JP2019526595A - 血液癌を治療するための抗ｃｄ２０抗体、ｐｉ３キナーゼ−デルタ阻害剤および抗ｐｄ−１抗体または抗ｐｄ−ｌ１抗体の組み合わせ - Google Patents

血液癌を治療するための抗ｃｄ２０抗体、ｐｉ３キナーゼ−デルタ阻害剤および抗ｐｄ−１抗体または抗ｐｄ−ｌ１抗体の組み合わせ Download PDF

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JP2019526595A
JP2019526595A JP2019512763A JP2019512763A JP2019526595A JP 2019526595 A JP2019526595 A JP 2019526595A JP 2019512763 A JP2019512763 A JP 2019512763A JP 2019512763 A JP2019512763 A JP 2019512763A JP 2019526595 A JP2019526595 A JP 2019526595A
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kinase
delta inhibitor
ubrituximab
antibody
weeks
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JP2019526595A5 (enExample
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エス． ワイス，マイケル
エス． ワイス，マイケル
ピー． ミスキン，ハリ
ピー． ミスキン，ハリ
スポルテリ，ピーター
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ティージー セラピューティクス，インコーポレイテッド
ティージー セラピューティクス，インコーポレイテッド
ルヒゼン ファーマスティカルズ エスエー
ルヒゼン ファーマスティカルズ エスエー
ラボラトワ フランセーズ デュ フラクションメント エ デ バイオテクノロジーズ
ラボラトワ フランセーズ デュ フラクションメント エ デ バイオテクノロジーズ
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2019512763A 2016-09-09 2017-09-08 血液癌を治療するための抗ｃｄ２０抗体、ｐｉ３キナーゼ−デルタ阻害剤および抗ｐｄ−１抗体または抗ｐｄ−ｌ１抗体の組み合わせ Pending JP2019526595A (ja)

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US201662385723P 2016-09-09 2016-09-09
US62/385,723 2016-09-09
PCT/US2017/050825 WO2018049263A1 (en) 2016-09-09 2017-09-08 Combination of an anti-cd20 antibody, pi3 kinase-delta inhibitor, and anti-pd-1 or anti-pd-l1 antibody for treating hematological cancers

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JP2019526595A true JP2019526595A (ja) 2019-09-19
JP2019526595A5 JP2019526595A5 (enExample) 2020-10-15

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EP (1) EP3509634A1 (enExample)
JP (1) JP2019526595A (enExample)
KR (1) KR20190068521A (enExample)
CN (1) CN110191720A (enExample)
AU (1) AU2017322501A1 (enExample)
BR (1) BR112019004185A2 (enExample)
CA (1) CA3035976A1 (enExample)
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EA (1) EA201990374A1 (enExample)
IL (1) IL265194A (enExample)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL321335A (en) 2016-06-29 2025-08-01 Checkpoint Therapeutics Inc PD-L1-specific antibodies and methods of using them
DK3448859T3 (da) 2017-03-20 2019-09-23 Forma Therapeutics Inc Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer
CN108743947B (zh) * 2018-07-04 2020-12-15 复旦大学附属肿瘤医院 一种治疗b细胞淋巴瘤的药物组合物
WO2020061378A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
JP7450610B2 (ja) 2018-09-19 2024-03-15 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ピルビン酸キナーゼｒの活性化
WO2020191022A1 (en) * 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
WO2021009509A1 (en) * 2019-07-15 2021-01-21 Johnson Matthey Public Limited Company Amorphous umbralisib monotosylate
MX2022003254A (es) 2019-09-19 2022-04-18 Forma Therapeutics Inc Composiciones activadoras de piruvato cinasa r (pkr).
CN117222413A (zh) * 2021-02-10 2023-12-12 同润生物医药(上海)有限公司 治疗肿瘤的方法和组合
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
IL314661A (en) * 2022-02-28 2024-09-01 Jasper Therapeutics Inc Compositions and methods for depletion of diseased hematopoietic stem cells
CN115141092A (zh) * 2022-07-27 2022-10-04 诚达药业股份有限公司 一种抗淋巴瘤药物相关化合物的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016505515A (ja) * 2012-11-02 2016-02-25 ティージー セラピューティクス インコーポレイテッド 抗ｃｄ２０抗体およびｐｉ３キナーゼ選択的阻害剤の組み合わせ

