JP2019503387A - 抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法 - Google Patents

抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法 Download PDF

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Publication number
JP2019503387A
JP2019503387A JP2018539118A JP2018539118A JP2019503387A JP 2019503387 A JP2019503387 A JP 2019503387A JP 2018539118 A JP2018539118 A JP 2018539118A JP 2018539118 A JP2018539118 A JP 2018539118A JP 2019503387 A JP2019503387 A JP 2019503387A
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antibody
nivolumab
antigen
dose
subjects
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JP2019503387A5 (enExample
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ネイサン・フェイス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2019503387A publication Critical patent/JP2019503387A/ja
Publication of JP2019503387A5 publication Critical patent/JP2019503387A5/ja
Priority to JP2021210901A priority Critical patent/JP2022046649A/ja
Priority to JP2024108149A priority patent/JP2024133611A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2018539118A 2016-01-27 2017-01-27 抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法 Pending JP2019503387A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021210901A JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2024108149A JP2024133611A (ja) 2016-01-27 2024-07-04 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662287717P 2016-01-27 2016-01-27
US62/287,717 2016-01-27
PCT/US2017/015333 WO2017132508A1 (en) 2016-01-27 2017-01-27 Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent

Related Child Applications (1)

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JP2021210901A Division JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Publications (2)

Publication Number Publication Date
JP2019503387A true JP2019503387A (ja) 2019-02-07
JP2019503387A5 JP2019503387A5 (enExample) 2020-03-05

Family

ID=58163189

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018539118A Pending JP2019503387A (ja) 2016-01-27 2017-01-27 抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2021210901A Pending JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2024108149A Pending JP2024133611A (ja) 2016-01-27 2024-07-04 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021210901A Pending JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2024108149A Pending JP2024133611A (ja) 2016-01-27 2024-07-04 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Country Status (6)

Country Link
US (3) US20210206854A1 (enExample)
EP (1) EP3408296A1 (enExample)
JP (3) JP2019503387A (enExample)
KR (1) KR20180101584A (enExample)
CN (1) CN108602892A (enExample)
WO (1) WO2017132508A1 (enExample)

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US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
CN105296433B (zh) 2014-08-01 2018-02-09 中山康方生物医药有限公司 一种ctla4抗体、其药物组合物及其用途
WO2016176503A1 (en) 2015-04-28 2016-11-03 Bristol-Myers Squibb Company Treatment of pd-l1-negative melanoma using an anti-pd-1 antibody and an anti-ctla-4 antibody
EP3288980B1 (en) * 2015-04-28 2021-03-10 Bristol-Myers Squibb Company Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody
MX383464B (es) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
MX392711B (es) 2015-08-11 2025-03-24 Wuxi Biologics Ireland Ltd Anticuerpos anti-pd-1 novedosos.
JP6869987B2 (ja) 2015-09-01 2021-05-12 アジェナス インコーポレイテッド 抗ｐｄ−１抗体及びその使用方法
US11072657B2 (en) 2015-11-18 2021-07-27 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-PD-1 antibody and an anti-CTLA-4 antibody
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
CN110300599B (zh) 2016-12-07 2024-07-02 艾吉纳斯公司 抗体和其使用方法
US12668635B1 (en) 2017-11-21 2026-06-30 Arcus Biosciences, Inc. Methods of treating solid tumors using an anti-PD-1 antibody or a fragment thereof
WO2019157124A1 (en) * 2018-02-08 2019-08-15 Bristol-Myers Squibb Company Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors
SG11202007590TA (en) 2018-02-13 2020-09-29 Merck Sharp & Dohme Methods for treating cancer with anti-pd-1 antibodies
EP3774911A1 (en) * 2018-03-30 2021-02-17 Bristol-Myers Squibb Company Methods of treating tumor
KR102673786B1 (ko) 2018-08-28 2024-06-07 주식회사 엘지에너지솔루션 원통형 전지 및 이의 제조 방법
BR112021008549A2 (pt) * 2018-11-05 2022-01-04 Iovance Biotherapeutics Inc Método de tratamento de carcinoma pulmonar de células não pequenas com uma população de linfócitos infiltrantes de tumor
AR122043A1 (es) * 2020-05-12 2022-08-03 Bristol Myers Squibb Co Dosificación y administración del anticuerpo anti-ctla-4 activable
CA3196496A1 (en) 2020-10-23 2022-04-28 Laurence David TOMS Lag-3 antagonist therapy for lung cancer
CN113945723B (zh) * 2021-10-28 2024-03-12 复旦大学附属中山医院 预测免疫检查点抑制剂治疗相关肺炎发生风险的系统、储存介质及其应用
CN117899200B (zh) * 2022-10-18 2025-11-07 华中科技大学 用于增强免疫治疗疗效的药物及其治疗肿瘤之应用

Citations (1)

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WO2015112900A1 (en) * 2014-01-24 2015-07-30 Dana-Farber Cancer Institue, Inc. Antibody molecules to pd-1 and uses thereof

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EP3530736A3 (en) * 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
BR112015007184A2 (pt) * 2012-10-02 2017-08-08 Bristol Myers Squibb Co combinação de anticorpos anti-kir e anticorpos anti-pd-1 para tratar câncer
CN107073090A (zh) * 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
JP2017515859A (ja) * 2014-05-15 2017-06-15 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｐｄ−１抗体と他の抗癌剤の組み合わせを使用する肺癌の処置
WO2016011357A1 (en) * 2014-07-18 2016-01-21 Advaxis, Inc. Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
AU2016271111B2 (en) * 2015-05-29 2022-04-28 Bristol-Myers Squibb Company Antibodies against OX40 and uses thereof
WO2019140150A1 (en) * 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer

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Publication number Priority date Publication date Assignee Title
WO2015112900A1 (en) * 2014-01-24 2015-07-30 Dana-Farber Cancer Institue, Inc. Antibody molecules to pd-1 and uses thereof

Non-Patent Citations (3)

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ANONYMOUS: "FDA APPROVES KEYTRUDA (PEMBROLIZUMAB) FOR THE TREATMENT OF PATIENTS WITH METASTATIC 以下備考", MERCK, JPN5019002036, 2 October 2015 (2015-10-02), pages 1 - 4, ISSN: 0004577176 *
J. ZHANG: "P2.01-097 - Phase 3 Study of Pembrolizumab vs Platinum-Based Chemotherapy for PD-L1+ NSCLC (ID2182)", IASLC, WCLC 2015, JPN5019002038, 2015, pages 1 - 2, ISSN: 0004577175 *
JOURNAL OF CLINICAL ONCOLOGY, vol. Vol. 33, No. 15 suppl, JPN6021001809, 20 May 2015 (2015-05-20), pages 8011, ISSN: 0004577177 *

Also Published As

Publication number Publication date
CN108602892A (zh) 2018-09-28
US20260092114A1 (en) 2026-04-02
US20230083487A1 (en) 2023-03-16
US20210206854A1 (en) 2021-07-08
JP2022046649A (ja) 2022-03-23
EP3408296A1 (en) 2018-12-05
WO2017132508A1 (en) 2017-08-03
KR20180101584A (ko) 2018-09-12
JP2024133611A (ja) 2024-10-02

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