JP2019505598A - Smad7の阻害を用いて、腸線維症を治療する方法 - Google Patents
Smad7の阻害を用いて、腸線維症を治療する方法 Download PDFInfo
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662298988P | 2016-02-23 | 2016-02-23 | |
| US62/298,988 | 2016-02-23 | ||
| PCT/US2017/019094 WO2017147276A1 (en) | 2016-02-23 | 2017-02-23 | Methods of treating intestinal fibrosis using smad7 inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019505598A true JP2019505598A (ja) | 2019-02-28 |
| JP2019505598A5 JP2019505598A5 (enExample) | 2020-04-16 |
Family
ID=59686543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563402A Pending JP2019505598A (ja) | 2016-02-23 | 2017-02-23 | Smad7の阻害を用いて、腸線維症を治療する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11162097B2 (enExample) |
| EP (1) | EP3420082A4 (enExample) |
| JP (1) | JP2019505598A (enExample) |
| WO (1) | WO2017147276A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11162097B2 (en) | 2016-02-23 | 2021-11-02 | Nogra Pharma Limited | Methods of treating intestinal fibrosis using SMAD7 inhibition |
| CN108753791B (zh) * | 2018-07-01 | 2020-10-13 | 中国农业科学院植物保护研究所 | 绿盲蝽decapentaplegic基因及其RNAi在害虫防控中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015169966A2 (en) * | 2014-05-09 | 2015-11-12 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| ES2388968T3 (es) | 2001-11-02 | 2012-10-22 | Giuliani International Limited | Inhibidores de Smad7 para el tratamiento de enfermedades del SNC |
| ITRM20030149A1 (it) * | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| RS56049B1 (sr) | 2008-11-13 | 2017-09-29 | Nogra Pharma Ltd | Antisens kompozicije i postupci za pripremu i upotrebu istih |
| KR102099990B1 (ko) | 2011-09-15 | 2020-04-13 | 노그라 파마 리미티드 | 항-smad7 요법의 반응성을 모니터링하는 방법 |
| JP6301844B2 (ja) * | 2012-02-09 | 2018-03-28 | ノグラ ファーマ リミテッド | 線維症の処置方法 |
| RU2667960C2 (ru) | 2012-04-18 | 2018-09-25 | Ногра Фарма Лимитед | Способы лечения диабета и/или улучшения выживания панкреатических островков после трансплантации |
| US9078918B2 (en) * | 2012-05-08 | 2015-07-14 | Northwestern University | Inhibition of fibrosis and AF by TGF-beta inhibition in the posterior left atrium (PLA) |
| LT2948137T (lt) * | 2013-01-18 | 2018-12-27 | Genfit | Fibrozės ir vėžio gydymo būdai |
| CN105008394B (zh) | 2013-03-15 | 2021-10-22 | 诺格尔制药有限公司 | 治疗结肠直肠癌的方法 |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| US20170247695A1 (en) | 2014-10-17 | 2017-08-31 | Celgene Corporation | Isotopologues of smad7 antisense oligonucleotides |
| WO2016059243A2 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limmited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
| EP3207136A1 (en) | 2014-10-17 | 2017-08-23 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| MA41271A (fr) | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
| JP2018529726A (ja) | 2015-09-30 | 2018-10-11 | セルジーン アルパイン インベストメント カンパニー Ii, エルエルシー | Tlr調節因子及び使用方法 |
| WO2017055611A2 (en) * | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
| MA44309A (fr) * | 2015-11-25 | 2018-10-03 | Nogra Pharma Ltd | Oligonucléotides antisens il-34 et leurs procédés d'utilisation |
| US11162097B2 (en) | 2016-02-23 | 2021-11-02 | Nogra Pharma Limited | Methods of treating intestinal fibrosis using SMAD7 inhibition |
| CA3014383A1 (en) | 2016-02-24 | 2017-08-31 | Nogra Pharma Limited | Methods of treating celiac disease using smad7 inhibition |
| US20200237801A1 (en) | 2016-05-12 | 2020-07-30 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
| US20190328770A1 (en) | 2016-12-30 | 2019-10-31 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
| WO2019023439A1 (en) | 2017-07-28 | 2019-01-31 | Celgene Corporation | PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDE COMPOUNDS |
-
2017
- 2017-02-23 US US16/079,059 patent/US11162097B2/en not_active Expired - Fee Related
- 2017-02-23 EP EP17757196.5A patent/EP3420082A4/en not_active Withdrawn
- 2017-02-23 JP JP2018563402A patent/JP2019505598A/ja active Pending
- 2017-02-23 WO PCT/US2017/019094 patent/WO2017147276A1/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015169966A2 (en) * | 2014-05-09 | 2015-11-12 | Nogra Pharma Limited | Methods for treating inflammatory bowel disease |
Non-Patent Citations (8)
| Title |
|---|
| BIOCHEM J, 2015, VOL.471, P.357-367, JPN6021006887, ISSN: 0004691366 * |
| EUR J CLIN INVEST, 2008, VOL.38 NO.6, P.410-420, JPN6021006883, ISSN: 0004691364 * |
| FLORIAN RIEDER: "ANIMAL MODELS OF INTESTINAL FIBROSIS: NEW TOOLS FOR THE UNDERSTANDING OF PATHOGENESIS AND 以下備考", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. VOL:303, NR:7, JPN5019001832, 9 August 2012 (2012-08-09), pages 786 - 801, ISSN: 0004453078 * |
| INFLAM BOWEL DIS., 2015, VOL.21 NO.5, P.1141-1150, JPN6021006886, ISSN: 0004691365 * |
| INFLAM REGENE., 2008, VOL.28 NO.1, P.31-35, JPN6021006892, ISSN: 0004453080 * |
| SILVIA SPECA: "CELLULAR AND MOLECULAR MECHANISMS OF INTESTINAL FIBROSIS", WORLD JOURNAL OF GASTROENTEROLOGY, vol. VOL:18, NR:28, JPN5019001831, 28 July 2012 (2012-07-28), pages 3635 - 3661, ISSN: 0004691367 * |
| 分子リウマチ, 2005, VOL.2 NO.1, P.22-27, JPN6021006889, ISSN: 0004691368 * |
| 日本薬学会第130年会要旨集4, 2010, P.179(28CI-AM01), JPN6021006890, ISSN: 0004453079 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20190055559A1 (en) | 2019-02-21 |
| US11162097B2 (en) | 2021-11-02 |
| EP3420082A1 (en) | 2019-01-02 |
| WO2017147276A1 (en) | 2017-08-31 |
| EP3420082A4 (en) | 2019-10-16 |
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