JP2019151582A - Dentifrice composition - Google Patents

Abstract

To provide a dentifrice composition that has excellent retentivity in gums even under dilution, and has suppressed stringiness while delivering a medicinal component to gingival sulci or the like.SOLUTION: A dentifrice composition has following components (A), (B), (C) and (D): (A) allantoin, (B) 20-60 mass% of erythritol, (C) 0.3-2 mass% of a binder containing xanthan gum (c1) of 55 mass% or more in the binder, and (D) 3-30 mass% of water, with a mass ratio between component (B) and component (c1) [(B)/(c1)] of 25-250.SELECTED DRAWING: None

Description

  The present invention relates to a dentifrice composition.

Periodontal disease is an inflammatory disease caused by bacterial infection. Bacteria stays in the gingival crevice between the teeth and gums (accumulation of plaque), and the margins of the gums become inflamed and red. Swell. And when inflammation spreads from the gingiva, the boundary between the teeth and the gums, called the periodontal pocket, deepens, then the base supporting the teeth (alveolar bone) melts and the teeth move, and finally the teeth must be removed .
Periodontal disease is difficult to deal with by removing plaque alone, and it is known that it is necessary to deliver a medicinal component directly to a local site such as a gingival crevice or a periodontal pocket. Technologies that improve delivery are being investigated.

  For example, Patent Document 1 contains sugar alcohols such as mannitol, glucopyranosyl sorbitol, glucopyranosyl mannitol and reduced palatinose, oil-soluble medicinal ingredients, water and a binder, and when reaching a local site An oral composition that immediately reduces the viscosity and enables the rapid release and action of medicinal ingredients is disclosed. Patent Document 2 discloses a toothpaste composition for periodontal disease containing a hydrogel particle containing a medicinal component, a binder and water, and delivering the hydrogel particle to the gingival crevice to Efficient action is intended. As a medicinal component for periodontal disease, anti-inflammatory agents such as glycyrrhetinic acids and allantoins, blood circulation promoters, antibacterial agents, bactericides, hemostatic agents, antioxidants, and the like are used.

  On the other hand, in a dentifrice composition, it is known that xanthan gum is used as a binder to impart viscosity to the composition (for example, Patent Document 3).

JP 2014-62049 A JP-A-2006-94468 JP 2011-68599 A

However, during actual use of the dentifrice composition, since it is gradually diluted with saliva during use, the conventional dentifrice composition greatly reduces the deliverability of medicinal ingredients under high dilution, resulting in sufficient medicinal efficacy. It was difficult to obtain and there was room for improvement.
In addition, in dentifrice compositions, blending high concentrations of xanthan gum is advantageous in terms of improving retention in the oral cavity, but due to its strong stringiness, it can be easily taken into a toothbrush and used in the oral cavity. From the viewpoint of usability such as spreading, the amount of xanthan gum inevitably has to be suppressed, and the actual amount is to be used by increasing the amount of other binders.

  The present invention relates to providing a dentifrice composition that has excellent retention in gingiva even under dilution, and that suppresses stringiness while delivering medicinal ingredients to the gingival crevice and the like.

  The inventor contains a predetermined amount of erythritol and xanthan gum together with allantoins and water, the xanthan gum is set to a predetermined amount or more with respect to the total amount of the binder, and the mass ratio of erythritol and xanthan gum is within a predetermined range. As a result, the retention of the dentifrice composition in the gingiva is high even under dilution, and more allantoin can be delivered to the gingival crevice and periodontal pocket. Have found that a dentifrice composition can be obtained.

That is, the present invention includes the following components (A), (B), (C) and (D):
(A) Allantoins (B) Erythritol 20-60% by mass
(C) Binder containing 55% by mass or more of xanthan gum (c1) in the binder 0.3 to 2% by mass
(D) Water 3-30 mass%
And a dentifrice composition having a mass ratio [(B) / (c1)] of 25 to 250 of the component (B) and the component (c1).

  According to the dentifrice composition of the present invention, even if it is diluted with saliva during use, the deliverability of allantoins can be ensured, and more allantoins can be delivered to the gingival crevice and periodontal pocket. Further, among the contents containing a large amount of xanthan gum, yarn string is suppressed and the usability is good.

