CN106310529B - Body mould and a kind of human body simulation body mould for Radiotherapy dosimetry measurement - Google Patents
Body mould and a kind of human body simulation body mould for Radiotherapy dosimetry measurement Download PDFInfo
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- CN106310529B CN106310529B CN201610798097.4A CN201610798097A CN106310529B CN 106310529 B CN106310529 B CN 106310529B CN 201610798097 A CN201610798097 A CN 201610798097A CN 106310529 B CN106310529 B CN 106310529B
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- A61N5/00—Radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
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Abstract
The present invention discloses a kind of Radiotherapy dosimetry that is used for and measures body mould and a kind of human body simulation body mould, the body mould includes the corresponding with various pieces and consistent with true form of the threedimensional model drafting based on medical image and the three-dimensional thin layer ghost component obtained by 3D printing, equivalent filler or/and radiation dose measurement material is separately filled with three-dimensional thin layer ghost component corresponding with various pieces, body mould is assembled by each three-dimensional thin layer ghost component for being filled with equivalent filler or radiation dose measurement material according to human anatomic structure.Body mould based on the present invention can be realized carries out the measurement of 3D personalizations Radiotherapy dosimetry according to demand, and body mould provided by the invention simulation human anatomic structure, appearance profile and tumor anatomical structure to greatest extent, the exposure dosage measured provides more valuable more reliable laboratory reference closer to actual value for the implementation of radiotherapy planning.
Description
Technical field
The present invention relates to radiotherapy technology field, more particularly to a kind of Radiotherapy dosimetry measuring method and one kind to be used for radiotherapeutic agents
The body mould of measurement, further relate to a kind of human body simulation body mould.
Background technology
Radiotherapy（That is radiotherapy）It is one of three big means of current treatment tumour, refers to the ray with various different-energies
Irradiate tumour, a kind for the treatment of method for the purpose of suppressing and kill cancer cell.Because tumour cell is destroyed and killed to radioactivity
While, also have destruction to normal surrounding tissue cell, thus the target of radiotherapy be increase as far as possible tumor target by
Exposure dose, and reduce the exposure dosage of the histoorgan around tumor target as far as possible simultaneously.Thus, obtain patient tumors
The exposure dosage of target area and surrounding tissue organ has important meaning to improving the control rate of tumour and reducing radiotherapy radiation.
At present, the exposure dosage for obtaining patient typically passes through TPS（Treatment Planning System, radiation are controlled
Treat planning system）Calculating acquisition is carried out according to the target area image sketched out, but what this mode obtained is theoretical value, it is not actual
Exposure dosage.And when being treated by radiotherapy to patient, only know the actual exposure dosage of patient, can be more
Dosage during radiotherapy is held well, to avoid the excessive caused extra dose of dosage and the very few caused tumour of dosage high
Recurrence rate.
And Radiotherapy dosimetry is measured, currently used method is with unified a body mould or measuring apparatus（Such as Delta4 and
The three-dimensional measurement instrument based on center probe matrix such as ArcCHECK4D）To simulate human body, to carry out the measurement of Radiotherapy dosimetry.This
Kind mode effectively measuring can adjust strong and three-dimensional conformal Radiotherapy dosimetry, but because they are canonical measure component, it is impossible to
Measuring condition is freely defined according to patient's actual anatomical structures, contours profiles and tumor anatomical structure, thus necessarily causes to survey
It is not exclusively accurate to measure result, i.e., can not obtain the actual exposure dosage of tumor target and dosage distribution situation.
The content of the invention
According to an aspect of the invention, there is provided a kind of implement for the body mould of Radiotherapy dosimetry measurement and by the body mould
Measuring method, it is at least one with what is solved the above problems.Meanwhile according to another aspect of the present invention, additionally provide one kind
Corresponding human body simulation body mould.The body mould for being used for Radiotherapy dosimetry measurement of the present invention is obtained by the following method：
Measurement target is obtained according to demand, and three-dimensional modeling is carried out to the irradiation sections comprising the measurement target, and by institute
The various pieces for stating irradiation sections are depicted as the three-dimensional thin layer ghost component consistent with true form；
Each three-dimensional thin layer ghost component is subjected to 3D printing, and the filling material of the three-dimensional thin layer ghost component to printing
Material, including to three-dimensional thin layer ghost component corresponding to measurement target, be filled by radiation dose measurement material, and to it
Remaining three-dimensional thin layer ghost component, is filled by equivalent filler；
The each three-dimensional thin layer ghost assembling components for filling good material are formed into an entirety according to human anatomic structure
Human body simulation body mould；
Wherein, the equivalent filler refers to the material similar to the attribute of human body appropriate section reception radiation.
