JP2019506897A - ヒトのセレブロンを発現するトランスジェニックマウス - Google Patents

ヒトのセレブロンを発現するトランスジェニックマウス Download PDF

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JP2019506897A
JP2019506897A JP2018555851A JP2018555851A JP2019506897A JP 2019506897 A JP2019506897 A JP 2019506897A JP 2018555851 A JP2018555851 A JP 2018555851A JP 2018555851 A JP2018555851 A JP 2018555851A JP 2019506897 A JP2019506897 A JP 2019506897A
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compound
crbn
mouse
human crbn
transgenic mouse
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JP2019506897A5 (cg-RX-API-DMAC10.html
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チョプラ ラジェシュ
チョプラ ラジェシュ
クリッペル アンケ
クリッペル アンケ
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Celgene Corp
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018555851A 2016-01-19 2017-01-18 ヒトのセレブロンを発現するトランスジェニックマウス Pending JP2019506897A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022020184A JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662280633P 2016-01-19 2016-01-19
US62/280,633 2016-01-19
PCT/US2017/013909 WO2017127414A1 (en) 2016-01-19 2017-01-18 Transgenic mouse expressing human cereblon

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JP2022020184A Division JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

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JP2019506897A true JP2019506897A (ja) 2019-03-14
JP2019506897A5 JP2019506897A5 (cg-RX-API-DMAC10.html) 2020-03-05

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JP2018555851A Pending JP2019506897A (ja) 2016-01-19 2017-01-18 ヒトのセレブロンを発現するトランスジェニックマウス
JP2022020184A Active JP7350911B2 (ja) 2016-01-19 2022-02-14 ヒトのセレブロンを発現するトランスジェニックマウス

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US (2) US11963520B2 (cg-RX-API-DMAC10.html)
EP (1) EP3405790B1 (cg-RX-API-DMAC10.html)
JP (2) JP2019506897A (cg-RX-API-DMAC10.html)
WO (1) WO2017127414A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018144832A1 (en) 2017-02-03 2018-08-09 Celgene Corporation Methods for measuring small molecule affinity to cereblon
JP6935383B2 (ja) * 2018-09-27 2021-09-15 公益財団法人実験動物中央研究所 免疫不全マウス
CN116121302A (zh) * 2018-09-27 2023-05-16 公益财团法人实验动物中央研究所 免疫缺陷小鼠
CA3157196A1 (en) 2019-11-05 2021-05-14 Celgene Corporation Combination therapy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide
CN112980882A (zh) * 2021-03-15 2021-06-18 上海科技大学 Crbn基因在构建GSPT1敏感模型中的用途
WO2025164957A1 (ko) * 2024-01-31 2025-08-07 남부대학교산학협력단 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037757A1 (en) * 1997-02-28 1998-09-03 Kirin Beer Kabushiki Kaisha Pluripotent cells having disrupted intrinsic genes
JP2004533826A (ja) * 2001-04-18 2004-11-11 ジーン ストリーム プロプライエトリー リミティッド 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物
JP2010514421A (ja) * 2006-12-22 2010-05-06 ジェネンテック， インコーポレイテッド ヒト化ｖｅｇｆを発現するトランスジェニックマウス
WO2014123267A1 (ko) * 2013-02-07 2014-08-14 광주과학기술원 Crbn ko 마우스의 제조방법 및 이의 용도
WO2015077058A2 (en) * 2013-11-08 2015-05-28 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US20020187931A1 (en) * 2000-04-13 2002-12-12 Michael Hayden Modulating cell survival by modulating huntingtin function
US6875904B2 (en) * 2000-09-20 2005-04-05 The Ohio State University Research Foundation Animal model for identifying agents that inhibit or enhance CTLA4 signaling
WO2004060053A2 (en) * 2002-12-16 2004-07-22 Genentech, Inc. Transgenic mice expressing human cd20
US20120134969A1 (en) 2009-05-25 2012-05-31 Hiroshi Handa Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells
WO2012149299A2 (en) 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
WO2014028445A2 (en) 2012-08-14 2014-02-20 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
EP3450571B1 (en) 2014-02-24 2023-04-05 Celgene Corporation Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
ES2843973T3 (es) 2014-06-27 2021-07-21 Celgene Corp Composiciones y métodos para inducir cambios conformacionales en cereblon y otras ubiquitina ligasas E3
WO2018144832A1 (en) 2017-02-03 2018-08-09 Celgene Corporation Methods for measuring small molecule affinity to cereblon

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037757A1 (en) * 1997-02-28 1998-09-03 Kirin Beer Kabushiki Kaisha Pluripotent cells having disrupted intrinsic genes
JP2004533826A (ja) * 2001-04-18 2004-11-11 ジーン ストリーム プロプライエトリー リミティッド 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物
JP2010514421A (ja) * 2006-12-22 2010-05-06 ジェネンテック， インコーポレイテッド ヒト化ｖｅｇｆを発現するトランスジェニックマウス
WO2014123267A1 (ko) * 2013-02-07 2014-08-14 광주과학기술원 Crbn ko 마우스의 제조방법 및 이의 용도
WO2015077058A2 (en) * 2013-11-08 2015-05-28 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias

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US20190037818A1 (en) 2019-02-07
WO2017127414A1 (en) 2017-07-27
US11963520B2 (en) 2024-04-23
JP7350911B2 (ja) 2023-09-26
US20240389562A1 (en) 2024-11-28
EP3405790A1 (en) 2018-11-28
JP2022078072A (ja) 2022-05-24
EP3405790A4 (en) 2019-10-02
EP3405790B1 (en) 2023-06-28

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