JP2019066689A - Individual patient-purpose three-dimensional (3d) print phantom preparation support device, individual patient-purpose three-dimensional (3d) print phantom preparation support program, and phantom as well as individual patient-purpose 3d print phantom preparation/verification support method - Google Patents

Abstract

To provide an individual patient-purpose three-dimensional (3D) print phantom preparation support device that enables dose verification of a radiation therapy plan using a 3D printer on the basis of a CT image data group, and can obtain a highly-accurate phantom in which a ray attenuation ratio of an outer shape of a human body and an organization in the human body is adjustable.SOLUTION: An individual patient-purpose 3D print phantom preparation support device of the present invention is configured to: reconstruct phantom-purpose image data on the basis of a CT image data group of a patient by image data reconstruction means 5; convert the phantom-purpose image data into 3D print data; use an output material adjusted so as to have a ray attenuation ratio simulating a ray attenuation ratio of each part of the patient on the basis of the 3D print data by a 3D printer 12 to have a body surface and soft organization corresponding to the 3D print data provided; output a phantom 21 equipped with a cavity region and a loading position; fill an equivalent substance simulating the ray attenuation ratio of a bone of the patient in the cavity region of the output phantom; and prepare a finished phantom having a dose verification measurement jig loaded at the loading position.SELECTED DRAWING: Figure 1

Description

  The present invention relates to an individual patient 3D print phantom creation support device, an individual patient 3D print phantom creation support program, a phantom, and an individual patient 3D print phantom creation / verification support method.

  In conventional radiation therapy, it is necessary to create a treatment plan so as not to be irradiated as much as possible to a normal tissue while concentrating a radiation dose, for example, on a tumor or the like using a radiation treatment planning device.

  However, since this treatment plan is calculated on a computer, it is not known whether the radiation is irradiated to the patient as calculated.

  Therefore, a phantom is used for each treatment plan of a patient to verify the accuracy of the treatment plan.

  However, conventionally used phantoms have an oval or cylindrical shape in the center, and there is a doll-shaped phantom in the shape created to simulate a human being, but the material is also X The attenuation of the ray is a homogeneous phantom, and does not accurately reflect the patient's body type actually treated and the attenuation of X-rays in the patient's body, and it is a reality that accurate verification has not been achieved. .

  As a technique related to the present invention, Patent Document 1 discloses a pre-treatment verification method in radiation therapy configured to insert an ionization chamber dosimeter into a cylindrical or elliptical phantom and perform dosimetry. Patent Document 2 discloses a phantom configured to measure a dose using a detector incorporated in advance in the phantom itself.

  However, although the techniques of Patent Document 1 and Patent Document 2 can construct a phantom close to a patient's body type, the inside of the phantom is equivalent to water and homogeneous, and reproduces typical body organs such as lungs and soft tissues. It is difficult to do the same, and as in the case described above, it can not faithfully reproduce the attenuation rate of the patient's body type and radiation (X-rays) in the body, and it includes the problem that accurate radiation treatment planning can not be verified. doing.

Japanese Patent Application Publication No. 2007-519426 JP, 2005-148033, A

  The present invention has been developed in view of the above-mentioned circumstances in the prior art, and a dose verification of a radiation treatment plan is possible using a 3D printer based on a group of CT image data of a patient used at the time of treatment planning An object of the present invention is to provide an individual patient 3D print phantom creation support apparatus capable of obtaining a high-precision phantom capable of adjusting the outer shape and the linear attenuation rate of tissue in the human body.

  The present invention is an individual patient 3D print phantom creation support apparatus for creating a phantom capable of performing dose verification of a treatment plan of radiation treatment for each patient, which is a group of CT image data of a patient imaged for radiation treatment plan Storage means for storing the image data, a process for automatically extracting phantom image data consisting of body surface, bone, soft tissue and air according to the CT value of each pixel in the CT image data group, and the image data for the phantom Data processing for filling the area of the body surface and the soft tissue with the output material of the 3D printer when outputting the 3D printer, data processing for making the bone area hollow based on the image data for the phantom, and the image for the phantom Image data reconstructing means for performing data processing for setting the loading position of the dose verification measuring instrument based on the data, and the image data Phantom image data storage means for storing the processing result of the reconstruction means, 3D print data conversion for performing the respective data processing and converting the phantom image data stored in the phantom image data storage means into 3D print data Means and an output material adjusted to have a linear attenuation rate simulating a linear attenuation rate of each part of the patient based on the 3D printing data transferred from the 3D printing data conversion means, using the output material 3D printer having a body surface corresponding to data for 3D printing, soft tissue, and outputting a phantom having a cavity area and a loading position, and a patient filled in the cavity area to make the outputted phantom a finished product The most important thing is to have an equivalent substance that simulates the rate of linear attenuation of bone and a dose verification tool to be loaded at the loading position. And features.

