JP2019099498A - Composition for promoting lipid metabolism - Google Patents

Abstract

To provide compositions for promoting lipid metabolism.SOLUTION: Provided is a composition for promoting lipid metabolism in obese people, comprising arginine, alanine, and phenylalanine as active ingredients, the total number of moles of arginine, alanine and phenylalanine being 60 moles or more when the total number of moles of all amino acids in the composition is 100 moles.SELECTED DRAWING: None

Description

  The present invention relates to a composition for promoting lipid metabolism in obese people, and a food and drink containing the composition.

  Obesity is a risk factor that causes metabolic syndrome and insulin resistance and increases the morbidity or mortality of hypertension, diabetes, cardiovascular disease, and cancer (Non-patent Document 1). Intervention techniques for weight loss include diet and exercise interventions and combinations of these, and such weight loss interventions result in decreased weight and body fat percentage, including blood pressure, serum lipids, blood glucose, and liver function. It is reported that it improves (a nonpatent literature 2-4).

  Conventionally, it has been reported that fat mass is reduced by combining long-term amino acid intake and exercise in combination (Non-patent documents 5 and 6), or lean body mass is increased (Non-patent document 7), etc. There is. Furthermore, it has been reported that fat metabolism during and after exercise is promoted when a composition containing arginine, alanine and phenylalanine in a specific weight ratio is administered to exercise trainers before exercise. (Non-Patent Document 8). However, all of these effects are the effects of the combination with high frequency exercise classrooms or the combination of high intensity resistance exercise, and the effects of combining with high intensity exercise have only been reported. The

  On the other hand, Patent Document 1 discloses an amino acid mixture containing arginine, alanine and phenylalanine, and when a healthy subject who exercised a high intensity exercise receives the amino acid mixture once, the lipid It has been reported that blood glycerol levels, free fatty acid levels and ketone body levels can be increased without significantly affecting hormone levels involved in glucose metabolism. Furthermore, in Patent Document 2, reduction in body fat can be seen by administering an acid composition containing L-arginine, L-glutamine, L-valine, L-isoleucine and L-leucine in specific amounts, respectively. It has been reported. Further, Patent Document 3 reports a substance for preventing, ameliorating or treating metabolic syndrome containing an amino acid having a glucagon secretion promoting action, a xanthine derivative, an isoflavone, and a carnitine or carnitine precursor.

  However, in obese persons, lipid metabolism is combined with long-term intake of a composition containing specific amounts of arginine, alanine and phenylalanine in combination with low-intensity exercise performed in daily life (enlightenment of increase in physical activity). It has not been known before that it can be promoted (improved).

JP, 2016-102064, A JP, 2005-27524, A JP 2008-291002 A

Hu FB. Obesity Epidemiology. Oxford University Press, New York, 2008 Miller WC, Koceja DM, Hamilton EJ. A meta-analysis of the past 25 years of weight loss research using diet, exercise or diet plus exercise intervention. Int J Obes Relat Metab Disord. 1997; 21: 941-7 Nakata Y, Okura T, Matsuo T, Tanaka K. Factors alleviating metabolic syndrome via diet-induced weight loss with or without exercise in over-weight Japanese women. Prev Med. 2009; 48: 351-6 Norris SL, Zhang X, Avenell A, et al. Long-term effectiveness of lifestyle and behavioral weight loss interventions in adults with type 2 diabetes: a meta-analysis. Am J Med. 2004; 117: 762-74 Elam RP. Morphological changes in adult males from resistance exercise and amino acid supplementation. J. Sports Med Phys Fitness. 1988 Mar; 28 (1): 35-9. Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti P. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training Am J Physiol Endocrinol Metab. 2006 Nov; 291 (5): E906-12. Epub 2006 Jun 13. Program in obese, insulin-resistant type 2 diabetic patients. Eur J Appl Physiol Occup Physiol. 1992; 65 (Schena F, Guerrini F, Tregnaghi P, Kayser B. Branched-chain amino acid supplementation during trekking at high altitude. The effects of body mass, body composition, and muscle power. 5): 394-8. Ueda K, Sanbongi C, Takai S, Ikegami S, Fujita S. Combination of aerobic exercise and an arginine, alanine, and phenylalanine mixture increase in fate body and body body synthesis. Biosci Biotechnol Biochem. 2017 Jul; 81 (7): 17 (7) 1424.

