JP2018532736A5 - - Google Patents
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- JP2018532736A5 JP2018532736A5 JP2018519039A JP2018519039A JP2018532736A5 JP 2018532736 A5 JP2018532736 A5 JP 2018532736A5 JP 2018519039 A JP2018519039 A JP 2018519039A JP 2018519039 A JP2018519039 A JP 2018519039A JP 2018532736 A5 JP2018532736 A5 JP 2018532736A5
- Authority
- JP
- Japan
- Prior art keywords
- neoepitope
- matched
- hla
- patient
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562240494P | 2015-10-12 | 2015-10-12 | |
| US62/240,494 | 2015-10-12 | ||
| PCT/US2016/056692 WO2017066357A1 (en) | 2015-10-12 | 2016-10-12 | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532736A JP2018532736A (ja) | 2018-11-08 |
| JP2018532736A5 true JP2018532736A5 (https=) | 2019-01-17 |
Family
ID=57882841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519039A Pending JP2018532736A (ja) | 2015-10-12 | 2016-10-12 | チェックポイント阻害物質への感受性を予測するｍｓｉおよびネオエピトープの探索のための系、組成物、および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11626187B2 (https=) |
| EP (1) | EP3362930A4 (https=) |
| JP (1) | JP2018532736A (https=) |
| KR (1) | KR20180087244A (https=) |
| CN (1) | CN108701173A (https=) |
| AU (1) | AU2016339035A1 (https=) |
| CA (1) | CA3003251A1 (https=) |
| HK (1) | HK1258091A1 (https=) |
| IL (1) | IL258679A (https=) |
| WO (1) | WO2017066357A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
| CA3003251A1 (en) | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
| WO2017139694A1 (en) | 2016-02-12 | 2017-08-17 | Nantomics, Llc | High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies |
| EP3500966B1 (en) | 2016-08-25 | 2021-04-21 | Nantomics, LLC | Immunotherapy markers and uses therefor |
| CN110651189B (zh) * | 2017-03-03 | 2024-10-25 | 特雷斯生物有限公司 | 肽疫苗 |
| WO2018237088A1 (en) * | 2017-06-20 | 2018-12-27 | Bio-Rad Laboratories, Inc. | DIGITAL AMPLIFICATION ASSAYS FOR GENETIC INSTABILITY |
| US11918634B2 (en) * | 2017-08-10 | 2024-03-05 | Good T Cells, Inc. | Method for activating T cells for cancer treatment |
| US11773449B2 (en) | 2017-09-01 | 2023-10-03 | The Hospital For Sick Children | Profiling and treatment of hypermutant cancer |
| WO2019133391A1 (en) * | 2017-12-20 | 2019-07-04 | Nantomics, Llc | Using cfrna for diagnosing minimal residual disease |
| WO2019206725A1 (en) * | 2018-04-25 | 2019-10-31 | Koninklijke Philips N.V. | Tumor functional mutation and epitope loads as improved predictive biomarkers for immunotherapy response |
| CA3106564A1 (en) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Cancer vaccines for breast cancer |
| US20220349010A1 (en) | 2018-07-26 | 2022-11-03 | Frame Pharmaceuticals B.V. | Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database |
| WO2020041561A1 (en) * | 2018-08-23 | 2020-02-27 | Nantcell, Inc. | Assessing microsatellite instability by liquid biopsy |
| JP7642530B2 (ja) | 2018-09-04 | 2025-03-10 | トレオス バイオ リミテッド | ペプチドワクチン |
| WO2020091944A1 (en) * | 2018-10-31 | 2020-05-07 | Nantomics, Llc | Genomic and immune infiltration differences between msi and mss gi tumors |
| CN110556164B (zh) * | 2019-09-09 | 2023-02-07 | 深圳裕策生物科技有限公司 | 用于目标区域捕获测序检测msi的方法、装置和存储介质 |
| CN110910957B (zh) * | 2019-12-31 | 2023-06-27 | 求臻医学科技(浙江)有限公司 | 一种基于单肿瘤样本高通量测序微卫星不稳定性探测位点筛选方法 |
| CN111785324B (zh) * | 2020-07-02 | 2021-02-02 | 深圳市海普洛斯生物科技有限公司 | 一种微卫星不稳定分析方法及装置 |