  According to the inventions of claims 1 and 2, it is possible to support creation of a phantom in a state of faithfully reproducing the tissue condition of an actual patient which could not be realized up to now, and by a 3D printer. For individual patients who can use the configuration to create and assemble multiple phantom elements that are integrated after printing output and become phantoms to support creation of phantoms in a state that faithfully reproduces the actual patient's tissue state A 3D print phantom creation support device can be realized and provided.

  According to the invention of claims 3 to 6, the creation support of the phantom is realized by the 3D print phantom creation support device for individual patients, and further, the CT value of each pixel of the CT image data group is more properly reflected. While being able to create a high-precision phantom, it is possible to realize subsequent data processing in which the bone area is hollowed so that the equivalent substance such as gypsum can be poured, and further optimization of the filling rate setting of the equivalent substance can be realized. A print phantom creation support program can be realized and provided.

  According to the invention of claims 7 to 10, it is possible to create and assemble a plurality of phantom elements that have a form that faithfully reproduces the actual patient's tissue condition, and are integrated after print output by the 3D printer. Furthermore, according to the CT value of the area of each element extracted from the patient's CT image data group, the linear attenuation rate of the output material of the 3D printer regarding the body surface, soft tissue, and the equivalent substance to be filled in the bone area By adjusting the filling rate, it is possible to realize and provide a phantom in which the linear attenuation rate of each region of each element can be adjusted.

  According to the invention as set forth in claims 11 and 12, the creation support of the phantom in a state of faithfully reproducing the tissue condition of the actual patient which could not be realized so far is performed or integrated after print output by the 3D printer Support the creation of multiple phantom elements to create an assembly phantom, and use the created phantom to accurately verify the accuracy of the radiation treatment plan for the patient. Can detect errors in radiation treatment plans that were difficult to achieve, and as a result, a method for creating and verifying 3D printed phantoms for individual patients that can realize more accurate and higher quality radiation treatment than ever before Can be realized and provided.

FIG. 1 is a block diagram showing an entire configuration of an individual patient 3D print phantom creation support apparatus according to an embodiment of the present invention. FIG. 2 is a flowchart showing a series of steps of the individual patient 3D print phantom creation / verification support method according to the present embodiment. FIG. 3 is a view showing an example of a CT image of a patient to be subjected to data processing by the individual patient 3D print phantom creation support device according to the present embodiment. FIG. 4 is a body surface, bone, soft tissue, air axial cross section (Axial), transverse cross section (Coronal), vertical cut surface (Sagital), extracted by the individual patient 3D print phantom creation support device according to the present embodiment. It is a figure which shows the example of a display of each image based on each image data of a body surface. FIG. 5 is a view showing a display example of a part of a sagittal image when the bone portion is set to be hollow by the individual patient 3D print phantom creation support device according to the present embodiment. FIG. 6 is a body surface, bone, soft tissue, body axial cross section (Axial), cross section (Coronal), vertical cut surface (Sagital), body surface, bone and soft tissue extracted by the individual patient 3D print phantom creation support device according to the present embodiment. It is a figure which shows the example of a display of each image at the time of setting data so that it can be divided | segmented into two with respect to each surface of each image data of a body surface. FIG. 7 shows the body surface, bone, soft tissue, body axial cross section (Axial), cross section (Coronal), and vertical cut surface (Sagital) of the body surface, bone and soft tissue extracted by the individual patient 3D print phantom creation support device according to the present embodiment. It is a figure which shows the example of a display of each image at the time of setting data so that it can divide into two with respect to each side of each image data. FIG. 8 left column, right column is a view showing an example of a two-part integral type phantom printed out by a 3D printer in the individual patient 3D print phantom creation support device according to the present embodiment.