Human body simulation body mould made from design based on the present invention include that threedimensional model based on medical image draws with
Various pieces are corresponding and consistent with true form and the three-dimensional thin layer ghost component that is obtained by 3D printing, with various pieces
Equivalent filler or/and radiation dose measurement material is separately filled with corresponding three-dimensional thin layer ghost component, the body mould is by filling out
Filled each three-dimensional thin layer ghost component of equivalent filler or radiation dose measurement material according to human anatomic structure assembling and
Into.
And the method that the improvement design based on the body mould carries out Radiotherapy dosimetry measurement includes：
Measurement target is obtained according to demand, and three-dimensional modeling is carried out to measurement target, obtains the threedimensional model of measurement target；
Threedimensional model is subjected to 3D printing, and the threedimensional model packing material to printing；
According to the threedimensional model of filling good material, simulation body mould is irradiated；
Body mould after irradiation is handled, measures exposure dosage.
Thus, it is possible to the measurement of Radiotherapy dosimetry is carried out according to the practical structures of measurement target and contours profiles, can be accurate
The actual exposure dosage of measurement target is obtained, realizes and carries out the measurement of 3D personalizations Radiotherapy dosimetry according to demand.To greatest extent
Simulation human anatomic structure, appearance profile and tumor anatomical structure, the exposure dosage measured is closer to actual value, to put
The implementation for treating plan provides more valuable more reliable laboratory reference data, effectively to prevent radiation therapy delivery process middle dosage excessive
The radiation brought and the very few high relapse rate brought.
In some embodiments, measurement target includes target area and histoorgan.Realize simultaneously to target area and histoorgan
The measurement of exposure dosage is carried out, the exposure dosage of target area and the exposure dosage of histoorgan can be detected, reduced to group
The radiation pollution of organ is knitted, so as to reduce radiotherapy radiation as far as possible.
In some embodiments, when it is target area to measure target, measurement target is obtained according to demand, and measurement target is entered
Row three-dimensional modeling, obtaining the threedimensional model of measurement target includes：Positioning obtains the medical image of measurement target, and according to measurement need
Seek carry out Target delineations；According to the medical image of acquisition and the tumor target image sketched out, three-dimensional modeling is carried out, it would be desirable to enter
The various pieces of row radiotherapy irradiation are depicted as the three-dimensional thin layer ghost component consistent with true form, wherein the drafting to target area is thin
Change to each target area, including draw out tumor target, clinical target area and plan field.Thus, it is possible to according to circumstances, pass through three-dimensional
Modeling freely define measurement target, by carrying out three-dimensional modeling by true form, also so that the threedimensional model exported is closer to people
Body real anatomy, appearance profile and tumor anatomical structure, so as to realize the measurement of 3D personalization Radiotherapy dosimetries.And it will survey
The target area of amount refine to each TV, can realize with reference to different sufferer demands and various actual conditions, to the target area of different TV
Actual exposure dosage measure, the accuracy of measurement result is improved, rationally to be adjusted according to actual conditions to greatest extent
Whole exposure dose.
In some embodiments, when it is histoorgan to measure target, measurement target is obtained according to demand, to measuring mesh
Mark carries out three-dimensional modeling, obtains the threedimensional model of measurement target and includes：Positioning obtains the medical image of measurement target, according to acquisition
Medical image, carry out three-dimensional modeling, it would be desirable to the various pieces for carrying out radiotherapy irradiation are depicted as three consistent with true form
Tie up thin layer ghost component.Thus, by the real simulation of three-dimensional modeling, Radiotherapy dosimetry measurement can be not only carried out to target area, also
Radiotherapy dosimetry measurement can be carried out to all histoorgans according to demand, so as to detect other histoorgans to radiotherapy
Real reaction, reference and support are provided to reduce radiotherapy side effect.
