JP2019099491A - Pest repellent - Google Patents

Abstract

To provide a pest repellent having improved persistence of a pest repellent effect by application to the skin of a repellent object such as fabrics, humans and pets.SOLUTION: A pest repellent contains (A) a pest repellent component, and (B) at least one selected from shellac and an alkylacrylate/diacetoneacrylamide copolymer.SELECTED DRAWING: None

Description

  The present invention relates to pest repellents. Specifically, the present invention relates to a pest repellent that improves the persistence of the pest repellent effect of the pest repellent component.

Many blood-sucking pests cause pathogens to cause infections in humans and animals, and also cause skin inflammation and the like. In particular, mosquitoes are very harmful to the environment because they transmit serious diseases to humans such as dengue fever, zika fever, yellow fever, encephalitis, malaria and the like.
In order to prevent damage from these blood-sucking pests, a number of proposals have been made with respect to pest repellent components for humans. Among them, Dieto (N, N-diethyl-m-toluamide) is one of the widely used pest repellent components, but Dieto has an unpleasant odor and also has a short duration due to its high skin permeability. There is a problem that is not. Also, in recent years, consumers are increasingly aware of safety, and various drugs containing natural ingredients as active ingredients have been studied. For example, natural essential oils selected from citronella oil, orange oil, cassia oil, etc. Pest repellents to be used as active ingredients, 1- (2-hydroxy-4-methylcyclohexyl) -1-methylethanol, etc., which are slightly contained in Eucalyptus leaves and have been found to have a repellent effect against mosquitoes etc. However, they have a problem that their duration is short due to their high volatility.

On the other hand, studies have also been made to improve the sustainability of these pest repellent components. For example, in Patent Document 1 below, in order to sustain the repellent effect of the pest repellent component, a pest repellent compounded with specific anhydrous silica particles Compositions have been proposed. Patent Document 2 below proposes a hygienic pest repellent for both human clothes that contains diet, alcohol and water in order not to cause deterioration of the clothing.
However, in the pest repellent composition of Patent Document 1, the silica particles mixed during storage settle on the bottom of the container, and it is necessary to stir each time in use, and the pest repellent composition is used without stirring. Then, problems such as clogging of a shed or applicator, or solidification of the silica particles on the jet surface or treatment surface may occur. Furthermore, when it sprays on cloth, in order that anhydrous silicic acid may remain on cloth, there also existed a problem of being hard to use to dark colored cloth.
Moreover, in the hygienic pest repellent agent of patent document 2, only that there is no influence on the fiber of clothing is verified, and the sustainability of a pest repellent effect can not be said to be sufficient.

JP-A-09-208406 JP, 2013-237636, A

  The present invention has been made in view of the above circumstances, and is applied to the skins of subjects such as clothes, curtains, sofas, etc. as well as the skin of subjects using repellents such as humans and pets. It is an issue to provide a pest repellent agent with improved sustainability.

MEANS TO SOLVE THE PROBLEM As a result of repeating earnest research, in order to solve the said subject, this inventor 1 or more types chosen from (A) pest repellent component, (B) shellac and alkyl acrylate / diacetone acrylamide copolymer. By using together, it discovers that the persistence of a pest repellent effect can be improved, and came to complete this invention.
The present invention finds that this combination provides a new effect of improving the sustainability of the pest repellent effect, and has solved the above-mentioned problems.

Specifically, the present invention is summarized as follows.
1. A pest repellent agent comprising one or more selected from (A) pest repellent components, (B) shellac and alkyl acrylate / diacetone acrylamide copolymer.
2. An insect repellent effect maintenance improver comprising at least one selected from shellac and alkyl acrylate / diacetone acrylamide copolymers.
3. (B) A method for improving the persistence of a pest repellent effect by using one or more selected from shellac and alkyl acrylate / diacetone acrylamide copolymer together with (A) a pest repellent component.

  Since the pest repellent agent of the present invention is applied not only to cloths such as clothes, curtains and sofas, but also to the skin of repellent objects such as humans and pets, the pest repellent effect is improved in long-term stability. Repellent effect can be obtained.

It is the test method schematic of the repelling effect confirmation tests 1 and 2 of the test examples 1 and 3 in an Example. It is a schematic diagram of the horizontal diffusion cell used for the percutaneous absorption test of Experiment 2 in an Example.

