CA3058503A1 - Isoflavonoid composition with improved pharmacokinetics - Google Patents
Isoflavonoid composition with improved pharmacokinetics Download PDFInfo
- Publication number
- CA3058503A1 CA3058503A1 CA3058503A CA3058503A CA3058503A1 CA 3058503 A1 CA3058503 A1 CA 3058503A1 CA 3058503 A CA3058503 A CA 3058503A CA 3058503 A CA3058503 A CA 3058503A CA 3058503 A1 CA3058503 A1 CA 3058503A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- formulation
- suppository
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318946P | 2016-04-06 | 2016-04-06 | |
| US62/318,946 | 2016-04-06 | ||
| AUPCT/AU2016/050674 | 2016-07-28 | ||
| PCT/AU2016/050674 WO2017173474A1 (en) | 2016-04-06 | 2016-07-28 | Improvements in cancer treatment |
| US201762480692P | 2017-04-03 | 2017-04-03 | |
| US62/480,692 | 2017-04-03 | ||
| PCT/AU2017/050301 WO2017173498A1 (en) | 2016-04-06 | 2017-04-06 | Isoflavonoid composition with improved pharmacokinetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3058503A1 true CA3058503A1 (en) | 2017-10-12 |
Family
ID=60000544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3058503A Abandoned CA3058503A1 (en) | 2016-04-06 | 2017-04-06 | Isoflavonoid composition with improved pharmacokinetics |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11559510B2 (enExample) |
| EP (2) | EP3439644B1 (enExample) |
| JP (1) | JP2019513828A (enExample) |
| AU (1) | AU2017247008B2 (enExample) |
| CA (1) | CA3058503A1 (enExample) |
| WO (1) | WO2017173498A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019513827A (ja) * | 2016-04-06 | 2019-05-30 | ノクソファーム リミティド | 標的化薬物送達 |
| EP3439642A4 (en) * | 2016-04-06 | 2019-11-13 | Noxopharm Limited | IMPROVEMENTS IN RADIOTHERAPY |
| WO2017173498A1 (en) | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| MX2021015418A (es) * | 2019-07-17 | 2022-04-12 | Noxopharm Ltd | Terapia inmunooncologica. |
| EP4125870A1 (en) | 2020-03-30 | 2023-02-08 | Noxopharm Limited | Methods for the treatment of inflammation associated with infection |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0676314B2 (ja) * | 1985-09-30 | 1994-09-28 | 花王株式会社 | 坐剤基剤及び坐剤 |
| AUPO203996A0 (en) | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| AUPQ008299A0 (en) | 1999-04-30 | 1999-05-27 | G.J. Consultants Pty Ltd | Isoflavone metabolites |
| US20090233999A1 (en) | 1999-09-06 | 2009-09-17 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPQ266199A0 (en) | 1999-09-06 | 1999-09-30 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPR363301A0 (en) | 2001-03-08 | 2001-04-05 | Novogen Research Pty Ltd | Dimeric isoflavones |
| US8178123B2 (en) | 2001-08-29 | 2012-05-15 | Femina Pharma Incorporated | Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration |
| AUPR846401A0 (en) | 2001-10-25 | 2001-11-15 | Novogen Research Pty Ltd | 6-Hydroxy isoflavones, derivatives and medicaments involving same |
| WO2003086386A1 (en) | 2002-04-09 | 2003-10-23 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflav-3-ene and isoflavan structures |
| CN1681386B (zh) * | 2002-07-24 | 2010-05-26 | 儿童医院医疗中心 | 含有对映体牛尿酚的组合物和产物及其制备方法 |
| AU2002951833A0 (en) * | 2002-10-02 | 2002-10-24 | Novogen Research Pty Ltd | Compositions and therapeutic methods invloving platinum complexes |
| AU2002952453A0 (en) | 2002-11-01 | 2002-11-21 | Novogen Research Pty Ltd | Aminated isoflavonoid derivatives and uses thereof |
| AU2004273910A1 (en) | 2003-09-18 | 2005-03-31 | Combinatorx, Incorporated | Combinations of drugs for the treatment of neoplasms |
| CN101123958A (zh) | 2003-11-19 | 2008-02-13 | 诺沃根研究股份有限公司 | 联合放射疗法与化学疗法的组合物和方法 |
| US20050154452A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| US7434690B2 (en) | 2004-04-30 | 2008-10-14 | Cutispharma, Inc. | Container and method for the preparation, storage and dispensing of compounded suppositories |
| EP1809618B1 (en) | 2004-09-21 | 2013-07-17 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| CN101056868B (zh) | 2004-09-21 | 2012-05-02 | 马休爱德华兹股份有限公司 | 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用 |
