JP2019516748A5 - - Google Patents
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- Publication number
- JP2019516748A5 JP2019516748A5 JP2018561278A JP2018561278A JP2019516748A5 JP 2019516748 A5 JP2019516748 A5 JP 2019516748A5 JP 2018561278 A JP2018561278 A JP 2018561278A JP 2018561278 A JP2018561278 A JP 2018561278A JP 2019516748 A5 JP2019516748 A5 JP 2019516748A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cell carcinoma
- inhibitor
- seq
- renal cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 16
- 239000003112 inhibitor Substances 0.000 claims description 14
- 238000002512 chemotherapy Methods 0.000 claims description 10
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 6
- 102000008096 B7-H1 Antigen Human genes 0.000 claims description 6
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 5
- 206010050513 Metastatic renal cell carcinoma Diseases 0.000 claims description 4
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 3
- 229950002916 avelumab Drugs 0.000 claims description 3
- 230000003993 interaction Effects 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 40
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 12
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 9
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 9
- 229910052697 platinum Inorganic materials 0.000 description 6
- 208000017604 Hodgkin disease Diseases 0.000 description 5
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 5
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 5
- 206010033128 Ovarian cancer Diseases 0.000 description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 description 5
- 208000009329 Graft vs Host Disease Diseases 0.000 description 3
- 208000024908 graft versus host disease Diseases 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 102000048776 human CD274 Human genes 0.000 description 2
- 230000001506 immunosuppresive effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 description 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000024340 acute graft versus host disease Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000017760 chronic graft versus host disease Diseases 0.000 description 1
- 208000013056 classic Hodgkin lymphoma Diseases 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 102000048362 human PDCD1 Human genes 0.000 description 1
- 102000048119 human PDCD1LG2 Human genes 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000011518 platinum-based chemotherapy Methods 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662341921P | 2016-05-26 | 2016-05-26 | |
| US62/341,921 | 2016-05-26 | ||
| US201662423358P | 2016-11-17 | 2016-11-17 | |
| US62/423,358 | 2016-11-17 | ||
| US201762471459P | 2017-03-15 | 2017-03-15 | |
| US62/471,459 | 2017-03-15 | ||
| PCT/EP2017/062213 WO2017202744A1 (en) | 2016-05-26 | 2017-05-22 | Pd-1 / pd-l1 inhibitors for cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019516748A JP2019516748A (ja) | 2019-06-20 |
| JP2019516748A5 true JP2019516748A5 (cg-RX-API-DMAC7.html) | 2020-07-02 |
Family
ID=58745241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561278A Pending JP2019516748A (ja) | 2016-05-26 | 2017-05-22 | がんを治療するためのｐｄ−１／ｐｄ−ｌ１阻害剤 |
Country Status (14)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101764096B1 (ko) * | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| BR112017018234A2 (pt) | 2015-02-26 | 2018-04-17 | Merck Patent Gmbh | inibidores de pd-1 / pd-l1 para o tratamento de câncer |
| CN107750166B (zh) | 2015-06-16 | 2022-02-11 | 默克专利股份有限公司 | Pd-l1拮抗剂组合治疗 |
| HK1250033A1 (zh) | 2015-07-13 | 2018-11-23 | Cytomx Therapeutics Inc. | 抗-pd-1抗体、可活化的抗-pd-1抗体、及其使用方法 |
