JP2019524851A5 - - Google Patents
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- JP2019524851A5 JP2019524851A5 JP2019510457A JP2019510457A JP2019524851A5 JP 2019524851 A5 JP2019524851 A5 JP 2019524851A5 JP 2019510457 A JP2019510457 A JP 2019510457A JP 2019510457 A JP2019510457 A JP 2019510457A JP 2019524851 A5 JP2019524851 A5 JP 2019524851A5
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- Prior art keywords
- adenocarcinoma
- cancer
- combination
- agent
- sarcoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 25
- 239000003795 chemical substances by application Substances 0.000 claims 14
- 201000011510 cancer Diseases 0.000 claims 12
- 101150098329 Tyro3 gene Proteins 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 8
- 201000009030 Carcinoma Diseases 0.000 claims 7
- 206010039491 Sarcoma Diseases 0.000 claims 7
- -1 bostinib Chemical compound 0.000 claims 7
- 206010025323 Lymphomas Diseases 0.000 claims 6
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- 210000000214 mouth Anatomy 0.000 claims 4
- 206010024612 Lipoma Diseases 0.000 claims 3
- 201000004458 Myoma Diseases 0.000 claims 3
- CXQHYVUVSFXTMY-UHFFFAOYSA-N N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CN=C2C=C(OCCCN3CCOCC3)C(OC)=CC2=C1OC(C(=C1)F)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 CXQHYVUVSFXTMY-UHFFFAOYSA-N 0.000 claims 3
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- QHADVLVFMKEIIP-UHFFFAOYSA-N n-[3-fluoro-4-[1-methyl-6-(1h-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide Chemical compound O=C1N(C=2C=CC(F)=CC=2)C(C)=CC=C1C(=O)NC(C=C1F)=CC=C1OC1=CC=2C=NN(C)C=2C=C1C=1C=NNC=1 QHADVLVFMKEIIP-UHFFFAOYSA-N 0.000 claims 3
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- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 claims 2
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- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 claims 2
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- KXMZDGSRSGHMMK-VWLOTQADSA-N 1-(6,7-dihydro-5h-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-n-[(7s)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5h-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine Chemical compound N1([C@H]2CCC3=CC=C(C=C3CC2)NC=2N=C(N(N=2)C=2N=NC=3C4=CC=CC=C4CCCC=3C=2)N)CCCC1 KXMZDGSRSGHMMK-VWLOTQADSA-N 0.000 claims 1
- ODIUNTQOXRXOIV-UHFFFAOYSA-N 1-[6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl]-1,3-benzothiazol-2-yl]-3-(2-morpholin-4-ylethyl)urea Chemical compound C1=CC(F)=CC=C1C1=NN2C(SC=3C=C4SC(NC(=O)NCCN5CCOCC5)=NC4=CC=3)=NN=C2C=C1 ODIUNTQOXRXOIV-UHFFFAOYSA-N 0.000 claims 1
- MJSHVHLADKXCML-UHFFFAOYSA-N 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol Chemical compound C12=NC(NCCCC)=NC=C2C(C=2C=CC(CN3CCN(C)CC3)=CC=2)=CN1C1CCC(O)CC1 MJSHVHLADKXCML-UHFFFAOYSA-N 0.000 claims 1
- ORRNXRYWGDUDOG-UHFFFAOYSA-N 4-[2-fluoro-4-[(2-phenylacetyl)carbamothioylamino]phenoxy]-7-methoxy-n-methylquinoline-6-carboxamide Chemical compound C1=CN=C2C=C(OC)C(C(=O)NC)=CC2=C1OC(C(=C1)F)=CC=C1NC(=S)NC(=O)CC1=CC=CC=C1 ORRNXRYWGDUDOG-UHFFFAOYSA-N 0.000 claims 1
- KAAPXWSYROPAEL-UHFFFAOYSA-N 4-[6-(butylamino)-3-(4-morpholin-4-ylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]cyclohexan-1-ol Chemical compound C12=NC(NCCCC)=NC=C2C(C=2C=CC(=CC=2)S(=O)(=O)N2CCOCC2)=NN1C1CCC(O)CC1 KAAPXWSYROPAEL-UHFFFAOYSA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- CTNPALGJUAXMMC-PMFHANACSA-N 5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-n-[(2s)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide Chemical compound C([C@@H](O)CNC(=O)C=1C(C)=C(\C=C/2C3=CC(F)=CC=C3NC\2=O)NC=1C)N1CCOCC1 CTNPALGJUAXMMC-PMFHANACSA-N 0.000 claims 1
- GUBJNPWVIUFSTR-UHFFFAOYSA-N 5-cyano-n-[2-(cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]phenyl]-1h-imidazole-2-carboxamide Chemical compound C1CN(C(=O)CN(C)C)CCC1C(C=C1C=2CCCCC=2)=CC=C1NC(=O)C1=NC(C#N)=CN1 GUBJNPWVIUFSTR-UHFFFAOYSA-N 0.000 claims 1
- DWHXUGDWKAIASB-CQSZACIVSA-N 6-[(1r)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one Chemical compound C=1N2C([C@@H](C)N3C=CC4=NC=C(C=C4C3=O)OCCOC)=NN=C2C(F)=CC=1C=1C=NN(C)C=1 DWHXUGDWKAIASB-CQSZACIVSA-N 0.000 claims 1
- KOAWAWHSMVKCON-UHFFFAOYSA-N 6-[difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline Chemical compound C=1C=C2N=CC=CC2=CC=1C(F)(F)C(N1N=2)=NN=C1C=CC=2C1=CC=NC=C1 KOAWAWHSMVKCON-UHFFFAOYSA-N 0.000 claims 1