  The present invention is based on CT image data used at the time of treatment planning making, it is possible to do dose verification of radiation treatment planning using a 3D printer, and high precision that can adjust the line attenuation rate of the human body outline and the tissue in the human body. Storage means for storing a group of CT image data of a patient imaged for radiation treatment planning, and a purpose of realizing and providing a 3D printing phantom creation support apparatus for individual patients capable of obtaining a large phantom, and the CT image data group Processing for automatically extracting image data for phantom consisting of body surface, bone, soft tissue and air according to the CT value of each pixel in 3D, and 3D region of body surface and soft tissue based on the image data for phantom Data processing for filling with output material in the 3D printer at the time of printer output, and data processing for making a bone region hollow based on the image data for phantoms, Image data reconstruction means for executing data processing for setting the loading position of the dose verification measurement tool based on the phantom image data, and phantom image data storage for storing the processing result of the image data reconstruction means Means, data conversion means for 3D printing which converts the image data for phantom stored in the image data storage means for phantom into the data for 3D printing by performing each data processing, and transferred from the data conversion means for 3D printing Body surface corresponding to the data for 3D printing, using a soft tissue, using an output material adjusted to have a linear attenuation rate simulating the linear attenuation rate of each part of the patient based on the data for 3D printing , A 3D printer that outputs a phantom having a cavity area and a loading position, and the phantom that is output as a finished product An equivalent material simulating the linear attenuation rate of the patient's bone to be filled in the cavity area and a dose verification measurement tool to be loaded at the loading position, and integrated after printing output by a 3D printer It is realized by the configuration which outputs a plurality of phantom elements which become a phantom.

  The individual patient 3D print phantom creation support device, 3D print phantom creation support program, phantom, and 3D print phantom creation / verification support method according to an embodiment of the present invention will be described in detail below with reference to the drawings.

  Here, the phantom is defined as a human-body model created by a material approximate to the human body tissue of a patient, and the following description will be made.

  This phantom can be used to calibrate the radiometer, or to obtain basic data for the patient during radiodiagnosis or radiotherapy, to achieve more accurate dosimetry, or to aid in medical care or treatment, or device performance. Have an application to check

  The individual patient 3D print phantom creation support device 1 according to the present embodiment, that is, the 3D print phantom creation support device 1 to be also referred to as patient individual verification, in other words, controls the entire device as shown in FIG. Control means 2 for performing the program, a program memory 3 storing a 3D print phantom creation support program (hereinafter simply referred to as "program"), storage means 4 for storing CT image data groups of patients imaged for radiation treatment planning, A process of automatically extracting phantom image data consisting of body surface, bone, soft tissue, air according to the CT value of each pixel in the CT image data group based on a program, based on the phantom image data The surface, the area of the soft tissue is filled with the output material in the 3D printer 11 when the 3D printer 12 outputs. Processing, data processing that makes the bone area a cavity based on the image data for phantom, data processing that sets the loading position of the dose verification measurement tool based on the image data for phantom, etc. Image data reconstructing means 5 for generating image data for image, phantom image data storing means 6 for storing the processing result of the image data reconstructing means 4 and image data storing means 6 for phantom data For example, 3D print data conversion means 7 for converting stored phantom image data into 3D print data in STL format, 3D print data storage means 8 for storing 3D print data, and 3D print data in STL format Transfer interface 9 for transfer to the outside, and display means 10 for displaying various images and the like , Input means 11 for inputting characters, numbers, etc. necessary for data processing, and each part of the patient based on the 3D print data transferred from the 3D print data storage means 8 through the transfer interface 9 Using an output material made of, for example, ABS resin etc. adjusted to have a linear attenuation rate that simulates the linear attenuation rate of the body, including a body surface corresponding to the 3D print data, a soft tissue, and equipped with a cavity area and a loading position 3D printer 12 for outputting the phantom 21 and the equivalent material such as gypsum (not shown) simulating the linear attenuation rate of the patient's bone to be filled in the hollow area in order to make the outputted phantom 21 a finished product Although not shown, a dose verification measurement tool such as a chamber apparatus is loaded at the loading position.