Hereinafter, the present invention will be described in detail.
The dentifrice composition of the present invention contains allantoins as component (A). Allantoin is a compound represented by the molecular formula C ₄ H ₆ N ₄ O ₃ , also called 5-ureidohydantoin, and is known to have anti-inflammatory action, anti-ulcer action and the like.
Allantoins include allantoin and condensates of allantoin and aluminum. Among these, allantoin aluminum salt is a preferred component because it provides a constricting action and brings a feeling of tightness of the gingiva. More preferred are allantoin hydroxyaluminum, allantoindihydroxyaluminum, allantoinchlorohydroxyaluminum, and more preferred are allantoindihydroxyaluminum and allantoinchlorohydroxyaluminum. Hereinafter, the notation “ALCA” means allantochlorohydroxyaluminum.

  In the dentifrice composition of the present invention, the content of the component (A) is preferably 0.01% by mass or more from the viewpoint of effectively providing a medicinal effect at a local site such as a gingival crevice and a periodontal pocket. Preferably it is 0.03 mass% or more, More preferably, it is 0.07 mass% or more. Further, the content of the component (A) is preferably 1% by mass or less, more preferably 0.7% by mass or less, and still more preferably 0.3% by mass or less, from the viewpoint of suppressing the taste and bitterness. It is. And content of a component (A) becomes like this in a dentifrice composition, Preferably it is 0.01-1 mass%, More preferably, it is 0.03-0.7 mass%, More preferably, it is 0.07. It is -0.3 mass%.

The dentifrice composition of this invention contains 20-60 mass% of erythritol as a component (B). By containing erythritol in such a predetermined amount, while maintaining the stringiness of xanthan gum, the retention of the dentifrice composition in the gums is kept high even under dilution, and more component (A) is delivered to the gingival crevice and periodontal pocket Can be made. Moreover, although the allantoin aluminum salt mentioned above has a metallic taste, the metallic taste can also be effectively suppressed by erythritol.
As the structure of erythritol, there are three isomers of L-erythritol, D-erythritol, and meso-erythritol, and any of these structures can be used in the present invention. As erythritol, those that are usually available can be used, and commercially available products such as those manufactured by Jumbunzlauer, Nikken Chemicals, Mitsubishi Chemical Foods, and Celestor are available. Erythritol having a large particle diameter can be pulverized to adjust the particle diameter. A roller mill, a hammer mill, a high-speed pulverizer, a pulverizer, etc. are generally used for pulverization of erythritol. Is preferred.

The particle diameter of erythritol is preferably 3 μm or more, more preferably 5 μm or more, still more preferably 7 μm or more, and even more preferably 10 μm or more, from the viewpoint of providing a good cooling sensation in the oral cavity during use. From the viewpoint of effectively suppressing the yarn string of xanthan gum, from the viewpoint of maintaining the deliverability of the component (A) to the gingival sulcus and the like, and from the viewpoint of effectively suppressing the metallic taste derived from the allantoin aluminum salt, preferably less than 355 μm, More preferably, it is less than 300 micrometers, More preferably, it is less than 250 micrometers, More preferably, it is less than 45 micrometers.
The particle diameter of erythritol can be measured as follows, but is only an example, and is not limited to the following measurement method.
Sieve: JIS standard sieve φ75mm
Aperture: From the top, a receiver is provided under a sieve having openings of 500 μm, 355 μm, 250 μm, 180 μm, 125 μm, 90 μm, 45 μm and 10 μm, respectively.
Shaker: Micro type electromagnetic vibrator M-2 type (Tsutsui Rikenki Co., Ltd.)
Method: Place 15 g of sample on 500 μm sieve and classify with electromagnetic vibrator for 5 minutes. The total amount of erythritol present on the sieve having openings of 355 μm, 250 μm, 180 μm, 125 μm, 90 μm, 45 μm and 10 μm is defined as erythritol having a particle diameter of 10 μm or more and less than 355 μm.

  In the dentifrice composition of the present invention, the content of the component (B) is preferably 20 masses from the viewpoint of effectively suppressing the yarn wrinkles of xanthan gum and maintaining the delivery of the component (A) to the gingival sulcus. % Or more, more preferably 27 mass% or more, and further preferably 32 mass% or more. Moreover, from a viewpoint of ensuring the stability of a composition, content of a component (B) becomes like this. Preferably it is 60 mass% or less, More preferably, it is 50 mass% or less, More preferably, it is 45 mass% or less. And content of a component (B) becomes like this in a dentifrice composition, Preferably it is 20-60 mass%, More preferably, it is 27-50 mass%, More preferably, it is 32-45 mass%.