Hereinafter, the pest repellent agent, the pest repellent effect persistence improving agent, and the method for improving the persistence of the pest repellent effect of the present invention will be described in detail.
Here, the pest according to the present invention is not particularly limited. Etc., Longleaf deer such as Kinpalanahashika, Anabalus japonicus such as Chinese anemonefish, Kohata Anabalidaka, Anemonefish such as Asimadarabuyu, Qiacio obuyu, Aphids such as Bovine Abalone, Iyoshiroobiabi etc., Acaridae such as house dust mites, house dust mites, ticks and other mites Blood-sucking and biting insect pests such as flyfishes, sea breams, tsetse flies, fleas, lice, bedbugs, snails, ticks, gooseworms, pokemon etc. , Aphis gossypii, Aphis gossypii, Aphid gossypii such as German cockroaches, Great Spotted cockroaches, American cockroaches, American cockroaches, American cockroaches, Pitted cockroaches, Cockroaches such as Tobirimochikokuri, Fly species, Black-billed ant, Black-winged ant, Tobi-rii-wari And stored insect pests such as bees, bees, geese, centipedes, stag beetles, moth beetles, tobacco beetles, beetles, beetles, and the like. In particular, blood-sucking and biting pests are preferred.

The pest repellent agent of the present invention contains (A) a pest repellent component.
<Regarding Component (A)>
The pest repellent component (A) in the present invention may be any known pest repellent component having a repellent action against blood-sucking or biting pests and a blood-sucking / bite-inhibiting action, without limitation. . Specifically, for example, dito (N, N-diethyl-m-toluamide), 3- (N-n-butyl-N-acetyl) aminopropionic acid ethyl ester (hereinafter referred to as "IR3535"), 2 -(2-Hydroxyethyl) -1-piperidinecarboxylic acid 1-methylpropyl ester (hereinafter referred to as "icuridine"), p-menthane-3,8-diol, phenothrin, 2-ethyl-1,3-hexane Diol, butyl 3,4-dihydro-2,2-dimethyl-4-oxo-2H-pyran-6-carboxylate, n-hexyltriethylene glycol monoether, methyl 6-n-pentyl-cyclohexene-1-carboxylate Dimethyl phthalate, eucalyptol, menthol, menthyl acetate, α-pinene, geraniol, citronellal, Toroneroru, citral, terpineol, camphor, linalool, terpenols, carboxylic, dioctyl phthalate, dibutyl phthalate, and naphthalene.
Other than these, for example, citronella, mint, peppermint, cedarwood, lavender, tea tree, chamomile, cinnamon, cinnamon, lemongrass, clover, ginseng, geranium, bergamot, laurel, pine, red bean, penny royal, eucalyptus, Indian sedan, It is possible to use essential oils and extracts extracted from ylang ylang tree, black cumin seeds, orange, rosemary and the like.
Although these compounds may have optical isomers, stereoisomers and the like, the present invention also includes a mixture containing any one or two or more of these isomers in any proportion.
These pest repellent components can be used alone or in combination of two or more.
The content of the (A) pest repellent component in the pest repellent agent of the present invention is not particularly limited and may be appropriately determined, but it is preferable to contain 0.01 to 70 w / v% with respect to the total amount of pest repellent agent. And 0.01 to 50 w / v% is more preferable. By setting it to 0.01 w / v% or more, an excellent pest repellent effect is obtained, and by setting it to 50 w / v% or less, since stickiness is reduced, it is more preferable.

