JP2019508448A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019508448A5 JP2019508448A5 JP2018548207A JP2018548207A JP2019508448A5 JP 2019508448 A5 JP2019508448 A5 JP 2019508448A5 JP 2018548207 A JP2018548207 A JP 2018548207A JP 2018548207 A JP2018548207 A JP 2018548207A JP 2019508448 A5 JP2019508448 A5 JP 2019508448A5
- Authority
- JP
- Japan
- Prior art keywords
- humanized antibody
- human
- seq
- composition
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000024908 graft versus host disease Diseases 0.000 claims description 29
- 238000001802 infusion Methods 0.000 claims description 29
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 27
- 230000000735 allogeneic effect Effects 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 18
- 150000001413 amino acids Chemical class 0.000 claims description 16
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 12
- 102000006495 integrins Human genes 0.000 claims description 12
- 108010044426 integrins Proteins 0.000 claims description 12
- 229960000485 methotrexate Drugs 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 11
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 8
- 229960001967 tacrolimus Drugs 0.000 claims description 8
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 8
- 229960004914 vedolizumab Drugs 0.000 claims description 8
- 230000003750 conditioning effect Effects 0.000 claims description 7
- 230000001154 acute effect Effects 0.000 claims description 6
- 208000024340 acute graft versus host disease Diseases 0.000 claims description 6
- 239000000090 biomarker Substances 0.000 claims description 6
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 claims description 6
- 208000026278 immune system disease Diseases 0.000 claims description 6
- 238000001990 intravenous administration Methods 0.000 claims description 6
- 208000032839 leukemia Diseases 0.000 claims description 6
- 239000012931 lyophilized formulation Substances 0.000 claims description 6
- 208000019838 Blood disease Diseases 0.000 claims description 5
- 208000014951 hematologic disease Diseases 0.000 claims description 5
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 5
- 230000003211 malignant effect Effects 0.000 claims description 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 4
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims description 4
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims description 4
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims description 4
- 102000013691 Interleukin-17 Human genes 0.000 claims description 4
- 108050003558 Interleukin-17 Proteins 0.000 claims description 4
- 102000004889 Interleukin-6 Human genes 0.000 claims description 4
- 108090001005 Interleukin-6 Proteins 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 201000005787 hematologic cancer Diseases 0.000 claims description 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 4
- 210000000987 immune system Anatomy 0.000 claims description 4
- 229940100601 interleukin-6 Drugs 0.000 claims description 4
- 230000000968 intestinal effect Effects 0.000 claims description 4
- 210000000265 leukocyte Anatomy 0.000 claims description 4
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 4
- 230000001400 myeloablative effect Effects 0.000 claims description 4
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 2
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 208000018240 Bone Marrow Failure disease Diseases 0.000 claims description 2
- 208000005623 Carcinogenesis Diseases 0.000 claims description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 208000014905 bone marrow failure syndrome Diseases 0.000 claims description 2
- 230000036952 cancer formation Effects 0.000 claims description 2
- 231100000504 carcinogenesis Toxicity 0.000 claims description 2
- 230000001186 cumulative effect Effects 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 208000034737 hemoglobinopathy Diseases 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000001506 immunosuppresive effect Effects 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 210000000440 neutrophil Anatomy 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 37
- 230000002265 prevention Effects 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 65
- 239000005557 antagonist Substances 0.000 description 8
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022116951A JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307896P | 2016-03-14 | 2016-03-14 | |
| US62/307,896 | 2016-03-14 | ||
| PCT/US2017/022065 WO2017160699A2 (en) | 2016-03-14 | 2017-03-13 | Method of preventing graft versus host disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116951A Division JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508448A JP2019508448A (ja) | 2019-03-28 |
| JP2019508448A5 true JP2019508448A5 (cg-RX-API-DMAC7.html) | 2020-05-14 |
Family
ID=58448610
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548207A Withdrawn JP2019508448A (ja) | 2016-03-14 | 2017-03-13 | 移植片対宿主病予防の方法 |
| JP2022116951A Pending JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022116951A Pending JP2022163078A (ja) | 2016-03-14 | 2022-07-22 | 移植片対宿主病予防の方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20200002422A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3430052A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2019508448A (cg-RX-API-DMAC7.html) |
| KR (1) | KR102710759B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN109071660A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017234009B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018068628A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3017743A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201892071A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL261750B2 (cg-RX-API-DMAC7.html) |
