JP2019509994A - 芦根抽出物を有効成分として含む抗癌剤副作用による疾患の予防、改善または治療用組成物 - Google Patents
芦根抽出物を有効成分として含む抗癌剤副作用による疾患の予防、改善または治療用組成物 Download PDFInfo
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Abstract
よって、本発明の芦根抽出物は、抗癌剤副作用による疾患の予防、改善及び治療用組成物として有用に用いられ、抗癌補助剤として抗癌剤と併用処方して抗癌剤の効果を高める可能性がある。
Description
1)芦根に抽出溶媒を加えて抽出する段階;
2)段階1)の抽出物をろ過する段階;及び
3)段階2)のろ過した抽出物を減圧濃縮し、乾燥して抽出物を製造する段階。
本発明の有効成分である芦根抽出物を製造するために、芦根を光明堂製薬(蔚山、大韓民国)から購入した。前記購入した芦根100gを粉砕した後、水2lと共に丸いフラスコに入れて混合した。冷却管の付いている還流抽出装置に連結された恒温水槽を加熱して1回2時間ずつ、計2回繰り返して抽出した。抽出された抽出物をろ過紙(Whatman No.2)及び真空ポンプ(GAST)を使って減圧ろ過した。回転濃縮器(EYELA)を用いてろ過された液状抽出物を減圧濃縮し、濃縮された抽出物を凍結乾燥した後、乳鉢で均質化して芦根抽出物を得た。これは実験の前まで密封プラスチック容器に入れて4℃の低温コンテナに保管した。
現在臨床で用いられている抗癌剤の造血毒性効果を確認するために、抗癌剤濃度によるマウス骨髄細胞での造血幹細胞の成長及び分化に及ぼす影響をex vivo、in vivo実験を通じて確認した。
マウスの大腿骨から骨髄細胞を分離した。次いで、ドセタキセル、ドキソルビシン、イリノテカン、パクリタキセル及びダウノルビシンが濃度別に添加されたマウス由来の組換え幹細胞因子(rm stem cell factor)、rm IL−3、ヒト由来の組換えIL−6(rh IL−6)及びrhエリスロポエチンを含むメソカルトGF M3434培地に前記骨髄細胞を7〜10日間培養して造血幹細胞の成長を誘導した。成長した造血幹細胞を収得し、コロニー形成ユニット分析(CFU assay)を行って抗癌剤が造血幹細胞の成長及び分化に及ぼす影響を観察した。
C57BL/6マウスに50、100及び150mg/kgのドセタキセルを腹腔注射した。3日後及び7日後、マウスの大腿骨から骨髄細胞を分離して計数し、生存率を測定した。
芦根抽出物が骨髄細胞で抗癌剤(15nMドセタキセル、100nMドキソルビシン、100μMイリノテカン、50nMパクリタキセル及び100nMダウノルビシン)によって誘導された造血毒性を緩和する効果があるかどうかを確認するために、15nMドセタキセル、100nMドキソルビシン、100μMイリノテカン、50nMパクリタキセルまたは100nMダウノルビシンと芦根抽出物とを併用処理して骨髄毒性の緩和効果を確認した。
芦根抽出物が骨髄抑制誘導動物モデルで造血毒性緩和効果を示すかどうかを確認するために、マウスにドセタキセルを腹腔注射して骨髄抑制を誘導した後、芦根抽出物による変化を確認した。
ドセタキセル投与群では、造血作用に関与する生体器官である脾臓及び胸腺の収縮及び重量減少が観察され、芦根抽出物投与群ではこのような減少が緩和する効果を確認した(表1)。
芦根抽出物が骨髄抑制誘導動物モデルで造血作用に関与するサイトカインの発現に及ぼす影響を確認するために、マウスにドセタキセルを腹腔注射して骨髄抑制を誘導した後、芦根抽出物による変化を確認した。
芦根抽出物が骨髄抑制誘導動物モデルの血液指標に及ぼす影響を確認するために、マウスにドセタキセルを腹腔注射して骨髄抑制を誘導した後、芦根抽出物による変化を確認した。
Claims (10)
- 芦根抽出物を有効成分として含む抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 前記抽出物は、水、C1〜C4の低級アルコールまたはこれらの混合物を溶媒として抽出することを特徴とする請求項1に記載の抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 前記抗癌剤は、抗腫瘍抗生物質、トポイソメラーゼ阻害剤、またはタキサン系抗癌剤であることを特徴とする請求項1に記載の抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 前記抗腫瘍抗生物質は、アクチノマイシンD、硫酸ブレオマイシン、ダウノマイシン、ダウノルビシン、ドキソルビシン、エピルビシン、イダルビシン、マイトマイシン、マイトマイシン−C及びミトラマイシンからなる群から選択されるいずれか一つ以上であることを特徴とする請求項3に記載の抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 前記トポイソメラーゼ阻害剤は、イリノテカン、カンプトテシン、ノボビオシン、エピルビシン、ダクチノマイシン、アムサクリン、テニポシド及びエトポシドからなる群から選択されるいずれか一つ以上であることを特徴とする請求項3に記載の抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 前記タキサン系抗癌剤は、パクリタキセル及びドセタキセルから選択されるいずれか一つ以上であることを特徴とする請求項3に記載の抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 前記抗癌剤副作用による疾患は、造血毒性、貧血及び好中球減少症から選択される一つ以上であることを特徴とする請求項1に記載の抗癌剤副作用による疾患の予防または治療用薬学組成物。
- 芦根抽出物を有効成分として含む抗癌剤副作用による疾患の予防または改善用の健康機能食品。
- 芦根抽出物を有効成分として含む抗癌補助剤。
- 前記抗癌補助剤は、抗癌剤投与によって引き起こされる造血毒性、貧血及び好中球減少症から選択される一つ以上の抗癌剤副作用による疾患を改善することを特徴とする請求項9に記載の抗癌補助剤。
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WO2017142371A1 (ko) | 2017-08-24 |
EP3417869A1 (en) | 2018-12-26 |
US20210205398A1 (en) | 2021-07-08 |
CN108697753A (zh) | 2018-10-23 |
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