JP2019167346A5 - - Google Patents

Info

Publication number

JP2019167346A5

JP2019167346A5 JP2019087445A JP2019087445A JP2019167346A5 JP 2019167346 A5 JP2019167346 A5 JP 2019167346A5 JP 2019087445 A JP2019087445 A JP 2019087445A JP 2019087445 A JP2019087445 A JP 2019087445A JP 2019167346 A5 JP2019167346 A5 JP 2019167346A5

Authority

JP

Japan

Prior art keywords

tumor

combination

bacterial cell

pharmaceutical composition

penetrating agent

Prior art date

2019-05-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 206010028980 Neoplasm Diseases 0.000 claims 36
• 210000004027 cell Anatomy 0.000 claims 32
• 230000001580 bacterial effect Effects 0.000 claims 31
• 239000003795 chemical substances by application Substances 0.000 claims 20
• 230000000149 penetrating effect Effects 0.000 claims 19
• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 108010003272 Hyaluronate lyase Proteins 0.000 claims 10
• 102000001974 Hyaluronidases Human genes 0.000 claims 10
• 229960002773 hyaluronidase Drugs 0.000 claims 10
• 239000002246 antineoplastic agent Substances 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 150000007523 nucleic acids Chemical class 0.000 claims 8
• 230000035515 penetration Effects 0.000 claims 8
• 241000607142 Salmonella Species 0.000 claims 7
• 230000000692 anti-sense effect Effects 0.000 claims 7
• 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 6
• 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 6
• 230000001506 immunosuppresive effect Effects 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 3
• 210000004881 tumor cell Anatomy 0.000 claims 3
• 230000028993 immune response Effects 0.000 claims 2
• 210000000987 immune system Anatomy 0.000 claims 2
• 230000004936 stimulating effect Effects 0.000 claims 2
• 102100021723 Arginase-1 Human genes 0.000 claims 1
• 101710129000 Arginase-1 Proteins 0.000 claims 1
• 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
• 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
• 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
• 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 claims 1
• 101001037261 Homo sapiens Indoleamine 2,3-dioxygenase 2 Proteins 0.000 claims 1
• 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 1
• 102100040062 Indoleamine 2,3-dioxygenase 2 Human genes 0.000 claims 1
• 102000003814 Interleukin-10 Human genes 0.000 claims 1
• 108090000174 Interleukin-10 Proteins 0.000 claims 1
• 102100029438 Nitric oxide synthase, inducible Human genes 0.000 claims 1
• 101710089543 Nitric oxide synthase, inducible Proteins 0.000 claims 1
• 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
• 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
• 230000001093 anti-cancer Effects 0.000 claims 1
• 239000003183 carcinogenic agent Substances 0.000 claims 1
• -1 pGE2 Proteins 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 230000002195 synergetic effect Effects 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1