  The dentifrice composition of this invention contains 0.3-2 mass% of binder as a component (C). Usually, a caking additive is mix | blended as an object for gelatinization and caking according to the form of a dentifrice composition.

In the dentifrice composition of this invention, 55 mass% or more of xanthan gum is contained in a component (C) as a component (c1). By containing xanthan gum at such a high concentration, the retention of the dentifrice composition in the gingiva can be kept high even under dilution, and more component (A) can be delivered to the gingival crevice and periodontal pocket.
Xanthan gum is only required to be used as a binder for dentifrice compositions, and the molecular weight and molecular weight distribution are not particularly limited.

  The content of component (c1) in component (C) is 55% by mass or more, preferably 60% by mass or more, from the viewpoint of maintaining the deliverability of component (A) to the gingival sulcus, etc. Preferably it is 62 mass% or more, More preferably, it is 64 mass% or more. In addition, the content of the component (c1) in the component (C) is preferably 90% by mass or less, more preferably 85% by mass from the viewpoint of securing the viscosity stability of the composition and suppressing yarn string. % Or less, and more preferably 80% by mass or less. Furthermore, content of the component (c1) in a component (C) becomes like this. Preferably it is 55-90 mass%, More preferably, it is 60-85 mass%, More preferably, it is 62-80 mass%, More More preferably, it is 64-80 mass%.

  Examples of binders other than xanthan gum include sodium alginate, sodium carboxymethylcellulose, carrageenan, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind Examples include gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and a methoxyethylene maleic anhydride copolymer. Among them, from the viewpoint of retaining and diffusing the composition in the vicinity of the tooth surface while having an appropriate viscosity, a cellulose-based binder such as sodium carboxymethylcellulose, and hydroxyalkylcellulose such as hydroxyethylcellulose and hydroxypropylcellulose is preferable, More preferred is sodium carboxymethylcellulose. Moreover, you may use a binder in combination of 1 type, or 2 or more types.

  As such sodium carboxymethylcellulose, sodium carboxymethylcellulose having an etherification degree of 0.95 to 1.5 is preferable. The degree of etherification of sodium carboxymethylcellulose is preferably 0.95 or more, more preferably 1.0 or more, from the viewpoint of imparting an appropriate viscosity to retain and diffuse the composition in the vicinity of the tooth surface. , Preferably 1.5 or less, more preferably 1.15 or less.

The degree of etherification of sodium carboxymethylcellulose refers to the degree of substitution of carboxymethyl groups per glucose unit. The degree of etherification can be obtained, for example, according to the CMC industry association analysis method (ashing method). Weigh precisely 1 g of sodium carboxymethylcellulose, put it in a magnetic crucible, incinerate at 600 ° C., titrate sodium oxide produced by incineration with N / 10 sulfuric acid using phenolphthalein as an indicator, and titrate per 1 g of sodium carboxymethylcellulose. YmL can be calculated by putting it in the following formula and the obtained degree of etherification can be shown.
Degree of etherification = (162 × Y) / (10,000-80 × Y)

  In the dentifrice composition of the present invention, the content of the component (C) is 0.3% by mass or more, preferably 0.32% by mass or more, from the viewpoint of storage stability and viscosity of the dentifrice composition, More preferably, it is 0.35 mass% or more. Moreover, content of a component (C) is 2 mass% or less from a viewpoint of the storage stability of a dentifrice composition, More preferably, it is 1.4 mass% or less, More preferably, it is 0.8 mass% or less. It is. And content of a component (C) is 0.3-2 mass% in a dentifrice composition, More preferably, it is 0.32-1.4 mass%, More preferably, it is 0.35-0. 0.8% by mass.