  The present inventors ingested the placebo composition by causing the obese to continuously exercise low intensity exercise and continuously taking a composition containing high concentrations of arginine, alanine and phenylalanine. It was found that the degree of decrease in abdominal fat area and / or decrease in blood triglyceride concentration was significantly increased as compared to the subject, and thus the composition was found to promote lipid metabolism. The present invention is based on this finding.

  An object of the present invention is to provide a composition for promoting (ameliorating) lipid metabolism in obese people, and a food and drink containing the composition.

According to the present invention, the following inventions are provided.
(1) A composition for promoting lipid metabolism in obese, which comprises arginine, alanine and phenylalanine as active ingredients, wherein the total number of moles of all amino acids in the composition is 100 moles And the total of the number of moles of alanine and phenylalanine is 60 moles or more.
(2) The composition according to (1), wherein the molar ratio of arginine, alanine and phenylalanine is 5.0 to 90.0: 5.0 to 90.0: 5.0 to 90.0.
(3) The composition according to (2), wherein the molar ratio of arginine, alanine and phenylalanine is 10.0 to 30.0: 20.0 to 60.0: 10.0 to 70.0.
(4) The composition according to any one of (1) to (3), wherein the total number of moles of arginine, alanine and phenylalanine is 90 to 100 moles when the total number of moles of all amino acids is 100 moles. object.
(5) The composition according to any one of (1) to (4) for reducing abdominal fat area.
(6) The composition according to any one of (1) to (5) for reducing blood neutral fat concentration.
(7) Food / beverage products which contain the composition in any one of (1)-(6).
(8) The food or drink according to (7), which is any one form selected from the group consisting of a beverage, granules, powder and liquid food.

  The composition for promoting lipid metabolism of the present invention can promote lipid metabolism in a subject who is to promote lipid metabolism, particularly in obese persons. In particular, the composition of the present invention can significantly promote lipid metabolism, particularly reduction of abdominal fat area and / or reduction of blood triglyceride concentration, when obese people perform weight loss by exercise. In addition, the effect of promoting lipid metabolism by the composition of the present invention is particularly remarkable in that it is significantly recognized even in combination with the increase of low intensity light exercise (physical activity), not intense (high intensity) exercise. It is advantageous. Furthermore, the composition of the present invention is also advantageous in that it exerts a lipid metabolism promoting effect at a low dose (for example, 1.5 g / day).

FIG. 1 is a graph showing the change in abdominal total fat area from the start of the test (week 0) to the 12 weeks after the start of the test (week 12). FIG. 2 is a graph showing the concentrations of triglycerides in blood at the beginning of the test (week 0) and at eight weeks after the start of the test (week 8).

Detailed Description of the Invention

  Hereinafter, the present invention will be described in detail. However, the present invention is not limited to the following preferred embodiments, and can be freely changed within the range in which the effects of the present invention are exhibited.

  The composition for promoting lipid metabolism of the present invention (also referred to herein as “the composition of the present invention”) contains arginine, alanine and phenylalanine as active ingredients.

  Arginine is one of non-essential amino acids, and D-form and L-form exist. L-Arginine Cas No. 74-79-3, (S) -2-amino-5-guanidinopentanoic acid, (S) -2-amino-5- (amidinoamino) valeric acid, L-(+)-arginine or Algi U It is sometimes called. In some cases, "Arg" or "R" is used as an abbreviation of arginine. Arginine is soluble in water and formic acid, soluble in dilute hydrochloric acid, and practically insoluble in ethanol (the 16th revised Japanese Pharmacopoeia). Arginine is known to be contained in various materials and foods such as various proteins such as meats. Arginine is biosynthesized as an intermediate of the urea cycle, but it is regarded as an essential amino acid in children because it is rapidly degraded. Arginine is known to be involved in promoting growth hormone secretion and improving immune function.

  Alanine (Alanine) is one of non-essential amino acids, and D-form and L-form exist. L-alanine Cas No. Is 56-41-7 and may also be referred to as (S) -2-aminopropionic acid, (2S) -2-aminopropanoic acid, α-alanine or L-(+)-alanine. In some cases, “Ala” or “A” is used as an abbreviation of alanine. Alanine is readily soluble in water and formic acid, and practically insoluble in ethanol (16th Amended Japanese Pharmacopoeia). Alanine is known to be contained in various materials and foods such as various proteins such as meats. Alanine is one of the constituent amino acids of proteins and is known to be a material of connective tissue.

