JP2019509041A5 - - Google Patents
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- Publication number
- JP2019509041A5 JP2019509041A5 JP2018545838A JP2018545838A JP2019509041A5 JP 2019509041 A5 JP2019509041 A5 JP 2019509041A5 JP 2018545838 A JP2018545838 A JP 2018545838A JP 2018545838 A JP2018545838 A JP 2018545838A JP 2019509041 A5 JP2019509041 A5 JP 2019509041A5
- Authority
- JP
- Japan
- Prior art keywords
- era
- amino acid
- trail
- variant
- fusion protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301806P | 2016-03-01 | 2016-03-01 | |
| US62/301,806 | 2016-03-01 | ||
| US201662347376P | 2016-06-08 | 2016-06-08 | |
| US62/347,376 | 2016-06-08 | ||
| US201762446026P | 2017-01-13 | 2017-01-13 | |
| US62/446,026 | 2017-01-13 | ||
| PCT/US2017/020090 WO2017151707A1 (en) | 2016-03-01 | 2017-03-01 | L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509041A JP2019509041A (ja) | 2019-04-04 |
| JP2019509041A5 true JP2019509041A5 (https=) | 2020-03-26 |
| JP7091248B2 JP7091248B2 (ja) | 2022-06-27 |
Family
ID=58314525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545838A Active JP7091248B2 (ja) | 2016-03-01 | 2017-03-01 | 低減されたｌ－グルタミナーゼ活性および増強された安定性を有するｌ－アスパラギナーゼ変異体および融合タンパク質 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10821160B2 (https=) |
| EP (1) | EP3423480A1 (https=) |
| JP (1) | JP7091248B2 (https=) |
| CN (1) | CN109153711B (https=) |
| CA (1) | CA3054286A1 (https=) |
| WO (1) | WO2017151707A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021520828A (ja) * | 2018-04-19 | 2021-08-26 | キンドレッド バイオサイエンシズ インコーポレイテッド | 医療用の変異体アスパラギナーゼポリペプチド |
| US20220362357A1 (en) | 2018-08-31 | 2022-11-17 | Stichting Radboud Universitair Medisch Centrum | Synergistic Combinations of Amino Acid Depletion Agent Sensitizers (AADAS) and Amino Acid Depletion Agents (AADA), and Therapeutic Methods of Use Thereof |
| KR102283626B1 (ko) * | 2019-10-31 | 2021-08-02 | 대상 주식회사 | glsB 유전자 불활성화에 의해 아미노산 생산능력이 향상된 균주 및 이의 제조방법 |
| KR102269634B1 (ko) * | 2019-10-31 | 2021-06-25 | 대상 주식회사 | ansB 유전자 불활성화에 의해 아미노산 생산능력이 향상된 균주 |
| WO2025026424A1 (en) * | 2023-08-02 | 2025-02-06 | The Hong Kong Polytechnic University | Bioengineered asparaginase fusion proteins |
| CN117165564B (zh) * | 2023-08-16 | 2025-01-28 | 云南师范大学 | 一种ii型l-天冬酰胺酶及其应用 |
| CN118460485B (zh) * | 2024-05-07 | 2025-06-17 | 山东凯密斯新材料科技有限公司 | 一种用于合成l-天冬酰胺的天冬酰胺合成酶a突变体及应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| SE9002213D0 (sv) | 1990-06-21 | 1990-06-21 | Hightech Receptor Ab | Albumin binding proteins |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| EP2180054A1 (en) | 1999-12-24 | 2010-04-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20020065397A1 (en) | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
| AU2004254600A1 (en) | 2003-06-26 | 2005-01-13 | Lifesensors, Inc. | Methods and compositions for enhanced protein expression and purification |
| JP5634008B2 (ja) | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
| US7985548B2 (en) | 2006-03-03 | 2011-07-26 | The United States Of America As Represented By The Department Of Health And Human Services | Materials and methods directed to asparagine synthetase and asparaginase therapies |
| FI20070455A0 (fi) | 2007-06-08 | 2007-06-08 | Reagena Ltd Oy | Menetelmä syöpäsairauksien tai tulehdussairauksien hoitoon |
| WO2009002947A2 (en) | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| EP2374481B1 (en) | 2008-07-21 | 2015-11-04 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
| CA2867252C (en) | 2008-12-05 | 2015-09-01 | Abraxis Bioscience, Llc | Albumin binding peptide-mediated disease targeting |
| WO2011003633A1 (en) * | 2009-07-06 | 2011-01-13 | Alize Pharma Ii | Pegylated l-asparaginase |
| US9322008B2 (en) | 2010-09-01 | 2016-04-26 | Indian Institute Of Technology | Mutants of L-asparaginase |
| WO2012170640A1 (en) | 2011-06-07 | 2012-12-13 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for trail-drug combination therapy |
| CA2849705A1 (en) | 2011-09-23 | 2013-03-28 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Modified albumin-binding domains and uses thereof to improve pharmacokinetics |
| MX355041B (es) | 2012-05-25 | 2018-03-28 | Janssen Biotech Inc | Dominios de union a albumina consenso no naturales. |
| WO2015038639A1 (en) | 2013-09-10 | 2015-03-19 | Sandia Corporation | Therapeutic asparaginases |
| NO2776305T3 (https=) | 2014-04-23 | 2018-01-27 | ||
| CN104371993B (zh) | 2014-10-22 | 2016-10-19 | 江南大学 | 一种酶活提高的天冬酰胺酶突变体 |
-
2017
- 2017-03-01 EP EP17711054.1A patent/EP3423480A1/en active Pending
- 2017-03-01 WO PCT/US2017/020090 patent/WO2017151707A1/en not_active Ceased
- 2017-03-01 CA CA3054286A patent/CA3054286A1/en active Pending
- 2017-03-01 CN CN201780014261.0A patent/CN109153711B/zh active Active
- 2017-03-01 US US16/080,435 patent/US10821160B2/en active Active
- 2017-03-01 JP JP2018545838A patent/JP7091248B2/ja active Active
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