In some embodiments, threedimensional model is subjected to 3D printing, and the threedimensional model packing material bag to printing
Include：Each three-dimensional thin layer ghost component is printed using 3D printer；Three-dimensional thin layer ghost component to measuring target, filling are put
Penetrate dosage measurement material；To remaining three-dimensional thin layer ghost component, filled by equivalent filler.Thus, by being radiated
Dosage measurement material and equivalent filling, human body target area and histoorgan can be gone out with real simulation, can effective guarantee measure
Exposure dose accuracy.Meanwhile each three-dimensional thin layer ghost component is printed and filled respectively, it is possible to achieve as needed
Selection measurement target is handled, and so that individualized measurement is better achieved, meets different measurement demands.
In some embodiments, according to populated threedimensional model, simulation body mould be irradiated including：Will filling
Good each three-dimensional thin layer ghost assembling components form human body simulation body mould into an entirety；Position condition is put according to patient is actual
Pendulum position is carried out to body mould, and body mould is irradiated according to equivalent radiotherapy planning.Thus, it is possible to according to the actual dissection of human body
Structure and knub position, real body mould is simulated, and radiotherapy is implemented according to actual radiotherapy condition, to survey to greatest extent
Actual exposure dose is measured, the reference experiment data of most worthy are provided for the implementation of radiotherapy planning.
In some embodiments, the body mould after irradiation is handled, measuring exposure dosage includes：From body mould
Three-dimensional thin layer ghost component corresponding to measurement target is taken out, and respectively from three-dimensional thin layer ghost component corresponding to each measurement target
Take out the radiation dose measurement material of filling；The radiation dose measurement material of taking-up is respectively processed, obtains absorbed dose of radiation
Value, to obtain the exposure dosage of each measurement target.Thus, it is possible to obtain as needed three-dimensional thin corresponding to corresponding measurement target
The packing material of exposure in layer ghost component is detected, to realize according to demand respectively to enter different measurement targets
Row detection, it is not necessary to which the repetition carried out again to different measurement targets repeatedly is tested, more convenient, improves efficiency.
In some embodiments, radiation dose measurement material is thermoluminescence material, to the radiation dose measurement material of taking-up
Material is respectively processed, and obtains absorbent value, is included with obtaining the exposure dosage of each measurement target：Pass through thermoluminescence material
Processing equipment is respectively heated to the thermoluminescence material of taking-up, and the energy exported according to the thermoluminescence material after heating, is obtained
Radiation agent value is taken, to obtain measuring the exposure dosage of target.Thus, it is possible to using existing equipment, to having measured target
The exposure dose of absorption is detected, and obtains actual exposure dosage, simple and convenient.
In some embodiments, histoorgan is jeopardizes histoorgan and plan jeopardizes histoorgan.By to jeopardizing
The measurement of the actual exposure dosage of histoorgan, can reduce the radiation to peripheral organs.And by jeopardizing tissue to plan
Organ carries out the measurement of exposure dosage, and patient is taken into account in situations such as Set-up errors, physical displacement of radiation therapy delivery process
Come, can more efficiently reduce radiotherapy radiation.
In some embodiments, medical image is CT images or MRI image.Three-dimensional is carried out according to CT or MRI image to build
Mould, altitude simulation human anatomic structure, contours profiles and tumor structure can be realized, so as to ensure the accurate of measurement structure
Rate.
Brief description of the drawings
Fig. 1 is the method flow schematic diagram of the Radiotherapy dosimetry measuring method of one embodiment of the present invention；
Fig. 2 is the method flow schematic diagram of the Radiotherapy dosimetry measuring method of another embodiment of the present invention；
Fig. 3 is the method flow schematic diagram of the Radiotherapy dosimetry measuring method of a further embodiment of this invention.
Embodiment
Embodiments of the present invention are described in detail below in conjunction with the accompanying drawings.
Fig. 1 schematically shows the method for Radiotherapy dosimetry measuring method according to one embodiment of the present invention
Flow chart.As shown in figure 1, this method includes：
Step S101：Three-dimensional modeling is carried out to measurement target, obtains the threedimensional model of measurement target.
According to the state of an illness of patient and dissection structure choice Radiotherapy dosimetry measurement target, and selectivity is carried out to measurement target and built
Mould, sketch out the threedimensional model of measurement target.When being modeled to measurement target, typically medical science figure is obtained by positioning first
Picture, so that the various pieces for measuring target are depicted as into the three-dimensional thin layer ghost component consistent with true form according to medical image.
Step S102：3D printing, and the threedimensional model packing material to printing are carried out to three-dimensional modeling.
