JPH01172303A - Repellent for biting vermin - Google Patents

Abstract

PURPOSE:To obtain the title repellent retainable stably on the skin surface and keeping the repelling effect over a long period, by compounding N,N-diethyl- m-toluamide with castor oil. CONSTITUTION:The title repellent can be produced by compounding 1pt.wt. of N,N-diethyl-m-toluamide with 0.2-3.0pts.wt. of castor oil. The repellent is resistant to be lost from the skin surface by evaporation, transcutaneous absorption, perspiration and abrasion with clothes when applied to the skin and keeps the repelling effect over a long period. The title preparation is used as a liquid, liniment, aerosol, non-aerosol spray, etc., in the form of a solution produced by dissolving or dispersing both components in an organic solvent (preferably ethanol) or in the form of an emulsion.

Description

Detailed Description of the Invention [Industrial Application Field] The present invention relates to a repellent for biting pests, and more specifically to N-N-diethyl-m-toluamide (hereinafter referred to as D), which is a repellent component.
This invention relates to a repellent for biting insects that has a sustained effect (referred to as EET).

[Prior Art] Dimethyl phthalate, 2-
Ethyl-1,3-hexanediol etc. are known,
In recent years, 2,3,4,5-bis(Δ1~butylene)tetrahydrofurfural, DEET, and the like are known.

These repellent ingredients are put to practical use in the form of alcoholic solutions in sprays and aerosols, or in the form of creams and liniments. In particular, DEET is widely used as a repellent ingredient because it has an excellent repellent effect, does not irritate the skin, and has no unpleasant odor.

[Problems to be solved by the invention] When a repellent ingredient is applied to the skin, volatilization from the skin surface,
Absorbed through the skin, released through sweating of the skin.

It is difficult to maintain the repellent effect over a long period of time because the repellent component is easily lost from the skin surface due to friction caused by clothing, etc.

In particular, liquid agents often use alcohol as a base, and since alcohol quickly evaporates, the repellent effect lasts for a short time.

Techniques for maintaining the repellent effect include the addition of powder (Japanese Patent Application Laid-open No. 199602/1986), but powder agents stain the skin white, liquid agents require shaking before use, and spray agents require shaking before use, and spray agents require nozzle This is undesirable as it causes clogging.

[Means for Solving the Problems] As a result of intensive research to solve the above problems, the present inventors found that a liquid formulation containing DEET and castor oil coexisted with DEET.
It was discovered that the retention of the skin on the skin surface was increased, and as a result, the repellent effect lasted for a long time, and based on this knowledge, the present invention was completed.

The formulation of the present invention is a biting pest repellent containing DEET and castor oil.

In the present invention, castor oil is 0% per 1 part by weight of DEET.
．． 2 to 3.0 parts by weight, preferably 0.5 to 2.0 parts by weight. Products in this range are free from stickiness and have a good feel when used.

If necessary, 2,3,4,5-bis(△2-butylene)tetrahydrofurfural, dimethyl phthalate, 2
-Pest repellents such as ethyl-1,3-hexanediol can also be used in conjunction with DEET.

In addition, emulsifiers, potency enhancers, spreading agents, stabilizers, fragrances, and the like may also be appropriately incorporated.

The formulations of the present invention can be used as liquids, liniments, aerosols, and non-aerosol sprays.

The formulation of the present invention can be produced, for example, as follows.

That is, castor oil is added to DEET and dissolved in an organic solvent to form a solution, or an emulsion is further formed by a conventional method. This is filled into a container with a coating stopper to form a liquid agent, or filled into a liniment container to form a liniment agent. Also, this can be filled into a non-aerosol type spray device to make a spray, or it can be filled into an aerosol container together with liquefied gas to make an aerosol.

Examples of the organic solvent include alcohols (methyl alcohol, ethyl alcohol, isopropyl alcohol, ethylene glycol, propylene glycol, etc.) and ketones (diisobutyl ketone).

2-octanone, etc.), ether M (tetrahydrofuran, methyl cellosolve, dipropylene glycol ethyl ether, etc.), hydrogen ashing (kerosene, solvent naphtha, turpentine oil, etc.), and esters (ethyl acetate, butyl acetate, etc.). Can be done. Among these, it is most desirable to use alcohols, especially ethyl alcohol.

As the liquefied gas, chlorofluorocarbons (Freon 11, Freon 12, Freon F-22, etc.), liquefied petroleum gas, etc. can be used.

[Effects of the Invention] According to the present invention, it is possible to provide a repellent for biting pests whose repellent effect lasts for a long time.

[Example] Hereinafter, the present invention will be specifically explained with reference to Examples and Test Examples.

(Example 1) 5 g of castor oil was added to 5 g of DEET and dissolved in ethanol to make the total amount 50 mQ. This was combined with 50 mQ of an equal total mixture of trichloromonofluoromethane (hereinafter referred to as Freon 11) and dichlorofluoromethane (hereinafter referred to as Freon 12) and filled into an aerosol container to prepare an aerosol agent.

(Example 2) 10 g of castor oil was added to 5 g of DEET and dissolved in ethanol, and an aerosol was prepared in the same manner as in Example 1.

(Example 3) 15 g of castor oil was added to 5 g of DEET and dissolved in ethanol to prepare an aerosol in the same manner as in Example 1.

(Example 4) 2 g of castor oil was added to 710 g of DEE and dissolved in ethanol to make the total volume 100 ml. This was filled into a non-aerosol type spray container to prepare a spray.

(Example 5) 15 g of castor oil was added to DEETlog and dissolved in ethanol to make the total volume 100 ml. A liquid preparation was prepared by filling this into a container equipped with a coating stopper.

(Example 6) 12 g of castor oil was added to DEETlog and dissolved in ethanol to make the total volume 100 ml. This was filled into a liniment container to prepare a liniment agent.

Test Example (1) Sample Preparation Examples 1, 2, 3, 4. The ethanol solutions prepared in the above were designated as samples A, B, C, and D, respectively.

20 g of castor oil was added to 5 g of DEET and dissolved in ethanol to prepare a solution with a total volume of 50 ml, which was designated as sample E.

Dissolve 710g of DEE in ethanol and make 100t of total amount.
A solution named d was prepared and used as a control.

(2) Test method One group consisted of five healthy adults, and one group was assigned to each sample. The corresponding samples were uniformly applied to each group's forearms (12 cm x 5) so that the amount of DEET applied was 250, and 100 Aedes albopictus (early) animals with blood-sucking ability were released into a wire mesh cage in advance. (30c
30cm x 3 Gcm) and the repellency time was measured.

The repellent time was defined as the time required for the DEET-applied surface to be exposed for 3 minutes in a wire mesh cage every 2 hours and for the force to start sucking blood.

The results are shown in the table below.

Patent applicant: Taisho Pharmaceutical Co., Ltd. Agent Patent Attorney Tomizo Doyo

Claims (2)

[Claims] (1) A biting insect repellent containing N-N-diethyl-m-toluamide and castor oil. (2) The biting pest repellent according to claim 1, wherein 0.2 to 3.0 parts by weight of the castor oil is blended per 1 part by weight of N-N-diethyl-m-toluamide.