JP2019513828A - 改善された薬物動態を有するイソフラボノイド組成物 - Google Patents
改善された薬物動態を有するイソフラボノイド組成物 Download PDFInfo
- Publication number
- JP2019513828A JP2019513828A JP2019503599A JP2019503599A JP2019513828A JP 2019513828 A JP2019513828 A JP 2019513828A JP 2019503599 A JP2019503599 A JP 2019503599A JP 2019503599 A JP2019503599 A JP 2019503599A JP 2019513828 A JP2019513828 A JP 2019513828A
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- JP
- Japan
- Prior art keywords
- formula
- compound
- rectal administration
- formulation
- suppository
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 Bc(c(*)c1)c(*)cc1O Chemical compound Bc(c(*)c1)c(*)cc1O 0.000 description 12
- ZZUBHVMHNVYXRR-UHFFFAOYSA-N Oc(cc1)ccc1C(COc1c2)=Cc1ccc2O Chemical compound Oc(cc1)ccc1C(COc1c2)=Cc1ccc2O ZZUBHVMHNVYXRR-UHFFFAOYSA-N 0.000 description 3
- RTRZOHKLISMNRD-UHFFFAOYSA-N O=C1c2ccccc2OCC1c1ccccc1 Chemical compound O=C1c2ccccc2OCC1c1ccccc1 RTRZOHKLISMNRD-UHFFFAOYSA-N 0.000 description 2
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318946P | 2016-04-06 | 2016-04-06 | |
| US62/318,946 | 2016-04-06 | ||
| AUPCT/AU2016/050674 | 2016-07-28 | ||
| PCT/AU2016/050674 WO2017173474A1 (en) | 2016-04-06 | 2016-07-28 | Improvements in cancer treatment |
| US201762480692P | 2017-04-03 | 2017-04-03 | |
| US62/480,692 | 2017-04-03 | ||
| PCT/AU2017/050301 WO2017173498A1 (en) | 2016-04-06 | 2017-04-06 | Isoflavonoid composition with improved pharmacokinetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019513828A true JP2019513828A (ja) | 2019-05-30 |
| JP2019513828A5 JP2019513828A5 (enExample) | 2020-05-21 |
Family
ID=60000544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503599A Ceased JP2019513828A (ja) | 2016-04-06 | 2017-04-06 | 改善された薬物動態を有するイソフラボノイド組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11559510B2 (enExample) |
| EP (2) | EP3439644B1 (enExample) |
| JP (1) | JP2019513828A (enExample) |
| AU (1) | AU2017247008B2 (enExample) |
| CA (1) | CA3058503A1 (enExample) |
| WO (1) | WO2017173498A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3439643A4 (en) * | 2016-04-06 | 2019-12-11 | Noxopharm Limited | TARGETED ACTIVE SUBSTANCE |
| CA3058492A1 (en) * | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Radiotherapy improvements |
| WO2017173498A1 (en) | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| BR112021026559A2 (pt) * | 2019-07-17 | 2022-02-15 | Noxopharm Ltd | Terapia imuno-oncológica usando compostos isoflavona |
| AU2021247415A1 (en) | 2020-03-30 | 2022-09-29 | Noxopharm Limited | Methods for the treatment of inflammation associated with infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007525485A (ja) * | 2003-11-19 | 2007-09-06 | ノボゲン リサーチ ピーティーワイ リミテッド | 複合的な放射線治療及び化学治療の組成物及び方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0676314B2 (ja) * | 1985-09-30 | 1994-09-28 | 花王株式会社 | 坐剤基剤及び坐剤 |
| AUPO203996A0 (en) | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| AUPQ008299A0 (en) | 1999-04-30 | 1999-05-27 | G.J. Consultants Pty Ltd | Isoflavone metabolites |
| US20090233999A1 (en) | 1999-09-06 | 2009-09-17 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPQ266199A0 (en) | 1999-09-06 | 1999-09-30 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPR363301A0 (en) | 2001-03-08 | 2001-04-05 | Novogen Research Pty Ltd | Dimeric isoflavones |
