JP2019525951A5 - - Google Patents
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- Publication number
- JP2019525951A5 JP2019525951A5 JP2019518175A JP2019518175A JP2019525951A5 JP 2019525951 A5 JP2019525951 A5 JP 2019525951A5 JP 2019518175 A JP2019518175 A JP 2019518175A JP 2019518175 A JP2019518175 A JP 2019518175A JP 2019525951 A5 JP2019525951 A5 JP 2019525951A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- pharmaceutical composition
- serum
- freeze
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 210000002966 serum Anatomy 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 150000004676 glycans Chemical class 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 210000003954 umbilical cord Anatomy 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000007975 buffered saline Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229940014259 gelatin Drugs 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000011343 solid material Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022145970A JP7473237B2 (ja) | 2016-06-16 | 2022-09-14 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
| JP2024060611A JP2024096781A (ja) | 2016-06-16 | 2024-04-04 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662350772P | 2016-06-16 | 2016-06-16 | |
| US62/350,772 | 2016-06-16 | ||
| PCT/US2017/037954 WO2017218942A1 (en) | 2016-06-16 | 2017-06-16 | Compositions and methods of treating dry syndrome and other traumatized non-keratinized epithelial surfaces |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022145970A Division JP7473237B2 (ja) | 2016-06-16 | 2022-09-14 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525951A JP2019525951A (ja) | 2019-09-12 |
| JP2019525951A5 true JP2019525951A5 (enExample) | 2020-07-30 |
| JP7148987B2 JP7148987B2 (ja) | 2022-10-06 |
Family
ID=60663416
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518175A Active JP7148987B2 (ja) | 2016-06-16 | 2017-06-16 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
| JP2022145970A Active JP7473237B2 (ja) | 2016-06-16 | 2022-09-14 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
| JP2024060611A Pending JP2024096781A (ja) | 2016-06-16 | 2024-04-04 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022145970A Active JP7473237B2 (ja) | 2016-06-16 | 2022-09-14 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
| JP2024060611A Pending JP2024096781A (ja) | 2016-06-16 | 2024-04-04 | 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US11191781B2 (enExample) |
| EP (1) | EP3471742A4 (enExample) |
| JP (3) | JP7148987B2 (enExample) |
| CN (1) | CN109862899A (enExample) |
| CA (1) | CA3027969A1 (enExample) |
| WO (1) | WO2017218942A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109862899A (zh) | 2016-06-16 | 2019-06-07 | 护眼国际有限责任公司 | 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法 |
| WO2019231133A1 (ko) * | 2018-05-31 | 2019-12-05 | 주식회사 엑소코바이오 | 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물 |
| US20200170998A1 (en) * | 2018-11-29 | 2020-06-04 | Cellula Llc | Umbilical cord blood serum and umbilical cord blood plasma preparation in combination with a nonsteroidal anti-inflammatory drug and freeze-drying the composition |
| KR20220008289A (ko) * | 2019-05-13 | 2022-01-20 | 본 테라퓨틱스 소시에테아노님 | 히알루론산 및 혈장 단백질을 포함하는 개선된 동결건조 제형 및 이의 용도 |
| IT201900010740A1 (it) * | 2019-07-02 | 2021-01-02 | Medacta Int Sa | Biocompatible compositions comprising a biocompatible thickening polymer and a chitosan derivative |
| EP4549859A1 (en) * | 2022-06-28 | 2025-05-07 | Compliance Consulting And Engineering Services, S.L. | System for controlling the freeze-drying process in a freeze dryer with a plate stack system and a method for generating a design space |
| US20240226181A1 (en) * | 2023-01-11 | 2024-07-11 | Biostem Technologies, Inc. | Human umbilical cord composition for treatment of peyronie's disease |
| CN117017945B (zh) * | 2023-08-14 | 2026-02-06 | 珠海横琴澳叶健康科技有限公司 | 一种离子响应型蒙花苷纳米粒子及其制备方法和应用 |
| WO2025165681A1 (en) * | 2024-01-31 | 2025-08-07 | Serorepair Llc | Serum compositions with additive for ocular delivery in animals |
