JP2019506390A5 - - Google Patents
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- Publication number
- JP2019506390A5 JP2019506390A5 JP2018537799A JP2018537799A JP2019506390A5 JP 2019506390 A5 JP2019506390 A5 JP 2019506390A5 JP 2018537799 A JP2018537799 A JP 2018537799A JP 2018537799 A JP2018537799 A JP 2018537799A JP 2019506390 A5 JP2019506390 A5 JP 2019506390A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- hapten
- class drug
- fentanyl class
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical class C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 6
- 239000011324 bead Substances 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 231100000636 lethal dose Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662281262P | 2016-01-21 | 2016-01-21 | |
| US62/281,262 | 2016-01-21 | ||
| PCT/US2017/013865 WO2017127390A1 (en) | 2016-01-21 | 2017-01-18 | Synthetic opioid vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506390A JP2019506390A (ja) | 2019-03-07 |
| JP2019506390A5 true JP2019506390A5 (https=) | 2020-02-27 |
Family
ID=59362842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018537799A Pending JP2019506390A (ja) | 2016-01-21 | 2017-01-18 | 合成オピオイドワクチン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11305010B2 (https=) |
| EP (1) | EP3405475B1 (https=) |
| JP (1) | JP2019506390A (https=) |
| CN (1) | CN108884127A (https=) |
| BR (1) | BR112018014908A2 (https=) |
| RU (1) | RU2018130106A (https=) |
| WO (1) | WO2017127390A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019094528A1 (en) | 2017-11-09 | 2019-05-16 | The Scripps Research Institute | An improved heroin vaccine |
| WO2020006563A1 (en) * | 2018-06-29 | 2020-01-02 | Marquette University | Fluorinated compounds as ph-sensitive analgesics |
| US20220409722A1 (en) * | 2019-11-08 | 2022-12-29 | Regents Of The University Of Minnesota | Fentanyl hapten, fentanyl hapten-conjugates, and methods for making and using |
| WO2021146334A1 (en) * | 2020-01-13 | 2021-07-22 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Fentanyl haptens for the preparation of a fentanyl vaccine |
| US20230126276A1 (en) * | 2020-03-13 | 2023-04-27 | Regents Of The University Of Minnesota | Fentanyl haptens, fentanyl hapten conjugates, and methods for making and using |
| WO2022240898A1 (en) * | 2021-05-10 | 2022-11-17 | Cornell University | Development of a highly efficient second generation fentanyl-conjugate vaccine to treat fentanyl addiction |
| EP4694925A2 (en) * | 2023-04-13 | 2026-02-18 | Avicenna Biotech Research, Llc | Compositions and methods for treating fentanyl dependence |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283066A (en) * | 1992-02-19 | 1994-02-01 | Development Center For Biotechnology | Method of stimulating an immune response by using a hapten |
| CA2132342A1 (en) | 1992-04-06 | 1993-10-14 | Kenneth F. Buechler | Novel opiate derivatives and protein and polypeptide opiate derivative conjugates and labels |
| US6262265B1 (en) | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
| US7109310B2 (en) * | 2001-11-16 | 2006-09-19 | Randox Laboratories, Ltd. | Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs |
| CA2487849A1 (en) * | 2002-07-18 | 2004-01-29 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| WO2004111202A2 (en) * | 2003-03-07 | 2004-12-23 | Incyte Corporation | Neurotransmission-association proteins |
| MXPA04006617A (es) | 2004-07-07 | 2006-01-12 | Inst Nac De Psiquiatria Ramon | Proceso para la preparacion y uso de una vacuna bivalente contra la adiccion a la morfina-heroina. |
| TR201901929T4 (tr) * | 2005-02-08 | 2019-03-21 | Genzyme Corp | TGFBeta'ya antikorlar. |
| US20110182918A1 (en) * | 2008-06-13 | 2011-07-28 | Nabi Biopharmaceuticals | Personalized drug treatment and smoking cessation kit and method |
| KR101047192B1 (ko) * | 2009-04-15 | 2011-07-06 | 포항공과대학교 산학협력단 | 표적 특이적 비항체 단백질 및 이의 제조 방법 |
| SG191716A1 (en) * | 2010-11-19 | 2013-08-30 | Toshio Imai | Neutralizing anti-ccl20 antibodies |
| JP2015502356A (ja) * | 2011-11-30 | 2015-01-22 | ウェルスタット ダイアグノスティクス，エルエルシー | ５−ｆｕに関連するアッセイ、抗体、免疫原および組成物 |
| CA2895702C (en) | 2011-12-21 | 2020-03-31 | The Scripps Research Institute | Heroin haptens, immunoconjugates and related uses |
| US20140093525A1 (en) * | 2012-09-17 | 2014-04-03 | Minneapolis Medical Research Foundation | Compositions and methods of treating opioid addiction |
| US9981043B2 (en) | 2013-02-08 | 2018-05-29 | Regents Of The University Of Minnesota | Analgesic conjugates |
| US9213029B2 (en) * | 2013-06-25 | 2015-12-15 | Samsung Electronics Co., Ltd. | Method for diagnosing breast cancer by detection of polymeric immunoglobulin receptor in vesicles isolated from patients |
-
2017
- 2017-01-18 US US16/071,199 patent/US11305010B2/en active Active
- 2017-01-18 RU RU2018130106A patent/RU2018130106A/ru unknown
- 2017-01-18 CN CN201780007832.8A patent/CN108884127A/zh active Pending
- 2017-01-18 EP EP17741829.0A patent/EP3405475B1/en active Active
- 2017-01-18 JP JP2018537799A patent/JP2019506390A/ja active Pending
- 2017-01-18 WO PCT/US2017/013865 patent/WO2017127390A1/en not_active Ceased
- 2017-01-18 BR BR112018014908-0A patent/BR112018014908A2/pt not_active Application Discontinuation
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