| US8178123B2 (en) | 2001-08-29 | 2012-05-15 | Femina Pharma Incorporated | Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration |
| AUPR846401A0 (en) | 2001-10-25 | 2001-11-15 | Novogen Research Pty Ltd | 6-Hydroxy isoflavones, derivatives and medicaments involving same |
| CN1646119A (zh) | 2002-04-09 | 2005-07-27 | 诺沃根研究有限公司 | 涉及异黄-3-烯和异黄烷结构的治疗方法和组合物 |
| BR0313182A (pt) * | 2002-07-24 | 2007-07-24 | Childrens Hosp Medical Center | composições e produtos contendo equol enantiomérico |
| AU2002951833A0 (en) * | 2002-10-02 | 2002-10-24 | Novogen Research Pty Ltd | Compositions and therapeutic methods invloving platinum complexes |
| AU2002952453A0 (en) | 2002-11-01 | 2002-11-21 | Novogen Research Pty Ltd | Aminated isoflavonoid derivatives and uses thereof |
| CA2538570A1 (en) | 2003-09-18 | 2005-03-31 | Combinatorx, Incorporated | Combinations of drugs for the treatment of neoplasms |
| US20050154452A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| US7434690B2 (en) | 2004-04-30 | 2008-10-14 | Cutispharma, Inc. | Container and method for the preparation, storage and dispensing of compounded suppositories |
| ATE532777T1 (de) | 2004-09-21 | 2011-11-15 | Marshall Edwards Inc | Substituierte chromanderivate, medikamente und anwendungen in der therapie |
| EP2436680B1 (en) | 2004-09-21 | 2016-05-18 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| DE102005009515A1 (de) | 2005-02-25 | 2006-09-07 | Exner, Heinrich, Dr. | Verfahren zur Herstellung einer Zubereitung einer DMSO-haltigen festen Silikonölemulsion zur Bindung von reaktiven Sauerstoffverbindungen im Körper von Menschen und Tieren |
| CN101203219B (zh) | 2005-03-24 | 2011-06-15 | 诺沃根研究控股有限公司 | 消炎用药程式 |
| WO2007035515A2 (en) | 2005-09-15 | 2007-03-29 | Umd, Inc. | A method of intraepithelial and systemic exposure of therapeutic agents following vaginal and oral cavity administration |
| US20070196381A1 (en) | 2006-02-17 | 2007-08-23 | Natures Benefit, Inc. | Herbal compositions, methods of stimulating immunomodulation and enhancement of immunomodulating agents using the herbal compositions |
| US20100152284A1 (en) * | 2006-10-30 | 2010-06-17 | Novogen Research Pty Ltd | Prevention and reversal of chemotherapy-induced peripheral neuropathy |
| JP2010531811A (ja) * | 2007-06-29 | 2010-09-30 | ノボゲン リサーチ ピーティーワイ リミテッド | 2−置換イソフラボノイド化合物、医薬及び使用 |
| EP2334296A4 (en) | 2008-08-29 | 2012-04-25 | Novogen Res Pty Ltd | IMMUNOMODULATING ACTIVITIES |
| EP2365955B1 (en) | 2008-11-14 | 2014-12-31 | Heartlink Limited | Aryl di-substituted propenone compounds |
| KR20110004525A (ko) * | 2009-07-08 | 2011-01-14 | 동의대학교 산학협력단 | 제니스테인과 trail을 포함하는 간암 치료용 조성물 |
| ES2365960B1 (es) | 2010-03-31 | 2012-06-04 | Palobiofarma, S.L | Nuevos antagonistas de los receptores de adenosina. |
| WO2013056217A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
| BR112015023256A2 (pt) | 2013-03-13 | 2017-07-18 | Oncoceutics Inc | terapia de combinação com 7-benzil-10-(2-metil-benzil)-2,6,7,8,9,10-hexaidroimidazol[1,2-a]pirido[4,3-d]pirimidin-5(3h)-ona. |
