JP2019514979A5 - - Google Patents
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- Publication number
- JP2019514979A5 JP2019514979A5 JP2018558293A JP2018558293A JP2019514979A5 JP 2019514979 A5 JP2019514979 A5 JP 2019514979A5 JP 2018558293 A JP2018558293 A JP 2018558293A JP 2018558293 A JP2018558293 A JP 2018558293A JP 2019514979 A5 JP2019514979 A5 JP 2019514979A5
- Authority
- JP
- Japan
- Prior art keywords
- inflammatory
- lipid
- pharmaceutical composition
- rofleponide
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002632 lipids Chemical class 0.000 claims 23
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 19
- 230000003110 anti-inflammatory effect Effects 0.000 claims 15
- 239000002105 nanoparticle Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical group C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 claims 11
- 229950004432 rofleponide Drugs 0.000 claims 11
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 6
- 229960004436 budesonide Drugs 0.000 claims 6
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 5
- 239000002260 anti-inflammatory agent Substances 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- 102000014702 Haptoglobin Human genes 0.000 claims 2
- 108050005077 Haptoglobin Proteins 0.000 claims 2
- 229930182558 Sterol Natural products 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims 2
- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 2
- 229940049918 linoleate Drugs 0.000 claims 2
- 229940105132 myristate Drugs 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003432 sterols Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- LRFJOIPOPUJUMI-KWXKLSQISA-N 2-[2,2-bis[(9z,12z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-n,n-dimethylethanamine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1 LRFJOIPOPUJUMI-KWXKLSQISA-N 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- NRLNQCOGCKAESA-KWXKLSQISA-N [(6z,9z,28z,31z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC\C=C/C\C=C/CCCCC NRLNQCOGCKAESA-KWXKLSQISA-N 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229940070765 laurate Drugs 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 229960002446 octanoic acid Drugs 0.000 claims 1
- 229940049964 oleate Drugs 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021212753A JP2022058438A (ja) | 2016-05-09 | 2021-12-27 | 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662333574P | 2016-05-09 | 2016-05-09 | |
| US62/333,574 | 2016-05-09 | ||
| US201662359429P | 2016-07-07 | 2016-07-07 | |
| US62/359,429 | 2016-07-07 | ||
| US201762449623P | 2017-01-24 | 2017-01-24 | |
| US62/449,623 | 2017-01-24 | ||
| PCT/EP2017/060891 WO2017194454A1 (en) | 2016-05-09 | 2017-05-08 | Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021212753A Division JP2022058438A (ja) | 2016-05-09 | 2021-12-27 | 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514979A JP2019514979A (ja) | 2019-06-06 |
| JP2019514979A5 true JP2019514979A5 (https=) | 2020-06-18 |
| JP7066632B2 JP7066632B2 (ja) | 2022-05-13 |
Family
ID=58671696
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558293A Active JP7066632B2 (ja) | 2016-05-09 | 2017-05-08 | 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法 |
| JP2021212753A Withdrawn JP2022058438A (ja) | 2016-05-09 | 2021-12-27 | 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021212753A Withdrawn JP2022058438A (ja) | 2016-05-09 | 2021-12-27 | 親油性抗炎症剤を含む脂質ナノ粒子およびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11458106B2 (https=) |
| EP (1) | EP3454835B1 (https=) |
| JP (2) | JP7066632B2 (https=) |
| CN (1) | CN109152735B (https=) |
| ES (1) | ES2871537T3 (https=) |
| WO (1) | WO2017194454A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202200502T1 (it) | 2014-06-25 | 2023-01-13 | Acuitas Therapeutics Inc | Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici |
| LT3313829T (lt) | 2015-06-29 | 2024-08-12 | Acuitas Therapeutics Inc. | Lipidai ir lipidų nanodalelių sudėtys, skirtos nukleorūgščių tiekimui |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP3454835B1 (en) | 2016-05-09 | 2021-03-31 | Astrazeneca AB | Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof |
| ES3063077T3 (en) * | 2016-10-26 | 2026-04-15 | Acuitas Therapeutics Inc | Lipid nanoparticle formulations |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| WO2018191657A1 (en) | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