The pest repellent agent of the present invention contains one or more selected from (B) shellac and alkyl acrylate / diacetone acrylamide copolymer.
<Regarding Component (B)>
Shellac bleaches and refines the insect cover which is secreted by several species of scale insects that are infested with leguminous plants such as bilnum and ketch and with mulberry plants such as akous and indobodaiji and their related species. Resinous substance obtained by Its chemical structure is believed to be a natural condensation product of oxycarboxylic acids chemically linked together as a lactone, but the complete structure has not been clarified. Shellac does not dissolve in organic solvents other than alcohol, has excellent oil resistance, is nontoxic, tasteless, odorless, has safety, and is recognized as a GRAS substance (generally regarded as safe) by the FDA (US Food and Drug Administration) It is recognized as
Specific examples of shellac commercially available products include Shellac NSC, Shellac CS, Shellac B. D. S. (As mentioned above, Nippon Shellac Industry Co., Ltd. product, Shellac GBN-D, Shellac PEARL-N811, Shellac GBN-DF (The above, Gifu-Cerac manufacturing plant make), etc. are mentioned.
The alkyl acrylate / diacetone acrylamide copolymer is an anionic polymer widely used as a cosmetic raw material such as a hair setting agent.
Specific examples of commercial products of alkyl acrylate / diacetone acrylamide copolymer include plus size L-9480B, plus size L-9540B, plus size L-9600, plus size L-53P, plus size L-9909B, etc. (As mentioned above, manufactured by Hikaru Kagaku Kogyo Co., Ltd.) and the like.
The content of at least one selected from (B) shellac and alkyl acrylate / diacetone acrylamide copolymer in the pest repellent agent of the present invention is not particularly limited and may be appropriately determined. On the other hand, it is preferable to contain 0.0001 to 50 w / v%, and it is more preferable to contain 0.001 to 30 w / v%. By setting the amount to 0.001 w / v% or more, the persistence of pest repellant is more preferably improved, and by setting the amount to 30 w / v% or less, the stickiness is further reduced, which is more preferable.
One or more selected from (A) pest repellent component and (B) shellac and alkyl acrylate / diacetone acrylamide copolymer in the present invention is a component (B) relative to 100 parts by weight of (A) pest repellent component It is preferable to contain 0.01-1000 weight part, and it is more preferable to contain 0.1-100 weight part. By blending at the above ratio, the duration of the pest repellent effect is further improved.

At least one component (B) selected from the shellac and the alkyl acrylate / diacetone acrylamide copolymer of the present invention is used as a pest repellent effect maintenance agent, and further as a penetration / absorption inhibitor into the skin. Function. The above-mentioned component (B) of the present invention can suppress penetration and absorption of the pest repellent component into the skin, and retain the pest repellent component on the treated surface for a long time. Thus, the component (B) of the present invention exerts the function of suppressing penetration and absorption of the pest repellent component into the skin by using in combination with the pest repellent component of the component (A), the pest of the component (A) The repellent component is retained on the skin surface to improve the stability of pest repellant stability over a long period of time.
In addition, for example, when Deat having high skin penetration ability is adopted as the pest repellent component, the component (B) of the present invention can suppress the penetration and absorption of Deat into the skin, and it is extremely irritating to the skin. It can be reduced well. Therefore, the above-mentioned component (B) of the present invention also exerts the skin irritation reducing action of Diet.
Furthermore, it is presumed that the component (B) of the present invention also functions as a penetration / absorption inhibitor into the interior of a fabric such as clothes, curtains, sofas and the like. Thus, the component (B) of the present invention exerts the function of suppressing penetration and absorption of the pest repellent component into the inside of the fabric by using in combination with the pest repellent component of the component (A), the pest of the component (A) Even when the repellent component is retained on the surface of the fabric and the pest repellent agent of the present invention is treated on the fabric, it is presumed that the persistence of pest repellent stability is improved over a long time.
That is, according to the present invention, mammalian skin or clothing or curtain is obtained by using (A) an insect repellent component and (B) at least one selected from shellac and alkyl acrylate / diacetone acrylamide copolymer. , And a method of suppressing the penetration and absorption of the interior of the fabric such as a sofa, thereby providing a method of improving the durability of the pest repellent effect.
The effects exerted by the pest repellent agent of the present invention, in particular the functions and actions exerted by the component (B) of the present invention, are particularly remarkable effects which the present inventor has found through many experiments for the first time.

  The pest repellent agent of the present invention contains the component (A) and the component (B), and the mixture may be used as it is, but is usually used as a preparation. The form of the preparation may be appropriately set according to the mode of use, for example, liquid, cream, lotion, emulsion, gel, ointment, wet tissue, patch (patch etc.), powder, granules, spray Or any of aerosols and the like. Further, the pest repellent agent of the present invention may be kneaded or impregnated into a resin, and the resin molded in a ring shape or the like may be mounted to obtain an effect. Among these formulation forms, the pest repellent agent of the present invention may be prepared as a liquid agent and used as a spray preparation such as a spray agent or an aerosol agent, or used as a wet tissue agent to maximize the performance of the pest repellent agent. It can be used to