, will be each using 3D printer after various pieces to be depicted as to the three-dimensional thin layer ghost component consistent with true form
Individual three-dimensional thin layer ghost component prints, to obtain the threedimensional model of corresponding ghost component.After carrying out 3D printing, it is also necessary to
Equivalent filling is carried out to ghost component.Wherein, equivalent here refers to that two kinds of materials receive the attribute of radiation（Keep off in other words
The ability of ray）It is similar, for example the muscle of people is similar to certain material to the reception attribute of radiation, then can is by this thing
Matter is filled as the equivalent of muscle, i.e., ghost component corresponding to muscle is filled up into this material, and fills this thing
The ghost component of matter is equivalent to histoorgan corresponding to muscle.
Preferably, in an embodiment of the present invention, the filling for measuring target can be used as using selective emission dosage measurement material
Thing, select the filler equivalent as other histoorgans, the i.e. three-dimensional thin layer ghost component in the measurement target printed
Middle filling radiation dose measurement material, and fill equivalent filler in remaining the three-dimensional thin layer ghost component printed.
Step S103：Populated threedimensional model simulation human body is subjected to radiotherapy irradiation.
Populated each three-dimensional thin layer ghost component is assembled into an entirety according to human anatomic structure, to form people
Body analogue body mould.Afterwards, pendulum position is carried out to analogue body mould according to the actual position condition of putting of patient, and according to equivalent radiotherapy planning pair
Analogue body mould is irradiated.
Step S104：Threedimensional model after irradiation is handled, measures exposure dosage.
After being irradiated with identical condition to analogue body mould, taken out from analogue body mould three-dimensional corresponding to measurement target
Thin layer ghost component, and the radiation dose measurement material of filling is taken out from three-dimensional thin layer ghost component, with the radiation to taking-up
Dosage measurement material is handled, and so as to obtain absorbent value, the dose value that is to say the exposure dosage of measurement target.
Wherein it is preferred to the measurement target in the embodiment of the present invention both can be target area or other organizers
Official, as jeopardized histoorgan or other normal structure organs for needing to measure Radiotherapy dosimetry around target area.Doctor in embodiment
Image is learned, both can be the CT that positioning obtains（Computed Tomography, CT scan）Image, also may be used
Be positioning obtain MRI（Magnetic Resonance Imaging, magnetic resonance imaging）Image.Radiological agent in embodiment
Measurement material is preferably thermoluminescence material.
Fig. 2 to measure target as tumor target, medical image is CT images, radiation dose measurement material is thermoluminescence material
Exemplified by, schematically show to tumor target carry out Radiotherapy dosimetry measurement method flow.As shown in Fig. 2 this method bag
Include：
Step S201：Positioning obtains CT images, and carries out Target delineations to CT images.
In this step, it is necessary first to obtain CT images by positioning CT scan, and software is delineated by 3D tumor targets
Target delineations are carried out to the CT images scanned.Wherein, each TV to be refine to delineating for target area（Target Volume）,
Including sketching out tumor target（GTV）, clinical target area（CTV）, plan field（PTV）, treatment region（TV）And irradiated region（IV）.
Step S202：Three-dimensional modeling is carried out according to the tumor target image and CT images sketched out, by each of CT images
Part is depicted as the three-dimensional thin layer ghost component consistent with true form, and the drafting to target area refine to each TV.
According to CT images and the tumor target image sketched out, the section that human body needs to carry out radiotherapy irradiation is passed through into three-dimensional
Modeling software（It is preferred that technical grade）Draw out.Wherein, when drawing, the embodiment of the present invention preferably delineates into each part
The three-dimensional thin layer ghost component consistent with true form.For example for tumor target, sketch out corresponding with the shape of tumor target
Three-dimensional thin layer ghost component, for clinical target area, delineate for three-dimensional thin layer ghost corresponding to the true form of clinical target area
Component etc..In the present embodiment, it is necessary to the irradiation area drawn by 3 d modeling software include target area, soft tissue, bone,
Cavity and circumference.Wherein, the drafting to target area needs to refine to each TV, the drafting to soft tissue needs to refine to fat
Fat, muscle etc., the drafting to bone need to refine to different sclerotin, to ensure the high simulating degree with human anatomic structure, to realize
Individualized measurement is carried out according to the actual conditions of patient.
Step S203：Each three-dimensional thin layer ghost component is printed using 3D printer.
