HK1258091A1 - 用於发现预测对检查点抑制剂敏感的 msi 和新表位的系统、组合物和方法 - Google Patents

用於发现预测对检查点抑制剂敏感的 msi 和新表位的系统、组合物和方法 Download PDF

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Publication number
HK1258091A1
HK1258091A1 HK19100475.3A HK19100475A HK1258091A1 HK 1258091 A1 HK1258091 A1 HK 1258091A1 HK 19100475 A HK19100475 A HK 19100475A HK 1258091 A1 HK1258091 A1 HK 1258091A1
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Hong Kong
Prior art keywords
neoepitopes
systems
methods
msi
discovery
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HK19100475.3A
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English (en)
Chinese (zh)
Inventor
Andrew Nguyen
Kayvan Niazi
Patrick Soon-Shiong
Stephen Charles BENZ
Shahrooz Rabizadeh
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Nantomics, Llc
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Publication of HK1258091A1 publication Critical patent/HK1258091A1/zh

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    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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HK19100475.3A 2015-10-12 2016-10-12 用於发现预测对检查点抑制剂敏感的 msi 和新表位的系统、组合物和方法 HK1258091A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562240494P 2015-10-12 2015-10-12
US62/240,494 2015-10-12
PCT/US2016/056692 WO2017066357A1 (en) 2015-10-12 2016-10-12 Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors

Publications (1)

Publication Number Publication Date
HK1258091A1 true HK1258091A1 (zh) 2019-11-01

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Country Status (10)

Country Link
US (2) US11626187B2 (https=)
EP (1) EP3362930A4 (https=)
JP (1) JP2018532736A (https=)
KR (1) KR20180087244A (https=)
CN (1) CN108701173A (https=)
AU (1) AU2016339035A1 (https=)
CA (1) CA3003251A1 (https=)
HK (1) HK1258091A1 (https=)
IL (1) IL258679A (https=)
WO (1) WO2017066357A1 (https=)

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CA3003251A1 (en) 2015-10-12 2017-04-20 Nantomics, Llc Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors
CA3014252A1 (en) 2016-02-12 2017-08-17 Nantomics, Llc High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies
EP3500966B1 (en) 2016-08-25 2021-04-21 Nantomics, LLC Immunotherapy markers and uses therefor
MA47678A (fr) * 2017-03-03 2021-05-26 Treos Bio Ltd Plateforme personnalisée d'identification de peptide immunogène
CN111373050A (zh) * 2017-06-20 2020-07-03 生物辐射实验室股份有限公司 用于遗传不稳定性的数字扩增试验
CN110997903B (zh) * 2017-08-10 2024-03-29 古德T细胞有限公司 用于癌症治疗的t细胞的活化方法
WO2019041045A1 (en) 2017-09-01 2019-03-07 The Hospital For Sick Children PROFILING AND TREATMENT OF HYPERMUTANT CANCER
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EP3784802A1 (en) * 2018-04-25 2021-03-03 Koninklijke Philips N.V. Tumor functional mutation and epitope loads as improved predictive biomarkers for immunotherapy response
CA3106562A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Off-the-shelf cancer vaccines
WO2020022899A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
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WO2020091944A1 (en) * 2018-10-31 2020-05-07 Nantomics, Llc Genomic and immune infiltration differences between msi and mss gi tumors
CN110556164B (zh) * 2019-09-09 2023-02-07 深圳裕策生物科技有限公司 用于目标区域捕获测序检测msi的方法、装置和存储介质
CN110910957B (zh) * 2019-12-31 2023-06-27 求臻医学科技(浙江)有限公司 一种基于单肿瘤样本高通量测序微卫星不稳定性探测位点筛选方法
CN111785324B (zh) * 2020-07-02 2021-02-02 深圳市海普洛斯生物科技有限公司 一种微卫星不稳定分析方法及装置
CN112183557A (zh) * 2020-09-29 2021-01-05 山西医科大学 基于胃癌组织病理图像纹理特征的msi预测模型构建方法
CN114974420A (zh) * 2021-10-29 2022-08-30 无锡臻和生物科技有限公司 预测胃肠肿瘤免疫检查点抑制剂疗效的标志物及其应用

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Publication number Publication date
IL258679A (en) 2018-06-28
EP3362930A1 (en) 2018-08-22
US20170032082A1 (en) 2017-02-02
CA3003251A1 (en) 2017-04-20
CN108701173A (zh) 2018-10-23
EP3362930A4 (en) 2019-06-19
US11626187B2 (en) 2023-04-11
AU2016339035A1 (en) 2018-05-10
WO2017066357A1 (en) 2017-04-20
US20230307090A1 (en) 2023-09-28
JP2018532736A (ja) 2018-11-08
KR20180087244A (ko) 2018-08-01

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