JP2019526261A5 - - Google Patents
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- Publication number
- JP2019526261A5 JP2019526261A5 JP2019511993A JP2019511993A JP2019526261A5 JP 2019526261 A5 JP2019526261 A5 JP 2019526261A5 JP 2019511993 A JP2019511993 A JP 2019511993A JP 2019511993 A JP2019511993 A JP 2019511993A JP 2019526261 A5 JP2019526261 A5 JP 2019526261A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- fhbp
- factor binding
- foreign peptide
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710186862 Factor H binding protein Proteins 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102100030386 Granzyme A Human genes 0.000 claims 11
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 108010060123 Conjugate Vaccines Proteins 0.000 claims 2
- 230000006229 amino acid addition Effects 0.000 claims 2
- 229940031670 conjugate vaccine Drugs 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 229940031937 polysaccharide vaccine Drugs 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1614687.0A GB201614687D0 (en) | 2016-08-31 | 2016-08-31 | fHbp scaffold |
| GB1614687.0 | 2016-08-31 | ||
| PCT/GB2017/052535 WO2018042178A1 (en) | 2016-08-31 | 2017-08-31 | Modified factor h binding protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526261A JP2019526261A (ja) | 2019-09-19 |
| JP2019526261A5 true JP2019526261A5 (Direct) | 2020-10-08 |
| JP7525093B2 JP7525093B2 (ja) | 2024-07-30 |
Family
ID=57119942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511993A Active JP7525093B2 (ja) | 2016-08-31 | 2017-08-31 | 改変ｈ因子結合タンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12497432B2 (Direct) |
| EP (1) | EP3506934A1 (Direct) |
| JP (1) | JP7525093B2 (Direct) |
| KR (1) | KR102643280B1 (Direct) |
| CN (1) | CN109890412B (Direct) |
| AU (1) | AU2017319218B2 (Direct) |
| BR (1) | BR112019003957A2 (Direct) |
| CA (1) | CA3035159A1 (Direct) |
| GB (2) | GB201614687D0 (Direct) |
| IL (1) | IL265078B2 (Direct) |
| MX (1) | MX420767B (Direct) |
| WO (1) | WO2018042178A1 (Direct) |
| ZA (1) | ZA201901862B (Direct) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| CN110903400A (zh) * | 2019-11-08 | 2020-03-24 | 苏州微超生物科技有限公司 | B群脑膜炎球菌fHBP多变体融合蛋白及其制备方法与应用 |
| CN111533792B (zh) | 2020-07-07 | 2020-10-16 | 康希诺生物股份公司 | 一种定点突变的载体蛋白及其在制备疫苗中的用途 |
| US20230365979A1 (en) * | 2020-09-29 | 2023-11-16 | Idemitsu Kosan Co.,Ltd. | Peptide tag and tagged protein including same |
| IN202321021121A (Direct) * | 2023-03-24 | 2024-04-19 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX339524B (es) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
| US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
| EP1549338B1 (en) * | 2002-10-11 | 2010-12-22 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| WO2004053091A2 (en) * | 2002-12-10 | 2004-06-24 | Lorantis Ltd. | STABILIZED IMMUNOGENIC HBc CHIMER PARTICLES |
| ES2383175T3 (es) * | 2003-01-30 | 2012-06-18 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| PL1670506T3 (pl) * | 2003-10-02 | 2013-04-30 | Novartis Ag | Płynne szczepionki przeciw wielu grupom serologicznym meningokoków |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB2414667A (en) * | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| WO2006011060A2 (en) * | 2004-07-23 | 2006-02-02 | Chiron Srl | Polypeptides for oligomeric assembly of antigens |
| GB0419408D0 (en) * | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
| CN101107007B (zh) * | 2005-01-27 | 2011-08-17 | 奥克兰儿童医院及研究中心 | 对脑膜炎奈瑟球菌所致疾病具有广谱保护作用的gna1870囊泡疫苗 |
| GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| EP1925318A1 (en) * | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| CA2716212A1 (en) * | 2008-02-21 | 2009-08-27 | Novartis Ag | Meningococcal fhbp polypeptides |
| EP2631245A1 (en) | 2008-03-10 | 2013-08-28 | Children's Hospital & Research Center at Oakland | Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use |