  In preparing the liquid preparation of the pest repellent agent of the present invention, surfactants such as nonionic, anionic and cationic surfactants can be blended, if necessary. Specifically, for example, alkyl aryl ethers, polyoxyethylene derivatives of alkyl aryl ethers, polyethylene glycol ethers, polyethylene glycol fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene polyoxypropylene copolymers, Nonionic surfactants such as polyoxyethylene hydrogenated castor oils, polyhydric alcohol esters and sugar alcohol derivatives, anionic surfactants such as alkyl sulfuric acid ester salts, alkyl sulfonates and alkyl aryl sulfonates, alkyl ammonium There may be mentioned cationic surfactants such as halides. Among them, when using the stock solution of the pest repellent agent of the present invention as an aqueous solution, for example, polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene hydrogenated castor oils, glycerin fatty acid esters, alkyl Preferably, nonionic surfactants such as glyceryl ethers, polyoxyethylene glyceryl ethers, sorbitan fatty acid esters and the like are blended.

The pest repellent agent of the present invention may be formulated with other known liquid carriers, gaseous carriers, solid carriers and other formulation aids.
Examples of the liquid carrier include aromatic or aliphatic hydrocarbons (xylene, toluene, alkyl naphthalene, phenyl xylyl ethane, kerosene, light oil, hexane, cyclohexane, liquid paraffin, etc.), halogenated hydrocarbons (chlorobenzene, dichloromethane , Dichloroethane, trichloroethane etc., alcohols (methanol, ethanol, isopropyl alcohol, butanol, hexanol, benzyl alcohol, ethylene glycol etc.), ethers (diethyl ether, ethylene glycol dimethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene glycol Monomethyl ether, tetrahydrofuran, dioxane etc., esters (ethyl acetate, butyl acetate, Isopropyl succinate, ethyl lactate, ethyl benzoate etc., ketones (acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone etc.), nitriles (acetonitrile, isobutyronitrile etc.), sulfoxides (dimethyl sulfoxide etc.), heterocyclic ring System solvents (sulfolane, γ-butyrolactone, N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone, N-octyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolidinone), acid amides N, N-dimethylformamide, N, N-dimethylacetamide, N-methyl-pyrrolidone, 3-methoxy-N, N-dimethylpropionamide, etc., alkylidene carbonates (propylene carbonate, etc.), vegetable oils (soybean oil, cottonseed oil, etc.) And water. In particular, when using a shellac as the component (B), the pest repellent agent of the present invention preferably contains an alcohol as a liquid carrier in consideration of the solubility of the shellac. The component (A) and the component (B) of the present invention may be used as an aqueous solution by using an alcohol solution and adding water to such an extent that it does not separate.
Further, examples of the gaseous carrier include butane gas, fluorocarbon gas, substitution fluorocarbon (such as HFO and HFC), liquefied petroleum gas (LPG), dimethyl ether, nitrogen gas and carbon dioxide gas, and examples of solid carriers include clay. (Kaolin, diatomaceous earth, bentonite, clay, acid clay etc), synthetic hydrous silicon oxide, talc, ceramic, other inorganic minerals (sericite, quartz, sulfur, activated carbon, calcium carbonate, hydrated silica etc.), porous material Etc.

As other pharmaceutical auxiliaries, fixing agents, dispersing agents, solubilizing agents, stabilizers and the like, specifically, for example, casein, gelatin, polysaccharides (starch, gum arabic, cellulose derivatives, alginic acid etc.), lignin derivatives, Saccharides, synthetic water-soluble polymers (polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acid, etc.), benzoates and salts, BHT (2,6-di-tert-butyl-4-methylphenol), and BHA (2-tert) A mixture of -butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol).
In the present invention, components such as rust inhibitors, preservatives, pH adjusters, and perfumes may be added as needed. As these components, those conventionally used in this field can be used. Specifically, as a rust inhibitor, Karen (trademark) No. 1 955, no. 906, no. 954, no. 958, no. 970 (Sanyo Chemical Industries, Ltd.) etc., as preservatives methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, isothiazolinone, sodium salicylate, sodium benzoate, sodium phenoxyethanol, potassium sorbate, Sodium dehydroacetate etc., and examples of pH adjusters include organic acids such as acetic acid, lactic acid, succinic acid, maleic acid, maleic acid, tartaric acid, citric acid, ascorbic acid, salicylic acid, benzoic acid, inorganic acids such as phosphoric acid, and salts thereof it can.