| CN112183557A (zh) * | 2020-09-29 | 2021-01-05 | 山西医科大学 | 基于胃癌组织病理图像纹理特征的msi预测模型构建方法 |
| CN114974420A (zh) * | 2021-10-29 | 2022-08-30 | 无锡臻和生物科技有限公司 | 预测胃肠肿瘤免疫检查点抑制剂疗效的标志物及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003207459A1 (en) | 2002-01-03 | 2003-07-24 | The Scripps Research Institute | Cancer-associated epitope |
| DK1601450T3 (da) | 2003-03-10 | 2013-09-08 | Expression Pathology Inc | Flydende vævspræparat ud fra histopatologisk bearbejdede biologiske prøver, væv og celler |
| CA2535976A1 (en) | 2003-08-20 | 2005-03-03 | Cleveland Clinic Foundation | A novel gene and protein associated with angiogenesis and endothelial apoptosis |
| US7767792B2 (en) | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| JP4852046B2 (ja) | 2004-10-12 | 2012-01-11 | クルセル ホランド ベー ヴェー | 癌の治療及び検出に用いる結合分子 |
| US7811993B2 (en) | 2005-06-29 | 2010-10-12 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treating melanoma |
| WO2008081008A1 (en) | 2007-01-05 | 2008-07-10 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
| EP2569633B1 (en) | 2010-05-14 | 2016-02-10 | The General Hospital Corporation | Compositions and methods of identifying tumor specific neoantigens |
| KR102042253B1 (ko) | 2010-05-25 | 2019-11-07 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ｂａｍｂａｍ：고처리율 서열분석 데이터의 병렬 비교 분석 |
| US9646134B2 (en) | 2010-05-25 | 2017-05-09 | The Regents Of The University Of California | Bambam: parallel comparative analysis of high-throughput sequencing data |
| HK1203971A1 (en) | 2012-05-15 | 2015-11-06 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| LT2901341T (lt) | 2012-09-28 | 2019-09-25 | The University Of Connecticut | Protekcinių vėžio epitopų identifikavimas, skirtas vėžio gydymui |
| EP2983702A2 (en) | 2013-04-07 | 2016-02-17 | The Broad Institute, Inc. | Compositions and methods for personalized neoplasia vaccines |
| AU2014337063A1 (en) | 2013-10-18 | 2016-05-19 | Adaptive Biotechnologies Corp. | Predicting patient responsiveness to immune checkpoint inhibitors |
| KR20230076867A (ko) * | 2013-12-20 | 2023-05-31 | 더 브로드 인스티튜트, 인코퍼레이티드 | 신생항원 백신과의 병용 요법 |
| EP3090066A4 (en) * | 2014-01-02 | 2017-08-30 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
| US20190099475A1 (en) | 2015-04-08 | 2019-04-04 | Nantomics, Llc | Cancer neoepitopes |
| BR112017022845A2 (pt) | 2015-04-23 | 2018-07-17 | Nantomics, Llc | neoepítopos de câncer |
| AU2016311444B2 (en) | 2015-08-25 | 2019-02-07 | Nantomics, Llc | Systems and methods for high-accuracy variant calling |
| CA3003251A1 (en) | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
-
2016
- 2016-10-12 CA CA3003251A patent/CA3003251A1/en active Pending
- 2016-10-12 KR KR1020187013060A patent/KR20180087244A/ko not_active Withdrawn
- 2016-10-12 JP JP2018519039A patent/JP2018532736A/ja active Pending
- 2016-10-12 AU AU2016339035A patent/AU2016339035A1/en not_active Abandoned
- 2016-10-12 US US15/292,021 patent/US11626187B2/en active Active
- 2016-10-12 WO PCT/US2016/056692 patent/WO2017066357A1/en not_active Ceased
- 2016-10-12 CN CN201680065549.6A patent/CN108701173A/zh not_active Withdrawn
- 2016-10-12 HK HK19100475.3A patent/HK1258091A1/zh unknown
- 2016-10-12 EP EP16856134.8A patent/EP3362930A4/en not_active Withdrawn
-
2018
- 2018-04-12 IL IL258679A patent/IL258679A/en unknown
-
2023
- 2023-02-02 US US18/163,664 patent/US20230307090A1/en active Pending
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