| US20150126597A1 (en) | 2013-11-07 | 2015-05-07 | Humanetics Corporation | Genistein cancer treatment regimen maximizing cancer radiation therapy benefits |
| MY195739A (en) | 2014-02-07 | 2023-02-08 | Novogen ltd | Functionalised Benzopyran Compounds and use Thereof |
| SMT202200285T1 (it) | 2014-08-11 | 2022-09-14 | Acerta Pharma Bv | Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| WO2016192680A1 (en) * | 2015-06-03 | 2016-12-08 | Triastek, Inc. | Dosage forms and use thereof |
| PL3334431T3 (pl) | 2015-08-11 | 2020-03-31 | Novartis Ag | 5-bromo-2,6-di-(1H-pirazol-1-ilo)pirymidyno-4-amina do zastosowania w leczeniu nowotworu złośliwego |
| CA3004530A1 (en) | 2015-11-07 | 2017-05-11 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| SG11201808777UA (en) | 2016-04-06 | 2018-11-29 | Noxopharm Ltd | Improvements in cancer treatment |
| WO2017173498A1 (en) | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| US20190117620A1 (en) | 2016-04-22 | 2019-04-25 | Noxopharm Limited | Chemotherapy improvements |
| CN110381997A (zh) | 2016-12-12 | 2019-10-25 | 茂体外尔公司 | 用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物 |
| WO2019240872A1 (en) | 2018-06-15 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing melanoma with s-equol |
| EP3806846A1 (en) | 2018-06-15 | 2021-04-21 | Board of Regents, The University of Texas System | Methods of treating and preventing breast cancer with s-equol |
| WO2020051644A1 (en) | 2018-09-13 | 2020-03-19 | Norbio No. 2 Pty Ltd | Treatment of peripheral nervous tissue inflammation |
-
2017
- 2017-04-06 WO PCT/AU2017/050301 patent/WO2017173498A1/en not_active Ceased
- 2017-04-06 JP JP2019503599A patent/JP2019513828A/ja not_active Ceased
- 2017-04-06 EP EP17778482.4A patent/EP3439644B1/en not_active Not-in-force
- 2017-04-06 AU AU2017247008A patent/AU2017247008B2/en not_active Ceased
- 2017-04-06 CA CA3058503A patent/CA3058503A1/en not_active Abandoned
- 2017-04-06 EP EP21214664.1A patent/EP4005567A1/en not_active Withdrawn
- 2017-04-06 US US16/091,716 patent/US11559510B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007525485A (ja) * | 2003-11-19 | 2007-09-06 | ノボゲン リサーチ ピーティーワイ リミテッド | 複合的な放射線治療及び化学治療の組成物及び方法 |
Non-Patent Citations (5)
| Title |
|---|
| "History of Changes for Study: NCT03041285", CLINICALTRIALS.GOV ARCHIVE [ONLINE], JPN6021011776, 31 January 2017 (2017-01-31), ISSN: 0004656810 * |
| DEFINITION OF IDRONOXIL SUPPOSITORY NOX66, NCI DRUG DICTIONARY [ONLINE], JPN6021011779, 25 March 2021 (2021-03-25), ISSN: 0004476623 * |
| 医療, vol. 29, no. 6, JPN6021011781, 1975, pages 94 - 103, ISSN: 0004656812 * |
| 日消外会誌, vol. 15, no. 1, JPN6021011777, 1982, pages 78 - 85, ISSN: 0004656811 * |
| 油化学, vol. 19, no. 8, JPN6021011778, 1970, pages 722 - 733, ISSN: 0004656813 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3439644A1 (en) | 2019-02-13 |
| AU2017247008B2 (en) | 2022-04-07 |
| EP3439644B1 (en) | 2022-01-12 |
| AU2017247008A1 (en) | 2018-11-01 |
| WO2017173498A1 (en) | 2017-10-12 |
| EP4005567A1 (en) | 2022-06-01 |
| US11559510B2 (en) | 2023-01-24 |
| EP3439644A4 (en) | 2019-10-30 |
| US20190117618A1 (en) | 2019-04-25 |
| CA3058503A1 (en) | 2017-10-12 |
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