JP2019503387A - 抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法 - Google Patents

抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法 Download PDF

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Publication number
JP2019503387A
JP2019503387A JP2018539118A JP2018539118A JP2019503387A JP 2019503387 A JP2019503387 A JP 2019503387A JP 2018539118 A JP2018539118 A JP 2018539118A JP 2018539118 A JP2018539118 A JP 2018539118A JP 2019503387 A JP2019503387 A JP 2019503387A
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antibody
nivolumab
antigen
dose
subjects
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JP2019503387A5 (enExample
Inventor
ネイサン・フェイス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2019503387A publication Critical patent/JP2019503387A/ja
Publication of JP2019503387A5 publication Critical patent/JP2019503387A5/ja
Priority to JP2021210901A priority Critical patent/JP2022046649A/ja
Priority to JP2024108149A priority patent/JP2024133611A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018539118A 2016-01-27 2017-01-27 抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法 Pending JP2019503387A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021210901A JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2024108149A JP2024133611A (ja) 2016-01-27 2024-07-04 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662287717P 2016-01-27 2016-01-27
US62/287,717 2016-01-27
PCT/US2017/015333 WO2017132508A1 (en) 2016-01-27 2017-01-27 Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent

Related Child Applications (1)

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JP2021210901A Division JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Publications (2)

Publication Number Publication Date
JP2019503387A true JP2019503387A (ja) 2019-02-07
JP2019503387A5 JP2019503387A5 (enExample) 2020-03-05

Family

ID=58163189

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018539118A Pending JP2019503387A (ja) 2016-01-27 2017-01-27 抗ｐｄ−１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2021210901A Pending JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2024108149A Pending JP2024133611A (ja) 2016-01-27 2024-07-04 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021210901A Pending JP2022046649A (ja) 2016-01-27 2021-12-24 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法
JP2024108149A Pending JP2024133611A (ja) 2016-01-27 2024-07-04 抗ｐｄ－１抗体および別の抗癌剤の組合せを用いる肺癌の処置法

Country Status (6)

Country Link
US (2) US20210206854A1 (enExample)
EP (1) EP3408296A1 (enExample)
JP (3) JP2019503387A (enExample)
KR (1) KR20180101584A (enExample)
CN (1) CN108602892A (enExample)
WO (1) WO2017132508A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105296433B (zh) 2014-08-01 2018-02-09 中山康方生物医药有限公司 一种ctla4抗体、其药物组合物及其用途
EP3288980B1 (en) * 2015-04-28 2021-03-10 Bristol-Myers Squibb Company Treatment of pd-l1-positive melanoma using an anti-pd-1 antibody
US10513558B2 (en) 2015-07-13 2019-12-24 Cytomx Therapeutics, Inc. Anti-PD1 antibodies, activatable anti-PD1 antibodies, and methods of use thereof
HRP20241381T1 (hr) 2015-08-11 2024-12-20 WuXi Biologics Ireland Limited Nova anti-pd-1 protutijela
KR20220131277A (ko) 2015-09-01 2022-09-27 아게누스 인코포레이티드 항-pd-1 항체 및 이를 이용하는 방법
TWI821748B (zh) 2015-11-18 2023-11-11 美商必治妥施貴寶公司 使用抗pd-1抗體與抗ctla-4抗體之組合以治療肺癌
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
CA3046082A1 (en) 2016-12-07 2018-06-14 Agenus Inc. Antibodies and methods of use thereof
WO2019157124A1 (en) * 2018-02-08 2019-08-15 Bristol-Myers Squibb Company Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors
WO2019191676A1 (en) * 2018-03-30 2019-10-03 Bristol-Myers Squibb Company Methods of treating tumor
KR102673786B1 (ko) 2018-08-28 2024-06-07 주식회사 엘지에너지솔루션 원통형 전지 및 이의 제조 방법
CN113945723B (zh) * 2021-10-28 2024-03-12 复旦大学附属中山医院 预测免疫检查点抑制剂治疗相关肺炎发生风险的系统、储存介质及其应用
CN117899200B (zh) * 2022-10-18 2025-11-07 华中科技大学 用于增强免疫治疗疗效的药物及其治疗肿瘤之应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015112900A1 (en) * 2014-01-24 2015-07-30 Dana-Farber Cancer Institue, Inc. Antibody molecules to pd-1 and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2439273B1 (en) * 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
US20150290316A1 (en) * 2012-10-02 2015-10-15 Bristol-Myers Squibb Company Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
CN107073090A (zh) * 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
CA2949121A1 (en) * 2014-05-15 2015-11-19 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
CN106999561A (zh) * 2014-07-18 2017-08-01 阿德瓦希斯股份有限公司 用于治疗前列腺癌的pd‑1拮抗剂和基于李斯特菌的疫苗的组合
UY36687A (es) * 2015-05-29 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Anticuerpos contra ox40 y sus usos
CN111770936A (zh) * 2018-01-12 2020-10-13 百时美施贵宝公司 抗il-8抗体和抗pd-1抗体联合治疗用于治疗癌症

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015112900A1 (en) * 2014-01-24 2015-07-30 Dana-Farber Cancer Institue, Inc. Antibody molecules to pd-1 and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "FDA APPROVES KEYTRUDA (PEMBROLIZUMAB) FOR THE TREATMENT OF PATIENTS WITH METASTATIC 以下備考", MERCK, JPN5019002036, 2 October 2015 (2015-10-02), pages 1 - 4, ISSN: 0004577176 *
J. ZHANG: "P2.01-097 - Phase 3 Study of Pembrolizumab vs Platinum-Based Chemotherapy for PD-L1+ NSCLC (ID2182)", IASLC, WCLC 2015, JPN5019002038, 2015, pages 1 - 2, ISSN: 0004577175 *
JOURNAL OF CLINICAL ONCOLOGY, vol. Vol. 33, No. 15 suppl, JPN6021001809, 20 May 2015 (2015-05-20), pages 8011, ISSN: 0004577177 *

Also Published As

Publication number Publication date
JP2024133611A (ja) 2024-10-02
JP2022046649A (ja) 2022-03-23
KR20180101584A (ko) 2018-09-12
WO2017132508A1 (en) 2017-08-03
CN108602892A (zh) 2018-09-28
EP3408296A1 (en) 2018-12-05
US20210206854A1 (en) 2021-07-08
US20230083487A1 (en) 2023-03-16

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