Each three-dimensional thin layer ghost component that three-dimensional modeling is obtained is printed by 3D printer, so as to obtain with respectively
The 3D models of multiple three-dimensional thin layer ghost components corresponding to individual part.
Step S204：The ghost component corresponding to thermoluminescence material filling target area, and equivalent filler is filled corresponding to use
Remaining ghost component.
Thermoluminescence material is filled in the model of three-dimensional thin layer ghost component corresponding to each target area, and in remaining ghost group
Equivalent filler corresponding with the part is filled in the model of part, for example, for the model of ghost component corresponding to soft tissue, is filled out
Fill equivalent corresponding with soft tissue；And in the model of ghost component corresponding with bone, fill equivalent corresponding with bone.It is right
The lexical or textual analysis of equivalent, referring to describing above.Suitable material is filled by three-dimensional modeling and in the ghost component model printed
Material, can simulation actual anatomical structures, contours profiles and tumor anatomical structure to greatest extent.
Step S205：By each populated ghost assembling components adult body analogue body mould.
By populated each ghost component, including ghost component corresponding to target area, ghost component, bone corresponding to soft tissue
Ghost component corresponding to ghost component corresponding to corresponding ghost component, cavity and circumference, tied according to the actual dissection of human body
Structure is assembled, so as to obtain human body simulation body mould.Due to being to draw modeling by true form and ghost component has been carried out etc.
Thing filling is imitated, so the human body simulation body mould now obtained being capable of the real structure of simulation human body, contours profiles to greatest extent
And tumor anatomical structure, it is the key for realizing personalized Radiotherapy dosimetry measurement.
Step S206：According to actual pendulum position mode and radiotherapy planning, human body simulation body mould is irradiated.
Simulation model is given according to the actual condition of irradiating of patient and irradiated, actual irradiation condition by identical for example including being put
Position carries out putting position and implements irradiation etc. according to identical radiotherapy planning to analogue body mould.Thus, can obtain effective and accurate
Actual exposure dose value.
Step S207：Ghost component corresponding to target area is taken out from the analogue body mould after irradiation, to corresponding to different TV
Ghost component carries out thermoluminescence processing respectively, obtains the actual exposure dosage of each TV target area.
After being irradiated, ghost component corresponding to each target area is taken out from analogue body mould, carries out thermoluminescence processing respectively,
To obtain the actual exposure dosage of corresponding target area, such as to tumor target, clinical target area and plan field, it is taken out respectively
Corresponding ghost component, and thermoluminescence processing is individually carried out to ghost component corresponding to tumor target, to obtain tumor target
Actual exposure dosage, thermoluminescence processing is also individually carried out for ghost component corresponding to clinical target area, to obtain clinical target area
Actual exposure dosage, other target areas are similarly individually handled, to obtain correspondingly actual exposure dosage.At thermoluminescence
Reason specifically includes the thermoluminescence material for being taken out from corresponding ghost component and having received irradiation, and is set by thermoluminescence material process
The standby thermoluminescence material to taking-up heats, and then thermoluminescence material processing apparatuses can export to the thermoluminescence material after heating
Energy measure, and output radiation dose value can obtain actual exposure dosage by reading the dose value.Thus,
Just the measurement to the Radiotherapy dosimetry of target area is realized.
Fig. 3 using measure target as jeopardize histoorgan, medical image is MRI image, radiation dose measurement material is that heat is released
Exemplified by luminescent material, the method flow for carrying out the measurement of Radiotherapy dosimetry to jeopardizing histoorgan is schematically showed.Such as Fig. 3 institutes
Show, this method includes：
Step S301：Positioning obtains MRI image, three-dimensional modeling is carried out according to MRI image, by the various pieces of MRI image
The three-dimensional thin layer ghost component consistent with true form is depicted as, the drafting for jeopardizing histoorgan is painted according to measurement demand selection
Scope and shape processed.
