHBOX-QIRCYJPOSA-K 0.000 claims 2
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- OINNEUNVOZHBOX-XBQSVVNOSA-N Geranylgeranyl diphosphate Natural products [P@](=O)(OP(=O)(O)O)(OC/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)O OINNEUNVOZHBOX-XBQSVVNOSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 241000168525 Haematococcus Species 0.000 claims 2
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims 2
- 241001478792 Monoraphidium Species 0.000 claims 2
- 229910002651 NO3 Inorganic materials 0.000 claims 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 claims 2
- 208000031513 cyst Diseases 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 235000001510 limonene Nutrition 0.000 claims 2
- 229940087305 limonene Drugs 0.000 claims 2
- 235000012661 lycopene Nutrition 0.000 claims 2
- 239000001751 lycopene Substances 0.000 claims 2
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims 2
- 229960004999 lycopene Drugs 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 230000000065 osmolyte Effects 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 235000011765 phytoene Nutrition 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 235000007586 terpenes Nutrition 0.000 claims 2
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims 2
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims 1
- 241001134016 Chlamydocapsa Species 0.000 claims 1
- 241000500710 Chloromonas Species 0.000 claims 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims 1
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 claims 1
- 241000223252 Rhodotorula Species 0.000 claims 1
- 241000277331 Salmonidae Species 0.000 claims 1
- 241000195663 Scenedesmus Species 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- 241001467333 Thraustochytriaceae Species 0.000 claims 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 claims 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 claims 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 235000012682 canthaxanthin Nutrition 0.000 claims 1
- 239000001659 canthaxanthin Substances 0.000 claims 1
- 229940008033 canthaxanthin Drugs 0.000 claims 1
- 150000001746 carotenes Chemical class 0.000 claims 1
- 235000005473 carotenes Nutrition 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 229940074393 chlorogenic acid Drugs 0.000 claims 1
- 235000001368 chlorogenic acid Nutrition 0.000 claims 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims 1
- OVSVTCFNLSGAMM-KGBODLQUSA-N cis-phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/C=C/C=C(C)/CCC=C(/C)CCC=C(C)C)C)C)C)C OVSVTCFNLSGAMM-KGBODLQUSA-N 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 229940097043 glucuronic acid Drugs 0.000 claims 1
- 230000009569 heterotrophic growth Effects 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000002267 larvicidal agent Substances 0.000 claims 1
- 235000012680 lutein Nutrition 0.000 claims 1
- 239000001656 lutein Substances 0.000 claims 1
- 229960005375 lutein Drugs 0.000 claims 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000000050 nutritive effect Effects 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 235000002677 phytofluene Nutrition 0.000 claims 1
- OVSVTCFNLSGAMM-UZFNGAIXSA-N phytofluene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=C\C=C(/C)\C=C\C=C(C)CCC=C(C)CCC=C(C)C OVSVTCFNLSGAMM-UZFNGAIXSA-N 0.000 claims 1
- ZYSFBWMZMDHGOJ-SGKBLAECSA-N phytofluene Natural products CC(=CCCC(=CCCC(=CCCC(=CC=C/C=C(C)/CCC=C(/C)C=CC=C(/C)CCC=C(C)C)C)C)C)C ZYSFBWMZMDHGOJ-SGKBLAECSA-N 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 239000000892 thaumatin Substances 0.000 claims 1
- 235000010436 thaumatin Nutrition 0.000 claims 1
- ZIUDAKDLOLDEGU-UHFFFAOYSA-N trans-Phytofluen Natural products CC(C)=CCCC(C)CCCC(C)CC=CC(C)=CC=CC=C(C)C=CCC(C)CCCC(C)CCC=C(C)C ZIUDAKDLOLDEGU-UHFFFAOYSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims 1
- 235000010930 zeaxanthin Nutrition 0.000 claims 1
- 239000001775 zeaxanthin Substances 0.000 claims 1
- 229940043269 zeaxanthin Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022133647A JP2022177001A (ja) | 2016-06-30 | 2022-08-24 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
| JP2024225562A JP2025041773A (ja) | 2016-06-30 | 2024-12-20 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662356896P | 2016-06-30 | 2016-06-30 | |
| US62/356,896 | 2016-06-30 | ||