  Next, an individual patient 3D print phantom creation / verification support method executed using the individual patient 3D print phantom creation support device 1 according to the present embodiment described above is also shown in FIGS. 2 and 3 to 8. Refer to the description.

  First, the image data reconstruction means 5 receives the T image data of the patient in the display form shown in FIG. 3 based on the program under the control of the control means 2 in accordance with the input operation from the input means 11 of the operator. A process of automatically extracting phantom image data consisting of a body surface, bone, soft tissue and air is performed according to the CT value of each pixel in the group.

  A display example of each image of a body axial cross section (Axial), a transverse cross section (Coronal), a longitudinal cross section (Sagital), and a body surface corresponding to the extracted image data for phantom is shown in FIG.

  Next, the image data reconstruction means 5 responds to the input operation from the input means 11 of the operator, based on the image data for phantom, the area of the body surface and the soft tissue when the 3D printer 12 outputs the 3D printer 12. Data setting to be filled with the output material at 12 and data setting processing to make the bone region hollow based on the image data for phantom are executed.

  In the data setting in which the area of the body surface and the soft tissue described above is filled with the output material in the 3D printer 12 when the 3D printer 12 outputs, the material of the output material according to the average CT value of the area of the patient's body surface and the soft tissue The setting to change the filling rate arbitrarily (50 to 100%) is also performed.

  Further, in the data setting in which the bone area is hollow, after the output of the phantom 21 by the 3D printer 12, the equivalent is adjusted to have the X-ray attenuation rate equivalent to the X-ray attenuation rate of the bone in the bone area. The data setting is performed so that the material, for example, gypsum can be poured.

  FIG. 5 shows a display example of a part of a sagittal image corresponding to phantom image data for which data setting has been performed to make a bone region hollow.

  Next, the image data reconstructing means 5 determines the axial cross section (Axial), the transverse cross section (Coronal), and the longitudinal cutting specified based on the image data for the phantom according to the input operation from the input means 11 of the operator. The image data of each surface of the surface (Sagital) and the body surface is edited so as to be phantom elements 21a and 21b separated into two after the output by the 3D printer 12 at the cross section.

  At this time, data editing of the cross-sectional position, data editing of the position where the verification film is loaded on the cross section (not shown), and data editing of male and female coupling shapes so that phantom elements separated (not shown) can be united integrally Do.

  An image display example corresponding to image data of each surface of the body axial cross section (Axial), the transverse cross section (Coronal), and the vertical cross section (Sagital) specified in FIGS. 6 and 7 is shown.

  Thus, the phantom image data subjected to the various data processing as described above is stored in the phantom image data storage means 6.

  Next, the 3D print data conversion means 7 receives the image data for phantom stored in the image data storage means for phantom 6 under the control of the control means 2 in accordance with the input operation from the input means 11 of the operator. Are converted to, for example, 3D print data in the STL format.

  The converted 3D print data is stored in the 3D print data storage means 8.

  The 3D print data stored in the 3D printing data storage unit 8 is transferred to the 3D printer 12 via the transfer interface 9 in response to an input operation from the input unit 11 of the operator.

  Thereby, the 3D printer 12 simulates the linear attenuation rate of the phantom 21 composed of phantom elements 21a and 21b corresponding to the image data for phantom based on the data for 3D printing, simulating the linear attenuation rate of each part of the patient. Using the output material that it has, for example, it prints out in the form shown in FIG.

  Next, the cavity area in the printed phantom 21 is filled with an equivalent substance such as gypsum simulating the line attenuation rate of the patient's bone, and the dose verification measuring instrument such as a chamber device is loaded at the loading position in the phantom 21 output. Load to make the phantom 21 a finished product.

  The left column and the right column in FIG. 8 show an example in which phantom elements 21a and 21b formed by two divisions are connected to form an integral phantom 21.

  And the dose verification based on the treatment plan of the said patient is performed using the phantom 21 completed through the process mentioned above.

  According to the individual patient 3D print phantom creation support device 1 of the present embodiment described above, the creation support of the phantom 21 in a state of faithfully reproducing the tissue condition of an actual patient which has been impossible until now is performed. Can.