The MRI image for jeopardizing histoorgan for needing to measure is obtained by positioning MRI, the 3-D view that MRI is rebuild turns
The 3-D view of technical grade 3 d modeling software is changed to, such as can need to be put by human body according to the MRI image of acquisition
The section for treating irradiation passes through 3 d modeling software（It is preferred that technical grade）Draw out.Wherein, when drawing, the embodiment of the present invention is excellent
Each part is depicted as the three-dimensional thin layer ghost component consistent with true form by choosing.Need what is drawn in the embodiment of the present invention
Part includes jeopardizing histoorgan, soft tissue, bone, cavity and circumference.Wherein, it is contemplated that human body may in actually irradiating
Situation about being shifted over, in order to improve the accuracy for the actual exposure dosage measured, the measurement target part also drawn out
Histoorgan can also be jeopardized including plan.Wherein, to jeopardizing histoorgan and when plan jeopardizes histoorgan and drawn,
The all or part of graphics of measurement destination organization organ can be drawn as needed, the drafting to soft tissue needs to refine to
Fat, muscle etc., the drafting to bone need to refine to different sclerotin, to ensure the high simulating degree with human anatomic structure, with reality
Now individualized measurement is carried out according to the actual conditions of patient.
Step S302：Each three-dimensional thin layer ghost component is printed using 3D printer.
Each three-dimensional thin layer ghost component that three-dimensional modeling is obtained is printed by 3D printer, so as to obtain with respectively
The 3D models of multiple three-dimensional thin layer ghost components corresponding to individual part.
Step S303：Jeopardize ghost component corresponding to histoorgan with the filling of thermoluminescence material, and equivalent corresponding to using fill out
Fill thing and fill remaining ghost component.
Thermoluminescence material is filled in the model of three-dimensional thin layer ghost component corresponding to histoorgan is jeopardized, and at remaining
Equivalent filler corresponding with the part is filled in the model of ghost component, for example, for ghost component corresponding to soft tissue
Model, fill equivalent corresponding with soft tissue；And in the model of ghost component corresponding with bone, filling is corresponding with bone etc.
Imitate thing.Lexical or textual analysis to equivalent, referring to describing above.Fill by three-dimensional modeling and in the ghost component model printed and close
Suitable material, can simulation actual anatomical structures, contours profiles and tumor anatomical structure to greatest extent.
Need what is illustrated, in the case where the plan of depicting jeopardizes histoorgan, histoorgan pair is jeopardized to plan
The model for the three-dimensional thin layer ghost component answered also fills thermoluminescence material, i.e. plan jeopardizes histoorgan and also serves as dosage measurement mesh
Mark, to improve the validity of measurement result and reliability.
Step S304：By each populated ghost assembling components adult body analogue body mould.
By populated each ghost component, including jeopardize histoorgan and plan jeopardizes ghost group corresponding to histoorgan
It is empty corresponding to ghost component corresponding to part, soft tissue, ghost component corresponding to bone, ghost component corresponding to cavity and circumference
Shell component, assembled according to human body actual anatomical structures, so as to obtain human body simulation body mould.Due to being drawn by true form
Modeling and equivalent filling is carried out to ghost component, so the human body simulation body mould now obtained being capable of simulation to greatest extent
The real structure of human body and contours profiles, it is the key for realizing personalized Radiotherapy dosimetry measurement.
Step S305：According to actual pendulum position mode and radiotherapy planning, human body simulation body mould is irradiated.
Simulation model is given according to the actual condition of irradiating of patient and irradiated, actual irradiation condition by identical for example including being put
Position carries out putting position and implements irradiation etc. according to identical radiotherapy planning to analogue body mould.Thus, can obtain effective and accurate
Actual exposure dose value.
Step S306：From the analogue body mould after irradiation take out jeopardize ghost component corresponding to histoorgan, to need into
The ghost component corresponding to histoorgan that jeopardizes of row measurement carries out thermoluminescence processing respectively, obtains the reality for respectively jeopardizing histoorgan
Exposure dosage.
After being irradiated, taken out from analogue body mould and jeopardize ghost component corresponding to histoorgan, depicting plan
In the case of jeopardizing histoorgan, in addition to taking-up plan jeopardizes histoorgan, and is endangered respectively to jeopardizing histoorgan and plan
And ghost component corresponding to histoorgan carries out thermoluminescence processing, to obtain the actual exposure dosage of corresponding histoorgan,
Such as jeopardize histoorgan to jeopardizing histoorgan and plan, its corresponding ghost component is taken out respectively, and to jeopardizing organizer
Ghost component individually carries out thermoluminescence processing corresponding to official, to obtain the actual exposure dosage for jeopardizing histoorgan, for meter
Draw and jeopardize the also individually progress thermoluminescence processing of ghost component corresponding to histoorgan, jeopardize the reality of histoorgan with acquisition plan
Exposure dosage.Thermoluminescence processing specifically includes the thermoluminescence material for being taken out from corresponding ghost component and having received irradiation, and
The thermoluminescence material of taking-up is heated by thermoluminescence material processing apparatuses, then thermoluminescence material processing apparatuses can pair plus
The energy of thermoluminescence material output after heat measures, and output radiation dose value, by the dose value for reading output
Obtain actual exposure dosage.Thus, just realize and jeopardize the Radiotherapy dosimetry of histoorgan to jeopardizing histoorgan and plan
Measurement.
