JP2019508032A5 - - Google Patents
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- Publication number
- JP2019508032A5 JP2019508032A5 JP2018539138A JP2018539138A JP2019508032A5 JP 2019508032 A5 JP2019508032 A5 JP 2019508032A5 JP 2018539138 A JP2018539138 A JP 2018539138A JP 2018539138 A JP2018539138 A JP 2018539138A JP 2019508032 A5 JP2019508032 A5 JP 2019508032A5
- Authority
- JP
- Japan
- Prior art keywords
- dcc
- somatic
- pharmaceutical composition
- cancerous disease
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 29
- 201000010099 disease Diseases 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 230000035772 mutation Effects 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
- 230000000392 somatic effect Effects 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 16
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 12
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 12
- 210000000349 chromosome Anatomy 0.000 claims description 12
- 102100039788 GTPase NRas Human genes 0.000 claims description 8
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims description 8
- 206010027476 Metastases Diseases 0.000 claims description 8
- 230000004075 alteration Effects 0.000 claims description 8
- 210000001165 lymph node Anatomy 0.000 claims description 8
- 230000009401 metastasis Effects 0.000 claims description 8
- 210000001082 somatic cell Anatomy 0.000 claims description 8
- 201000001441 melanoma Diseases 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 229940125431 BRAF inhibitor Drugs 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000035755 proliferation Effects 0.000 claims description 4
- 208000015891 sexual disease Diseases 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims description 2
- 210000005005 sentinel lymph node Anatomy 0.000 claims description 2
- 229960003787 sorafenib Drugs 0.000 claims description 2
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims description 2
- 229960003862 vemurafenib Drugs 0.000 claims description 2
- 238000009098 adjuvant therapy Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000005746 immune checkpoint blockade Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16152883.1 | 2016-01-27 | ||
| EP16152883.1A EP3199641B1 (en) | 2016-01-27 | 2016-01-27 | Means and methods for staging, typing and treating a cancerous disease |
| PCT/EP2017/051789 WO2017129753A1 (en) | 2016-01-27 | 2017-01-27 | Means and methods for staging, typing and treating a cancerous disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508032A JP2019508032A (ja) | 2019-03-28 |
| JP2019508032A5 true JP2019508032A5 (https=) | 2020-03-05 |
Family
ID=55310656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018539138A Pending JP2019508032A (ja) | 2016-01-27 | 2017-01-27 | がん性疾患をステージング、タイピングおよび処置するための手段および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11702701B2 (https=) |
| EP (2) | EP3199641B1 (https=) |
| JP (1) | JP2019508032A (https=) |
| KR (1) | KR20180102674A (https=) |
| CN (1) | CN108770360B (https=) |
| AU (1) | AU2017211976B2 (https=) |
| CA (1) | CA3012404A1 (https=) |
| ES (1) | ES2905208T3 (https=) |
| SG (1) | SG11201805990XA (https=) |
| WO (1) | WO2017129753A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL141749A0 (en) | 1998-09-18 | 2002-03-10 | Micromet Ag | Dna amplification of a single cell |
| WO2002037113A2 (en) * | 2000-11-03 | 2002-05-10 | Michael Giesing | Clinical and functional validation of targets from disseminated cancer cells |
| ITRM20110149A1 (it) * | 2011-03-25 | 2012-09-26 | Massimo Zollo | Biomarcatore per la rilevazione di cellule tumorali circolanti e relativi metodi e kit di rilevazione. |
| US20140227692A1 (en) * | 2011-07-08 | 2014-08-14 | Deborah W. Neklason | Methods of detecting hereditary cancer predisposition |
| EP2788768A1 (en) * | 2011-12-10 | 2014-10-15 | Abbott Molecular Inc. | Materials and methods for diagnosis of malignant melanoma and prognosis of metastasis of malignant melanoma |
| WO2015023552A1 (en) * | 2013-08-13 | 2015-02-19 | Bionumerik Pharmaceuticals, Inc. | Administration of karenitecin for the treatment of advanced ovarian cancer, including chemotherapy-resistant and/or the mucinous adenocarcinoma sub-types |
| CA2931140C (en) | 2014-02-05 | 2022-08-30 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Error-free sequencing of dna |
-
2016
- 2016-01-27 EP EP16152883.1A patent/EP3199641B1/en active Active
- 2016-01-27 ES ES16152883T patent/ES2905208T3/es active Active
-
2017
- 2017-01-27 AU AU2017211976A patent/AU2017211976B2/en active Active
- 2017-01-27 KR KR1020187024606A patent/KR20180102674A/ko active Pending
- 2017-01-27 EP EP17706412.8A patent/EP3408411A1/en not_active Withdrawn
- 2017-01-27 CA CA3012404A patent/CA3012404A1/en active Pending
- 2017-01-27 US US16/073,271 patent/US11702701B2/en active Active
- 2017-01-27 WO PCT/EP2017/051789 patent/WO2017129753A1/en not_active Ceased
- 2017-01-27 SG SG11201805990XA patent/SG11201805990XA/en unknown
- 2017-01-27 CN CN201780008861.6A patent/CN108770360B/zh active Active
- 2017-01-27 JP JP2018539138A patent/JP2019508032A/ja active Pending
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