| PCT/US2017/040486 WO2018006068A1 (en) | 2016-06-30 | 2017-06-30 | Improved heterotrophic production methods for microbial biomass and bioproducts |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022133647A Division JP2022177001A (ja) | 2016-06-30 | 2022-08-24 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019527052A JP2019527052A (ja) | 2019-09-26 |
| JP2019527052A5 true JP2019527052A5 (https=) | 2020-08-13 |
| JP7549444B2 JP7549444B2 (ja) | 2024-09-11 |
Family
ID=59351112
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018569171A Active JP7549444B2 (ja) | 2016-06-30 | 2017-06-30 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
| JP2022133647A Withdrawn JP2022177001A (ja) | 2016-06-30 | 2022-08-24 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
| JP2024225562A Pending JP2025041773A (ja) | 2016-06-30 | 2024-12-20 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022133647A Withdrawn JP2022177001A (ja) | 2016-06-30 | 2022-08-24 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
| JP2024225562A Pending JP2025041773A (ja) | 2016-06-30 | 2024-12-20 | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11034968B2 (https=) |
| EP (1) | EP3478850A1 (https=) |
| JP (3) | JP7549444B2 (https=) |
| CA (1) | CA3028227A1 (https=) |
| WO (1) | WO2018006068A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11419350B2 (en) | 2016-07-01 | 2022-08-23 | Corbion Biotech, Inc. | Feed ingredients comprising lysed microbial cells |
| US11377675B2 (en) * | 2019-01-16 | 2022-07-05 | Kuehnle Agrosystems, Inc. | Subterranean microalgae for production of microbial biomass, substances, and compositions |
| WO2021057709A1 (zh) * | 2019-09-23 | 2021-04-01 | 山东拜昂生物技术有限公司 | 一种培养雨生红球藻生产虾青素的方法 |
| US20220356504A1 (en) * | 2019-09-23 | 2022-11-10 | Bioalgo (Wf) Co., Ltd. | Method for producing astaxanthin by heterotrophic culture of haematococcus pluvialis |
| CN110804639B (zh) * | 2019-11-27 | 2022-04-08 | 中国科学院天津工业生物技术研究所 | 促进微藻虾青素酯化的方法 |
| KR102445369B1 (ko) * | 2019-12-03 | 2022-09-21 | 한양대학교 산학협력단 | 미세조류로부터 기능성 오일을 추출하는 방법 및 기능성 오일을 포함하는 유화액 |
| EP4210663B1 (en) * | 2020-09-10 | 2026-04-29 | The Procter & Gamble Company | Late-stage product differentiation process for personal care products |
| USPP34488P3 (en) | 2020-10-30 | 2022-08-09 | Kuehnle Agrosystems, Inc. | Haematococcus microalga named ‘KAS1601-WG7’ |
| KR20240014474A (ko) * | 2021-05-27 | 2024-02-01 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 포르밀글리신 함유 폴리펩티드의 절단을 조절하는 방법 |
| EP4122330A1 (en) * | 2021-07-22 | 2023-01-25 | Alver World SA | Methods of growing microalgae & products thereof |
| WO2023074226A1 (ja) * | 2021-10-27 | 2023-05-04 | 本田技研工業株式会社 | 緑藻クラミドモナスの培養方法 |
| CN115024428B (zh) * | 2022-06-15 | 2024-05-24 | 广州希望饲料有限公司 | 一种具有改善水禽免疫力与肠道的无抗饲料添加剂及其制备方法 |
| US20260047991A1 (en) * | 2022-08-08 | 2026-02-19 | University Of Florida Research Foundation, Inc. | Stimuli-responsive chromogenic materials, methods of making and methods of use |
| WO2024258936A2 (en) * | 2023-06-13 | 2024-12-19 | Kuehnle Agrosystems, Inc. | Improved edible compositions comprising an improved chlamydomonas reinhardtii component |
| KR102897913B1 (ko) * | 2023-12-26 | 2025-12-12 | 전제은 | 미세조류로부터 관심 생성물을 고수율로 수득하기 위한 방법 |
| CN120183511A (zh) * | 2025-05-22 | 2025-06-20 | 成都英德生物医药设备有限公司 | 生物反应器的动态优化方法以及系统 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US6680426B2 (en) | 1991-01-07 | 2004-01-20 | Auburn University | Genetic engineering of plant chloroplasts |
| US5882849A (en) | 1989-10-10 | 1999-03-16 | Aquasearch, Inc. | Method of control of Haematococcus spp, growth process |
| IL116995A (en) | 1996-02-01 | 2000-08-31 | Univ Ben Gurion | Procedure for large-scale production of astaxanthin from haematococcus |
| WO2002010398A2 (en) | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| WO2003027267A1 (en) | 2001-09-26 | 2003-04-03 | Parry Nutraceuticals Ltd. | Process to produce astaxanthin from haematococcus biomass |
| US7329789B1 (en) | 2001-10-25 | 2008-02-12 | Phasex Corporation | Method for extraction and concentration of carotenoids using supercritical fluids |
| EP1361280A1 (en) | 2002-05-08 | 2003-11-12 | Wageningen University | Process for continuous production and extraction of carotenoids from natural sources |
| EP1724357A4 (en) | 2004-03-04 | 2010-11-17 | Suntory Holdings Ltd | PROCESS FOR THE MANUFACTURE OF LIPIDS CONTAINING ASTAXANTHIN |
| WO2006107736A1 (en) | 2005-04-01 | 2006-10-12 | Algaen Corporation | Extractability and bioavailability of the natural antioxidant astaxanthin from a green alga, haematococcus pluvialis |