  Further, according to the individual patient 3D print phantom creation / verification support method of the present embodiment, the creation support of the phantom 21 in a state in which the tissue condition of the actual patient which has not been realized until now is faithfully reproduced Furthermore, it is possible to accurately verify the radiation treatment plan for the patient using the created phantom 21 and to detect errors in the radiation treatment plan that were difficult to detect with existing phantoms so far. As a result, it is possible to realize radiotherapy with higher accuracy and quality than ever before.

  In the prior art, although there is a technique for constructing a phantom close to the shape of a patient, the inside of the phantom in this case is water equivalent and homogeneous, and representative organs such as the patient's lung and soft tissue are high. It could not be reproduced with accuracy.

However, according to the phantom 21 according to the present embodiment, by using the CT image information group and the technique of the 3D printer 12, in the phantom 21, X-rays in voxel units corresponding to the patient's body shape and tissue in the body The rate of attenuation can be reproduced, and it is possible to more closely simulate the situation where the actual patient was irradiated.
Here, referring to the relationship between the CT value of each part included in the CT image and the output material of the 3D printer 12, the relationship between the filling ratio of the soft tissue and the CT value, and gypsum, the average CT value of the soft tissue: 12.1 ± 124.5 HU for patients, 13.0 ± 144.3 HU for phantom 21, bone: 771.5 ± 405.3 HU for patients, 439.5 ± 137.0 HU for phantom 21 it can.
In addition, soft tissue is made of PLA at a filling rate of 100%, and bone is made by mixing water and gypsum at a ratio of 2: 1.
For soft tissue, the filling rate is 10% and CT value is -850 HU, 20%-750 HU, 30%-650 HU, 40%-550 HU, 50%-450 HU, 60%-350 HU, 70% Examples are -250 HU, 80%-150 HU, 90%-50 HU, 100%-25 HU.
Furthermore, with regard to gypsum which is an equivalent substance, liquid gypsum is poured and solidified.

  That is, although it was impossible to change the X-ray attenuation rate in voxel units in the conventional technique of creating a normal mold and creating a phantom, according to the phantom 21 according to the present embodiment, Problem can be solved.

  Further referring to the individual patient 3D print phantom creation support device 1 of this embodiment and the individual patient 3D print phantom creation / verification support method, two or more regions including bone and soft tissue are extracted from the CT image data group The bone and soft tissue areas are not output by the 3D printer 12 (modeling data is automatically created), and the data is sent to the 3D printer 12 to output the phantom 21 as described above. it can.

  Then, by pouring an equivalent substance having a linear attenuation rate equal to that of bone and soft tissue into the area (cavity) corresponding to bone and soft tissue generated by not outputting, the X reduction rate in the patient's external body and in the body It is also possible to create a phantom 21 which can faithfully reproduce V in units of voxels.

  At this time, it is important that the equivalent substance poured into the space of the bone and the soft tissue has a structure which does not leak out.

  Also, in the created phantom 21, a chamber apparatus for measuring the dose of X-rays at any position, a film, or a structure to which any structure can be inserted can be optionally modeled.

  Furthermore, the 3D printer 12 can output as a structure that can be completed as a phantom 21 in which two phantom elements 21a and 21b in a divided state are joined together and integrated.

  In addition, it is possible to fill in a hole with another material at a portion where another structural element is in contact in the target region into which the equivalent substance is to be poured to prevent leakage to the outside.

  Furthermore, in the target area into which a substance having a radiation attenuation rate equivalent to that of bone and soft tissue is to be poured, an area which is completely in contact with neither the outside of the body surface nor the cut surface and is completely contained in the other area By automatically generating a connection to any of the outside of the body, the cut surface, and another area, it is possible to allow the substance to flow from the outside.

  Furthermore, in the phantom 21 to be created, various dosimeters such as an ionization chamber dosimeter, a film or a structure capable of inserting an arbitrary structure at an arbitrary position can be easily set by data setting of image data for phantom transferred to the 3D printer 12 Can be realized.