In the dentifrice composition of the present invention, the mass ratio [(B) / (c1)] of the component (B) and the component (c1) is 25 to 250. By maintaining such a mass ratio between the component (B) and the component (c1), it is possible to increase the concentration of the component (c1) while suppressing the string of the component (c1).
The mass ratio [(B) / (c1)] of the component (B) and the component (c1) suppresses the string of the component (c1) and delivers the component (A) to the gingival sulcus and periodontal pocket at a high rate From the viewpoint, it is 25 or more, preferably 40 or more, more preferably 60 or more, and further preferably 75 or more. In addition, the mass ratio [(B) / (c1)] of the component (B) and the component (c1) suppresses the string of the component (c1) and increases the component (A) to the gingival sulcus and periodontal pocket From the viewpoint of delivery, it is 250 or less, preferably 200 or less, more preferably 170 or less, and even more preferably 150 or less. Furthermore, the mass ratio [(B) / (c1)] of the component (B) and the component (c1) is 25 to 250, preferably 40 to 200, more preferably 60 to 170, and still more preferably. Is 75-150.

  In the dentifrice composition of the present invention, from the viewpoint of exhibiting better component (A) delivery and foaming properties of the composition, along with component (C), the oil absorption is further increased to 200 mL / 100 g or more and 400 mL / 100 g or less. It is preferable to contain viscous silica. The thickening silica is a silica having a large oil absorption, and is different from the silica used as an abrasive. Here, the amount of oil absorption indicates the amount of oil that can be supported by silica, and the measuring method is specified by the method of JIS K5101-13-2 (established in 2004) and specified by the amount of oil that is absorbed in the boiled sea bream. Means the value to be As the thickening silica, silicia, silopure (made by Fuji Silysia Chemical), sorbosyl (made by Ineos silica), fine seal (made by Tokuyama), carplex (made by EVONIC), nip gel (made by Tosoh Silica), etc. Commercial products can be used. The oil absorption amount of the thickening silica is preferably 200 to 380 mL / 100 g, more preferably 230 to 260 mL / 100 g.

  The content of the thickening silica is preferably 1% by mass in the dentifrice composition of the present invention, in view of better delivery of the component (A) and foaming property of the composition in combination with the component (C). It is above, More preferably, it is 3 mass% or more, Preferably it is 8 mass% or less, More preferably, it is 6 mass% or less.

The dentifrice composition of this invention contains 3-30 mass% of water as a component (D). The water in the dentifrice composition means not only purified water blended in the dentifrice composition but also the total moisture including the moisture contained in each component. Water in the dentifrice composition can disperse the composition satisfactorily by dispersing or dissolving each component while maintaining an appropriate viscosity.
In the dentifrice composition of the present invention, the content of the component (D) is 3% by mass or more, preferably 8% by mass or more, more preferably 15%, from the viewpoint of ensuring good viscosity of the dentifrice composition. It is at least mass%. Moreover, content of a component (D) is 30 mass% or less from a viewpoint of ensuring the storage stability of a dentifrice composition, Preferably it is 27 mass% or less, More preferably, it is 25 mass% or less. Furthermore, content of a component (D) is 3-30 mass% in a dentifrice composition, Preferably it is 8-27 mass%, More preferably, it is 15-25 mass%. In addition, content of a component (D) can be calculated from the water content in the mix | blended and the water content in each other component mix | blended, and can also be measured with a Karl Fischer moisture meter, for example.

  The dentifrice composition of the present invention preferably further contains an anionic surfactant as component (E). By containing an anionic surfactant, good foaming can be produced even when the above-mentioned allantoin aluminum salt is used. Moreover, even if diluted with saliva, the dentifrice composition can be kept in the gingiva in a foamed state.

  Anionic surfactants include N-acyl taurine salts, N-methyl long chain acyl taurine salts, N-acyl glutamates, and N-acyl amino acid salts such as sodium N-lauroylsarcosine; sodium lauryl sulfate, and sodium myristyl sulfate. Alkyl sulfates such as sodium alkyl phosphate; higher fatty acid sulfonated monoglyceride salts; fatty acid ester salts such as isethionate; polyoxyalkyl phosphates such as polyoxyethylene monoalkyl phosphate Alkylbenzene sulfonates such as sodium dodecylbenzene sulfonate; alkyl sulfoacetates such as sodium lauryl sulfoacetate; α-olefin sulfonates. As the salt, an alkali metal salt is preferable, and a sodium salt is preferable. Among these, N-acyl taurine salt, N-acyl glutamate, N-lauroyl sarcosine salt, and sodium lauryl sulfate are more preferable from the viewpoint of imparting good foaming to the dentifrice composition. You may use it in combination of a seed | species or 2 or more types, It is further more preferable to use it combining N-acyl taurine salt and an anionic surfactant among them.