  Phenylalanine (Phenylalanine) is one of the essential amino acids, and D-form and L-form exist. L-Phenylalanine Cas No. Is 63-91-2, (S)-. Alpha.-aminobenzenepropanoic acid, (2S) -2-amino-3-phenylpropanoic acid, (S) -3-phenyl-2-aminopropionic acid, L- It may also be referred to as β-phenylalanine or L-(-)-phenylalanine. As an abbreviation of phenylalanine, "Phe" or "F" may be used. Phenylalanine is easily soluble in formic acid, slightly soluble in water, soluble in dilute hydrochloric acid, and practically insoluble in ethanol (16th revised Japanese Pharmacopoeia). It is known that phenylalanine is contained in various materials and foods such as various proteins such as meats.

  The content of arginine, alanine and phenylalanine in the composition of the present invention is 60 moles or more and 70 moles or more when the total number of moles of all the amino acids contained in the composition is 100 moles. The amount is preferably 80 mol or more, more preferably 90 mol or more, and particularly preferably 100 mol.

  Further, the molar ratio of arginine, alanine and phenylalanine (arginine: alanine: phenylalanine) contained in the composition of the present invention is not particularly limited as long as the effects of the present invention are not impaired. It is preferable that it is 5.0 to 90.0: 5.0 to 90.0, and more preferably 5.0 to 50.0: 5.0 to 50.0: 5.0 to 80.0. More preferably, it is 10.0 to 30.0: 20.0 to 60.0: 10.0 to 70.0, and 19.5 to 20.4: 37.5 to 38.4: 41.5. It is even more preferable that it is ~ 42.4, and it is particularly preferable that it is 20: 38: 42.

  The blending amounts of arginine, alanine and phenylalanine in the composition of the present invention can be appropriately determined according to the form of the composition, the age, weight and condition of the subject taking the composition, the use and the like. The blending amounts of arginine, alanine and phenylalanine in the composition of the present invention are not particularly limited as long as the effects of the present invention are not impaired, but the total amount of arginine, alanine and phenylalanine relative to the composition is 0.2 to 100% by weight Is preferable, 0.3 to 100% by weight is more preferable, and 0.4 to 100% by weight is particularly preferable.

  Arginine, phenylalanine and alanine contained in the composition of the present invention may be either D-form or L-form.

  Since arginine, alanine and phenylalanine are suitable for eating and drinking and oral intake, the composition of the present invention containing these at high concentration is excellent in flavor. Therefore, the composition of the present invention has the advantage of not impairing the taste of food or drink or pharmaceutical preparation to which it is added.

  The composition of the present invention may further contain other amino acids besides arginine, phenylalanine and alanine. Other amino acids are not particularly limited as long as the effect of the present invention is not impaired, but glycine, proline, lysine, tyrosine, threonine, leucine, valine, isoleucine, glutamic acid, tryptophan, histidine, serine, methionine and aspartic acid etc. It can be mentioned. Any other amino acid may be contained in the composition of the present invention, or two or more may be contained in combination.

When the composition of the present invention further contains other amino acids, the content of the other amino acids is not particularly limited as long as the effects of the present invention are not impaired, but the total number of moles of all amino acids contained in the composition Of one amino acid or two or more of the other amino acids, respectively. Glycine 0.01 to 4 moles Proline 0.01 to 4 moles Lysine 0.01 to 2 moles Tyrosine 0.01 to 2 moles Threonine 0 0.01 to 2 moles leucine 0.01 to 2 moles valine 0.01 to 2 moles isoleucine 0.01 to 2 moles glutamic acid 0.01 to 1 mole tryptophan 0.01 to 1 mole histidine 0.01 to 1 mole serine 0. It is preferable to contain it in the quantity of 0.01-1 mole of methionine 0.01-0.2 mole aspartic acid 0.01-0.1 mole.

  All of arginine, phenylalanine, alanine and other amino acids contained in the composition of the present invention may be in the form of free base, and may be in the form of hydrate or salt. The salt is not particularly limited as long as the effects of the present invention are not impaired, but, for example, organic acids (acetic acid, tartaric acid, fatty acids, etc.), organic bases, inorganic acids (hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, perchlorine And salts with inorganic bases (such as potassium, sodium and zinc).

  Furthermore, arginine, phenylalanine, alanine and other amino acids contained in the composition of the present invention can be prepared from materials, foods and the like containing those amino acids using known methods such as squeezing, concentration, purification, crystallization and extraction. It can be obtained by using. Furthermore, it is also possible to use one produced using a microorganism or one synthesized chemically. The solvent used for the extraction from the raw material and the food is not particularly limited as long as the effect of the present invention is not impaired, but, for example, water, alcohols, hydrocarbons, organic acids, organic bases, organic acids, inorganic acids, inorganic substances Solvents commonly used for extraction, such as bases and supercritical fluids, may be mentioned. One of these solvents may be used alone, or two or more thereof may be used in combination.