By the method for the embodiment of the present invention, can implement to customize measurement as needed, i.e., according to different demands or
Different sufferer situation of person etc., positioning obtains the medical image for the target for needing to measure, and carries out three-dimensional according to medical image and build
Mould, the three-dimensional thin layer ghost component model of measurement target is obtained, ghost component is subjected to 3D printing and equivalent is filled, you can mould
Actual human anatomic structure, contours profiles and tumor structure are drawn up, so as to be irradiated by actual irradiation condition, to realize radiotherapy
3D measurements in dosage are personalized.Because the measuring method of the embodiment of the present invention is to be customized according to the actual requirements with situation, and
And by three-dimensional modeling, 3D printing and filling, its model can altitude simulation human body real structure, the exposure agent because obtained from
Value and the actual exposure dosage degree of approach are very high, and the ginseng of most worthy can be provided for the implementation of radiotheraping method and plan
Examine.
, wherein it is desired to explanation, the core of measuring method of the present invention are to draw out and actual shape by three-dimensional modeling
The consistent ghost component of shape, ghost component is subjected to 3D printing, equivalent filling and is irradiated by physical condition.By these
Core processing step, purpose are intended to be obtained and the close analogue body mould of human body topnotch according to actual conditions.But the present invention is implemented
The simply part of the embodiment that example is listed, not to the limitation of the inventive method, it should be understood that every to be based on " according to reality
Border situation obtains the analogue body mould close with human anatomic structure, appearance profile and tumor anatomical structure topnotch, to pass through reality
Border irradiation condition analogue body mould is irradiated, so as to measure actual exposure dosage " keynote idea, obtain corresponding three
Dimension module, and the method that actual irradiation condition carries out 3D individualized measurements is simulated, belong to protection scope of the present invention.And it is based on
The core concept, it will be understood by those of skill in the art that the present invention measurement target can personalized customization according to demand, and
It is not limited to the target area of above-described embodiment, jeopardizes histoorgan and plan jeopardizes histoorgan, can also be other arbitrary group
Knit organ.
Above-described is only some embodiments of the present invention.For the person of ordinary skill of the art, not
On the premise of departing from the invention design, various modifications and improvements can be made, these belong to the protection model of the present invention
Enclose.
Claims (9)
1. a kind of body mould for Radiotherapy dosimetry measurement, it is characterised in that the body mould is made by the following method：
Measurement target is obtained according to demand, and three-dimensional modeling is carried out to the irradiation sections comprising the measurement target, and by the photograph
The various pieces for penetrating section are depicted as the three-dimensional thin layer ghost component consistent with true form；
Each three-dimensional thin layer ghost component is subjected to 3D printing, and the three-dimensional thin layer ghost component packing material to printing, bag
Include to three-dimensional thin layer ghost component corresponding to measurement target, be filled by radiation dose measurement material, and to remaining
Three-dimensional thin layer ghost component, is filled by equivalent filler；
The each three-dimensional thin layer ghost assembling components for filling good material are formed by human body into an entirety according to human anatomic structure
Analogue body mould；
Wherein, the equivalent filler refers to the material similar to the attribute of human body appropriate section reception radiation.
2. body mould according to claim 1, it is characterised in that the measurement target is the target area part in medical image,
It is empty that the three-dimensional thin layer ghost component drawn out according to irradiation sections includes target area three-dimensional thin layer ghost component, soft tissue three-dimensional thin layer
Shell component, bone three-dimensional thin layer ghost component, cavity three-dimensional thin layer ghost component and circumference three-dimensional thin layer ghost component,
The target area three-dimensional thin layer ghost component includes tumor target three-dimensional thin layer ghost component, clinical target area three-dimensional thin layer ghost
Component, plan field three-dimensional thin layer ghost component, treatment region three-dimensional thin layer ghost component and irradiated region three-dimensional thin layer ghost component；
Wherein, each target area three-dimensional thin layer ghost component is filled with radiation dose measurement material, to the soft tissue three
Tie up thin layer ghost component, bone three-dimensional thin layer ghost component, cavity three-dimensional thin layer ghost component and circumference three-dimensional thin layer ghost
Component is filled with equivalent filler.