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US6190370B1 (en) 1997-07-25 2001-02-20 Arrow International, Inc. Devices, systems and methods for determining proper placement of epidural catheters
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
FR2844455B1 (fr) 2002-09-13 2007-12-14 Lab Francais Du Fractionnement Traitement des pathologies echappant a la reponse immune par des anticorps optimises
PT1572744E (pt) 2002-12-16 2010-09-07 Genentech Inc Variantes de imunoglobulina e utilizações destas
CN101899114A (zh) 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
FR2858235B1 (fr) 2003-07-31 2006-02-17 Lab Francais Du Fractionnement Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
FR2879204B1 (fr) 2004-12-15 2007-02-16 Lab Francais Du Fractionnement Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b.
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
KR101411165B1 (ko) 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
CA2702637A1 (en) * 2007-10-22 2009-04-30 Schering Corporation Fully human anti-vegf antibodies and methods of using
PL2242773T3 (pl) 2008-02-11 2017-11-30 Cure Tech Ltd. Przeciwciała monoklonalne do leczenia nowotworu
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
EP2927240A1 (en) 2008-08-25 2015-10-07 Amplimmune, Inc. Compositions of pd-1 antagonists and methods of use
CA2735006A1 (en) 2008-08-25 2010-03-11 Amplimmune, Inc. Pd-1 antagonists and methods of use thereof
WO2010077634A1 (en) 2008-12-09 2010-07-08 Genentech, Inc. Anti-pd-l1 antibodies and their use to enhance t-cell function
HRP20171537T1 (hr) 2009-11-05 2017-12-15 Rhizen Pharmaceuticals S.A. Novi modulatori benzopiran kinaze
NZ599405A (en) 2009-11-24 2014-09-26 Medimmune Ltd Targeted binding agents against b7-h1
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
LT2734551T (lt) 2011-07-24 2018-04-10 Cure Tech Ltd. Humanizuotų imunomoduliuojančių monokloninių antikūnų variantai
WO2013022091A1 (ja) * 2011-08-11 2013-02-14 小野薬品工業株式会社 Ｐｄ－１アゴニストからなる自己免疫疾患治療剤
EP2785375B1 (en) 2011-11-28 2020-07-22 Merck Patent GmbH Anti-pd-l1 antibodies and uses thereof
US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
LT2870157T (lt) 2012-07-04 2017-12-11 Rhizen Pharmaceuticals S.A. Selektyvieji pi3k delta inhibitoriai
JP6461800B2 (ja) 2012-10-04 2019-01-30 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヒトモノクローナル抗ｐｄ−ｌ１抗体および使用方法
SMT202100532T1 (it) 2014-05-27 2021-11-12 Rhizen Pharmaceuticals S A Sale tosilato cristallino di un inibitore 5 selettivo di pi3k delta per l’uso in formulazioni farmaceutiche
SI3179992T1 (sl) * 2014-08-11 2022-09-30 Acerta Pharma B.V. Terapevtske kombinacije zaviralca BTK, zaviralca PD-1 in/ali zaviralca PD-L1
KR20170060042A (ko) * 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016505515A (ja) * 2012-11-02 2016-02-25 ティージー セラピューティクス インコーポレイテッド 抗ｃｄ２０抗体およびｐｉ３キナーゼ選択的阻害剤の組み合わせ

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLINICAL LYMPHOMA, MYELOMA & LEUKEMIA, vol. 17, no. 1, JPN6021030570, 8 September 2016 (2016-09-08), pages 1 - 6, ISSN: 0004567121 *
CLINICALTRIALS.GOV ARCHIVE,[ONLINE], JPN6021030572, 13 April 2016 (2016-04-13), ISSN: 0004742841 *
HUMAN PATHOLOGY, vol. 54, JPN6021030571, 1 April 2016 (2016-04-01), pages 17 - 24, ISSN: 0004567120 *

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CL2019000585A1 (es) 2020-05-29
EA201990374A1 (ru) 2019-09-30
CA3035976A1 (en) 2018-03-15
KR20190068521A (ko) 2019-06-18
WO2018049263A1 (en) 2018-03-15
AU2017322501A1 (en) 2019-03-28
US20190247399A1 (en) 2019-08-15
IL265194A (en) 2019-05-30
BR112019004185A2 (pt) 2019-09-03
CN110191720A (zh) 2019-08-30
MX2019002728A (es) 2019-08-16

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