  A wide range of known propellants can be used as propellants to be used when the pest repellent agent of the present invention is filled into an aerosol spray container, such as butane gas, fluorocarbon gas, alternative fluorocarbons (such as HFO and HFC), There may be mentioned liquefied petroleum gas (LPG), dimethyl ether, nitrogen gas and carbon dioxide gas. In this pest repellent, the amount of propellant can be 10 to 95% by volume, particularly 30 to 90% by volume of the whole pest repellent. In producing the pest repellent agent of the present invention, methods commonly used in this field can be widely used. Among them, as a typical method, the ingredients are mixed by heating (30 to 50 ° C.) as necessary to prepare a uniform solution, and then a rust inhibitor, preservative and the like are added, and the resulting solution is aerosol spray The method of putting into a container and filling a propellant and making it into a product etc. can be mentioned. The pest repellent agent of the present invention thus obtained can be maintained stable and uniform even under severe conditions for a long period of time, and can be jetted into air as fine particles at one touch when desired.

When the pest repellent agent of the present invention is used as the above-mentioned wet tissue agent, it is preferable that the coating weight of the support is 20 to 80 g / m ² . Moreover, it is preferable to hold | maintain 70-300 ml / m < ² > of pest repellent components on a support body about 0.1-5 mm in thickness. As the support, woven fabrics such as flannel, cotton, silk, polyester, nylon, and those made of these; Polyester, polyolefin, nylon, cotton, rayon, vinylon, cellulose, nonwoven fabrics of those made of these, etc .; A sheet-like resin foam made of polyethylene, polypropylene, ethylene-vinyl acetate copolymer, polyvinyl chloride or the like can be used.

  Since the pest repellent agent of the present invention may touch human skin indirectly or directly, medicinal active ingredients such as moisturizing the skin may be appropriately blended within the range that does not impair the effects of the present invention. . These medicinal ingredients include avocado extract, amacha extract, altea extract, arnica extract, apricot extract, apricot kernel extract, apricot kernel extract, Ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, etinia leaf extract, oinaba extract, barley extract and holly mustard extract , Hydrolysed wheat powder, hydrolyzed silk, carrot extract, prickly green leaf extract, kiwi extract, kiwi extract, kina extract, cucumber extract, guanosine, kumaza extract, walnut extract, grapefruit extract, clematis extract, yeast extract, confrey extract, bilberry extract, saiko extract , Saitai extract, salvia extract, sapon extract, sasa extract, hawthorn extract, shiitake extract, diow extract, shikon extract, linden extract, Shimotsuke Ume extract, Shobu root extract, birch extract, Japanese anise extract, honeysuckle extract, Azalea extract, Azalea extract, Azalea extract, Azalea extract, Azalea extract, Zinnia extract, Serratia extract, Laminaria extract, Chigaya extract, tomato extract, natto extract, Novara extract Hibiscus extract, Bakumondow extract, Parsley extract, Parietaria extract, Hikiokoshi extract, Bisaborol, Fusida dandelion extract, Touhi extract, Bokuryo extract, Butcherbroom extract, Grape extract, Propolis, Hechima extract, Bodice extract, Hop extract, Pine extract, Maronie extract , Mizuboshi extract, Mukuroji extract, peach leaf extract, cornflower extract, apple extract, lettuce extract, lotus root Uekisu, rose extract, and the like.

The pest repellent agent of the present invention may be used by directly spraying on clothes or may be used by spraying on fabric products such as curtains and sofas in a space where it is desired to control blood-feeding and biting pests. Examples of fabric products that can use the pest repellent agent of the present invention include curtains, sofas, cushions, carpets, wallpaper, etc. mainly in indoor spaces, and sheets etc. in cars, in addition to footwear such as clothes and shoes. Can. Even in outdoor space, it can be used for tents and strollers.
As described above, the component (B) of the present invention also functions as an agent for suppressing penetration and absorption of the inside of the fabric such as clothes, curtains and sofas, so by treating the pest repellent agent of the present invention to fabric, The pest repellent component of the component (A) is retained on the surface of the fabric to maintain a stable pest repellent effect for a long time.

The present invention will be described in more detail by the following formulation examples and test examples, but the present invention is not limited to these examples.
In the examples, parts mean parts by weight unless otherwise specified.