3. body mould according to claim 1, it is characterised in that the measurement target is the histoorgan portion in medical image
Point, the three-dimensional thin layer ghost component drawn out according to irradiation sections include jeopardize histoorgan three-dimensional thin layer ghost component, soft group
Knit three-dimensional thin layer ghost component, bone three-dimensional thin layer ghost component, cavity three-dimensional thin layer ghost component and circumference three-dimensional thin layer
Ghost component,
Wherein, the histoorgan three-dimensional thin layer ghost component that jeopardizes is filled with radiation dose measurement material, to described
Soft tissue three-dimensional thin layer ghost component, bone three-dimensional thin layer ghost component, cavity three-dimensional thin layer ghost component and circumference are three-dimensional
Thin layer ghost component is filled with equivalent filler.
4. body mould according to claim 3, it is characterised in that the three-dimensional thin layer ghost component drawn out according to irradiation sections
Also jeopardize histoorgan three-dimensional thin layer ghost component including plan, it is filled with radiation dose measurement material.
5. the body mould according to any one of Claims 1-4, it is characterised in that the radiation dose measurement material is released for heat
Luminescent material.
6. the body mould according to any one of claim 2 to 4, it is characterised in that the medical image is that CT images or MRI scheme
Picture.
A kind of 7. human body simulation body mould, it is characterised in that drawn including the threedimensional model based on medical image and various pieces
Three-dimensional thin layer ghost component that is corresponding and consistent with true form and being obtained by 3D printing, it is described corresponding with various pieces
Three-dimensional thin layer ghost component in be separately filled with equivalent filler or/and radiation dose measurement material, the body mould is by filling
The each three-dimensional thin layer ghost component of equivalent filler or radiation dose measurement material assembles according to human anatomic structure；
Wherein, the equivalent filler refers to the material similar to the attribute of human body appropriate section reception radiation.
8. body mould according to claim 7, it is characterised in that the radiation dose measurement material is thermoluminescence material.
9. the body mould according to claim 7 or 8, it is characterised in that the medical image is CT images or MRI image.
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| EP3585484A1 (en) * | 2017-02-22 | 2020-01-01 | The Board of Regents of The University of Texas System | Methods, apparatuses, and systems for creating a patient-specific soft bolus for radiotherapy treatment |
| CN109147952A (en) * | 2018-09-19 | 2019-01-04 | 泰山医学院 | A kind of Radiotherapy dosimetry verification method, processor and system |
| CN113331852A (en) * | 2021-07-08 | 2021-09-03 | 苏州大学 | Human body phantom for radiation dose measurement and preparation method and application thereof |
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| CN201051145Y (en) * | 2007-05-11 | 2008-04-23 | 北京大北华光科技发展有限责任公司 | 3D dosage measurement device |
| JP2010057549A (en) * | 2008-09-01 | 2010-03-18 | Mitsubishi Electric Corp | Particle beam treatment regimen assisting device |
| WO2015077881A1 (en) * | 2013-11-27 | 2015-06-04 | Dalhousie University | System and method for manufacturing bolus for radiotherapy using a three-dimensional printer |
| CN104888355A (en) * | 2015-05-05 | 2015-09-09 | 倪昕晔 | Verification method for ensuring accurate operation of intensity modulated radiation therapy |
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|---|---|---|---|---|
| CN201051145Y (en) * | 2007-05-11 | 2008-04-23 | 北京大北华光科技发展有限责任公司 | 3D dosage measurement device |
| JP2010057549A (en) * | 2008-09-01 | 2010-03-18 | Mitsubishi Electric Corp | Particle beam treatment regimen assisting device |
| WO2015077881A1 (en) * | 2013-11-27 | 2015-06-04 | Dalhousie University | System and method for manufacturing bolus for radiotherapy using a three-dimensional printer |
| CN104888355A (en) * | 2015-05-05 | 2015-09-09 | 倪昕晔 | Verification method for ensuring accurate operation of intensity modulated radiation therapy |
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