| MA (1) | MA44408A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2018011169A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017160699A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019512493A (ja) * | 2016-03-14 | 2019-05-16 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 移植片対宿主病の処置または予防の方法 |
| JP7202893B2 (ja) | 2016-06-12 | 2023-01-12 | 武田薬品工業株式会社 | 炎症性腸疾患を治療する方法 |
| CN111971052B (zh) * | 2018-02-08 | 2024-07-05 | 小利兰.斯坦福大学托管委员会 | 用于异基因造血干细胞移植的方法 |
| WO2021222239A1 (en) * | 2020-04-27 | 2021-11-04 | Children's Hospital Medical Center | Precision dosing regimen |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル． モリソン，シェリー | ドメイン‐変性不変部を有する抗体 |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| EP0808367B1 (en) | 1995-02-10 | 2007-07-11 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressins and uses thereof |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| EP2402309A1 (en) | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| CN101077867B (zh) | 2002-11-18 | 2012-10-10 | 坎莫森特里克斯公司 | 芳基磺酰胺 |
| MX350383B (es) | 2004-01-09 | 2017-09-04 | Pfizer | Anticuerpos contra madcam. |
| PT1784426E (pt) | 2004-09-03 | 2012-03-06 | Genentech Inc | Antagonistas humanizados anti-beta7 e suas utilizações |
| ES2516690T5 (es) * | 2005-06-07 | 2017-11-21 | The Regents Of The University Of Colorado, A Body Corporate | Inhibidores de la actividad de serina proteasa y su uso en métodos y composiciones para el tratamiento de rechazo de injertos y promoción de supervivencia de injertos |
| US20070122404A1 (en) | 2005-11-17 | 2007-05-31 | O'keefe Theresa L | Humanized immunoglobulin reactive with alpha4beta7 integrin |
| AU2009313039B2 (en) * | 2008-11-07 | 2015-06-18 | Amgen Research (Munich) Gmbh | Treatment of pediatric acute lymphoblastic leukemia |
| MX338969B (es) * | 2009-03-20 | 2016-05-06 | Amgen Inc | Anticuerpo de antagonista especifico de heterodimero alfa-4-beta-7. |
| CN103260627A (zh) * | 2010-11-12 | 2013-08-21 | 真蒂奥姆有限公司 | 去纤维蛋白多核苷酸用于预防和/或治疗移植物抗宿主病(gvhd) |
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| ES2646717T3 (es) * | 2011-05-02 | 2017-12-15 | Millennium Pharmaceuticals, Inc. | Formulación para anticuerpo anti- 4 7 |
| MX370199B (es) * | 2012-02-16 | 2019-12-05 | Santarus Inc | Composiciones farmaceuticas de anticuerpo anti-antigeno muy tardio (cd49a). |
| NZ622452A (en) * | 2012-06-21 | 2017-10-27 | Compugen Ltd | Lsr antibodies, and uses thereof for treatment of cancer |
| BR112017003546A2 (pt) * | 2014-08-21 | 2017-12-05 | Glaxosmithkline Ip Dev Ltd | amidas heterocíclicas como inibidores de rip1 quinase como medicamentos |
| MA41636A (fr) * | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
| JP2019512493A (ja) * | 2016-03-14 | 2019-05-16 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 移植片対宿主病の処置または予防の方法 |
-
2017
- 2017-03-13 CN CN201780017510.1A patent/CN109071660A/zh active Pending
- 2017-03-13 KR KR1020187027194A patent/KR102710759B1/ko active Active
- 2017-03-13 CN CN202211678697.9A patent/CN116327920A/zh active Pending
- 2017-03-13 AU AU2017234009A patent/AU2017234009B2/en active Active
- 2017-03-13 EP EP17714328.6A patent/EP3430052A2/en active Pending
- 2017-03-13 JP JP2018548207A patent/JP2019508448A/ja not_active Withdrawn
- 2017-03-13 BR BR112018068628A patent/BR112018068628A2/pt unknown
- 2017-03-13 IL IL261750A patent/IL261750B2/en unknown
- 2017-03-13 US US16/084,383 patent/US20200002422A1/en active Pending
- 2017-03-13 CA CA3017743A patent/CA3017743A1/en active Pending
- 2017-03-13 EA EA201892071A patent/EA201892071A1/ru unknown
- 2017-03-13 MX MX2018011169A patent/MX2018011169A/es unknown
- 2017-03-13 WO PCT/US2017/022065 patent/WO2017160699A2/en not_active Ceased
- 2017-03-13 MA MA044408A patent/MA44408A/fr unknown
-
2018
- 2018-09-14 MX MX2025001934A patent/MX2025001934A/es unknown
-
2022
- 2022-07-22 JP JP2022116951A patent/JP2022163078A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20250361304A1 (en) | Methods of treating her2-positive cancer | |
| Gruessner et al. | Calcineurin inhibitor-and steroid-free immunosuppression in pancreas-kidney and solitary pancreas transplantation | |
| Gelfand et al. | Ocrelizumab and other CD20+ B-cell-depleting therapies in multiple sclerosis | |
| Sandherr et al. | Antiviral prophylaxis in patients with solid tumours and haematological malignancies—update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) | |
| Niederhaus et al. | Induction therapy in pancreas transplantation | |
| JP2019508448A5 (cg-RX-API-DMAC7.html) | ||
| McKeage et al. | Basiliximab: a review of its use as induction therapy in renal transplantation | |
| Koch et al. | Pharmacokinetics, pharmacodynamics, and immunodynamics of daclizumab in a two-dose regimen in liver transplantation1 | |
| Grimbert et al. | mTOR inhibitors and risk of chronic antibody‐mediated rejection after kidney transplantation: where are we now? | |
| Taylor et al. | Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions | |
| JP2024023247A (ja) | 抗ｃｄ３８抗体の皮下投与 | |
| Padiyar et al. | Induction antibody therapy in kidney transplantation | |
| Park et al. | Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation | |
| van de Donk et al. | T-cell redirecting bispecific and trispecific antibodies in multiple myeloma beyond BCMA | |
| Getts et al. | Current landscape for T-cell targeting in autoimmunity and transplantation | |
| US20160272715A1 (en) | Treatment of c1013g/cxcr4-associated waldenström's macroglobulinemia with an anti-cxcr4 antibody | |
| Lin et al. | Immune checkpoint inhibitors in malignant lymphoma: Advances and perspectives | |
| Raj | Immune thrombocytopenia: pathogenesis and treatment approaches | |
| JP2022163078A (ja) | 移植片対宿主病予防の方法 | |
| CA3127928A1 (en) | Methods of treating multiple myeloma | |
| Lustig et al. | Use of immunosuppressive agents in uveitis | |
| JP2022137024A (ja) | 移植片対宿主病の処置または予防の方法 | |
| Mottershead et al. | Daclizumab | |
| Salvarani et al. | Management of large-vessel vasculitis | |
| Viklicky et al. | Developments in immunosuppression |