| AU2009262893B2 (en) * | 2008-05-30 | 2015-05-21 | The U.S.A., as represented by The Secretary of the Army, on behalf of Walter Reed Army Institute Of Research | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
| US20100105875A1 (en) * | 2008-06-09 | 2010-04-29 | Maria Scarselli | Antibodies against neisserial factor H binding protein |
| US8470340B2 (en) * | 2008-09-03 | 2013-06-25 | Children's Hospital & Research Center Oakland | Peptides presenting an epitope of a domain of factor H binding protein and methods of use |
| GB0819633D0 (en) * | 2008-10-25 | 2008-12-03 | Isis Innovation | Composition |
| NZ595234A (en) * | 2009-03-24 | 2013-12-20 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
| MX2011011512A (es) * | 2009-04-30 | 2012-02-13 | Novartis Vaccines & Diagnostic | Proteinas de union de factor h quimericas (fhbp) y metodos de uso. |
| EP3017828A1 (en) * | 2009-08-27 | 2016-05-11 | GlaxoSmithKline Biologicals SA | Hybrid polypeptides including meningococcal fhbp sequences |
| CN102917730A (zh) * | 2009-10-27 | 2013-02-06 | 诺华有限公司 | 修饰的脑膜炎球菌fHBP多肽 |
| US20130004530A1 (en) * | 2010-03-10 | 2013-01-03 | Jan Poolman | Vaccine composition |
| EP3327028B1 (en) * | 2010-03-30 | 2022-03-16 | Children's Hospital & Research Center at Oakland | Factor h binding proteins (fhbp) with altered properties and methods of use thereof |
| WO2011125015A2 (en) * | 2010-04-05 | 2011-10-13 | Bar-Ilan University | Protease-activatable pore-forming polypeptides |
| CA2803239A1 (en) * | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
| KR101584871B1 (ko) * | 2010-09-10 | 2016-01-22 | 와이어쓰 엘엘씨 | 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체 |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
| JP2015505309A (ja) * | 2011-12-29 | 2015-02-19 | ノバルティス アーゲー | 髄膜炎菌ｈ因子結合タンパク質のアジュバントされた組み合わせ |
| JP2015517089A (ja) * | 2012-03-08 | 2015-06-18 | ノバルティス アーゲー | タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ |
| SA115360586B1 (ar) * | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| BR122016004924A2 (pt) * | 2012-03-09 | 2019-07-30 | Pfizer Inc. | Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos |
| NZ630133A (en) * | 2012-06-14 | 2016-10-28 | Novartis Ag | Vaccines for serogroup x meningococcus |
| GB201215005D0 (en) * | 2012-08-23 | 2012-10-10 | Isis Innovation | Stabilised meningitis vaccine |
| EP2964665B1 (en) * | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
| US20160030544A1 (en) * | 2013-03-14 | 2016-02-04 | Isis Innovation Limited | Immunogenic composition to neisseria |
| CA2923129C (en) * | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| RS61246B1 (sr) * | 2014-02-28 | 2021-01-29 | Glaxosmithkline Biologicals Sa | Modifikovani meningokokni fhbp polipeptidi |
| CN106715464B (zh) * | 2014-07-23 | 2021-03-16 | 奥克兰儿童医院及研究中心 | 因子h结合蛋白变体及其使用方法 |
| JP2017536823A (ja) | 2014-11-28 | 2017-12-14 | ヤンセン ヴァクシーンズ アンド プリベンション ビー．ブイ． | 髄膜炎ｂワクチン |
| WO2016132294A1 (en) * | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| US10183070B2 (en) * | 2017-01-31 | 2019-01-22 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
-
2016
- 2016-08-31 GB GBGB1614687.0A patent/GB201614687D0/en not_active Ceased
-
2017
- 2017-08-31 CA CA3035159A patent/CA3035159A1/en active Pending
- 2017-08-31 GB GB1903866.0A patent/GB2568440B/en active Active
- 2017-08-31 AU AU2017319218A patent/AU2017319218B2/en active Active
- 2017-08-31 CN CN201780060701.6A patent/CN109890412B/zh active Active
- 2017-08-31 MX MX2019002248A patent/MX420767B/es unknown
- 2017-08-31 US US16/328,340 patent/US12497432B2/en active Active
- 2017-08-31 WO PCT/GB2017/052535 patent/WO2018042178A1/en not_active Ceased
- 2017-08-31 EP EP17762178.6A patent/EP3506934A1/en active Pending
- 2017-08-31 BR BR112019003957A patent/BR112019003957A2/pt unknown
- 2017-08-31 JP JP2019511993A patent/JP7525093B2/ja active Active
- 2017-08-31 KR KR1020197008694A patent/KR102643280B1/ko active Active
-
2019
- 2019-02-27 IL IL265078A patent/IL265078B2/en unknown
- 2019-03-26 ZA ZA2019/01862A patent/ZA201901862B/en unknown