  Further, regarding the program, according to the CT value of each pixel of the CT image data group of the patient imaged for the radiation treatment plan, the image data for phantom consisting of body surface, bone, soft tissue and air is automatically made. In the extraction process, based on the CT value of the output material of the 3D printer 12 measured in advance, the filling rate of the equivalent substance for reproducing a region having a CT value different from the CT value of the output material is automatically made. It is also possible to add data processing to be calculated and to replace the area with grid-like or honeycomb-like pattern data based on the calculated filling factor, thereby adjusting the output material for the phantom 21 by the 3D printer 12 It is possible to obtain a high accuracy phantom 21 that more accurately reflects the CT value of each pixel of the CT image data group by the output material having a more appropriate CT value That.

  Further, regarding the program, according to the CT value of each pixel of the CT image data group of the patient imaged for the radiation treatment plan, the image data for phantom consisting of body surface, bone, soft tissue and air is automatically made. In the process of extraction, an internal region with a low CT value is further extracted from the image of the extracted bone region, and a portion corresponding to the volume of the internal region is eliminated from the outside, thereby hollowing the shape of the bone region inside. It is also possible to add data processing to replace the data of bone shape having equivalent volume which does not have, so that the subsequent data processing to make the bone area hollow so that equivalent material such as gypsum can be poured, and further equivalent It is possible to realize the setting of the filling rate of the substance properly.

  The phantom according to the present invention can be suitably used as preparation and verification of a treatment plan in radiation therapy and as a calibration phantom of a radiation generating apparatus. Furthermore, the present invention can be widely applied as a phantom creation support technique based on magnetic resonance tomographic images (MRI tomographic images), positron emission tomographic images, etc., in addition to X-ray computed tomography images.

1 individual patient 3D print phantom creation support device 2 control means 3 program memory 4 storage means 5 image data reconstruction means 6 phantom image data storage means 7 3D print data conversion means 8 3D print data storage means 9 transfer interface 10 display Means 11 Input means 12 3D printer 21 phantom 21a phantom element 21b phantom element

Claims (12)