  In the dentifrice composition of the present invention, the content of the component (E) anionic surfactant is preferably 0.1% by mass or more, more preferably 0.00%, from the viewpoint of realizing good foaming of the dentifrice composition. It is 3 mass% or more, More preferably, it is 0.5 mass% or more. Moreover, from a viewpoint of suppressing harmfulness to the oral cavity, it is preferably 2% by mass or less, more preferably 1.5% by mass or less, and further preferably 1.2% by mass or less. Furthermore, the content of the component (E) is preferably 0.1 to 2% by mass, more preferably 0.3 to 1.5% by mass, and still more preferably 0.5% in the dentifrice composition. It is -1.2 mass%.

The dentifrice composition of the present invention preferably has a pH at 25 ° C. when diluted to 30% by mass with water from the viewpoint of ensuring the stability of the composition and better delivering component (A) to the gingival crevice and the like. Is 4.0 or more, more preferably 4.5 or more, still more preferably 5.0 or more, preferably 6.5 or less, more preferably 6.2 or less, still more preferably Is 5.9 or less.
Since the pH of the dentifrice composition of the present invention cannot be accurately measured in the case of a composition having a high viscosity such as a toothpaste, for example, a composition diluted to 30% by mass with water is used. It is the pH of the dentifrice composition.

  In addition to the above components, the dentifrice composition of the present invention includes, for example, medicinal components other than allantoins, foaming agents other than anionic surfactants, abrasives, antioxidants, and the like within the range that does not inhibit the effects of the present invention. , Wetting agents, sweetening agents, flavoring agents, pH adjusting agents, preservatives, and the like may be appropriately blended.

  Such a medicinal component may be oil-soluble or water-soluble as long as it has a preventive or ameliorating effect on periodontal disease. For example, azulenes, tocopherols, glycyrrhetinic acids, triclosan, isopropylmethylphenol, hinokitiol, fluorine Examples include ion supply compounds and quaternary ammonium compounds.

  As abrasives, silica such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, gluconosilicate, calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, aluminum hydroxide, alumina, magnesium carbonate, magnesium phosphate Etc. In the dentifrice composition of the present invention, the content of the abrasive is preferably 0 to 15% by mass, and more preferably 1 to 12% by mass.

  Examples of the wetting agent include glycerin, sorbitol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, and the like.

  Examples of the fragrances include menthol, carvone, anethole, eugenol, limonene, osimene, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool, ethyl linalool, walin. , Thymol, camphor, peppermint oil, spearmint oil, sage clary oil, lemon oil, cinnamon oil, orange oil, sage oil, thyme oil, fennel oil, rosemary oil, cinnamon oil, clove oil, nutmeg oil, eucalyptus oil, mint Examples include oil, anise oil, anisaldehyde, benzaldehyde, anisole and the like.

  Examples of the pH adjuster include citric acid and its salt, phosphoric acid and its salt, malic acid and its salt, gluconic acid and its salt, maleic acid and its salt, aspartic acid and its salt, succinic acid and its salt, Examples include glucuronic acid and its salt, fumaric acid and its salt, glutamic acid and its salt, adipic acid and its salt, hydrochloric acid, alkali metal hydroxide and the like.

  In the dentifrice composition of the present invention, a large amount of the component (A) in the dentifrice composition is delivered to a local site such as a gingival crevice by a normal brushing operation, that is, brushing. Therefore, the dentifrice composition of the present invention is useful as a dentifrice composition for preventing and / or improving periodontal disease.

Examples 1-5 and Comparative Examples 1-4
According to the formulation shown in Table 1, each dentifrice composition, which is a toothpaste, was prepared. In Comparative Example 2, each component was not dispersed, did not become a paste, and a toothpaste could not be prepared. Next, using each dentifrice composition, the amount of allantoin delivered to the periodontal pocket and the length of the yarn string were determined according to the following method. Furthermore, metal taste was evaluated.
Moreover, in Examples 1-5 and Comparative Examples 1-4, the fragrance | flavor shown in Table 2 was used.
The results are shown in Table 1.