- JGEBLDKNWBUGRZ-HXUWFJFHSA-N 9-[[[(2r)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine Chemical compound C=1C=C2C=CC3=NC=C(C4=CN(C)N=C4)C=C3C(=O)C2=CC=1NS(=O)(=O)N(C)C[C@@H]1COCCO1 JGEBLDKNWBUGRZ-HXUWFJFHSA-N 0.000 claims 1
- HEAIZQNMNCHNFD-UHFFFAOYSA-N AMG-208 Chemical compound C=1C=NC2=CC(OC)=CC=C2C=1OCC(N1N=2)=NN=C1C=CC=2C1=CC=CC=C1 HEAIZQNMNCHNFD-UHFFFAOYSA-N 0.000 claims 1
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- VNBRGSXVFBYQNN-UHFFFAOYSA-N N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamide Chemical compound O=C1C(C(=O)NC=2C=C(F)C(OC=3C(=C(N)N=CC=3)Cl)=CC=2)=C(OCC)C=CN1C1=CC=C(F)C=C1 VNBRGSXVFBYQNN-UHFFFAOYSA-N 0.000 claims 1
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- AHYMHWXQRWRBKT-UHFFFAOYSA-N tepotinib Chemical compound C1CN(C)CCC1COC1=CN=C(C=2C=C(CN3C(C=CC(=N3)C=3C=C(C=CC=3)C#N)=O)C=CC=2)N=C1 AHYMHWXQRWRBKT-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662379169P | 2016-08-24 | 2016-08-24 | |
| US62/379,169 | 2016-08-24 | ||
| US201762521176P | 2017-06-16 | 2017-06-16 | |
| US62/521,176 | 2017-06-16 | ||
| PCT/US2017/048075 WO2018039275A1 (en) | 2016-08-24 | 2017-08-22 | Combinations for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524851A JP2019524851A (ja) | 2019-09-05 |
| JP2019524851A5 true JP2019524851A5 (enExample) | 2020-09-24 |
Family
ID=61246270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019510457A Pending JP2019524851A (ja) | 2016-08-24 | 2017-08-22 | がんを治療するための組み合わせ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190224200A1 (enExample) |
| EP (1) | EP3503887A4 (enExample) |
| JP (1) | JP2019524851A (enExample) |
| CN (1) | CN109715157A (enExample) |
| WO (1) | WO2018039275A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1608378A1 (en) | 2003-04-02 | 2005-12-28 | Nexmed (Holdings), Inc. | Prostaglandin compositions and their use for the treatment of vasospasm |
| US11247990B1 (en) | 2017-12-07 | 2022-02-15 | Array Biopharma Inc | Bicyclic fused pyridine compounds as inhibitors of TAM kinases |
| US11946094B2 (en) * | 2017-12-10 | 2024-04-02 | Augusta University Research Institute, Inc. | Combination therapies and methods of use thereof |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| WO2020124043A1 (en) * | 2018-12-13 | 2020-06-18 | Gordon Erlinda M | Methods of exploiting oncogenic drivers along the human cyclin g1 pathway for cancer gene therapy |
| US20220089540A1 (en) * | 2019-01-17 | 2022-03-24 | Board Of Trustees Of Michigan State University | Compositions and methods for immune modulation and treatment of cancer |
| EP4149483A4 (en) * | 2020-05-15 | 2024-09-11 | Fred Hutchinson Cancer Center | COMPOSITIONS AND METHODS FOR IMPROVING CANCER IMMUNOTHERAPY |
| WO2021244551A1 (zh) * | 2020-06-02 | 2021-12-09 | 正大天晴药业集团股份有限公司 | c-Met激酶抑制剂和抗PD-L1抗体的联用药物组合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA023521B1 (ru) | 2011-11-14 | 2016-06-30 | Сефалон, Инк. | ПРОИЗВОДНЫЕ УРАЦИЛА В КАЧЕСТВЕ ИНГИБИТОРОВ AXL И c-MET КИНАЗЫ |
| EP3027623A4 (en) | 2013-08-02 | 2017-03-01 | Ignyta, Inc. | METHODS OF TREATING VARIOUS CANCERS USING AN AXL/cMET INHIBITOR ALONE OR IN COMBINATION WITH OTHER AGENTS |
| ES2763429T5 (es) * | 2013-12-17 | 2023-06-21 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres usando antagonistas de la unión al eje de PD-1 y taxanos |
| US9649309B2 (en) * | 2014-04-11 | 2017-05-16 | The University Of North Carolina At Chapel Hill | Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity |
| CN105085680A (zh) * | 2014-05-23 | 2015-11-25 | 复旦大学 | 人源化抗PD-1及c-MET双特异性抗体及其制备方法和应用 |
| RS63364B1 (sr) * | 2014-08-11 | 2022-07-29 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora, pd-1 inhibitora i/ili pd-l1 inhibitora |
| KR20170066546A (ko) * | 2014-10-03 | 2017-06-14 | 노파르티스 아게 | 조합 요법 |
| EP3233902B1 (en) * | 2014-12-18 | 2020-09-09 | Aravive Biologics, Inc. | Antifibrotic activity of gas6 inhibitor |
-
2017
- 2017-08-22 WO PCT/US2017/048075 patent/WO2018039275A1/en not_active Ceased
- 2017-08-22 EP EP17844308.1A patent/EP3503887A4/en not_active Withdrawn
- 2017-08-22 CN CN201780056350.1A patent/CN109715157A/zh active Pending
- 2017-08-22 JP JP2019510457A patent/JP2019524851A/ja active Pending
- 2017-08-22 US US16/327,301 patent/US20190224200A1/en not_active Abandoned
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