JP2019506390A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019506390A5 JP2019506390A5 JP2018537799A JP2018537799A JP2019506390A5 JP 2019506390 A5 JP2019506390 A5 JP 2019506390A5 JP 2018537799 A JP2018537799 A JP 2018537799A JP 2018537799 A JP2018537799 A JP 2018537799A JP 2019506390 A5 JP2019506390 A5 JP 2019506390A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- hapten
- class drug
- fentanyl class
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical class C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 6
- 239000011324 bead Substances 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 231100000636 lethal dose Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662281262P | 2016-01-21 | 2016-01-21 | |
| US62/281,262 | 2016-01-21 | ||
| PCT/US2017/013865 WO2017127390A1 (en) | 2016-01-21 | 2017-01-18 | Synthetic opioid vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506390A JP2019506390A (ja) | 2019-03-07 |
| JP2019506390A5 true JP2019506390A5 (https=) | 2020-02-27 |
Family
ID=59362842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018537799A Pending JP2019506390A (ja) | 2016-01-21 | 2017-01-18 | 合成オピオイドワクチン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11305010B2 (https=) |
| EP (1) | EP3405475B1 (https=) |
| JP (1) | JP2019506390A (https=) |
| CN (1) | CN108884127A (https=) |
| BR (1) | BR112018014908A2 (https=) |
| RU (1) | RU2018130106A (https=) |
| WO (1) | WO2017127390A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019094528A1 (en) | 2017-11-09 | 2019-05-16 | The Scripps Research Institute | An improved heroin vaccine |
| WO2020006563A1 (en) * | 2018-06-29 | 2020-01-02 | Marquette University | Fluorinated compounds as ph-sensitive analgesics |
| EP4054571A4 (en) * | 2019-11-08 | 2024-01-10 | Regents of the University of Minnesota | FENTANYL HAPTEN, FENTANYL HAPTEN CONJUGATES, AND METHODS OF MAKING AND USING THE SAME |
| US20230100186A1 (en) * | 2020-01-13 | 2023-03-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Fentanyl haptens for the preparation of a fentanyl vaccine |
| WO2021183913A1 (en) * | 2020-03-13 | 2021-09-16 | Regents Of The University Of Minnesota | Fentanyl haptens, fentanyl hapten conjugates, and methods for making and using |
| US20240307517A1 (en) * | 2021-05-10 | 2024-09-19 | Cornell University | Development of a highly efficient second generation fentanyl-conjugate vaccine to treat fentanyl addiction |
| EP4694925A2 (en) * | 2023-04-13 | 2026-02-18 | Avicenna Biotech Research, Llc | Compositions and methods for treating fentanyl dependence |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283066A (en) * | 1992-02-19 | 1994-02-01 | Development Center For Biotechnology | Method of stimulating an immune response by using a hapten |
| AU3941893A (en) | 1992-04-06 | 1993-11-08 | Biosite Diagnostics Incorporated | Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels |
| US6262265B1 (en) | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
| ATE358275T1 (de) * | 2001-11-16 | 2007-04-15 | Randox Lab Ltd | Verfahren und kit zum nachweis, oder zum quantifizieren von, metaboliten von fentanyl und metaboliten von fentanyl analoga |
| NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| WO2004111202A2 (en) * | 2003-03-07 | 2004-12-23 | Incyte Corporation | Neurotransmission-association proteins |
| MXPA04006617A (es) | 2004-07-07 | 2006-01-12 | Inst Nac De Psiquiatria Ramon | Proceso para la preparacion y uso de una vacuna bivalente contra la adiccion a la morfina-heroina. |
| WO2006086469A2 (en) * | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
| US20110182918A1 (en) * | 2008-06-13 | 2011-07-28 | Nabi Biopharmaceuticals | Personalized drug treatment and smoking cessation kit and method |
| WO2010120121A2 (ko) * | 2009-04-15 | 2010-10-21 | 포항공과대학교 산학협력단 | 표적 특이적 비항체 단백질 및 이의 제조 방법 |
| SG10201509499RA (en) * | 2010-11-19 | 2015-12-30 | Eisai R&D Man Co Ltd | Neutralizing anti-ccl20 antibodies |
| JP2015502356A (ja) * | 2011-11-30 | 2015-01-22 | ウェルスタット ダイアグノスティクス，エルエルシー | ５−ｆｕに関連するアッセイ、抗体、免疫原および組成物 |
| AU2011383735A1 (en) | 2011-12-21 | 2014-08-14 | The Scripps Research Institute | Heroin haptens, immunoconjugates and related uses |
| US20140093525A1 (en) * | 2012-09-17 | 2014-04-03 | Minneapolis Medical Research Foundation | Compositions and methods of treating opioid addiction |
| US9981043B2 (en) | 2013-02-08 | 2018-05-29 | Regents Of The University Of Minnesota | Analgesic conjugates |
| US9213029B2 (en) * | 2013-06-25 | 2015-12-15 | Samsung Electronics Co., Ltd. | Method for diagnosing breast cancer by detection of polymeric immunoglobulin receptor in vesicles isolated from patients |
-
2017
- 2017-01-18 US US16/071,199 patent/US11305010B2/en active Active
- 2017-01-18 JP JP2018537799A patent/JP2019506390A/ja active Pending
- 2017-01-18 CN CN201780007832.8A patent/CN108884127A/zh active Pending
- 2017-01-18 EP EP17741829.0A patent/EP3405475B1/en active Active
- 2017-01-18 RU RU2018130106A patent/RU2018130106A/ru unknown
- 2017-01-18 WO PCT/US2017/013865 patent/WO2017127390A1/en not_active Ceased
- 2017-01-18 BR BR112018014908-0A patent/BR112018014908A2/pt not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019506390A5 (https=) | ||
| RU2018130106A (ru) | Вакцина против синтетических опиоидов | |
| Sulczewski et al. | Nanoparticle vaccines against viral infections | |
| JP2016516074A5 (https=) | ||
| JP2014513725A5 (https=) | ||
| JP2014515406A5 (https=) | ||
| JP6389559B2 (ja) | 不活化全粒子ワクチンを含有するマイクロニードルアレイ製剤およびその投与方法 | |
| JP2013534248A5 (https=) | ||
| RU2014141545A (ru) | Нацеливающие аминокислотные липиды | |
| JP2012017342A5 (https=) | ||
| JP2006527762A5 (https=) | ||
| Zhou et al. | pH-Sensitive and biodegradable Mn3 (PO4) 2· 3H2O nanoparticles as an adjuvant of protein-based bivalent COVID-19 vaccine to induce potent and broad-spectrum immunity | |
| JP2012522802A5 (https=) | ||
| TWI578997B (zh) | 用於預防或治療菸鹼成癮之共軛體 | |
| Crouse et al. | A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models | |
| JP2019536761A5 (https=) | ||
| Lockner et al. | A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity | |
| JP2018505882A5 (https=) | ||
| ES2565578T3 (es) | Vacunas contra el cáncer que contienen epítopos de antígeno oncofetal | |
| EP3823620A4 (en) | OPIOID HAPTENES, CONJUGATES, VACCINES AND METHODS OF GENERATING ANTIBODIES | |
| ES2612357T3 (es) | Composiciones antigénicas y métodos | |
| Cossette et al. | Intranasal subunit vaccination strategies employing nanomaterials and biomaterials | |
| US20210107862A1 (en) | Methods and compositions for substance use disorder vaccine formulations and uses thereof | |
| CN103768595A (zh) | 唑来膦酸佐剂及含唑来膦酸佐剂的疫苗 | |
| TW201733616A (zh) | 包含固定化病毒粒子之疫苗 |