An individual patient 3D printed phantom creation support apparatus for creating a phantom capable of performing dose verification of a treatment plan of radiation therapy for each patient,
Storage means for storing a group of CT image data of a patient imaged for radiation treatment planning;
A process for automatically extracting phantom image data consisting of body surface, bone, soft tissue and air according to the CT value of each pixel in the CT image data group, body surface based on the phantom image data, soft Data processing that fills the area of the tissue with the output material in the 3D printer when the 3D printer is output, data processing that makes the bone area the cavity based on the image data for phantom, dose verification measurement based on the image data for phantom Image data reconstructing means for executing data processing for setting the loading position of the tool;
Phantom image data storage means for storing processing results of the image data reconstruction means;
3D print data conversion means for performing the respective data processing and converting the phantom image data stored in the phantom image data storage means into 3D print data;
For 3D printing using an output material adjusted to have a linear attenuation rate simulating a linear attenuation rate of each part of the patient based on the 3D printing data transferred from the 3D printing data conversion means A 3D printer that outputs a phantom having a body surface corresponding to data, soft tissue, and a cavity area and a loading position;
An equivalent substance simulating a linear attenuation rate of a patient's bone to be filled in the cavity region and a dose verification measurement tool to be loaded at the loading position, in order to make the output phantom a finished product;
An individual patient 3D printing phantom creation support device characterized by having.   In the image data for phantom in the image data reconstruction means, in addition to the extraction data of body surface, bone, soft tissue, air, two or more regions including at least bone and soft tissue are extracted, and one or more further The data includes a set cutting plane, and the 3D printer outputs a plurality of phantom elements that are divided according to the set cutting plane and integrated after printing output to become a phantom. Item 3. The individual patient 3D printing phantom creation support device according to item 1. An individual patient 3D printed phantom creation support program for creating a phantom capable of performing dose verification of a treatment plan of radiation therapy for each patient,
A process of automatically extracting image data for a phantom consisting of body surface, bone, soft tissue and air according to the CT value of each pixel of a patient's CT image data group imaged for radiation treatment planning;
Data processing for filling the area of the body surface and the soft tissue with the output material of the 3D printer when the 3D printer is output;
Data processing in which the bone area is hollow;
Data processing for setting the loading position of the dose verification measuring instrument based on the image data for the phantom;
Computer-executable 3D print phantom creation support program for individual patients. The process for automatically extracting phantom image data consisting of body surface, bone, soft tissue, and air according to the CT value of each pixel of the patient's CT image data group imaged for the radiation treatment plan,
4. The individual patient 3D print phantom creation support program according to claim 3, further comprising data processing for extracting two or more regions including at least bone and soft tissue and setting one or more cut surfaces. The process for automatically extracting phantom image data consisting of body surface, bone, soft tissue, and air according to the CT value of each pixel of the patient's CT image data group imaged for the radiation treatment plan,
Based on the CT value of the output material of the 3D printer measured in advance, the filling factor of the equivalent substance for reproducing the area having a CT value different from the CT value of the output material is automatically calculated, and the area is The 3D print phantom creation support program for an individual patient according to claim 3 or 4, further comprising data processing for replacing with grid or honeycomb pattern data based on the calculated filling rate. The process for automatically extracting phantom image data consisting of body surface, bone, soft tissue, and air according to the CT value of each pixel of the patient's CT image data group imaged for the radiation treatment plan,
An internal volume with a low CT value is further extracted from the image of the extracted bone area, and an equivalent volume without a cavity inside of the shape of the bone area is deleted by removing from the outside an amount corresponding to the volume of the internal area. The 3D print phantom creation support program for individual patients according to any one of claims 3 to 5, comprising data processing to be replaced with data of bone shape having. A phantom capable of performing dose verification of treatment plan for radiation therapy for each patient,
The area of body surface, bone, soft tissue, air is set according to the CT value of the CT image data group of the patient imaged for radiation treatment planning, and the area of body surface, soft tissue is output material in 3D printer Image data for phantom is set with data to be filled in, data to be hollowed in the bone area, and data to be loaded in the dose verification measurement tool is converted to data for 3D printing, and the line of each part of the patient A 3D printer using an output material having a linear attenuation rate that simulates an attenuation rate to obtain a phantom comprising a body surface, soft tissue, a cavity area and a loading position,
A phantom characterized in that the hollow area is filled with an equivalent substance simulating a linear attenuation rate of a patient's bone, and a dose verification measurement tool is loaded at the loading position to obtain a finished product.   8. The phantom according to claim 7, wherein the phantom is an integrated unit of a plurality of phantom elements divided and output corresponding to a cutting plane previously set by the 3D printer after print output. .   The linear attenuation ratio of each region of each element can be adjusted by adjusting the linear attenuation ratio of the output material of the 3D printer and the filling ratio of the equivalent substance. Or the phantom according to 8.   Adjust the linear attenuation rate of the output material of 3D printer for soft tissue and the filling rate of equivalent substance to be filled in the bone area according to the CT value of the area of each element extracted from the patient's CT image data group The phantom according to any one of claims 7 to 9, wherein the linear attenuation rate of each region of each element is adjustable. An individual patient 3D printed phantom creation / verification support method for creating a phantom capable of performing dose verification of a treatment plan for radiation therapy for each patient and performing dose verification,
Automatically extracting phantom image data consisting of body surface, bone, soft tissue and air according to the CT value of each pixel of the patient's CT image data group imaged for radiation treatment planning;
Performing data setting in which the region of the body surface and the soft tissue is filled with the output material in the 3D printer at the time of the 3D printer output based on the image data for phantoms;
Performing data setting in which a bone region is made hollow based on the image data for phantoms;
Setting data of the loading position of the dose verification measuring instrument based on the image data for the phantom;
Converting the phantom image data for which the above-described data settings have been made into data for 3D printing;
Outputting a phantom corresponding to the image data for a phantom by a 3D printer based on the data for 3D printing using an output material having a linear attenuation rate simulating a linear attenuation rate of each part of the patient;
Filling the cavity region in the output phantom with an equivalent substance simulating the linear attenuation rate of the patient's bone, and loading a dose verification measurement tool at the loading position in the output phantom to make the phantom a finished product;
Performing a dose verification based on the treatment plan of the patient using the completed phantom;
An individual patient 3D printing phantom creation / verification support method characterized by including.   According to the CT value of each pixel of the CT image data group of the patient imaged for the radiation treatment plan, at least the step of automatically extracting the image data for phantom consisting of body surface, bone, soft tissue and air The method according to claim 11, further comprising the steps of extracting two or more regions including bone and soft tissue and further setting one or more cut surfaces as data. .