JP2019519488A5 - - Google Patents
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- JP2019519488A5 JP2019519488A5 JP2018558225A JP2018558225A JP2019519488A5 JP 2019519488 A5 JP2019519488 A5 JP 2019519488A5 JP 2018558225 A JP2018558225 A JP 2018558225A JP 2018558225 A JP2018558225 A JP 2018558225A JP 2019519488 A5 JP2019519488 A5 JP 2019519488A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- polymer
- polymer matrix
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 86
- 229920000642 polymer Polymers 0.000 claims description 51
- 239000011159 matrix material Substances 0.000 claims description 34
- 239000000419 plant extract Substances 0.000 claims description 22
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 20
- 239000004480 active ingredient Substances 0.000 claims description 19
- 229930015704 phenylpropanoid Natural products 0.000 claims description 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 14
- 244000223014 Syzygium aromaticum Species 0.000 claims description 13
- 150000002995 phenylpropanoid derivatives Chemical class 0.000 claims description 13
- 239000000341 volatile oil Substances 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 12
- 229920001282 polysaccharide Polymers 0.000 claims description 12
- 239000005017 polysaccharide Substances 0.000 claims description 12
- 108060003345 Adrenergic Receptor Proteins 0.000 claims description 10
- 102000017910 Adrenergic receptor Human genes 0.000 claims description 10
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 10
- 239000005770 Eugenol Substances 0.000 claims description 10
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 10
- 229960002217 eugenol Drugs 0.000 claims description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 10
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
- 239000003961 penetration enhancing agent Substances 0.000 claims description 10
- 229920001577 copolymer Polymers 0.000 claims description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 8
- SCCDQYPEOIRVGX-UHFFFAOYSA-N Acetyleugenol Chemical compound COC1=CC(CC=C)=CC=C1OC(C)=O SCCDQYPEOIRVGX-UHFFFAOYSA-N 0.000 claims description 8
- ZMQAAUBTXCXRIC-UHFFFAOYSA-N safrole Chemical compound C=CCC1=CC=C2OCOC2=C1 ZMQAAUBTXCXRIC-UHFFFAOYSA-N 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 7
- 229930016911 cinnamic acid Natural products 0.000 claims description 7
- 235000013985 cinnamic acid Nutrition 0.000 claims description 7
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 7
- 229920000084 Gum arabic Polymers 0.000 claims description 6
- 235000010489 acacia gum Nutrition 0.000 claims description 6
- 239000000205 acacia gum Substances 0.000 claims description 6
- -1 cavicol Chemical compound 0.000 claims description 6
- 229920000609 methyl cellulose Polymers 0.000 claims description 5
- 239000001923 methylcellulose Substances 0.000 claims description 5
- 235000010981 methylcellulose Nutrition 0.000 claims description 5
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 150000003505 terpenes Chemical class 0.000 claims description 4
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical group CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims description 3
- 229930182837 (R)-adrenaline Natural products 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 244000215068 Acacia senegal Species 0.000 claims description 3
- 102000009027 Albumins Human genes 0.000 claims description 3
- 108010088751 Albumins Proteins 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 229920002101 Chitin Polymers 0.000 claims description 3
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000004373 Pullulan Substances 0.000 claims description 3
- 229920001218 Pullulan Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 229920001615 Tragacanth Polymers 0.000 claims description 3
- 229960004538 alprazolam Drugs 0.000 claims description 3
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000305 astragalus gummifer gum Substances 0.000 claims description 3
- 230000001851 biosynthetic effect Effects 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 239000000412 dendrimer Substances 0.000 claims description 3
- 229920000736 dendritic polymer Polymers 0.000 claims description 3
- 229960003529 diazepam Drugs 0.000 claims description 3
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 3
- 229960005139 epinephrine Drugs 0.000 claims description 3
- 235000010417 guar gum Nutrition 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
- 229960002154 guar gum Drugs 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 229920000587 hyperbranched polymer Polymers 0.000 claims description 3
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 3
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 3
- 239000004584 polyacrylic acid Substances 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 3
- 235000019423 pullulan Nutrition 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229920003169 water-soluble polymer Polymers 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims description 2
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 2
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims description 2
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims description 2
- 229940117916 cinnamic aldehyde Drugs 0.000 claims description 2
- 229930002886 farnesol Natural products 0.000 claims description 2
- 229940043259 farnesol Drugs 0.000 claims description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 2
- 235000020778 linoleic acid Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229930004725 sesquiterpene Natural products 0.000 claims description 2
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims description 2
- 235000007586 terpenes Nutrition 0.000 claims description 2
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims description 2
- 125000001474 phenylpropanoid group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001851 cinnamic acid derivatives Chemical class 0.000 claims 1