  In addition, the composition of the present invention may be further formulated, if desired, using pharmaceutically acceptable additives, and such an embodiment is also encompassed by the present invention. The pharmaceutically acceptable additive is not particularly limited as long as the effects of the present invention are not impaired, and, for example, excipients, binders, disintegrants, lubricants, flavoring agents, solubilizers, suspensions Agents, coatings, solvents, tonicity agents, and the like. Moreover, as an agent containing the composition of this invention, the thing of dosage forms, such as a tablet (tablet), a capsule, a granule, a powder, a syrup, a solution, and a suspension agent, is mentioned, for example. Furthermore, these agents may be blended with appropriate amounts of vitamins, minerals, organic acids, saccharides, peptides and / or amino acids not listed above, etc., as long as the effects of the present invention are not impaired. . In addition, these agents can be taken or administered by routes such as oral, tube and vein.

  In addition, the composition of the present invention can be in various forms without particular limitation as long as the effects of the present invention are not impaired, and can be suitably taken orally. Specifically, the composition of the present invention can be in the form of a solid, such as powder or granules, a paste, a gel, a liquid, or a suspension.

  According to the present invention, there are provided a medicine, a food and drink, a nutritional composition, a supplement and the like containing the composition of the present invention. Among these, food and drink containing the composition of the present invention are preferable, and as food and drink, for example, special purpose food, nutritive functional food, nutraceutical food, health food, pharmaceutical additive, food for specified health use and Functional indication food etc. are mentioned. More specifically, various foods (milk, soft drink, fermented milk, yogurt, cheese, bread, biscuit, cracker, pizza crust, prepared milk powder, liquid food, sick food, nutritional food, frozen food, processed food) And other commercially available foods). In the present specification, "containing" the composition of the present invention includes the meaning of "including" and "as a raw material" of the composition of the present invention.

  Water, proteins, carbohydrates, lipids, vitamins, minerals, organic acids, organic bases, fruit juices, flavors and the like can be blended into food and drink products containing the composition of the present invention. Examples of proteins include whole milk powder, skimmed milk powder, partially skimmed milk powder, casein, whey powder, whey protein, whey protein concentrate, whey protein isolate, whey protein hydrolyzate, α-casein, β-casein, κ -Animal and vegetable proteins such as casein, β-lactoglobulin, α-lactalbumin, lactoferrin, soy protein, chicken egg protein, meat protein, etc., their decomposition products, butter, whey mineral, cream, whey, non-protein nitrogen, sialic Examples include various milk-derived components such as acids, phospholipids and lactose. It may contain a peptide such as casein phosphopeptide or an amino acid. Examples of the sugar include saccharides, modified starch (in addition to texturin, soluble starch, British starch, oxidized starch, starch ester, starch ether, etc.), dietary fiber and the like. Examples of lipids include lard, fish oil, etc., animal fats and oils such as fractionated oil, hydrogenated oil, transesterified oil, palm oil, safflower oil, corn oil, rapeseed oil, coconut oil, etc. Vegetable fats and oils such as fractionated oil, hydrogenated oil, transesterified oil, etc. may be mentioned. As vitamins, for example, vitamin A, carotene, vitamin B group, vitamin C, vitamin D group, vitamin E, vitamin K group, vitamin P, vitamin Q, niacin, nicotinic acid, pantothenic acid, biotin, inositol, choline And folic acid. As minerals, calcium, potassium, magnesium, sodium, copper, iron, manganese, zinc, selenium etc. are mentioned, for example. Examples of the organic acid include malic acid, citric acid, lactic acid, tartaric acid, erythorbic acid and the like. These ingredients may be used alone or in combination of two or more kinds, and synthetic products and / or foods containing a large amount of these may be used. The form of these foods may be liquid, paste, gel, solid, powder or the like.

  The daily intake of the composition of the present invention can be appropriately determined according to the content of the active ingredient in the composition, the age, weight and condition of the subject taking the composition, the use, and the like. Although the daily intake of the composition of the present invention is not particularly limited as long as the effects of the present invention are not impaired, for example, the total amount of arginine, alanine and phenylalanine contained in the composition is 0.3 as a solid content. The intake can be set to 30 g, preferably 0.8 to 8 g, more preferably 1 to 5 g, still more preferably 1.3 to 3.5 g, and most preferably about 1.5 g.