| DE102005009515A1 (de) | 2005-02-25 | 2006-09-07 | Exner, Heinrich, Dr. | Verfahren zur Herstellung einer Zubereitung einer DMSO-haltigen festen Silikonölemulsion zur Bindung von reaktiven Sauerstoffverbindungen im Körper von Menschen und Tieren |
| CN101184756B (zh) | 2005-03-24 | 2011-08-03 | 诺沃根研究控股有限公司 | 异类黄酮二聚物 |
| CA2622746A1 (en) | 2005-09-15 | 2007-03-29 | Umd, Inc. | A method of intraepithelial and systemic exposure of therapeutic agents following vaginal and oral cavity administration |
| US20070196381A1 (en) | 2006-02-17 | 2007-08-23 | Natures Benefit, Inc. | Herbal compositions, methods of stimulating immunomodulation and enhancement of immunomodulating agents using the herbal compositions |
| CA2668008A1 (en) * | 2006-10-30 | 2008-05-08 | Novogen Research Pty Ltd | Prevention and reversal of chemotherapy-induced peripheral neuropathy |
| EP2160385A4 (en) | 2007-06-29 | 2010-10-27 | Novogen Res Pty Ltd | 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS AND MEDICAMENTS THEREOF AND APPLICATIONS THEREOF |
| MX2011002144A (es) | 2008-08-29 | 2011-07-29 | Novogen Res Pty Ltd | Actividades inmunomoduladoras. |
| EP2365955B1 (en) | 2008-11-14 | 2014-12-31 | Heartlink Limited | Aryl di-substituted propenone compounds |
| KR20110004525A (ko) | 2009-07-08 | 2011-01-14 | 동의대학교 산학협력단 | 제니스테인과 trail을 포함하는 간암 치료용 조성물 |
| ES2365960B1 (es) | 2010-03-31 | 2012-06-04 | Palobiofarma, S.L | Nuevos antagonistas de los receptores de adenosina. |
| US9249468B2 (en) | 2011-10-14 | 2016-02-02 | The Ohio State University | Methods and materials related to ovarian cancer |
| MX2015012636A (es) | 2013-03-13 | 2017-02-06 | Oncoceutics Inc | Terapia de combinacion de 7-bencil-10-(2-metilbencil)-2,6,7,8,9,10 -hexahidroimidazol[1,2-a] pirido [4,3-d] pirimidin-5(3h)-ona. |
| US20150126597A1 (en) | 2013-11-07 | 2015-05-07 | Humanetics Corporation | Genistein cancer treatment regimen maximizing cancer radiation therapy benefits |
| RU2676766C2 (ru) | 2014-02-07 | 2019-01-11 | Новоген Лимитед | Функционализованные соединения бензопирана и их применение |
| SMT202200285T1 (it) | 2014-08-11 | 2022-09-14 | Acerta Pharma Bv | Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| CA3254279A1 (en) * | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| SI3334431T1 (sl) | 2015-08-11 | 2020-01-31 | Novartis Ag | 5-bromo-2,6-di-(1h-pirazol-l-il)pyrimidin-4-amin za uporabo v zdravljenju raka |
| JP2018532810A (ja) | 2015-11-07 | 2018-11-08 | マルチビア インコーポレイテッド | がんの処置のための腫瘍抑制因子遺伝子治療および免疫チェックポイント治療を含む組成物 |
| WO2017173498A1 (en) | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| JP2019510830A (ja) | 2016-04-06 | 2019-04-18 | ノクソファーム リミティド | がん処置における改善 |
| EP3445347B1 (en) | 2016-04-22 | 2022-03-30 | Noxopharm Limited | Chemotherapy improvements with idronoxil |
| AU2017375958A1 (en) | 2016-12-12 | 2019-07-04 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| WO2019240871A1 (en) | 2018-06-15 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing breast cancer with s-equol |
| WO2019240872A1 (en) | 2018-06-15 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Methods of treating and preventing melanoma with s-equol |
| WO2020051644A1 (en) | 2018-09-13 | 2020-03-19 | Norbio No. 2 Pty Ltd | Treatment of peripheral nervous tissue inflammation |
-
2017
- 2017-04-06 WO PCT/AU2017/050301 patent/WO2017173498A1/en not_active Ceased
- 2017-04-06 US US16/091,716 patent/US11559510B2/en active Active
- 2017-04-06 JP JP2019503599A patent/JP2019513828A/ja not_active Ceased
- 2017-04-06 AU AU2017247008A patent/AU2017247008B2/en not_active Ceased
- 2017-04-06 EP EP17778482.4A patent/EP3439644B1/en not_active Not-in-force
- 2017-04-06 EP EP21214664.1A patent/EP4005567A1/en not_active Withdrawn
- 2017-04-06 CA CA3058503A patent/CA3058503A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017173498A1 (en) | 2017-10-12 |
| US20190117618A1 (en) | 2019-04-25 |
| US11559510B2 (en) | 2023-01-24 |
| AU2017247008A1 (en) | 2018-11-01 |
| AU2017247008B2 (en) | 2022-04-07 |
| EP3439644B1 (en) | 2022-01-12 |
| EP4005567A1 (en) | 2022-06-01 |
| EP3439644A1 (en) | 2019-02-13 |
| EP3439644A4 (en) | 2019-10-30 |
| JP2019513828A (ja) | 2019-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20230704 |