[Delivery test]
About 1 g of the prepared dentifrice composition was placed on the maxillary molar part (No. 5-7) of a periodontal disease model jaw (periodontal pocket ≧ 4 mm), and water was added so that the dilution rate would be doubled. Next, “Deep Clean Gum Care Care Brush Regular Regular” was installed on the brushing machine, and 40 strokes (2 Hz) were performed at a load of 200 g. Thereafter, ALCA contained in the periodontal pocket of the jaw model was collected with a rolling pin, and quantified by HPLC using 10 μL of the solution obtained by extraction with ultrasonic waves for 60 minutes while immersed in 1 mL of water. . Separately, the calibration curve was prepared by adjusting the ALCA to be 25, 50, and 100 μg / mL.
(HPLC analysis conditions)
Measuring instrument: LC-2030C 3D, Shimadzu Corporation Detector: Photodiode array detector (measurement wavelength: 210 nm)
Column: A stainless tube with an inner diameter of 4.6 mm and a length of 250 mm is packed with 5 μm of strongly basic ion exchange resin for liquid chromatography.
Column temperature: Constant temperature around 40 ° C Mobile phase: 0.002 mol / L Potassium dihydrogen phosphate aqueous solution Flow rate: 0.8 mL per minute

[Yarn property test]
Using NEVA METER IMI-0501 (Ishikawa Iron Works Co., Ltd.), the elongation (mm) of the dentifrice composition when 0.06 mL of the dentifrice composition was pulled vertically at 10 mm / s was measured.

[Taste evaluation test]
Sensory evaluation was conducted by three specialist panels. In the sensory evaluation, the metal taste when brushed with water after brushing for about 1 g with a dentifrice composition was evaluated according to the following criteria, and the score was determined by consultation.
3: No metallic taste 2: Feels a little metallic 1: Feels a metallic taste

* 1 ALCA: Rona Care Aluminum chloride hydroxide allantoin, Merck * 2 Erythritol: Erythritol with a particle size distribution of 3% to less than 45μm 82%, 45μm to less than 200μm 18%, volume average diameter 30μm
* 3 Xanthan gum: Keldent, viscosity 1200-1700mPa · s (value at 25 ° C 0.01% by weight aqueous solution), DSP Gokyo Co., Ltd. * 4 CMC · Na: Sunrose F35SH, degree of etherification 1.00 to 1.15, Nippon Paper Chemicals * 5 Abrasive silica: Solvosil AC77, oil absorption = 70 to 130mL / 100g, made by Ineos Silica * 6 Thickening silica: Carplex # 80, oil absorption = 230 to 260mL / 100g, made by EVONIC

As is clear from Table 1, the dentifrice compositions of Examples 1 to 5 had a greater amount of allantochlorohydroxyaluminum delivered to the periodontal pocket than Comparative Examples 1 to 4. Moreover, even if the ratio of the xanthan gum in the binder was large, the length of the yarn string was suppressed. Moreover, the metallic taste derived from allantoin chlorohydroxyaluminum was also suppressed.
In contrast, Comparative Example 1 in which the content of xanthan gum in the binder is less than 55% by mass has a small amount of allantochlorohydroxyaluminum delivered, and the mass ratio (B) / (c1) is less than 25. In Comparative Example 3 and Comparative Example 4 using sorbitol instead of erythritol, the delivery amount of allantochlorohydroxyaluminum was small, and the stringiness was strong, and the metallic taste derived from allantochlorohydroxyaluminum was also felt.

Claims (4)

The following components (A), (B), (C) and (D):
(A) Allantoins (B) Erythritol 20-60% by mass
(C) Binder containing 55% by mass or more of xanthan gum (c1) in the binder 0.3 to 2% by mass
(D) Water 3-30 mass%
A dentifrice composition having a mass ratio [(B) / (c1)] of 25 to 250 of the component (B) and the component (c1).   The dentifrice composition according to claim 1, wherein component (A) is an allantoin aluminum salt.   The dentifrice composition according to claim 1 or 2, wherein the component (B) is erythritol having a particle size of 3 µm or more and less than 355 µm.   The dentifrice composition according to any one of claims 1 to 3, further comprising (E) an anionic surfactant.