- 125000002871 cinnamic aldehydes group Chemical group 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 239000006071 cream Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023104610A JP2023134518A (ja) | 2016-05-05 | 2023-06-27 | 透過性増強された医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662331993P | 2016-05-05 | 2016-05-05 | |
| US62/331,993 | 2016-05-05 | ||
| PCT/US2017/031170 WO2017192923A1 (en) | 2016-05-05 | 2017-05-04 | Pharmaceutical compositions with enhanced permeation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023104610A Division JP2023134518A (ja) | 2016-05-05 | 2023-06-27 | 透過性増強された医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019519488A JP2019519488A (ja) | 2019-07-11 |
| JP2019519488A5 true JP2019519488A5 (https=) | 2020-06-25 |
Family
ID=58708068
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558225A Pending JP2019519488A (ja) | 2016-05-05 | 2017-05-04 | 透過性増強された医薬組成物 |
| JP2023104610A Pending JP2023134518A (ja) | 2016-05-05 | 2023-06-27 | 透過性増強された医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023104610A Pending JP2023134518A (ja) | 2016-05-05 | 2023-06-27 | 透過性増強された医薬組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20170290776A1 (https=) |
| EP (1) | EP3452024A1 (https=) |
| JP (2) | JP2019519488A (https=) |
| KR (1) | KR102536696B1 (https=) |
| CN (1) | CN109310647A (https=) |
| BR (1) | BR112018072467A2 (https=) |
| CA (1) | CA3022797A1 (https=) |
| IL (2) | IL262751B2 (https=) |
| WO (1) | WO2017192923A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| KR20230137362A (ko) * | 2016-05-05 | 2023-10-04 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| MX389336B (es) | 2016-11-15 | 2025-03-20 | Klaria Pharma Holding Ab | Formulacion farmaceutica. |
| WO2018129499A1 (en) * | 2017-01-09 | 2018-07-12 | Verily Life Sciences Llc | Systems and methods for wearable emergency drug injection devices |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| CA3076815A1 (en) * | 2017-09-27 | 2019-04-04 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| IL313551A (en) * | 2017-09-27 | 2024-08-01 | Aquestive Therapeutics Inc | Enhanced delivery epinephrine and prodrug compositions |
| CN107903322B (zh) * | 2017-10-10 | 2022-03-08 | 宜宾学院 | 一种基于黄樟素环氧化改性制备抗菌胶原的方法 |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US11648197B2 (en) | 2018-06-28 | 2023-05-16 | Arx, Llc | Dispensing method for producing dissolvable unit dose film constructs |
| JP7637616B2 (ja) * | 2018-09-07 | 2025-02-28 | アクエスティブ セラピューティクス インコーポレイテッド | 厳密な活性剤溶解プロファイルを有する口腔用フィルム組成物及び剤形 |
| BR112022008294A2 (pt) * | 2019-11-01 | 2022-07-26 | Aquestive Therapeutics Inc | Composições de profármaco e métodos de tratamento |
| WO2021097247A1 (en) * | 2019-11-14 | 2021-05-20 | Aquestive Therapeutics, Inc. | Multimodal compositions and methods of treatment |
| EP4072516A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Oral product comprising a cannabinoid |
| DE102020122557A1 (de) * | 2020-08-28 | 2022-03-03 | Lts Lohmann Therapie-Systeme Ag | Mucosa-Perforierung |
| WO2022074127A2 (en) * | 2020-10-08 | 2022-04-14 | Catalent U.K. Swindon Zydis Limited | Stable oral dispersible formulation for epinephrine and salts or solvates thereof |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| EP4422607A4 (en) | 2021-10-25 | 2025-09-03 | Aquestive Therapeutics Inc | ORAL AND NASAL COMPOSITIONS AND METHODS OF TREATMENT |
| JP2025029732A (ja) | 2023-08-22 | 2025-03-07 | 三菱電機株式会社 | ゲート駆動装置 |
| CN120037250B (zh) * | 2025-04-07 | 2026-03-03 | 江苏知原药业股份有限公司 | 一种伊维菌素外用药物组合物、制备方法及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1357891A (en) | 1920-07-15 | 1920-11-02 | Henry S Murray | Portable instantaneous water-heater |
| US20040265353A1 (en) * | 1995-07-28 | 2004-12-30 | Zars, Inc. | Systems and methods for treating panic attacks |
| US7666337B2 (en) | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US7425292B2 (en) | 2001-10-12 | 2008-09-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
| UA84277C2 (ru) * | 2002-10-25 | 2008-10-10 | Лабофарм Инк. | Композиция трамадола с пролонгированным высвобождением с 24-часовым действием |
| US20040096569A1 (en) * | 2002-11-15 | 2004-05-20 | Barkalow David G. | Edible film products and methods of making same |
| US20050266085A1 (en) * | 2004-05-28 | 2005-12-01 | Warner Kevin S | Gelled emulsion and microemulsion formulations for dermal drug delivery |
| US20070202163A1 (en) * | 2005-09-09 | 2007-08-30 | Mutasem Rawas-Qalaji | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| IL175338A0 (en) * | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| DK2457581T3 (da) * | 2009-07-23 | 2014-03-31 | Igisu Co Ltd | Sammensætning omfattende CNP eller BNP for et udvendigt præparat til hud til behandling af dermatitis |
| AR082189A1 (es) * | 2010-07-06 | 2012-11-21 | Gruenenthal Gmbh | Formas de dosificacion gastrorretentivas, procedimiento |
| KR20140084176A (ko) * | 2011-10-28 | 2014-07-04 | 권성윤 | 편두통을 치료하기 위한 용해성 고용체 퍼포레이터 패치 |
| KR20230137362A (ko) * | 2016-05-05 | 2023-10-04 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
-
2017
- 2017-05-04 WO PCT/US2017/031170 patent/WO2017192923A1/en not_active Ceased
- 2017-05-04 US US15/587,376 patent/US20170290776A1/en not_active Abandoned
- 2017-05-04 JP JP2018558225A patent/JP2019519488A/ja active Pending
- 2017-05-04 CN CN201780037588.XA patent/CN109310647A/zh active Pending
- 2017-05-04 IL IL262751A patent/IL262751B2/en unknown
- 2017-05-04 CA CA3022797A patent/CA3022797A1/en active Pending
- 2017-05-04 KR KR1020187035236A patent/KR102536696B1/ko active Active
- 2017-05-04 IL IL318880A patent/IL318880A/en unknown
- 2017-05-04 BR BR112018072467-0A patent/BR112018072467A2/pt not_active Application Discontinuation
- 2017-05-04 EP EP17723617.1A patent/EP3452024A1/en active Pending
-
2023
- 2023-06-27 JP JP2023104610A patent/JP2023134518A/ja active Pending
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