| WO2018200943A1 (en) | 2017-04-28 | 2018-11-01 | Acuitas Therapeutics, Inc. | Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| CA3073020A1 (en) | 2017-08-16 | 2019-02-21 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US11524932B2 (en) | 2017-08-17 | 2022-12-13 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| EP3668834B1 (en) | 2017-08-17 | 2024-10-02 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| WO2019036028A1 (en) | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS |
| IL281615B2 (en) | 2018-09-21 | 2026-01-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| JP7543259B2 (ja) | 2018-10-18 | 2024-09-02 | アクイタス セラピューティクス インコーポレイテッド | 活性剤の脂質ナノ粒子送達のための脂質 |
| MY202837A (en) | 2019-01-11 | 2024-05-24 | Acuitas Therapeutics Inc | Lipids for lipid nanoparticle delivery of active agents |
| CN114173826A (zh) * | 2019-05-08 | 2022-03-11 | 阿斯利康(瑞典)有限公司 | 使用脂质纳米颗粒用于递送编码vegf-a多肽的经修饰的rna的方法和包含其的药物组合物 |
| CN110974954B (zh) * | 2019-12-24 | 2021-03-16 | 珠海丽凡达生物技术有限公司 | 一种用于增强核酸疫苗免疫效果的脂质纳米颗粒及其制备方法 |
| KR20230002300A (ko) * | 2020-01-21 | 2023-01-05 | 이더알엔에이 이뮤노테라피스 엔브이 | 지질 나노입자 |
| WO2022016070A1 (en) | 2020-07-16 | 2022-01-20 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
| WO2023286059A1 (en) | 2021-07-13 | 2023-01-19 | Technion Research & Development Foundation Limited | Compositions and methods for treating a medical condition |
| EP4427740A4 (en) * | 2021-11-05 | 2025-10-22 | G2Gbio Inc | PHARMACEUTICAL KIT FOR PARENTERAL CO-ADMINISTRATION |
| CA3242402A1 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| WO2023148303A1 (de) * | 2022-02-02 | 2023-08-10 | Mslsolutions Gmbh | Verfahren zur medikament- und impfstoffherstellung |
| CN114617980A (zh) * | 2022-03-09 | 2022-06-14 | 广州国家实验室 | 可电离脂质纳米颗粒及其应用 |
| US20240226133A1 (en) * | 2023-01-09 | 2024-07-11 | Claudia Chimisso Dos Santos | Microrna-based particle for the treatment of dysregulated immune response |
| WO2025215636A1 (en) | 2024-04-08 | 2025-10-16 | Yeda Research And Development Co. Ltd. | Anti-defense system polypeptides and uses thereof |
| WO2026009227A1 (en) | 2024-07-04 | 2026-01-08 | Yeda Research And Development Co. Ltd. | Compositions for downregulating zeb2 in macrophages and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR002009A1 (es) * | 1994-12-22 | 1998-01-07 | Astra Ab | Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco. |
| US20060062841A1 (en) * | 2004-09-01 | 2006-03-23 | Leaf Huang | Liposomal vectors |
| CN101708338B (zh) | 2008-12-26 | 2014-06-04 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 含甾体结构的前药及其高度分散制剂 |
| MX342785B (es) | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| NZ597504A (en) * | 2009-06-15 | 2013-10-25 | Alnylam Pharmaceuticals Inc | Lipid formulated dsrna targeting the pcsk9 gene |
| CA2805265A1 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
| WO2012127037A2 (en) * | 2011-03-24 | 2012-09-27 | Leo Pharma A/S | A composition comprising lipid nanoparticles and a corticosteroid or vitamin d derivative |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| CN104114572A (zh) * | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| EP2638896A1 (en) * | 2012-03-14 | 2013-09-18 | Bioneer A/S | Cationic liposomal drug delivery system for specific targeting of human cd14+ monocytes in whole blood |
| HUE052599T2 (hu) | 2013-05-03 | 2021-05-28 | Selecta Biosciences Inc | CD4+ szabályozó T-sejtek fokozására szolgáló eljárások és készítmények |
| SMT202200502T1 (it) | 2014-06-25 | 2023-01-13 | Acuitas Therapeutics Inc | Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici |
| EP3454835B1 (en) | 2016-05-09 | 2021-03-31 | Astrazeneca AB | Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof |
-
2017
- 2017-05-08 EP EP17721707.2A patent/EP3454835B1/en active Active
- 2017-05-08 US US15/589,181 patent/US11458106B2/en active Active
- 2017-05-08 CN CN201780026989.5A patent/CN109152735B/zh active Active
- 2017-05-08 JP JP2018558293A patent/JP7066632B2/ja active Active
- 2017-05-08 ES ES17721707T patent/ES2871537T3/es active Active
- 2017-05-08 WO PCT/EP2017/060891 patent/WO2017194454A1/en not_active Ceased
-
2021
- 2021-12-27 JP JP2021212753A patent/JP2022058438A/ja not_active Withdrawn
-
2022
- 2022-08-02 US US17/879,362 patent/US20220370370A1/en not_active Abandoned
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