<Test Example 1: Repellent Effect Confirmation Test 1 (Fabric Treatment)>
The test specimens (Examples 1 to 16 and Comparative Examples 1 to 4) shown in Tables 1 and 2 were sprayed on a cotton black fabric (5 cm × 5 cm) at a distance of about 10 cm and 0.3 mL spray treated, and then they were rubber gloves It stuck on the middle part of the instep. As shown in FIG. 1, the hand wearing the rubber glove is put in a metal cage (25 cm × 25 cm × 25 cm) from which Aedes albopictus (50 chicks) has been released, and the landing number on the black fabric portion is changed with time Three minutes were counted, and it was set as "the processing division landing number." The number of landings was similarly counted also about the untreated fabric which does not spray-process a test sample, and it was set as "the untreated area landing number."
The repellent rate (%) was calculated according to the following formula, and used as an index of the mosquito repellent effect of each test sample, and was evaluated in five stages according to the following evaluation criteria.
[a formula]
Repellency rate (%) = (number of untreated area landings-number of treated area landings) / number of untreated area landings x 100
[Evaluation criteria]
“◎”: Repellency rate of 80% or more after 3 hours “O”: Repellency rate of 70% to less than 80% after 3 hours “C”: Repulsion rate of 50% to 70% after 3 hours Less than "x": Repellency rate after 3 hours is 10% or more and less than 50% "× x": Repulsion rate after 3 hours is 0% or more and less than 10% Retraction rate after 3 hours (%) is 70 It was judged that% or more, ie, evaluation criteria "(double-circle)"-"(circle)", had a practical pest repellent effect.
The composition of the test sample, the repelling effect (%), and the evaluation results of the repelling effect are summarized in Tables 1-2.
The following were used as component (B) of the present invention.
B-1: Shellac resin: dried transparent white rack (manufactured by Nippon Shellac Industries, Ltd.)
B-2: Alkyl acrylate / diacetone acrylamide copolymer: Plus size L-9600 (manufactured by Aka Kagaku Kogyo Co., Ltd.)

  From the results of Tables 1 and 2, the component (A) pest repellent component of the present invention is combined with the component (B) (Examples 1 to 16) to be a pest repellent component alone (Comparative Examples 1 to 3) or a component It became clear that it can be set as the pest repellent agent which the sustainability of the pest repellent effect improved greatly compared with the combination (comparative example 4) of B, and a different component. Further, from the results of Examples 8 to 16 and Comparative Examples 3 and 4 in Table 2, the persistence of the pest repellent effect is large by combining with the component (B) of the present invention in any of the widely used pest repellent components. It also became clear that there was no change in improvement.

<Test Example 2: Transdermal Absorption Test>
(Test sample)
Component (A) The test specimen shown in Table 3 (Examples 17, 18 and Comparative Example 5) containing an alkyl acrylate / diacetone acrylamide copolymer shown below as a diet and a component (B) as a pest repellent component Prepared.
The following were used as component (B) of the present invention.
B-2: Alkyl acrylate / diacetone acrylamide copolymer: Plus size L-9600 (manufactured by Aka Kagaku Kogyo Co., Ltd.)
B-3: Alkyl acrylate / diacetone acrylamide copolymer: Plus size L-9480B (manufactured by Aka Kagaku Kogyo Co., Ltd.)

(Test method)
As a test apparatus, a horizontal diffusion cell (a flat membrane horizontal palm cell manufactured by Bead Rex Co., Ltd.) shown in FIG. 2 was used.
(1) A mouse skin 1 (Raboskin, manufactured by Hoshino Laboratory Animal Co., Ltd.) was attached to a horizontal diffusion cell 10 so that the dermal side of the skin 1 was located on the receptor cell 2 side.
(2) About 45 μL of the test sample (Examples 17, 18 and Comparative Example 5) is treated on the stratum corneum side (4.9 cm ² ) of the skin 1, covered with the aluminum foil 8, and the skin 1 Fixed.
(3) The receptor cell 2 was filled with 50 mL of physiological saline 9 containing no pest repellent component, Diet.
(4) During the test, the receptor cell 2 stirs the saline in the cell with the stirrer 3 and the water jacket 4 covering the receptor cell 2 circulates the hot water of 37 ° C. with the heater / circulator 5 The temperature in cell 2 was maintained at 37 ° C.
(5) Immediately after the temperature in the receptor cell 2 reaches 37 ° C. and 1, 2 or 3 hours later, 3 mL of physiological saline 9 is sampled from the sampling port 7 of the receptor cell 2, and then the same amount of diet is included No saline was returned and the fluid volume was made constant.
(6) The amount of diet in the sampling solution was measured by HPLC.