| CN118662706B (zh) * | 2024-06-17 | 2025-01-10 | 韶关朗圣药业有限公司 | 一种人体润滑液及其制备方法和应用 |
| EP4740931A1 (en) * | 2024-11-06 | 2026-05-13 | Oral Care Solutions GmbH | Oral care composition for use in the treatment of dry mouth |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9713980D0 (en) | 1997-07-03 | 1997-09-10 | Danbiosyst Uk | New conjugates |
| PT1128809E (pt) * | 1998-11-20 | 2005-04-29 | Medidom Lab | Formulacoes oftalmicas aquosas comprendendo quitosano |
| JP2005530768A (ja) * | 2002-05-09 | 2005-10-13 | メディジーンズ | 血漿または血清を含有した創傷治療用医薬組成物 |
| US20080299212A1 (en) * | 2005-02-25 | 2008-12-04 | Medigenes Co., Ltd | Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising Blood Plasma or Serum |
| ES2668551T3 (es) * | 2005-09-26 | 2018-05-18 | Lifecell Corporation | Composición seca de plaquetas |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| US20090223080A1 (en) * | 2007-03-19 | 2009-09-10 | Hemcon Medical Technologies, Inc. | Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma |
| US7776022B2 (en) * | 2007-03-19 | 2010-08-17 | Hemcon Medical Technologies | Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma |
| WO2010085792A1 (en) * | 2009-01-26 | 2010-07-29 | Oregon Biomedical Engineering Institute | Dehydrated plasma kit |
| CN101829048B (zh) * | 2010-01-21 | 2012-04-18 | 厦门大学 | 一种滴眼液及其制备方法 |
| WO2013003356A1 (en) | 2011-06-27 | 2013-01-03 | Emory University | Compositions, uses, and preparation of platelet lysates |
| ES2368394B1 (es) * | 2011-07-13 | 2012-06-08 | Banc De Sang I Teixits | Composición que comprende plasma de sangre de cordon umbilical para el tratamiento de patologías de la superficie ocular y procedimiento de obtención de la misma. |
| US9688434B2 (en) * | 2012-08-17 | 2017-06-27 | Archon Pharmaceutical Consulting Llc | System for compounding and packaging ready to reconstitute ophthalmic drug powders to a solution or to a suspension for administration to an eye of patient |
| CA2914610C (en) | 2013-03-13 | 2022-08-02 | University Of Maryland | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| WO2015048774A2 (en) | 2013-09-30 | 2015-04-02 | Bioactive Regenerative Therapeutics, Inc. | Biomimetic hybrid gel compositions and methods of use |
| ES2904359T3 (es) * | 2014-02-20 | 2022-04-04 | Ortho Regenerative Tech Inc | Composiciones poliméricas liofilizadas para mezclar con plasma rico en plaquetas para formar implantes para la reparación de tejidos y/o composiciones para inyecciones terapéuticas intraarticulares |
| WO2015142853A1 (en) * | 2014-03-17 | 2015-09-24 | Encompass Development, Inc. | Ocular formulations |
| EP3139903B1 (en) * | 2014-05-07 | 2019-07-03 | Croma-Pharma Gesellschaft m.b.H. | Aqueous ophthalmic solution and method for treating dry eye syndrome |
| CA2963435A1 (en) | 2014-10-06 | 2016-04-14 | Fondazione Irccs Ca' Granda - Ospedale Maggiore Policlinico | Umbilical cord blood plasma for treatment of corneal pathology |
| DE102015205293A1 (de) * | 2015-03-24 | 2016-09-29 | Marc Schrott | Verfahren zur Herstellung von Augentropfen |
| CN109862899A (zh) | 2016-06-16 | 2019-06-07 | 护眼国际有限责任公司 | 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法 |
-
2017
- 2017-06-16 CN CN201780050143.5A patent/CN109862899A/zh active Pending
- 2017-06-16 WO PCT/US2017/037954 patent/WO2017218942A1/en not_active Ceased
- 2017-06-16 EP EP17814202.2A patent/EP3471742A4/en active Pending
- 2017-06-16 US US16/309,810 patent/US11191781B2/en active Active
- 2017-06-16 CA CA3027969A patent/CA3027969A1/en active Pending
- 2017-06-16 JP JP2019518175A patent/JP7148987B2/ja active Active
-
2021
- 2021-11-09 US US17/454,117 patent/US11534459B2/en active Active
-
2022
- 2022-09-14 JP JP2022145970A patent/JP7473237B2/ja active Active
- 2022-12-07 US US18/077,105 patent/US12661374B2/en active Active
-
2024
- 2024-04-04 JP JP2024060611A patent/JP2024096781A/ja active Pending
-
2026
- 2026-01-27 US US19/460,821 patent/US20260151428A1/en active Pending
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