| EP2147113A1 (en) | 2007-05-23 | 2010-01-27 | Cognis IP Management GmbH | Efficient astaxanthin production strains derived from haematococcus pluvialis |
| EP1995325A1 (en) | 2007-05-23 | 2008-11-26 | Cognis IP Management GmbH | Efficient astaxanthin production strains derived from Haematococcus pluvialis |
| AU2009231810A1 (en) | 2008-03-31 | 2009-10-08 | Kuehnle Agrosystems, Inc. | Nuclear based expression of genes for production of biofuels and process co-products in algae |
| US8278090B1 (en) | 2008-07-03 | 2012-10-02 | Solazyme, Inc. | Heterotrophic cultivation of hydrocarbon-producing microalgae |
| CH701253A1 (de) | 2009-06-12 | 2010-12-15 | Mibelle Ag | Verwendung eines Extraktes aus Schneealgen in kosmetischen oder dermatologischen Formulierungen. |
| ES2732493T3 (es) | 2009-09-18 | 2019-11-22 | Phycoil Biotechnology Int Inc | Fermentación de microalgas usando iluminación controlada |
| US9428779B2 (en) * | 2010-02-03 | 2016-08-30 | Sapphire Energy, Inc. | Transformation of algae for increasing lipid production |
| USPP23858P3 (en) | 2011-04-18 | 2013-08-27 | Karl Y. Biel | Chlamydomonas reinhardtii alga variety named ‘DG8-108’ |
| CN103571906B (zh) | 2012-07-27 | 2018-12-11 | 上海泽元海洋生物技术有限公司 | 一种利用微藻高效生产虾青素的新方法 |
| WO2014074772A1 (en) | 2012-11-09 | 2014-05-15 | Heliae Development, Llc | Mixotrophic, phototrophic, and heterotrophic combination methods and systems |
| RU2541455C1 (ru) * | 2014-10-03 | 2015-02-10 | Институт биологии южных морей им. А.О. Ковалевского | Способ культивирования одноклеточной зеленой водоросли haematococcus pluvialis для получения астаксантина |
-
2017
- 2017-06-30 JP JP2018569171A patent/JP7549444B2/ja active Active
- 2017-06-30 US US15/640,246 patent/US11034968B2/en active Active
- 2017-06-30 WO PCT/US2017/040486 patent/WO2018006068A1/en not_active Ceased
- 2017-06-30 EP EP17740210.4A patent/EP3478850A1/en active Pending
- 2017-06-30 CA CA3028227A patent/CA3028227A1/en active Pending
-
2021
- 2021-03-10 US US17/197,484 patent/US20210198680A1/en active Pending
-
2022
- 2022-08-24 JP JP2022133647A patent/JP2022177001A/ja not_active Withdrawn
-
2024
- 2024-12-20 JP JP2024225562A patent/JP2025041773A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019527052A5 (https=) | ||
| Geada et al. | Algal proteins: Production strategies and nutritional and functional properties | |
| JP2022177001A (ja) | 微生物バイオマスのための改善された従属栄養生産方法およびバイオ製品 | |
| Matos | The impact of microalgae in food science and technology | |
| Bhosale et al. | Microbial xanthophylls | |
| Koller et al. | Microalgae as versatile cellular factories for valued products | |
| Jin et al. | Microalgal biotechnology: carotenoid production by the green algae Dunaliella salina | |
| Danesi et al. | Effect of reducing the light intensity on the growth and production of chlorophyll by Spirulina platensis | |
| Chen et al. | Enhancing production of lutein by a mixotrophic cultivation system using microalga Scenedesmus obliquus CWL-1 | |
| Indra Arulselvi et al. | Screening of yellow pigment producing bacterial isolates from various eco-climatic areas and analysis of the carotenoid produced by the isolate | |
| Hemantkumar et al. | Microalgae and its use in nutraceuticals and food supplements | |
| Maldonade et al. | Selection and characterization of carotenoid-producing yeasts from Campinas region, Brazil | |
| Scaife et al. | Efficient extraction of canthaxanthin from Escherichia coli by a 2-step process with organic solvents | |
| de Boer | Biotechnological production of colorants | |
| Ng et al. | Valuable compounds produced by microalgae | |
| Aly et al. | Microalgae in food and feed: Safety and toxicological aspects | |
| Tangerås et al. | Coloring of salmonids in aquaculture: the yeast Phaffia rhodozyma as a source of astaxanthin | |
| JP2016514470A (ja) | クロレラ（Ｃｈｌｏｒｅｌｌａ）属の微細藻類により産生される酸化感受性代謝物を安定化する方法 | |
| Cunha et al. | A road to the microalgae market: Allmicroalgae case study | |
| Yaamini et al. | Valuable bio-products from algae and their commercial applications | |
| Sutthiwong et al. | Production of biocolours | |
| Rosales et al. | Intermediate renewal rates enhance the productivity of the cyanobacterium Synechococcus sp. in semicontinuous cultures | |
| CN104922098A (zh) | 一种天然脂溶物的应用 | |
| Ali et al. | Evaluation of the Growth Performance of Spirulina platensis in Different Concentrations of Kosaric Medium (KM) and Papaya Skin Powder Medium (PSPM) | |
| Stunda-Zujeva et al. | Growing and drying Spirulina/Arthrospira for producing food and nutraceuticals: A Review |