From the measurement results of the amount of diet, the residual amount on the skin and the residual ratio on the skin were calculated by the following formula.
[Calculation formula of residual amount on skin]
Remaining amount on skin (mg / cm ² ) = {Deat amount of treatment− (Deat amount in sampling solution / 3 × 50 + Cumulative collected deet amount)} / 4.9
The "cumulatively collected deate amount" in the formula means the total of the deet amount in the sampling liquid collected at each sampling.
[Formula for calculation of residual rate on skin]
Persistence on skin (%) = Persistence on skin of each time / Persistence on skin for 0 hour x 100
The residual amount on the skin (mg / cm ² ) was rounded to the third decimal place, and the residual rate on the skin (%) was the number rounded to the first decimal place.
The results of residual amount on the skin (mg / cm ² ) and residual rate on the skin (%) are shown in Table 3.

From the results of Table 3, compared with Comparative Example 5 in which Diet alone was used, the combination of Diet and the component (B) of the present invention (Examples 17 and 18) resulted in remaining on the skin after a certain period of time. It was revealed that the amount of diet was high and the residual rate on the skin was high.
From these results, it is understood that the pest repellent is applied to the skin for a longer time by applying it as the pest repellent agent in combination with the component (B) of the present invention rather than applying the pest repellent component such as Diet alone to the skin to be repellent It is believed to remain on top and exert a pest repellent effect. Furthermore, it is possible to suppress the penetration and absorption of the diet inside the skin, and it is possible to reduce the skin irritation very well.

<Test Example 3: Repellent Effect Confirmation Test 2 (Skin Treatment)>
The test specimen (Example 19, Comparative Example 6) shown in Table 4 was treated with about 1.34 μL / cm ² on the back of the hand, and then a rubber glove having a hole of 5 cm × 5 cm was attached to the back of the hand. As shown in FIG. 1, put the hand wearing the above rubber gloves in a metal cage (25 cm × 25 cm × 25 cm) from which Aedes albopictus (50 chicks) was released, and the number of landings on the exposed part of the back of the hand changes over time Three minutes were counted, and it was set as "the processing division landing number." The number of landings was similarly counted also about the untreated fabric which does not spray-process a test sample, and it was set as "the untreated area landing number."
The repellent rate (%) was calculated according to the formula described in “Test Example 1”, and was used as an index of the repellent effect of mosquitoes in each test sample, and evaluated in five steps according to the same evaluation criteria as “Test Example 1”.
It was determined that the repellent rate (%) after 3 hours was 70% or more, that is, the evaluation criteria “◎” to “「 ”had a practical pest repellent effect.
The composition of the test sample, the repelling effect (%) and the evaluation results of the repelling effect are summarized in Table 4.
The following were used for "B-2" in Table 4.
B-2: Alkyl acrylate / diacetone acrylamide copolymer: Plus size L-9600 (manufactured by Aka Kagaku Kogyo Co., Ltd.)

  From the results of Table 4, the component (A) pest repellent component of the present invention is combined with the component (B) (Example 19) even when directly treated on the skin in the same manner as Test Example 1 treated with fabric. It became clear that it can be considered as a pest repellent that the durability of the pest repellent effect is greatly improved as compared to the pest repellent component alone (Comparative Example 6).

  The pest repellent agent of the present invention can suppress penetration and absorption of the pest repellent component into the skin and can retain the pest repellent component on the skin surface for a long time. Thereby, even when, for example, a diet is employed as a pest repellent component, it is possible to suppress the penetration and absorption of the diet into the skin, and it is possible to extremely reduce the skin irritation. Moreover, the pest repellent agent of the present invention exerts a stable pest repellent effect for a long time because the pest repellent component stays on the skin surface for a long time.

1. Skin 2. Receptor cell 3. Stirrer 4. Water jacket 5. Heater / circulator 6. Tightening knob 7. Sampling port 8. Aluminum foil 9. Saline 10. Horizontal diffusion cell

Claims (3)

  A pest repellent agent comprising one or more selected from (A) pest repellent components, (B) shellac and alkyl acrylate / diacetone acrylamide copolymer.   An insect repellent effect maintenance improver comprising at least one selected from shellac and alkyl acrylate / diacetone acrylamide copolymers.   (B) A method for improving the persistence of a pest repellent effect by using one or more selected from shellac and alkyl acrylate / diacetone acrylamide copolymer together with (A) a pest repellent component.