| US11274154B2 (en) * | 2016-10-06 | 2022-03-15 | Pfizer Inc. | Dosing regimen of avelumab for the treatment of cancer |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| US11168144B2 (en) | 2017-06-01 | 2021-11-09 | Cytomx Therapeutics, Inc. | Activatable anti-PDL1 antibodies, and methods of use thereof |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| TWI809427B (zh) | 2018-07-13 | 2023-07-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| EP3870566A1 (en) | 2018-10-24 | 2021-09-01 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| EP3876940A1 (en) * | 2018-11-05 | 2021-09-15 | Pfizer Inc. | Combinations for treating cancer |
| US20210403557A1 (en) * | 2018-11-05 | 2021-12-30 | Merck Sharp & Dohme Corp. | Dosing regimen of anti-tigit antibody for treatment of cancer |
| CN113164599B (zh) * | 2018-12-24 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 抗pd-l1单克隆抗体治疗癌症的用途 |
| US20220257619A1 (en) | 2019-07-18 | 2022-08-18 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| US20210030885A1 (en) * | 2019-07-22 | 2021-02-04 | Seagen Inc. | Humanized anti-liv1 antibodies for the treatment of cancer |
| CN113018429A (zh) * | 2019-12-24 | 2021-06-25 | 正大天晴药业集团南京顺欣制药有限公司 | 治疗卵巢癌的药物组合 |
| WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| KR20230041654A (ko) | 2020-05-05 | 2023-03-24 | 테온 테라퓨틱스, 인크. | 칸나비노이드 수용체 유형 2 (cb2) 조정제 및 그의 용도 |
| WO2023034530A1 (en) | 2021-09-02 | 2023-03-09 | Teon Therapeutics, Inc. | Methods of improving growth and function of immune cells |
| WO2023081730A1 (en) | 2021-11-03 | 2023-05-11 | Teon Therapeutics, Inc. | 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer |
| WO2023097211A1 (en) | 2021-11-24 | 2023-06-01 | The University Of Southern California | Methods for enhancing immune checkpoint inhibitor therapy |
| KR20230128690A (ko) * | 2022-02-28 | 2023-09-05 | 주식회사 시선테라퓨틱스 | 핵산 복합체를 포함하는 폐암 예방 또는 치료용 조성물 |
| WO2024015372A1 (en) | 2022-07-14 | 2024-01-18 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| AU5632296A (en) | 1995-04-27 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| AU760562B2 (en) | 1997-12-05 | 2003-05-15 | Scripps Research Institute, The | Humanization of murine antibody |
| KR101764096B1 (ko) * | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | 항-ｐｄ-ｌ1 항체 및 그의 용도 |
| BR112016005303A2 (pt) * | 2013-09-11 | 2017-09-12 | Medimmune Ltd | anticorpos anti-b7-h1 para tratamento de tumores |
| AU2015289672A1 (en) * | 2014-07-15 | 2017-03-02 | Genentech, Inc. | Compositions for treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
| BR112017018234A2 (pt) * | 2015-02-26 | 2018-04-17 | Merck Patent Gmbh | inibidores de pd-1 / pd-l1 para o tratamento de câncer |
| CN107750166B (zh) * | 2015-06-16 | 2022-02-11 | 默克专利股份有限公司 | Pd-l1拮抗剂组合治疗 |
-
2017
- 2017-05-22 CA CA3025391A patent/CA3025391A1/en not_active Abandoned
- 2017-05-22 WO PCT/EP2017/062213 patent/WO2017202744A1/en not_active Ceased
- 2017-05-22 MX MX2018014435A patent/MX2018014435A/es unknown
- 2017-05-22 EP EP17724821.8A patent/EP3464356A1/en not_active Withdrawn
- 2017-05-22 RU RU2018145184A patent/RU2018145184A/ru not_active Application Discontinuation
- 2017-05-22 AU AU2017269675A patent/AU2017269675A1/en not_active Abandoned
- 2017-05-22 JP JP2018561278A patent/JP2019516748A/ja active Pending
- 2017-05-22 BR BR112018073920-0A patent/BR112018073920A2/pt not_active Application Discontinuation
- 2017-05-22 KR KR1020187037522A patent/KR20190012201A/ko not_active Withdrawn
- 2017-05-22 CN CN201780032522.1A patent/CN109195989A/zh active Pending
- 2017-05-22 US US16/304,338 patent/US20190144545A1/en not_active Abandoned
- 2017-05-22 SG SG11201810423XA patent/SG11201810423XA/en unknown
- 2017-05-25 TW TW106117304A patent/TW201800108A/zh unknown
-
2018
- 2018-11-21 IL IL263178A patent/IL263178A/en unknown
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