  In addition, the composition of the present invention may be taken simultaneously with a conventionally known food / drink product having a lipid metabolism promoting effect, a pharmaceutical product or the like, or may be taken before or after the intake thereof.

  The present invention relates to the use of arginine, alanine and phenylalanine (method of use) for producing a composition for promoting lipid metabolism, wherein the total number of moles of all amino acids in the composition is 100 moles. Also included is the use wherein the total number of moles of arginine, alanine and phenylalanine is 60 moles or more.

  Furthermore, the present invention also encompasses a method of promoting lipid metabolism in a subject, comprising administering the composition of the present invention to the subject.

  The subject receiving the composition of the present invention may be any person, regardless of the need to promote lipid metabolism, but in view of the lipid metabolism promoting action of the composition, Can be thought of as those who want to promote lipid metabolism. Therefore, the subjects include not only those whose physicians indicate obesity or hyperlipidemia, but also healthy people who want to improve obesity and promote lipid metabolism. Also, in the following examples, it is demonstrated that lipid metabolism by adding light exercise (increasing the number of steps per day by 1000 steps) is promoted by the intake of the composition of the present invention. However, since daily exercise before adding light exercise varies from person to person, it is not necessary to condition addition of daily exercise when taking the composition of the present invention, and each subject in each subject Depending on the amount of exercise, it is considered that the promoting effect of lipid metabolism can be obtained. On the other hand, since the lipid metabolism promoting effect of the composition of the present invention is enhanced by increasing the amount of exercise, the present invention is applied to a subject whose exercise amount per day is increased more than before to promote lipid metabolism. Ingestion of the composition of (1) is a preferred embodiment of the present invention.

  EXAMPLES Hereinafter, the present invention will be more specifically described by way of examples, but the present invention is not limited by these examples.

Example 1: Preparation of a composition of the present invention The molar ratio of arginine, alanine and phenylalanine is 20:38: 42 (total of moles of arginine, alanine and phenylalanine when total amount of moles of all amino acids is 100 moles) The mixture was made into a composition of the present invention (hereinafter also referred to as "A-mix").

Example 2: Examination of the lipid metabolism promoting effect of the composition of the present invention In this example, the combination of continuous intake of the composition (A-mix) of the present invention and enlightenment of increase in physical activity is lipid metabolism in obese people We conducted a clinical trial of 200 people, with the goal of being able to promote In enlightenment of physical activity increase, intake of A-mix containing drink (1.5 g / day) with intervention of "let's increase 1000 steps a day, increase step number" recommended by health Japan 21 of Ministry of Health, Labor and Welfare The effect of combining 12 weeks was evaluated. The details of the specific test were as follows.

The subjects were subjects who were obese I (BMI 25 or more and less than 30) at the age of 20 to 64 years old, and those who did not satisfy any of the items in the “exclusion criteria” below were recruited. 200 subjects were included in this study.
Exclusion criteria
・ Obesity, hyperlipidemia, those who use / take medications that may affect lipid metabolism ・ severe liver disorder, cardiovascular disorder, respiratory disorder, endocrine disorder, metabolic disorder, food allergy disorder Who are suffering from obesity, who have obesity, hyperlipidemia, who can not stop the intake of health foods and supplements that may affect lipid metabolism, drug dependence, and a history of alcoholism or medical history Person, person who can not abstain from 2 days before the inspection day (Visit 2, 3, 6, 8, 10, 11) Person who has metal in the CT scan measurement site by surgery etc. Heart pacemaker, implantable defibrillator Person who has been diagnosed ・ who has been diagnosed with phenylketonuria or hyperphenylalaninemia ・ who has been diagnosed with familial hyperlipidemia ・ who is pregnant or lactating, or who is testing Person who wants pregnancy during period Those who have an irregular diet or life cycle such as late-night work, those who are participating in trials of using / taking medications / tests for taking / testing on other foods, taking medicines, those who are willing to participate・ Afflicted with claustrophobia ・ Others, who are judged as unsuitable as study participants at the discretion of the investigator

The subject background is summarized in Table 1 below.

Study Design This study was a double blind randomized parallel parallel comparison study.

Test food
Test food to be ingested in A-mix group: 500 mL of plastic bottle beverage containing 1500 mg of A-mix Control food ingested to placebo group: plastic bottle beverage without A-mix

Evaluation items The 3-month change in abdominal total fat area and the 2-month absolute value of blood triglyceride concentration were evaluated.

Study schedule The number of visits to the test site during the test was 11 times in total (1st: study participation briefing session, 2nd: screening test, 3rd: pre-intake test, 4th: first face-to-face exercise classroom, 5 The second: the second face-to-face exercise classroom, the sixth: the first month examination, the seventh: the third face-to-face exercise school, the eighth: the second month examination, the ninth: the fourth face-to-face exercise classroom, the tenth: three months Eye inspection, 11th: Post-hoc inspection).

  Specifically, 200 subjects were selected and selected at the first to third visits, and exercise and food instruction were given once a month for 4 to 10 third months. In addition, the test food was ingested once a day during these three months. In the exercise instruction, while enlightening the increase in the number of steps more than 1000 steps a day, I did the practice of stretching and muscle training. In the food guidance, we provided the "Food Balance Guide" of the Ministry of Agriculture, Forestry and Fisheries, and instructed them to keep a balanced diet in mind.

  The total abdominal area was measured twice at the third and tenth visits. In pre-infusion test, 1-month test, 2-month test, 3-month test, and post-test, we performed health check by blood test, urine test, medical interview, and checked the amount of food and activity .

Statistical analysis Basic statistics (mean and standard deviation) at 0 and 12 weeks were calculated for abdominal total fat area. For intra-group comparisons, comparison between week 0 and week 12 was performed by paired t-test. Also, comparisons between groups were performed by unpaired t-test.
Also, for blood neutral fat concentration, basic statistics (mean value and standard deviation) were calculated at 0 and 8 weeks. For intra-group comparisons, comparison between week 0 and week 8 was performed by paired t-test. Also, comparisons between groups were performed by unpaired t-test.

Results The changes in abdominal total fat area from week 0 to week 12 are shown in FIG. 1, and the blood neutral fat concentrations at week 0 and week 8 are shown in FIG. In FIG. 2, two bar graphs are shown for each of week 0 and week 8, but the left side is the data of the group (A-mix group) that received the test food (A-mix), and the right side is the control It is data of the group who took food (placebo group).

With regard to abdominal total fat area, changes in the placebo group compared to the beginning of the test as a result of intake of control food (placebo group) or test food (A-mix group) for 12 weeks and increase in physical activity-8 The change in the A-mix group is -18.3 cm ² (95% CI, -25.8 to -10, while it is .3 cm ² (95% CI, -14.5 to -2.2 cm ² ) 8 cm ² ), and a significant decrease in total abdominal fat area was observed in the A-mix group as compared to the placebo group.
In addition, blood neutral fat concentration, 8 weeks after intake of each food starts as a result of intake of control food (placebo group) or test food (A-mix group) and physical activity enlightenment, 118. While it was 5 mg / dL (95% CI, 102.0 to 135.0 mg / dL), in the A-mix group, 98.0 mg / dL (95% CI, 87.1 to 108.9 mg) / DL), and showed significantly lower values in the A-mix group as compared to the placebo group.

  Therefore, intake of the composition of the present invention significantly promotes the promotion of lipid metabolism, particularly the reduction of abdominal fat area and the reduction of blood triglyceride concentration, in combination with the awareness of increasing physical activity, as compared with placebo. It became clear that

  According to the present invention, it is possible to develop an agent for promoting lipid metabolism, a food, a food and a drug, etc. which can effectively consume fat in obese people and can expect an effect of lipid metabolism even with low intensity exercise load. Become.

Claims (8)

  A composition for promoting lipid metabolism in obese, comprising arginine, alanine and phenylalanine as active ingredients, wherein the total number of moles of all amino acids in the composition is 100 moles, arginine, alanine and The composition, wherein the total number of moles of phenylalanine is 60 moles or more.   The composition according to claim 1, wherein the molar ratio of arginine, alanine and phenylalanine is 5.0 to 90.0: 5.0 to 90.0: 5.0 to 90.0.   The composition according to claim 2, wherein the molar ratio of arginine, alanine and phenylalanine is 10.0 to 30.0: 20.0 to 60.0: 10.0 to 70.0.   The composition according to any one of claims 1 to 3, wherein the total number of moles of arginine, alanine and phenylalanine is 90 to 100 moles when the total number of moles of all amino acids is 100 moles.   A composition according to any one of the preceding claims for reducing abdominal fat area.   The composition according to any one of claims 1 to 5, for reducing blood neutral fat concentration.   Food-drinks which are made to contain the composition as described in any one of Claims 1-6.   The food or drink according to claim 7, which is any one form selected from the group consisting of a beverage, granules, powder and liquid food.